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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Farmasi Udayana Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Pharmacy Reports Prosiding Workshop dan Seminar Nasional Farmasi (WSNF)
Ni Putu Linda Laksmiani
Jurusan Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES

 1 
OPTIMASI METODE EKSTRAKSI CAIR-CAIR SENYAWA-SENYAWA PADA TABLET EKSTASI DITENTUKAN DENGAN SPEKTROFOTODENSITOMETER Ida Bagus Gde Agung Raditya Eka Putra; Ni Putu Linda Laksmiani; I.N.K. Widjaja
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 5 (2015): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2015.v05.i01.p01

Abstract

A research concerned on liquid-liquid extraction method optimation has been carried out. The optimation was held to choose the extraction solvent and variation of pH. The simulation solution which contained methylendioxy methampethamine, methampethamine, ketamine, and amitryptiline as the internal standard were analyzed by TLC-Spectrophotodensitometry. The extract was spotted on TLC Si 60 G F254 chromatography plate, then eluted by TB mobile phase (cyclohexhane : toluene : dietylamine = 75:15:10). The chromatography plate was scanned at 202 nm. The chromatogram was analyzed based on the ratio between the area under curve (AUC) of the analyte and the AUC of the internal standard. The concentration and the recovery of the extract was determined.The simulation solution was extracted into chloroform and toluene solvent, the best solvent was selected. The selected solvent (chloroform) was used to extract the sample in pH range 10-12. The pH 11.5 was the best condition to extract the sample.The result showed that the optimum liquid-liquid extraction of the compounds on ecstasy was chloroform as the solvent with pH 11.5. This optimum condition give recovery of MDMA (99.192%), MA (98.203%) and ketamine (88.114%).
STUDI PENGARUH BAHAN TAMBAHAN PADA POLA PUNCAK KROMATOGRAM TABLET PARASETAMOL DENGAN TLC-SPEKTROFOTODENSITOMETRI UNTUK DRUG PROFILING Kadek Joni Prayoga; Ni Putu Linda Laksmiani; I Nengah Kadjeng Widjaja
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 5 (2015): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2015.v01.i01.p04

Abstract

The study of chromatogram peak pattern by influence of excipient in paracetamol tablet with TLC- Spectrophotodensitometry method for drug profiling has been done. Sample (6 kind of paracetamol tabletsfrom different factory) and reference compounds were analyzed with TB (cyclohexane : toluene:diethylamine = 75:15:10) and TAEA (toluene : acetone : ethanol: ammonia = 45:45:7:3) as mobile phase andAl-TLC Si 60 G F254 as stationary phase.The initial step was non analyte peak reduction on Al-TLC plate with washing method, drying time and temperature variation. Sample was extracted with 1 ml chloroform and Na2CO3 buffer pH 10 and spotted onAL-TLC plate. First, sample extract from same factory was spotted on one plate, continued by sample extractfrom 6 different factories on one plate which is replicated five fold on each plate that different. Plate was eluted and scanned at 210 nm. Chromatogram was analyzed by cosine and cluster function. C95 value thatwas calculated from sample was used as a parameter to determine the influence of excipient towardchromatogram peak pattern.The result of this research showed that each tablet from same factory gave C95 value near 100 if calculated with cosine function (96 - 98,7 for TB and 78 - 83 for TAEA), whereas if all tablets from 6different factories was used, the excipient from each tablet will give C95 value alteration (63 for TB and 68 for TAEA). Cluster analysis will divide sample into 3 different groups for TB and 1 group for TAEA.
STUDI TINGKAT PENYALAHGUNAAN NARKOBA PADA PELAJAR SLTA (SMA/SMK) DI KABUPATEN TABANAN Ni Putu Linda Laksmiani; Ni Putu Eka Sulastini
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 4 (2014): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The level of drug abuse and drug knowledge among senior high school students in Tabanan regency has been assessed. A simple random sampling method was used to select the students. Under 90% confidence level was obtained 270 students, who involved in this study. The students were asked to answer the questionnaire to find out their knowledge of drug abuse effects. They also followed a urine screen test using rapid EMIT-test for the amphetamine, methamphetamine, opiate, cocaine, cannabis and benzodiazepine. More than 95% of students had a bad level knowledge of drug abuse effect. We found out a positive correlation between frequency students to access drug information online and attending drug-abuser prevention course to their knowledge. Base on screen test was found out just one student positive to benzodiazepine.
Skrining dan Determinasi Senyawa Golongan Opiat pada Sampel Urin dengan Teknik Immunoassay dan KLT-Spektrofotodensitometri Ni Putu Diah Kusuma Dewi; Ni Wayan Intan Indayanti; I Komang Niko Sanjaya; Anak Agung Intan Kharisma Dewi; Ni Putu Linda Laksmiani
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 9 No 2 (2019): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2019.v09.i02.p03

Abstract

Opiates are a class of substances, both natural and semisynthetic that have the ability to relieve pain (analgesics), put to sleep (hypnotics), and cause feelings of joy (euphoric). Repeated use will lead to tolerance (immunity to substances) and dependence. Therefore opiate class compounds besides can be used in medicine, are also very vulnerable to abuse. So that we need a method to detect the presence of opiates in biological specimens, one of which is in the urine. In this study, testing of simulated samples that have been added with certain narcotic compounds. The process of screening of compounds in the urine can be done using the immunoassay technique with a strip test. The test results showed positive for opiates. Confirmation test using TLC Spectrophotodensitometry in the TE mobile phase system (ethyl acetate: methanol: ammonia 85: 10: 5% v/v/v) and the mobile phase TAE (methanol 100% v / v) shows the confirmation of the content of opiate compounds in urine samples simulation is morphine. The next step is the determination test with TLC Spectrophotodensitometry in the TE motion system (ethyl acetate: methanol: ammonia 85: 10: 5% v/v/v) using six series solutions with different concentrations (100, 300, 500, 700, 900, and 1100 ng / µL). The resulting correlation coefficient is 0.9762, LOD is 493.24 ng, and LOQ is 1494.66 ng. In the simulation urine sample morphine levels were 25.55 ?g / mL, 17.56 25.55 ?g / mL, and 14.96 25.55 ?g / mL at three replications. Opiates are a class of substances, both natural and semisynthetic that have the ability to relieve pain (analgesics), put to sleep (hypnotics), and cause feelings of joy (euphoric). Repeated use will lead to tolerance (immunity to substances) and dependence. Therefore opiate class compounds besides can be used in medicine, are also very vulnerable to abuse. So that we need a method to detect the presence of opiates in biological specimens, one of which is in the urine. In this study, testing of simulated samples that have been added with certain narcotic compounds. The process of screening of compounds in the urine can be done using the immunoassay technique with a strip test. The test results showed positive for opiates. Confirmation test using TLC Spectrophotodensitometry in the TE mobile phase system (ethyl acetate: methanol: ammonia 85: 10: 5% v/v/v) and the mobile phase TAE (methanol 100% v / v) shows the confirmation of the content of opiate compounds in urine samples simulation is morphine. The next step is the determination test with TLC Spectrophotodensitometry in the TE motion system (ethyl acetate: methanol: ammonia 85: 10: 5% v/v/v) using six series solutions with different concentrations (100, 300, 500, 700, 900, and 1100 ng / µL). The resulting correlation coefficient is 0.9762, LOD is 493.24 ng, and LOQ is 1494.66 ng. In the simulation urine sample morphine levels were 25.55 ?g / mL, 17.56 25.55 ?g / mL, and 14.96 25.55 ?g / mL at three replications.
Co-Authors A. A.W. Lestari A. B. S. Pawarrangan A.A. Bagus Yoga Saputra A.A.I.K. Dewi Adhyaksa, I Nyoman Mahesa Praba Adiluhur M. A. Anak Agung Intan Kharisma Dewi Andika Prayoga Andini, Kadek Lia Anggreni, Ni Ketut Sri Anggreni, Ni Putu Ruscita Anjani, Ni Luh Ari Krisma Arifin, Muhammad Fajar Arimbawa I.B.S. Cahyani, Ni Ketut Nitya Cokorda Istri Sri Arisanti Cokorda Istri Tirta Rusmala Dewi Coky N. W. C. D.M. Nita Pratiwi Deddi Prima Putra Dewa Ayu Pramesti Utari Dewa Ayu Swastini Dewantari A. A. I. S. H Dewi L. R. Dewi Puspita Apsari Dewi, Cokorda Istri Tirta Rusmala Dewi, Komang Dian Merta Sari Dewi, Ni Kadek Diah Parwati Diarini A. S. Dwivayana, I Kadek Diva E.I. Setyawan Edy Meiyanto Febyani, Putu Dewi Fitriari, Diah Mawarni G. A. K. Amarawati G.A.D. Mayagita H. Prabowo I G.P. Putra I Gusti Ayu Made Srinadi I Gusti Ngurah Agung Dewantara Putra I K. Duantara I K. N. Sanjaya I K.N. Sanjaya I Ketut Gede Gilang Gama Harta I Komang Niko Sanjaya I Made Agus Gelgel Wirasuta I N.K. Widjaja I Nengah Kadjeng Widjaja I P.W. I P. W. Nugraha I P.Y. Astara Putra I W. A. Widiantara I W. I. Prayoga I W. Suwartawan I.G.A. Januarta I.G.N.A.D. Putra I.K. Subagia I.N.K. Widjaja I.P. Priyasana Ida Bagus Gde Agung Raditya Eka Putra K. D. Adnyani K. D. Adnyani K. M. Arianti K. R. Reynaldi K.M. Limba K.R Suciptha K.W. Astuti Kadek Joni Prayoga Ketut Widyani Astuti Ketut Yuantarisa Kartika Putri Krisnayana, I Gede Bayu L. W. E. Lestari L.P.F. Larasanty M. A. P. P. Rashid M. B. O. Rastini M. D. Widyastuti M. I. Widiastari Mahaswari, Anak Agung Istri Rani Mirayanti, Ni Putu Dinda N. K. M. Giantari N. K. M. Giantari N. K. M. Noviyanti N. K.S. Ani N. L. P. V. Paramita N.K. Cornelia Ayu Trisna N.N.A.S. Devi N.P.A.D. Wijayanti N.P.M.P.P. Winarni N.PA.D. Wijayanti Ni Kadek Warditiani Ni Luh Ari Krisma Anjani Ni Luh Putu Cintya Pramesti Ni Made Ary Sarasmita Ni Made Pitri Susanti Ni Made Rita Wiantini Ni Putu Ayu Dewi Wijayanti Ni Putu Diah Kusuma Dewi Ni Putu Eka Leliqia Ni Putu Eka Sulastini Ni Putu Ruscita Anggreni Ni Wayan Intan Indayanti Nyunda, Ricky Putra Banyim Oka M. P. A. I. A. Siaka P. V. P. Putri P.D. Wilantari P.P. Pramita Dewi Pande Made Nova Armita Sari, Pande Made Nova Pradnyana Putra Pradnyana, I Gusti Ngurah Agung Pradnyaswari, G. A. Desya Pramesti, Ni Luh Putu Cintya Pratama, I Putu Ari Anggara Catur Pujasari, Luh Wayan Sita Purnama, I.G.P.P Putra, I Made Harimbawa Putra, Komang Dian Aditya Putra, Made Ferdio Amarta Putri, Ketut Yuantarisa Kartika Putri, Lucienne Agatha Larasati Nugraha Putri, Putu Rika Jesika Putri, Wahyu Nadi Eka Putu Rika Jesika Putri Rashid, M.A.P.P Ratna Asmah Susidarti Rismayanti, A. A. M. I. Ritmaleni, Ritmaleni Rumiyati, Rumiyati Saputra, Made Agus Widiana Sari, Ida Ayu Yadnyaningtias Permata Sasi Ani Silawarti, Putu Ayu Karunia Sismindari . Sonia Sonia Suastika, I.G.A. Sunariyani, P. E. A. Suryadewi, Kadek Dinda Ulfatul Husnaa Utari, Dewa Ayu Pramesti V. Rahmadinha Wayan Suwartawan Wiantini, Ni Made Rita Widjaja, I. N. K. Widjaja, I. N. K.. Winarti, N.W. Wiratama Nugraha Yan Ramona Yudiastra, I.K. Yustiantara, Putu Sanna