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All Journal Jurnal Pendidikan dan Pembelajaran Khatulistiwa (JPPK) PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman Science and Technology Indonesia JURNAL ATOMIK Acta Chimica Asiana Jurnal Riset Kefarmasian Indonesia Narra J Jurnal Ilmiah Sains Jurnal Bahan Alam Terbarukan Jurnal Abdimas Mahakam
Eva Marliana, Eva
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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TEST OF AMYLASE INHIBITION ACTIVITY OF METHANOL EXTRACT SINGKIL LEAF (Premna cordifolia Roxb.) Anggriani, Yusnia Wati; Astuti, Winni; Marliana, Eva
PROSIDING SEMINAR KIMIA Vol 2 No 1 (2023): Prosiding SNK 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Singkil (Premna cordifolia Roxb.) is a plant that is widely found un Kalimantan. The people of Kalimantan are often used singkil leaf by as traditional medicine are believed to have medicinal properties as a cure for intestinal worms, colds, and antidiabetic. In this research, it used phytochemical screening and inhibition activity amylase test on singkil’s methanol extract. The objective of this study was to determine in-vitro enzyme amilase inhibition activity against sampel by DNS method. The result of this research was phytochemical screening in singkil’s methanol extract contains alkaloids, flavonoids, saponins and phenolics. Singkil leaf methanol extract at a concentration of 10 µg/mL can inhibit the activity of the amylase enzyme with an inhibition value of 60,93 %. Acarbose used as a positive control in this study showed activity against the amylase of 44,79 %. Amylase inhibition activity of methanol extract was higher than acarbose, the singkil leaf methanol extract has the potential as an antidiabetic drug. Keywords: Premna cordifolia Roxb., Amylase inhibition, Secondary Metabolites.
OPTIMATION TIME PRODUCTION SECONDARY METABOLITES ENDOFIT BACTERIES EXTRACT OF PUCUK MERAH LEAVES (Syzygium myrtifolium Walp.) Rahimah, Priliza; Astuti, Winni; Marliana, Eva
PROSIDING SEMINAR KIMIA Vol 2 No 1 (2023): Prosiding SNK 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Pucuk Merah (Syzygium myrtifolium Walp.) is an ornamental plant that has benefits as an antioxidant, antibacterial, antiplatelet, antiulcerative, antimalarial, antiviral, antihyperglycemic and anti-inflammatory. This research aims to determine the optimum time for the production of secondary metabolites of pucuk merah endophytic bacteria for amylase and protease inhibition. Production of secondary metabolites was carried out at various times of 24 hours, 48 ​​hours and 72 hours. The method for the amylase inhibition test used the DNS method and the protease inhibition test used the Bradford method. The results showed that the optimum time for the production of secondary metabolites was 48 hours. Keywords: Syzygium myrtifolium Walp., Endophyte Bacteria, Production Time.
THE POTENTIAL OF EXTRACT SINGKIL LEAVES (Premna cordifolia Roxb.) AS ANTIBACTERIAL AGENTS AGAINST Propionibacterium acnes Az-zahra, Deannisa Khoiru; Astuti, Winni; Marliana, Eva
PROSIDING SEMINAR KIMIA Vol 2 No 1 (2023): Prosiding SNK 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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One of the causes of acne is infection by the bacteria Propionibacterium acnes. Singkil (Premna cordifolia Roxb.) is a kind of herb plant from Kutai Kartanegara which is used as a traditional herb including for acne’s treatment. This study aims to know the content of secondary metabolites compound in singkil’s extract and determine the antibacterial activity against Propionibacterium acnes KCCM 41747 bacteria. In this study, it’s phytochemical screening and antibacterial activity test using the disc diffusion method on methanol extract, n-hexane, ethyl acetate and water-methanol fractions. the result of phytochemical screening revealed that methanol extract of singkil contains alkaloids, flavonoids, steroids, and saponins. The n-hexane fraction contains steroids and the ethyl acetate fraction contains alkaloids, flavonoids, and phenolics while the water-methanol fraction contains alkaloids, flavonoids, and phenolics. The antibacterial activity test extract with a concentration of 10% showed that the diameter of clear zone of the metanol extract, n-hexane fraction, ethyl acetate fraction, and water-methanol fraction were 13 mm, 9 mm, 13,67 mm and 6 mm, respectively. The ethyl acetate fraction had the highest antibacterial activity among the four extracts. A minimum inhibitory concentration value of the ethyl acetate fraction against Propionibacterium acnes KCCM 41747 was 0,625%. The ethyl acetate fraction have the potential as an antibacterial against the bacteria Propionibacterium acnes KCCM 41747. Keywords: Premna cordifolia Roxb., Secondary metabolites, Propionibacterium acnes KCCM 41747
UJI AKTIVITAS ANTIBAKTERI RIMPANG KUNYIT PUTIH (Kaempferia rotundaL.) TERHADAP Streptococcus sobrinus DAN Salmonella typhi -, Nurfadzillah; Marliana, Eva; Ruga, Ritbey
JURNAL ATOMIK Vol 6 No 2 (2021)
Publisher : Jurusan Kimia FMIPA UNMUL

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An infectious disease caused by bacteria is a disease that often occurs in tropical areas. The used of plant extract is an interesting object of study to overcome these infectious diseases and because of an increase in bacterial resistance to antibiotics. White turmeric rhizome widely used by Indonesia society as an herb which has been used for the treatment of diarrhea and abdominal pain. This study aims to determine the content of secondary metabolities and inhibitory of white turmeric rhizome (Kaempferia rotunda L.) against Streptococcus sobrinus KCCM 11898 and Salmonella typhi ATCC 422 bacteria. The results of phytochemical screening white turmeric rhizome contained compound triterpenoids, steroids, phenolics, and saponins. An antibacterial activity test used agar diffusion method against Streptococcus sobrinus KCCM 11898 and Salmonella typhi ATCC 422 bacteria. Antibacterial activity white turmeric rhizome (Kaempferia rotunda L.) with concentration 1, 2, 4, 8% have an inhibition zone diameter against Streptococcus sobrinus KCCM 11898 bacteria is 10.33, 10.67, 17 and 25.17 mm respectively with the antibacterial strength is strong, meanwhile in Salmonella typhi ATCC 422 bacteria have an inhibition zone diameter was 8, 8.3, 11.83 and 13 mm respectively with the antibacterial strength is intermediate. Keywords: Antibacterial, White Turmeric Rhizome (Kaempferia rotunda L.), Agar Difussion
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL KULIT BUAH PISANG AMBON (Musa paradisiaca var. sapientum (L.) Kunt.) DENGAN METODE DPPH Tullah, Mirna Hidaya; Marliana, Eva; Erwin, Erwin
JURNAL ATOMIK Vol 8 No 2 (2023)
Publisher : Jurusan Kimia FMIPA UNMUL

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Test of antioxidant activity of ambon banana peel (Musa paradisiaca var. sapientum (L.) Kunt.) methanol extract has been done. Test were carried out using a UV-Vis spectrophotometer based on the DPPH radical scavenging method with positive control of vitamin C. Antioxidant activity was obtained based on the IC50 value of 104,31 mg/L. IC50 value indicates that the peel of Ambon banana (Musa paradisiaca var. sapientum (L.) Kunt.) has antioxidant activity which is included in the moderate category.
POTENSI ANTIBAKTERI EKSTRAK ETANOL MENIRAN (Phyllanthus niruri L.) TERHADAP BAKTERI Streptococcus sobrinus DAN Salmonella typhi Rakasiwi, Dea; Astuti, Winni; Marliana, Eva
JURNAL ATOMIK Vol 8 No 1 (2023)
Publisher : Jurusan Kimia FMIPA UNMUL

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Meniran (Phyllanthus niruri L.) is one of the herb plants used as traditional medicine, such as toothache medicine and diarrhea medicine. The purposed of this study was to determined the type of secondary metabolites in the ethanol extract of meniran herb and to determined the minimum inhibitory concentration (MIC) value of the ethanol extract of meniran (Phyllanthus niruri L.) to Streptococcus sobrinus KCCM 11898 and Salmonella typhi ATCC 422. The ethanol extract of meniran was tested for phytochemicals. The MIC value of the ethanol extract of meniran herb for the test bacteria was obtained by varying the concentration of the ethanol extract of meniran herbs. Phytochemical test results showed that the ethanol extract of meniran herbs contains alkaloids, phenolics and steroids. The minimum inhibitory concentration value of the ethanol extract of meniran herb at the bacteria Streptococcus sobrinus KCCM 11898 and Salmonella typhi ATCC 422 each was 0.625%. Keywords: Phyllanthus niruri L, minimum inhibitory concentration (MIC), Streptococcus sobrinus KCCM 11898, Salmonella typhi ATCC 422
PHYTOCHEMICAL TEST AND TOXICITY (Brine Shrimp Lethality Test) IN ETHANOL EXTRACT, ETHYL ACETATE FRACTION AND RESIDUAL ETHANOL FRACTION OF AJERAN LEAVES (Bidens pilosa L.) Audia, Nuraini Meti; -, Daniel; Marliana, Eva
JURNAL ATOMIK Vol 5 No 2 (2020)
Publisher : Jurusan Kimia FMIPA UNMUL

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Phytochemical test and toxicity in ethanol extract, ethyl acetate fraction and residual ethanol fraction of ajeran leaves (Bidens pilosa L.) has been done. The method used to determine secondary metabolites is clualitative test and the value of Lethal Concentration (LC50) with the Brine Shrimp Lethality Test (BSLT). Phytochemical test results showed that the ethanol extract and ethyl acetate fraction contained flavonoid, steroid and phenol compound. Residual ethanol fraction contained flavonoid and phenol compound. Toxicity test showed ethanol extract had LC50 value of 862.19 ppm. Ethyl acetate fraction has LC50 value of 8.26 ppm. Residual ethanol fraction had LC50 value of 275.24 ppm. The results of the toxicity test can be concluded that the ethyl acetate fraction very toxic category, ethanol extract and residual ethanol fraction included toxic category. The results that obtained from GC-MS characterization were steroid
TEST OF AMYLASE INHIBITION ACTIVITY OF Melicope PLANTS WHICH POTENTIAL AS ANTIDIABETIC AGENTS Nurjanah, Siti; Marliana, Eva; Astuti, Winni
JURNAL ATOMIK Vol 5 No 2 (2020)
Publisher : Jurusan Kimia FMIPA UNMUL

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The test of amylase inhibition activity of the leaves of Melicope lunu-ankenda and bark of Melicope glabra (BI.) T.G. Hartley extracts were done. The objective of this study was to determine in-vitro α-amylase inhibition activity against two samples by DNS method. The result showed that two samples of Melicope lunu-ankenda leaves and bark of Melicope glabra (BI.) TG Hartley displayed the enzyme inhibitory effect with percent inhibitions of 48.71% and 46.36%. Two sample extracts can inhibit amylase. It can be suggested that about sample were potential as antidiabetic agents.
UJI AKTIVITAS TABIR SURYA EKSTRAK HERBA MENIRAN (Phyllanthus niruri L.) Nabila, Sahira Fara; Koesnarpadi, Soerja; Widodo, Nanang Tri; Isyahro, Novia Rahmawati; Marliana, Eva
JURNAL ATOMIK Vol 7 No 2 (2022)
Publisher : Jurusan Kimia FMIPA UNMUL

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Tests of sunscreen activity of meniran (Phyllanthus niruri L.) herbs extract has been done. The methodwas carried out using an UV-Vis spectrophotometer in vitro based on the method of A. J. Petro. The sunscreenactivity based on the value of the Sun Protection Factor (SPF) meniran herbs extract, respectively, was 1,826;3,337; 6,096; 11,132 and 20,354. The SPF value of sunscreen activity showed that meniran herbs extract has aminimum to ultra protection category.
RESPON TRAKEOSPASMOLITIK EKSTRAK METANOL DAUN Macaranga lamellata Whitmore SECARA IN VITRO Afandi, Irvan; Astuti, Winni; Marliana, Eva
JURNAL ATOMIK Vol 7 No 1 (2022)
Publisher : Jurusan Kimia FMIPA UNMUL

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The research about in vitro trakeospasmolytic response of methanol extract of Macaranga lamellata Whitmore leaves was carried out. This research was conducted to determine the spasmolytic effect of the methanol extract of Macaranga lamellata Whitmore leaves on changes in separate organ of the guinea pig ring tracheal. The methods used include the bioassay isolated organ with two groups of treatment, control group and extract group. Methanol extract was given cumulatively on the organ bath. Positive control is used aminofilin and negative control is used DMSO solvent. Phytochemical test results showed that total methanol extract contained alkaloids, polyphenol, steroids, flavonoids dan saponins while phytochemical test results showed on ethyl acetate fraction contained alkaloids, polyphenol, steroids, quinons dan flavonoids. The Percentage change in tracheal smooth muscle as a spasmolytic response by using methanol extract with cumulative concentration of 0.3, 1 dan 3 mg/mL respectively -24.925%; -29.865% and -36.795% . This research is shown methanol extract of Macaranga lamellata Whitmore leaves have antiasthma effect based on the tracheospasmolytic activity. Keywords: Antiasthma, Bioassay isolated organ, Macaranga lamellata Whitmore, Marmot, Trakeopasmolytic.
Co-Authors -, Nurfadzillah Afandi, Irvan Agustina R. M. Alma Yulvita Pebriana Amalia, Elfiza Aman S. Panggabean Amantha, Dhita Novalia Anggriani, Yusnia Wati Aryoga Oktabriangga Saputra Audia, Nuraini Meti Ayu Mellyanti Az-zahra, Deannisa Khoiru Chairul salaeh Daniel Daniel -, Daniel Daniel Daniel Daniel Daniel Daniel Daniel Daniel Daniel Dewi, Dynda Rosiana Djihan Ryn Pratiwi Djihan Ryn Pratiwi, Djihan Ryn Doni Prio Atmoko Dwi Lestari Ersa Marina Rahmawati Erwin Erwin Erwin Erwin Erwin Erwin Erwin Erwin Fikriah, Ika Firmansyah, Muchammad Ravi Husnul Chatimah Ika Yekti Liana Sari Indra Masmur irfa Ashari Hyahara Isyahro, Novia Rahmawati Jumaidil Awal K Y Margiati, K Y Kim, Soo-Ya Kim, Yong-ung Kusuma, Irawan W. Madaniah Fathirah Magdaleni, Agustina Rahayu Masmur, Hestina Masruhin, Muhammad A. Medi Hendra Medi Hendra, Medi Mikdariawan, Adha Muh. Naufal Hisyam Muhammad Marion Akbar Mulyadi Tanjung Mulyana Mulyana Mulyana Mulyana Nabila, Sahira Fara Nanang Tri Widodo Nanang Tri Widodo Nanang Tri Widodo Nisa, Nahdia Khairun Noor Hindryawati Noor Hindryawati, Noor Novia Rahmawati Isyahro Novia Rahmawati Isyahro Nur Aina Nur Hidayah Nur Khasanah Nur Khsanah Nurul Jannah Pramana, Aditiya Hadi Ryan Purnamasari, Ade Rezki Rachman, Ferry Aditya Rahimah, Priliza Rahmat Gunawan Rakasiwi, Dea Ramadhani, Riski Vebryanti Ratih Dewi Saputri Ratna Kusuma Rismawati Rismawati Rita Hairani Ritbey Ruga Ritson Purba, Ritson Rudi Kartika, Rudi Ruga, Ritbey Saibun Sitorus Saleh, Chairul Siti Halidjah Siti Mariyatul Ulfah Siti Nurjanah Soerja Koesnarpadi Subur P Pasaribu Swandari Paramita Syamsul Arifin T, Nurnaningsi Teguh Wirawan, Teguh Tjitjik Sri Tjahjandarie Tjitjik Srie Tjahjandarie Tullah, Mirna Hidaya Winni Astuti Winni Astuti, Winni