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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cermin Dunia Kedokteran Indonesian Journal of Cancer
Bidasari Lubis
Department Of Child Health, Universitas Sumatera Utara Medical School, Medan, North Sumatra
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Perbandingan Pemberian Vitamin K Dosis Tunggal Intramuskular pada Bayi Prematur dan Aterm Terhadap Masa Protrombin Asrul Asrul; Nancy Ervani; Bugis M Lubis; Emil Azlin; Lily Emsyah; Bidasari Lubis; Guslihan D Tjipta
Sari Pediatri Vol 9, No 1 (2007)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp9.1.2007.17-22

Abstract

Latar belakang. Defisiensi vitamin K atau hypoprothrombinemia pada bayi baru lahir dapat menyebabkanperdarahan karena faktor koagulasi yang bergantung vitamin K tidak adekuat. Bayi prematur kurangmemperlihatkan respon optimal dengan pemberian vitamin K disebabkan imaturitas sel hati.Tujuan penelitian. Mengetahui apakah vitamin K dosis tunggal intramuskular sama efektifnya padabayi prematur dibandingkan dengan bayi aterm terhadap masa protrombin.Metode. Uji klinis bayi baru lahir prematur dan aterm yang dirawat antara bulan Februari – Juli 2006 diRumah Sakit Pirngadi Medan. Kriteria eksklusi ialah menggunakan antibiotik, bayi denganhiperbilirubinemia. Pemeriksaan masa protrombin (PT) dilakukan sebelum pemberian vitamin K padahari pertama dan diulapng pemeriksaan PT pada hari ketiga terhadap bayi prematur dan aterm. Analisisstatistik secara uji t independen dan berpasangan, indeks kepercayaan 95%, kemaknaan p<0,05.Hasil. Dari 38 bayi prematur, 20 laki-laki, 18 perempuan dan 38 bayi aterm, 18 laki, 20 perempuan.Nilai PT bayi prematur hari pertama; rata-rata 38,7±18,4 detik, hari ketiga; 22,9±6,6 detik. Pada bayiaterm PT hari pertama; rata-rata 30,0±17,7 detik, pada hari ketiga rata-rata 16.9±7.3 detik. Tidak bermaknanilai PT pada hari pertama, namun terdapat perbedaan bermakna nilai PT pada hari ketiga antara bayiprematur dan aterm. Rata-rata terjadi penurunan nilai PT pada hari ketiga.Kesimpulan. Terdapat perbedaan bermakna nilai PT antara bayi prematur dengan aterm sebelum dan sesudahdiberikan vitamin K dosis tunggal intramuskular. Perubahan nilai PT antara hari pertama dengan hari ketigabaik pada bayi aterm maupun prematur setelah diberikan vitamin K
Terapi dan Suplementasi Besi pada Anak Dedy Gunadi; Bidasari Lubis; Nelly Rosdiana
Sari Pediatri Vol 11, No 3 (2009)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp11.3.2009.207-11

Abstract

Anemia defisiensi besi (ADB) merupakan jenis anemia yang paling sering ditemukan di dunia, terutama di negara yang sedang berkembang. Hal ini sehubungan dengan kemampuan ekonomi yang terbatas, masukan protein hewani yang rendah, dan infestasi parasit. Dari hasil survei rumah tangga di Indonesia pada tahun 1995 didapati ADB 40,5% pada anak balita dan 47,2% pada anak usia sekolah. Defisiensi besi dapat menyebabkan gangguan terhadap respon imun sehingga rentan terhadap infeksi, gangguan gastrointestinal, gangguan fungsi kognitif, tumbuh kembang, dan perubahan tingkah laku. Diagnosis ditegakkan berdasarkan gejala pucat menahun tanpa disertai perdarahan maupun pembesaran organ dan dipastikan dengan pemeriksaan kadar besi dalam serum. Terapi besi dengan dosis 3-6 mg besi elemental/kgBB/hari diberikan kepada semua pasien ADB dengan monitor kenaikan kadar hemoglobin setelah 2-4 minggu. Terapi dilanjutkan 4-6 bulan setelah kadar hemoglobin mencapai normal untuk menambah isi cadangan besi, dan terapi terhadap penyakit dasarnya harus diberikan. Suplementasi besi harus diberikan pada bayi yang mempunyai risiko tinggi terhadap kejadian ADB seperti bayi berat badan lahir rendah (BBLR), prematur, bayi yang mendapat susu formula rendah besi, dan bayi lahir dari ibu yang menderita anemia selama kehamilan
Dampak Kardiotoksik Obat Kemoterapi Golongan Antrasiklin Irwan Harpen Siahaan; Tina Christina Tobing; Nelly Rosdiana; Bidasari Lubis
Sari Pediatri Vol 9, No 2 (2007)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp9.2.2007.151-6

Abstract

Pengobatan kanker semakin pesat beberapa tahun terakhir dengan pilihan kombinasi obat kemoterapi,radioterapi dan pembedahan. Salah satu obat kemoterapi yaitu golongan antrasiklin, tetapi obat inimempunyai efek samping terhadap jantung yang tergantung dosis kumulatif pemakaian obat. Efek terhadapjantung dibagi menjadi efek cepat dan lambat. Efek cepat terjadi pada <1% kasus kanker. Sering ditemukanadalah efek lambat, dan seringkali subklinis. Mekanisme kerja obat diduga melalui proses ikatan denganDNA. Setelah pemberian obat intravena kadar obat dalam plasma akan menurun cepat dan bertahan lamadi jaringan, sehingga diperlukan pemantauan seumur hidup. Prosedur diagnostik untuk mendeteksi efekini adalah EKG, ekokardiografi, angiografi dan biopsi endomiokardium. Pencegahan yang dapat dilakukanyaitu penggunaan analog obat, membatasi jumlah obat yang masuk, mencari alternatif cara pemberianobat, dan pemberian obat yang disertai dengan obat yang melindungi jantung. Tantangan pemberian obatgolongan antrasiklin adalah bagaimana mengurangi efek toksik terhadap jantung sementara efek obatterhadap kanker tidak berkurang.
Peran Eritropoetin pada Anemia Bayi Prematur Lily Rahmawati; Bidasari Lubis
Sari Pediatri Vol 7, No 3 (2005)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp7.3.2005.143-8

Abstract

Anemia sering terjadi pada bayi prematur, ditandai oleh penurunan nilai hematokrit,retikulosit dan kadar eritropoetin endogen rendah. Di Amerika Serikat, 60-80% bayiberat lahir sangat rendah (BBLSR) mengalami anemia dan membutuhkan transfusi seldarah merah berulang sehingga mempunyai risiko terjadi komplikasi penularan penyakit.Salah satu upaya menurunkan kebutuhan transfusi tersebut dengan pemberianeritropoetin eksogen yaitu recombinant human eritropoietin (r-HU EPO) yang berfungsimerangsang proliferasi, diferensiasi dan maturasi sel darah merah dalam sumsum tulang.Walaupun pada bayi prematur dijumpai kadar eritropoetin yang sangat rendah, namunprogenitor eritroid tetap sensitif terhadap eritropoetin eksogen. Pemberian r-HU EPOdapat meningkatkan eritropoesis sehingga bermanfaat mengurangi kebutuhan transfusipada anemia bayi prematur. Pemberian dalam dosis cukup pada usia dini, suplementasipreparat besi dan protein mempunyai efektifitas yang baik. Berbagai penelitian terhadappenggunaan r-HU EPO pada anemia bayi prematur telah dilakukan tetapi belum adakesepakatan mengenai protokol pemberian, termasuk waktu, dosis, cara, dan durasipemberian. [
Prevalence and risk factors of hearing loss in children with solid tumors treated with platinum-based chemotherapy Eka D Edward; Nelly Rosdiana; Farhat Farhat; Olga Rasiyanti Siregar; Bidasari Lubis
Paediatrica Indonesiana Vol 55 No 3 (2015): May 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.793 KB) | DOI: 10.14238/pi55.3.2015.121-5

Abstract

Background The platinum-based chemotherapy drugs, cisplatin and carboplatin, are widely used in the treatment of several types of solid tumors. However, the treatment has side effects including hearing loss.Objective To evaluate the prevalence of hearing loss related to platinum-based chemotherapy and to identify associated factors.Methods A cross-sectional study was performed in Adam Malik Hospital, Medan, North Sumatera, from April to July 2012. Twenty-two subjects who fulfilled the eligibility criteria underwent otoacoustic emission evaluations. Eleven children had received cisplatin and eleven had received carboplatin. The association between hearing loss and risk factors was assessed using Fisher’s exact and Chi-square tests.Results Seven subjects with hearing loss were identified. Five of these patients (5 out of 11) had received cisplatin and 2 patients (2 out of 11) had received carboplatin. There was no statistically significant difference between carboplatin- and cisplatin-associated hearing loss (P=0.361). Neither gender (P=0.452) nor age (P=0.212) was related to hearing loss. However, higher cumulative chemotherapy doses (cisplatin >600 mg/m² and carboplatin >1800 mg/m²) were associated with hearing loss (P=0.022 and P=0.004, respectively).Conclusion Patients who had higher cumulative doses of platinum-based chemotherapy are at risk for developing hearing loss.
Quality of life in children with cancer and their normal siblings Hilda Hilda; Bidasari Lubis; Hakimi Hakimi; Olga Rasiyanti Siregar
Paediatrica Indonesiana Vol 55 No 5 (2015): September 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.585 KB) | DOI: 10.14238/pi55.5.2015.243-7

Abstract

Background Cancer treatment in children influences the quality of life of patients and their families. The Pediatric Quality of Life (PedsQL) inventory is a questionnaire to assess quality of life of the healthy and ill children. Objective To compare quality of life in children with cancer and their normal siblings, and to compare quality of life in those with hematologic malignancies to those with solid tumors. Methods A cross-sectional study was conducted among 5-to-18- year-olds at the Hematology-Oncology Division at Haji Adam Malik Hospital, Medan, North Sumatera, from May to July 2012. The case group (subjects with cancer) filled the PedsQL 3.0 and 4.0 questionnaires, while the control group (normal siblings) filled only the PedsQL 4.0 questionnaire. Independent T-test was used to compare the quality of life between children with cancer and their normal siblings. Results There were 46 children in each group. The PedsQL 4.0 results in children with cancer and their normal siblings, and PedsQL 3.0 between hematology malignant and solid cancer were as follows: physical function 36.9 vs. 80.7, respectively (95%CI of differences -52.639 to -34.990; P= 0.0001), emotional function 40.4 vs. 69.3, respectively (95%CI of differences -35.912 to -21.914; P=0.0001), social function 71.5 vs. 93.9, respectively (95%CI of differences - 29.238 to -15.587; P=0.0001), school function 20.7 vs. 74.2, respectively (95%CI of differences - 62.124 to -44.832; P=0.0001), and total score 42.1 vs. 79.3, respectively (95%CI of differences - 43.066 to -31.344; P=0.0001). School function was the most affected parameter in children with cancer compared to their normal siblings. Conclusion There is a significant difference in quality of life between children with cancer and their normal siblings, for all four parameters examined by the PedsQL inventory. However, there are no significant differences in quality of life between children with hematologic malignancy and those with solid cancer.
Hematological scoring system as an early diagnostic tool for neonatal sepsis Fathia Meirina; Bidasari Lubis; Tiangsa Sembiring; Nelly Rosdiana; Olga Siregar
Paediatrica Indonesiana Vol 55 No 6 (2015): November 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.432 KB) | DOI: 10.14238/pi55.6.2015.315-21

Abstract

Background Sepsis was the leading cause of death in babies by 30%-50% in developing countries. Early diagnosis of neonatal sepsis is still a difficult problem because of clinical features are not specific. Blood culture is the gold standard, but it takes several days and is expensive. The hematological scoring system (HSS) consists of hematologic parameters (leucocyte count, polymorphonuclear (PMN) cells, degenerative changes, and platelet count) for early diagnosis of neonatal sepsis. Objective To measure HSS as an early diagnostic tool for neonatal sepsis. Methods A cross sectional study was conducted in March to June 2013. Samples were collected by consecutive sampling. Fourty neonates suspected sepsis in neonatology unit H. Adam Malik Hospital, Medan, North Sumatera, underwent routine blood count, blood culture, and peripheral blood smear. Each hematologic parameters were analysed using the HSS of Rodwell et al. The hematologic parameters were total leucocyte count, total PMN cells, total PMN immature, I:T PMN ratio, I:M PMN ratio, degenerative changes, and platelet count. The total value revealed HSS score. Diagnostic study parameters were calculated. Results Ten of fourty neonates had sepsis based on blood culture results. The HSS score >=4 had sensitivity 80%, specificity 90%, with positive predictive value (PPV) 73%, negative predictive value (NPV) 93%, ROC curve showed cut off point 0.902 (95% CI 0.803 to 1.0). Conclusion Score HSS >=4 could be used as an early diagnostic tool for neonatal sepsis.
Parental knowledge, attitude and practice on malaria in Mandailing Natal district Syafruddin Haris; Sri Sofyani; Bidasari Lubis; Munar Lubis; Syahril Pasaribu; Iskandar Z. Lubis
Paediatrica Indonesiana Vol 47 No 4 (2007): July 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.312 KB) | DOI: 10.14238/pi47.4.2007.161-5

Abstract

Background Malaria is still considered to be an important healthproblem in Indonesia. Malaria has been found in islands withdifferent degree of endemicity. Behavior of the community isone of the factors affecting the incidence of malaria in MandailingNatal district.Objective To know the parental knowledge, attitude, and practiceamong parents whose children suffered from malaria or not.Methods A cross sectional study was conducted in six primaryschools and one health centre in October 2004. Subjects wereparents whose children were malaria positive and malaria negativebased on laboratory examination. Sample size was 85 parents foreach group. Selected respondents were interviewed usingstructured questionnaire. Degree of knowledge, attitude, andpractice on malaria were established using scoring system withinthree categories: good, less, and poor. Data were collected andpresented using chi-square and P<0.05 was considered as a levelof significant.Results The mean age of 85 parents whose children were positivemalaria, was 38.47 years (SD 6.67) and the mean age of thosewhose children were negative malaria was 40.41 years (SD 8.05).Parent’s education level was 62.9% primary school and 90% oftheir children were school-aged. There were significant differenceson parental knowledge, attitude and practice in each group(P<0.05). There was also a significant correlation betweenoccupation and knowledge, but not between parental educationlevel and parental age. Parental knowledge and attitude on theincidence of malaria in Mandailing Natal district were good,though their practice were poor.Conclusion There are significant differences on parentalknowledge, attitude and practice, between parents whose childrenwere positive and negative for malaria.
Delayed cord clamping for prevention of iron deficiency anemia in term infants Olga Rasiyanti Siregar; Bugis Lubis; Muara Lubis; Bidasari Lubis; Guslihan Dasa Tjipta
Paediatrica Indonesiana Vol 52 No 4 (2012): July 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.655 KB) | DOI: 10.14238/pi52.4.2012.223-8

Abstract

Background Iron deficiency childhood is a concern due to its potentially detrimental effectson development, some of which may be irreversible even after irontreatment. Delayed cord clamping may prevent IDA by increasingan infant's iron reserve at birth.Objective We aimed to evaluate the effect of delayed umbilicalcord clamping at birth on the iron status in newborns at age 24hours of life.Methods This randomized, single􀁒blind study was conducted fromMarch to May 2009, at two general hospitals in Medan, NorthSumatera Province. Eligible newborn infants were randomlyassigned to one of two groups: early cord clamping (Eee)performed 15 seconds after delivery or delayed cord clamping(DeC) performed 2 minutes after delivery. Infants were placed ontheir mothers' abdomens before the umbilical cords were clamped.Hematologic status was determined from umbilical cord blood.Results Sixty􀁒three subjects were included in our study, consistingof31 infants in the Eee group and 32 infants in the Dec group.We found that mean neonatal hemoglobin level was higher inthe Dec group than in the Eee group ( 18.4 g% and 16.2 g%,respectively, P=O.OOOl). Also, mean ferritin level was higher inthe Dec group than in the Eee group (556 mg/dL and 329 mg/dL, respectively, p=o.o 15). Other hematological status indicators,including mean hematocrit and mean corpuscular volume (MeV)level, were also higher in the Dec group. However, mean redblood cell levels were not significantly groups. Nor was there a significant level between the Dec and Eee groups.Concl usion Dela y ed cord c l a m p i n g m a y improve ironstatus and prevent IDA in term infants. [Paediatr Indones.2012;52:223-8].
Effect of iron and zinc supplementation in the treatment of malaria in children Danny Dasraf; Bugis Mardina Lubis; Bidasari Lubis; Nelly Rosdiana; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.527 KB) | DOI: 10.14238/pi47.6.2007.256-60

Abstract

Background Iron and zinc administration for children withmalaria in endemic area were known to decrease parasitemia butdata on their effectiveness when given together to increasereticulocytes as erythropoiesis parameter and hemoglobin isinsufficient.Objective To determine the effect of zinc to increase ironabsorption in the treatment of Plasmodium falciparum malaria inchildren.Methods Children with positive Plasmodium falciparum on theirblood smear (n=86) examination were randomly assigned to dailysupplementation of iron 6 mg per kg body weight per day plusplacebo or iron plus zinc 10 mg per day for 30 days. Venous bloodspecimens were collected at the start and at the end of the study.Results Sixty-nine children completed the supplementations andhad both baseline and follow-up blood specimen study. After 30-day supplementation, the iron plus placebo and iron plus zincgroups showed significant difference on hemoglobin concentration(0.58 and 0.09 g/dl; P<0.05). There was no significant differencein reticulocyte production index and reticulocyte count beforeand after intervention in both groups. There was only significantdifference in red blood cells concentration after supplementationof iron plus placebo and iron plus zinc (4.7 in 4.5 million/μl;P<0.05).Conclusions Iron supplementation with or without zinc showssignificant increase of hemoglobin concentration. It is slightlyhigher in iron plus placebo group.
Co-Authors Ade Hariza Harahap Adi Koesoema Aman Adi Koesoema Aman Adi Sutjipto Adi Sutjipto Adi Sutjipto Adillida Adillida Ahmad Faisal Ani Ariani Arman J. O. Panjaitan Asrul Asrul Aznan Lelo Bebi Trianita Sari Bistok Saing Budi Andri Ferdian Bugis Lubis Bugis M Lubis Bugis Mardina Lubis Chairuddin P. Lubis Charles Siregar Dachrul Aldy Danny Dasraf Dedi Gunadi Dedy Gunadi Dedy Gunadi Dina Lyfia Dini Lailani Eka D Edward Elvi Andriani Emil Azlin Emil Azlin Erlina Masniari Napitupulu Farhat Farhat Fathia Meirina, Fathia Fera Wahyuni Guslihan D Tjipta Guslihan D Tjipta Guslihan Dasa Tjipta Guslihan Dasa Tjipta Hakimi Hakimi Hakimi Hakimi Helena Siregar Herman Hariman Herman Hariman Hilda Hilda Ichwan HH Batubara Irwan Harpen Siahaan Iskandar Z. Lubis Leon Agustian Leon Agustian, Leon Lily Emsyah Lily Rahmawati Lubis, Irania Thariaty Malayana R Nasution Masyitah Sri Wahyuni Melda Deliana Muara Lubis Muhammad Ali Muhammad Ali Muhammad Ali Munar Lubis Nancy Ervani Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Netty D. Lubuis Noersida Raid Nofareni Nofareni Nurdiani Nurdiani Olga R. Siregar OLGA RASIYANTI SIREGAR, OLGA RASIYANTI Olga Siregar Paulina K. Bangun Perjuangan Dapot Hamonangan Simbolon Pertin Sianturi Putri Chadijah Tampubolon Reni Suryanty Ridwan M. Daulay Rina A C Saragih Rina A.C. Saragih Rina AC Saragih Rita Angraini Rita Carmelia Rita Carmelia Rosmayanti Syafriani Siregar Rusdi Andid Rusdidjas -, Rusdidjas Saur L Margaretha Selvi Nafianti Selvi Nafianti, Selvi Sembiring, Krisnarta Sisca Silvana Sisca Silvana, Sisca Sri Sofyani Sri Sofyani Syafruddin Haris Syahril Pasaribu T. Mirda Zulaicha Tiangsa Sembiring Tiangsa Sembiring Tiangsa Sembiring, Tiangsa Tina Christina Tobing Trie Hariweni Trie Hariweni Vinisia Setiadji Wisman Dalimunte Y Dimyati Yoyoh Yusroh