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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cermin Dunia Kedokteran Indonesian Journal of Cancer Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute

Bidasari Lubis

Department Of Child Health, Universitas Sumatera Utara Medical School, Medan, North Sumatra

Author-ID : 309005

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Articles

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Comparison of once a day and three times a day iron treatment in 9-12 year old elementary school children with iron deficiency anemia Dedy Gunadi; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Background The compliance of iron deficiency anemia treatmentthat is administered three times daily in children is low. Thecompliance will be better if therapy is administered once daily.Objective To compare the iron therapy response of once per dayvs. three times a day administration in 9-12 year old children withiron deficiency anemia.Methods Children with iron deficiency anemia were randomlyallocated into a ferrous sulfate once-daily group or a ferrous sulfatethree times-daily group with the same dose of 5 mg/kg /day ofelemental iron for 30 days. Iron deficiency anemia was definedas Hb < 12 g/dL (World Health Organization criteria), MCV< 70 fl, RDW > 16 %, Mentzer index > 13 and RDW index >220. Iron treatment response was characterized by the increase inHb level 30 days after treatment. Peripheral blood samples werecollected at the start and end of the study.Results Ninety seven children were enrolled. There weresignificant increases in Hb levels in both groups after 30 days ofiron therapy, but there was no significant difference in Hb levelbetween the two groups (P=0.55).Conclusion The administration of a once daily dose of ferroussulfate did not show a significant difference in the increase ofHblevels compared to a three times daily dose.

Effect of iron treatment on nutritional status of children with iron deficiency anemia Leon Agustian; Tiangsa Sembiring; Ani Ariani; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 3 (2009): May 2009
Publisher : Indonesian Pediatric Society

Background Iron has been shown to improve growth in childrenwith iron deficiency anemia (IDA), as indicted by increases inheight and weight. Frequently, malnutrition and iron deficiencycoexist.Objective To determine the effect of iron treatment on nutritionalstatus in children with IDA.Methods A randomized placebo-controlled clinical trial wasconducted at Bilah Hulu, a subdistrict of Labuhan Batu, NorthSumatera, Indonesia, between November 2006 and February2007. Iron deficiency anemia was diagnosed if there anemiawas present along with MCHC <31%, RDW index >220 andMentzer index> 13. Elementary school children (8-12 years old)with IDA were randomly assigned to either receive a daily therapyof 6 mg iron/kg/day or a placebo for three months. Nutritionalstatus was evaluated by anthropometric assessment before andafter intervention.Results From 300 subjects recruited, there were 111 (3 7 .2%)with iron deficiency anemia; 108 of them completed the therapy.After intervention, the iron and placebo groups had differentmean hemoglobin concentrations (P <0.05), but there was nosignificant difference in mean weight and height gain betweenthe two groups.Conclusion A significant increase in hemoglobin concentrationwas seen when iron was given, but did not affect weight and height increase in the subjects.

Impact of iron therapy on Mentzer index and red cell distribution width index in primary school children with iron deficiency anemia Budi Andri Ferdian; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 4 (2009): July 2009
Publisher : Indonesian Pediatric Society

Background Iron deficiency anemia (IDA) remains a commonnutritional problem, especially in school-age children. Due tothe many examinations that are needed to be performed and the invasive gold standard procedure, an easy and simple alternative examination to diagnose IDA is needed.Objective To determine the impact of iron therapy on Mentzerand red cell distribution width (RDW) indexes of children withIDA.Methods A randomized open clinical trial was conducted inprimary school aged children in North Aek Nabara, betweenNovember 2006 and November 2007. IDA was determined basedon WHO criteria. Subjects with severe anemia were excluded.Subjects were randomly assigned to groups that received eitheriron therapy or a placebo.Results Three-hundred subjects from aged 9 to 12 years oldwere recruited and 104 subjects completed the study. The meanRDW index of the iron and placebo groups after three monthsobservation were 239.96 (SD 39.25) and 235.17 (SD 31.77),respectively. The mean Mentzer index mean for the iron therapyand placebo groups after three months observation were 16.08(SD 1.98) and 16.20 (SD 2.27), respectively.Conclusion After therapy, there are no significant differences ineither the Mentzer or RDW indexes between the therapy andplacebo groups.

Growth velocity in elementary school children with iron deficiency anemia after iron therapy Dina Lyfia; Melda Deliana; Hakimi Hakimi; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Background Iron supplementation in children with iron deficiencyanemia could decrease the incidence of stunting.Objective To study the effect of iron therapy on growth velocityin children with iron deficiency anemia.Methods A randomized clinical trial study was conducted atLabuhan Batu on November 2006 to May 2007. Iron deficiencyanemia was diagnosed if there were anemia, with mean corpuscular hemoglobin concentration <31 %, red cell distribution width index > 220, and Mentzer index> 13. Elementary school children (6-12 year old) with iron deficiency anemia were randomly assigned either to iron therapy group (children were given 6 mg iron/kg/day) or to placebo group for 3 months.Results Among 300 children recruited, there were 125 children,who suffered from iron deficiency anemia. After one month ofiron therapy, means of hemoglobin concentration were 12.4 g/dl in iron group and 11.7 g/dl in placebo group. There was a significant increase of height in iron group (129.9 (SD 7.58) em vs. 132.2 (SD 7.23) em) and in placebo (130.8 (SD 8.78) em vs. 128.7 (SD 8. 79) em), However, no significant difference was found in the mean of growth velocity between placebo and iron groups (2.1 (SD 0.01) em vs. 2.0 (SD 0.9) em.Conclusion There is a significant increase in height, but nosignificant difference between both groups in growth velocity.

Behavior of elementary schoolchildren with iron deficiency anemia after iron therapy Rina A.C. Saragih; T. Mirda Zulaicha; Sri Sofyani; Bidasari Lubis; Iskandar Z. Lubis
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Background Some studies had been performed to determine theassociation between iron status and children's behavior yet it isstill controversial.Objective To investigate whether iron therapy has an effect onthe behavior of children with iron deficiency anemia (IDA).Method A randomized placebo-controlled clinical trial wasconducted in Labuhan Batu on November 2006-April2007. IDAwas defined as Hb < 12 g/dl, MCHC< 31%, ROW index > 220and Mentzer index> 13. Elementary school children (6-12 yearsold) with IDA were randomly assigned to the treatment groupwith a daily therapy of 6 mg iron/kg/day or placebo group for three months. The subjects' behavior was evaluated with child behavior check list (CBCL) before and six months after intervention.Results After six months, 110 subjects completed the therapy.Scores of CBCL in iron group after intervention were internalizing42.64 (SO 9.95), externalizing 37.13 (SO 9.04) & total score 38.24 (SO 10.20). There was significant decreased on externalizing and total problems score in the treatment group after intervention (P< 0.05). However, there was no significant difference on scores between groups.Conclusion Iron therapy had significantly decrease CBCL scoreon externalizing and total problems in the treatment group,however there was no significant difference on scores if comparedwith placebo group.

Liver dysfunction in children with hematologic malignancy or solid tumor Rita Carmelia; Bidasari Lubis; Adi Sutjipto; Trie Hariweni
Paediatrica Indonesiana Vol 43 No 4 (2003): July 2003
Publisher : Indonesian Pediatric Society

Background Deficiencies in liver synthetic function can only bedetected if the damage is severe, which are more often due to nonhepatic factors such as malignancies, both hematologic and solidtumor.Objective To assess liver function in children with either hemato-logic malignancy or solid tumor and to find out which one of themmostly affects liver function.Methods A retrospective study was conducted on 125 childrenwith malignancies in the Sub division of Hemato-Oncology De-partment of Child Health, Adam Malik Hospital, Medan, from Janu-ary 1999 until May 2000. The inclusion criteria included all pa-tients who were younger than 15 years and had not received anytreatment yet. The differences between prevalent liver dysfunctionin both groups were assessed by using chi-square test; Fisherâ€™sexact test was used to know the type of liver cell damage.Results Liver dysfunction occurred in both types of malignancies. Adecrease of albumin level was not significant in both groups. Therewas a statistically significant difference between the prolongedprothrombine time (PT) in hematologic malignancy (26.4%) and thatin solid tumor (10.4%) with p=0.03. There was no significant differ-ence in the elevation of serum transaminase concentration, totalbilirubin, and alkaline phosphatase. Based on aspartate aminotrans-ferase (AST) and alanine aminotransferase (ALT) ratio, we foundthat the type of liver cell damages was infiltrative disorders, occurred13 out of 20 cases with elevated AST and ALT.Conclusion Liver dysfunction occurred in both types of malig-nancy; it occurred more frequently in hematologic malignancy thanin solid tumors

Hemoglobin level and cardiothoracic ratio in children with chronic severe anemia Fera Wahyuni; Muhammad Ali; Bidasari Lubis; Netty D. Lubuis; Tina Christina Tobing
Paediatrica Indonesiana Vol 51 No 5 (2011): September 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.5.2011.262-5

Background Chronic severe anemia is known to increase cardiac output when the hemoglobin levels are < 7 g/dL for more than three months. Chronic severe anemia is also associated with a high incidence of cardiac enlargement and congestive heart failure.Objective To determine the relationship between hemoglobin level and cardiothoracic ratio in children with chronic severe anemia.Methods We conducted a cross-sectional study in Haji Adam Malik Hospital, Medan, Indonesia from October to December 2009. Subjects had chronic severe anemia and were aged 1 to 15 years. Hematological data was collected at the beginning of the study. The heart was considered enlarged if the cardiothoracic ratio (CTR) was greater than 50% (0.50) by chest roentgenogram. We used simple linear regression to analyze the relationship between hemoglobin and CTR values.Results Thirty subjects enrolled in our study. Their mean age was 115.7 months (SD 56.95). Hemoglobin levels ranged from 2.1 to 6.9 g/dL. The mean hemoglobin level and duration of anemia were 4.71 g/dL (SD 1.48) and 3.9 months (SD 0.70), respectively. Heart enlargement was observed in 23 patients (76.6%). The CTR ranged from 0.52 to 0.69, with a mean of 0.54 (SD 0.06). We found a significant correlation between CTR and hemoglobin levels with Pearsonâ€™s correlation coefficient, (r) = - 0.612 and P = 0.001.Conclusion Low hemoglobin levels significantly correlated with high CTR values in children with chronic severe anemia. [Paediatr Indones. 2011;51:262-5].

Quality of life assessment of children with thalassemia Masyitah Sri Wahyuni; Muhammad Ali; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 51 No 3 (2011): May 2011
Publisher : Indonesian Pediatric Society

Background Thalassemia is a chronic disease that is becoming aÂ major health problem in the world, including the Mediterranean,Â as well as Malaysia, Thailand and Indonesia. This condition clearlyÂ affects the patient's quality of life, because of the condition itself andthe effects of treatment. Assessment is needed to detennine actionsÂ to be taken to improve the quality of life in thalassemic children.Objective To assess the differences in quality of life of thalassemicÂ children compared to their normal siblings.Methods We perfonned a crossô€Œsectional study from May 2010Â until June 2010 in H. Adam Malik Hospital, Medan and the homeÂ of a member of the North Sumatra Chapter of the Association ofÂ Parents of Thalassemia Sufferers (perhimpunan Orangtua PenderitaTalasemia Indonesia, POPTI). Thalassemic children aged 5-18Â years and their age and genderô€Œadjusted siblings were divided intoÂ two groups: case group and control group. Parents and childrenÂ were asked to fill the PedsQL (Pediatric Quality of life Inventory)version 4.0 questionnaire to assess their quality of life.Results There were 59 children in each group. The assessments ofÂ four quality of life domains in the thalassemic group vs the controlÂ group showed the folloMng: physical function 53.1 vs 71.5 (95%Â CI -21.41 to -15.26, Pô€O.OOOI), emotional function 50.9 vs 62.9Â (95% CI -16.82 to -7 .41, Pô€O.OOO 1), social function 62.5 vs 72.8Â (95% CI-13.50 to -7.01, Pô€O.OOOI) and school function 36.2 vsÂ 56.0 (95% CI -22.95 to -16.71, Pô€O.OOOI). Total scores were 50.9Â vs 66.1 (95% CI -18.20to -13.12, Pô€O.OOOI). School function wasÂ the most affected parameter studied, with thalassemic childrenÂ scoring lower than the control group.Conclusion There were significant decreases in the quality ofÂ life parameters in the thalassemic group compared to the controlÂ group. Thalassemic children have poorer quality oflife comparedÂ to their nonnal siblings, Mth school function being the mostaffected domain.Â

The relation of BCG vaccination and severe malnutrition with the occurrence of tuberculous meningitis Nofareni Nofareni; Bistok Saing; Ridwan M. Daulay; Bidasari Lubis
Paediatrica Indonesiana Vol 44 No 1 (2004): January 2004
Publisher : Indonesian Pediatric Society

Objectives To assess BCG vaccination and nutritional states inchildren with tuberculous meningitis and their relations with theoccurrence of tuberculous meningitis.Methods A case-control study was conducted at the Divisionof Neurology, Department of Child Health, Adam Malik Hospi-tal, Medan, from January 1997 to December 2000. Subjects ofthis study were all tuberculous meningitis patients and primarytuberculosis patients as the control group. Odds ratio (OR) wasused to assess the risk of tuberculous meningitis in patientswith positive BCG vaccination and (1-OR) was used to assessthe efficacy of BCG to prevent tuberculous meningitis.Results Four out of sixteen tuberculous meningitis patients werevaccinated, while 10 of 16 primary tuberculosis patients were vac-cinated (p=0.03). OR of vaccinated patients to get tuberculousmeningitis was 0.2 (95%CI 0.04;0.91). The efficacy of BCG vacci-nation to prevent tuberculous meningitis was 1-0.2 = 0.8. The riskof severe malnourished patients to get tuberculous meningitis was2.33 (95%CI 0.52;10.48; p=0.26).Conclusion Most tuberculous meningitis patients were not BCGvaccinated. Severe malnutrition did not play role in the occurrenceof this disease

The effectiveness of chloroquine compared to Fansidar in treating falciparum malaria Emil Azlin; Ichwan HH Batubara; Wisman Dalimunte; Charles Siregar; Bidasari Lubis; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 44 No 1 (2004): January 2004
Publisher : Indonesian Pediatric Society

Background The most difficult problem in eradicating malaria isthe resistance of P. falciparum to drugs. Mandailing Natal has thehighest malaria incidence in North Sumatera.Objective This study aimed to investigate the efficacy of chloro-quine and Fansidar in treating falciparum malaria.Methods A randomized double-blind study was done from April toMay 2001. Eighty-three patients with acute uncomplicated P.falciparum malaria infection were randomized into two groups.Group I (35 patients) received chloroquine and group II (48 pa-tients) received Fansidar. Blood examinations were performed onthe 1 st , 2 nd , 7 th , and 28 th days.Results The resistance of P. falciparum to drugs in the chloro-quine group were found in 10 patients with R II and 1 patients withR III, while in the Fansidar group, there were 14 patients with R II.Conclusion The efficacy of chloroquine and Fansidar in treatingfalciparum malaria was not significantly different

Co-Authors Ade Hariza Harahap Adi Koesoema Aman Adi Koesoema Aman Adi Sutjipto Adi Sutjipto Adi Sutjipto Adillida Adillida Ahmad Faisal Ani Ariani Arman J. O. Panjaitan Asrul Asrul Aznan Lelo Bebi Trianita Sari Bistok Saing Budi Andri Ferdian Bugis Lubis Bugis M Lubis Bugis Mardina Lubis Candini, Naura Anindya Chairuddin P. Lubis Charles Siregar Dachrul Aldy Damayanti R. Sjarif Damayanti Rusli Sjarif Danny Dasraf Dedi Gunadi Dedy Gunadi Dedy Gunadi Dina Lyfia Dini Lailani Eka D Edward Elvi Andriani Emil Azlin Emil Azlin Erlina Masniari Napitupulu Farhat Farhat Fathia Meirina, Fathia Fera Wahyuni Fitri Primacakti, Fitri Guslihan D Tjipta Guslihan D Tjipta Guslihan Dasa Tjipta Guslihan Dasa Tjipta Hakimi Hakimi Hakimi Hakimi Helena Siregar Herman Hariman Herman Hariman Hilda Hilda Ichwan HH Batubara Irwan Harpen Siahaan Iskandar Z. Lubis Joedo Prihartono Leon Agustian Leon Agustian, Leon Lily Emsyah Lily Rahmawati Lubis, Irania Thariaty Malayana R Nasution Masyitah Sri Wahyuni Melda Deliana Muara Lubis Muhammad Ali Muhammad Ali Muhammad Ali Munar Lubis Nancy Ervani Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Netty D. Lubuis Noersida Raid Nofareni Nofareni Novie Amelia Chozie Nurdiani Nurdiani Olga R. Siregar OLGA RASIYANTI SIREGAR, OLGA RASIYANTI Olga Siregar Paulina K. Bangun Perjuangan Dapot Hamonangan Simbolon Pertin Sianturi Pustika Amalia Wahidiyat, Pustika Amalia Putri Chadijah Tampubolon Ramadhani, Nadhifa Tazkia Reni Suryanty Ridwan M. Daulay Rina A C Saragih Rina A.C. Saragih Rina AC Saragih Rita Angraini Rita Carmelia Rita Carmelia Rosmayanti Syafriani Siregar Rusdi Andid Rusdidjas -, Rusdidjas Salsabila, Sheila Claudhea Saur L Margaretha Selvi Nafianti Selvi Nafianti, Selvi Sembiring, Krisnarta Sisca Silvana Sisca Silvana, Sisca Sri Sofyani Sri Sofyani Sukartini, Ninik Syafruddin Haris Syahril Pasaribu T. Mirda Zulaicha Tiangsa Sembiring Tiangsa Sembiring Tiangsa Sembiring, Tiangsa Tina Christina Tobing Trie Hariweni Trie Hariweni Vinisia Setiadji Wisman Dalimunte Y Dimyati Yoyoh Yusroh

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