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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cermin Dunia Kedokteran Indonesian Journal of Cancer Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute

Bidasari Lubis

Department Of Child Health, Universitas Sumatera Utara Medical School, Medan, North Sumatra

Author-ID : 309005

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hemolytic anemia in falciparum and vivax malarial patients based on serum bilirubin examination Yoyoh Yusroh; Bidasari Lubis; Syahril Pasaribu; Munar Lubis; Tiangsa Sembiring; Adillida Adillida
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Objective To examine hemolysis in falciparum and vivax malarialpatients based on serum bilirubin examination.Methods A cross sectional study was conducted on childrenyounger than 15 years of age who visited public health center inthe district of Mandailing Natal with complaints of fever, shivering,pale, jaundice, diarrhea, or headache between April 9 th and April19 th 2001. Variables recorded were age, gender, body weight, bodyheight, symptoms and signs, anti malarial drugs, and laboratorytest results. Thin and thick blood smears were done as diagnostictools of malaria. Thin blood smear was also performed to deter-mine the level of malaria parasites in blood (parasitemia) and toexamine the morphology of red blood cells. Hemolysis was deter-mined by bilirubin examination.Results In P. falciparum malaria, there was a moderate correlation(r=0.68, p<0.0001) between parasitemia and indirect bilirubin con-centration. While in P. vivax malaria, there was only a weak corre-lation (r=0.46, p=0.007) between parasitemia and indirect bilirubinconcentration. It was also found that in falciparum malaria, para-sitemia, total and indirect bilirubin concentrations were significantlyhigher than that in vivax malaria, with p values of 0.009, 0.015 and0.003, respectively.Conclusion Hemolysis in falciparum malaria is more severe thanthat in P. vivax malaria, with marked elevation of indirect bilirubin.The elevation of serum bilirubin correlated with parasitemia

Correlation between parasitemia and spleen size in patients with P. falciparum infection Dini Lailani; Munar Lubis; Bidasari Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Background Spleen is an important organ in immunity to malariainfection which is always affected in malaria patients. Enlargementof the spleen is one of the main clinical symptoms of malaria. Levelof parasitemia is related to the risk of complications.Objective To describe the correlation between parasitemia andspleen size in patients with P.falciparum infection.Methods One hundred and four patients including children andadults with fever, pale, jaundice, diarrhea, and headache who vis-ited public health centers in 5 villages in Mandailing Natal, NorthSumatera were enrolled in this study. The diagnosis of malariawas based on blood smears stained by Giemsa method, while thespleen size was measured using Hackett method. Correlation be-tween parasitemia and spleen size was tested by Spearman rankcorrelation.Results Splenomegaly was found in 37 of 104 patients (35.6 %)with the size of H1 in 10.6 %, H2 in 15.4 %, H3 in 9.6 %. The meanparasite count between patients with and without splenomegalywas different, and the difference was significant between patientswith spleen size of H0 and H3. The higher the parasitemia, thebigger the spleen size was (r=0.291; p=0.03).Conclusion There was a correlation between parasitemia andspleen size in falciparum malarial infection

The effect of vitamin A supplementation on morbidity due to Plasmodium falciparum Adillida Adillida; Yoyoh Yusroh; Munar Lubis; Bidasari Lubis; Tiangsa Sembiring; Syahril Pasaribu
Paediatrica Indonesiana Vol 44 No 4 (2004): July 2004
Publisher : Indonesian Pediatric Society

Objective To investigate the effect of vitamin A supplementationon malaria morbidity.Methods The study was a randomized double-blind placebo-con-trolled trial, conducted in Panyabungan, Mandailing Natal, NorthSumatera from April 2001 to April 2002. Children aged 6-60 monthssuffering from falciparum malaria were randomly assigned to highdose vitamin A or placebo every 4 months for a year. All childrenwere treated in accordance with health center policy. Malaria mor-bidity was assessed from health center visit due to fever, diarrhea,cough, or abdominal pain. Parents gave reports if their child re-ceived malaria treatment from other health centers.Results The number of febrile episodes (probable malaria illness)was lower in the treatment group than that of control, but not sig-nificant. The parasitemia was not different between both groups.There was a significant difference in spleen enlargement betweenthe treatment group and control (p=0.04). There was no differencein health center visit between the two groups.Conclusion The findings suggest that vitamin A supplementationhas only effect on spleen enlargement in malaria.

Comparison of absolute neutrophil count between premature and term infants Ahmad Faisal; Guslihan D Tjipta; Bidasari Lubis; Dachrul Aldy
Paediatrica Indonesiana Vol 44 No 5 (2004): September 2004
Publisher : Indonesian Pediatric Society

Background Neutrophils are very important in the body defenseagainst bacterial infection. Absolute neutrophil count (ANC) couldbe used for the recognition of early-onset bacterial sepsis inneonates.Objective The aim of this study was to compare the value of ANCbetween premature and term infants, to assess the prevalence ofearly-onset neutropenia in premature infants and its relationshipwith prematurity, and to find out the correlation between gesta-tional age and ANC.Methods A cross-sectional study was conducted during Februaryto May 2003. Subjects were newborn infants with gestational ageof less than 37 weeks who were born in Adam Malik and PirngadiHospitals, Medan. Newborn infants with severe asphyxia (5-minuteApgar score of less than 4), fever, seizure, and maternalhypertension were excluded. Complete blood count was done bymeans of automatic cell counter (Micros (R) , Germany). Term healthyinfants were used as control subjects.Results ANC differed significantly between both groups (p=0.0001).The prevalence of early-onset neutropenia in premature infantswas 9% (95%CI 0.065;0.21). Prematurity was related with theincidence of neutropenia with a prevalence ratio of 1.1. Therewas a weak positive correlation between gestational age andANC with an r-value of 0.49 (p=0.0001).Conclusions ANC in premature infants differs from that in terminfants. The prevalence of early-onset neutropenia in prematureinfants was 9% (95%CI 0.065;0.21). Prematurity is related with theincidence of early-onset neutropenia in newborn infants. There isa correlation between gestational age and ANC

Association between soil-transmitted helminthiasis and hemoglobin concentration in primary school children Rita Angraini; Y Dimyati; Bidasari Lubis; Syahril Pasaribu; Chairuddin P Lubis
Paediatrica Indonesiana Vol 45 No 1 (2005): January 2005
Publisher : Indonesian Pediatric Society

Objectives To determine the association between intestinal hel-minthiasis and hemoglobin (Hb) concentration and to observe theeffect of single dose albendazole treatment on Hb concentration.Methods An experimental study was carried out from March toJuly 2002 on primary school children at Suka Village, Tiga PanahSubdistrict, Karo Regency, North Sumatera Province. From 366children who suffered from helminthiasis, 113 were selected assubjects by simple random sampling. Subjects were treated with asingle oral dose of 400 mg albendazole. Hb concentration wasexamined using the cyanide method twice i.e., prior to and threemonths after treatment with albendazole.Results It was found that among 113 subjects, the prevalences ofAscaris lumbricoides, Trichuris trichiura, and mixed infestation were18.3%, 40.4%, and 41.3%, respectively, while the prevalence ofanemia was 33.0%. There was no significant difference in age,gender, nutritional status, and mean Hb concentration betweenchildren suffering from the different types of worm infestation(P>0.05). For each type of infestation, there were significant differ-ences in mean Hb concentration and anemia prevalence beforeand after treatment (P<0.05).Conclusions There was no difference between the Hb concen-trations of children suffering from Ascaris lumbricoides, Trichuristrichiura, and mixed-type worm infestations. Single dose 400 mgalbendazole was beneficial in increasing Hb concentration andreducing the occurrence of anemia

The effect of iron versus iron plus zinc supplementation in children with malaria Bugis Mardina Lubis; Danny Dasraf; Nelly Rosdiana; Bidasari Lubis; Munar Lubis; Syahril Pasaribu; Chairuddin P Lubis
Paediatrica Indonesiana Vol 46 No 1 (2006): January 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.1.2006.7-12

Introduction Little is known about the potential interaction of ironand zinc given to increase hemoglobin and serum ferritin in chil-dren with malaria.Objective To study the effect of iron compared with a combination ofiron and zinc supplementation on children with falciparum malaria.Method Children with positive Plasmodium falciparum (n=86) wererandomly assigned to a daily supplementation of 6 mg iron/kg perday plus placebo or plus 10 mg zinc per day for 30 days. All childrenwere treated with the same regimen for the treatment of P. falciparum.Venous blood samples were collected at the start and end of thestudy. After 30 days of supplementation, the baseline and follow-upblood samples were analyzed.Results The increase of hemoglobin concentration in the ironplus placebo group was 0.58 g/dl, while in the iron plus zinc groupwas 0.09 g/dl (P<0.05). Serum ferritin concentration was high inboth groups before trial, yet there was no significant differenceafter iron supplementation.Conclusions Iron supplementation showed significant increasein hemoglobin concentration in children with positive P. falciparumtreated with the same regimen of treatment. Supplementation ofiron alone as well as iron plus zinc had been proven ineffective toiincrease serum ferritin in children with malaria.

Nasopharyngeal carcinoma in childhood Bidasari Lubis; Nelly Rosdiana; Saur L Margaretha
Paediatrica Indonesiana Vol 45 No 6 (2005): November 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.6.2005.280-4

Nasopharyngeal carcinoma (NPC) is a raretumor which originates from thenasopharyngeal epithelium. It accountsfor <1% of childhood malignancy cases,whereas almost all adult nasopharyngeal cancers arecarcinomas. In children, nasopharyngealmalignancies are mostly rhabdomyosarcomas andonly 20-30% are carcinomas or lymphomas.Approximately one third of the undifferentiated typeNPC is diagnosed in adolescents or young adults.

Correlation between hemoglobin level and left ventricular systolic functions and dimensions in children with chronic severe anemia Erlina Masniari Napitupulu; Fera Wahyuni; Tina Christina L. Tobing; Muhammad Ali; Bidasari Lubis
Paediatrica Indonesiana Vol 51 No 2 (2011): March 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.2.2011.79-83

Background Chronic severe anemia is a connnon disease. Cardiac output may increase when the hemoglobin (Hb) level decreases to < 7 g/dL for 3 months or more. Alteration of left ventricular (LV) function occurs frequently in children 'With chronic severe anemia, in the {onn of concentric LV hypertrophy, LV dilatation with or v.ithout LV hypertrophy, or systolic dysfunction.Â Objective To examine the correlation between Hb level and alteration of LV systolic function in children with chronic severe anemia.Â Methods We conducted a cross-sectional study in Adam Malik Hospital from October to December 2009. Subjects were chronic severely anemic children. Left ventricular systolic function (ejection fraction/EF, fractional shortening/FS) and dimensions (left ventricular end diastolic diameter/LVEDD and left ventricular end systolic diameter/LVESD) were measured using Hitachi EUB 5500 echocardiography unit. Univariate analysisÂ and Pearson correlation were performed.Results Thirty children were enrolled in the study. The mean of age was 113.5 months (SD 53.24). Hb values ranged from 2.1 to 6.9 g/dL with mean value of 4.6 g/dL (SD 1.44). Mean duration of anemia was 3.9 months (SD 0.70). Chronic severe anemia was not associated \\lith decreased LV systolic function [EF 62.2% (SD 9.16), r =0.296, P=0.112; FS 33.8% (SD 7.26), r =0.115, P=0.545], nor LV dimension changes [LVEDD 40.2 mm (SD 6.85), r = -0.192, P=0.308; LVESD 26.2 mm (SD 4.98), r=-0.266, P=0.156].Â Conclusion There was no correlation between Hb level in chronically anemic children and changes in LV systolic function or dimension.

Clinical features of children with retinoblastoma in Adam Malik Hospital, Medan, Indonesia Bidasari Lubis
Paediatrica Indonesiana Vol 41 No 9-10 (2001): September 2001
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi41.5.2001.234-6

We reviewed patents with retinoblastoma treated at the Department of Child Health, Adam Malik Hospital, Medan from January 1995 to December 1999. Clinical staging was based on Reese-Ellsworth classification (when the disease was limited to the eyeball) or on St Jude Children's Research Hospital (when the disease has extended beyond the eyeball). A total 19 retinoblastoma patients were available, from which 9 were males. Fifteen patients were less than 5 years old, and the average age at diagnosis was 3 years 8 months. In most patients the disease started at the age of less than 5 years, and they presented themselves with advanced stage as usually seen in developing countries. In nine patients the retinoblastoma affected the right eye, 8 affected the left eye, and in 2 patients the tumor was bilateral. The most common presenting symptom on admission was proptosis. Pathological confirmation was obtained in all patients. Bone marrow puncture was done in 15 patients; of whom 13 showed bone marrow metastasis. Since 1998 the standard treatment for patients with proptosis in stage III or IV of the disease was pre-operative chemotherapy followed by enucleation, radiation and chemotherapy.

Risk factors of childhood leukemia Paulina K. Bangun; Bidasari Lubis; Sri Sofyani; Nelly Rosdiana; Olga R. Siregar
Paediatrica Indonesiana Vol 54 No 6 (2014): November 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi54.6.2014.358-64

Background The incidence of childhood leukemia has increasedannually. Recent studies have shown that childhood leukemia isinitiated in utero, and have focused on prenatal risk factors suchas birth weight and parental age. Exposure to pesticides andradiation, as well as parental smoking, breastfeeding, and thenumber of older siblings have also been sugges ted as risk factorsfor childhood leukemia.Objective To evaluate possible risk factors for childhood leukemia,including birth weight, parental age, and other risk factors.Methods This case-con trol study was conducted from October2011 to February 2012 in Haji Adam Malik Hospital, Medan .Case subjects were children aged below 18 years and diagnosedwith leukemia. Control subjects were children aged below 18years who were diagnosed with any non-cancerous acute illnessesin this hospital, and individually matched for age and gen der tothe case subject group. Patients and parents were asked to fill astructured questionnaire. Data was analyzed using conditionallogistic regression .Results A total of 140 subjects were eligible, with 70 subjects ineach group. Birth weight 2: 4000 g and maternal age 2:35 yearswere significant risk factors with OR 10.13 (95%CI 1.124 to 91.2 7)and OR 4.98 (95%CI 1.276 to 19.445), respectively. Paternal ageof 2:35 years was not a significant risk factor. Exposure to pesticideswas also noted as another significant risk factor (OR= 6.66; 95%CI2.021 to 21.966) .Conclusion High birth weight, advan ced maternal age, andexposure to pesticides are risk factors of childhood leukemia.

Co-Authors Ade Hariza Harahap Adi Koesoema Aman Adi Koesoema Aman Adi Sutjipto Adi Sutjipto Adi Sutjipto Adillida Adillida Ahmad Faisal Ani Ariani Arman J. O. Panjaitan Asrul Asrul Aznan Lelo Bebi Trianita Sari Bistok Saing Budi Andri Ferdian Bugis Lubis Bugis M Lubis Bugis Mardina Lubis Candini, Naura Anindya Chairuddin P. Lubis Charles Siregar Dachrul Aldy Damayanti R. Sjarif Damayanti Rusli Sjarif Danny Dasraf Dedi Gunadi Dedy Gunadi Dedy Gunadi Dina Lyfia Dini Lailani Eka D Edward Elvi Andriani Emil Azlin Emil Azlin Erlina Masniari Napitupulu Farhat Farhat Fathia Meirina, Fathia Fera Wahyuni Fitri Primacakti, Fitri Guslihan D Tjipta Guslihan D Tjipta Guslihan Dasa Tjipta Guslihan Dasa Tjipta Hakimi Hakimi Hakimi Hakimi Helena Siregar Herman Hariman Herman Hariman Hilda Hilda Ichwan HH Batubara Irwan Harpen Siahaan Iskandar Z. Lubis Joedo Prihartono Leon Agustian Leon Agustian, Leon Lily Emsyah Lily Rahmawati Lubis, Irania Thariaty Malayana R Nasution Masyitah Sri Wahyuni Melda Deliana Muara Lubis Muhammad Ali Muhammad Ali Muhammad Ali Munar Lubis Nancy Ervani Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Netty D. Lubuis Noersida Raid Nofareni Nofareni Novie Amelia Chozie Nurdiani Nurdiani Olga R. Siregar OLGA RASIYANTI SIREGAR, OLGA RASIYANTI Olga Siregar Paulina K. Bangun Perjuangan Dapot Hamonangan Simbolon Pertin Sianturi Pustika Amalia Wahidiyat, Pustika Amalia Putri Chadijah Tampubolon Ramadhani, Nadhifa Tazkia Reni Suryanty Ridwan M. Daulay Rina A C Saragih Rina A.C. Saragih Rina AC Saragih Rita Angraini Rita Carmelia Rita Carmelia Rosmayanti Syafriani Siregar Rusdi Andid Rusdidjas -, Rusdidjas Salsabila, Sheila Claudhea Saur L Margaretha Selvi Nafianti Selvi Nafianti, Selvi Sembiring, Krisnarta Sisca Silvana Sisca Silvana, Sisca Sri Sofyani Sri Sofyani Sukartini, Ninik Syafruddin Haris Syahril Pasaribu T. Mirda Zulaicha Tiangsa Sembiring Tiangsa Sembiring Tiangsa Sembiring, Tiangsa Tina Christina Tobing Trie Hariweni Trie Hariweni Vinisia Setiadji Wisman Dalimunte Y Dimyati Yoyoh Yusroh

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