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All Journal Medical Journal of Indonesia Universa Medicina Journal of General Procedural Dermatology and Venereology Indonesia Majalah Kedokteran Andalas Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Jurnal Kedokteran Meditek Ophthalmologica Indonesiana
Wresti Indriatmi B. Makes
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Bali Dermatology Venereology and Aesthetic Journal

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Discrepancy of PCR and serologic test on genital herpes: a case report Jhauharina Rizki Fadhilla; Wresti Indriatmi; Hanny Nilasari; Yudo Irawan
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/s440xr58

Abstract

Background: Laboratory investigation for genital herpes (GH) includes serologic tests and polymerase chain reaction (PCR) with different sensitivity and specificity; occasionally, the results are not conclusive. Clinical symptoms are often atypical. We report a case of GH in HIV-infected patients with a non-reactive serologic test but positive PCR. Case Description: A 29-years old HIV-positive man presented with multiple painful shallow ulcers with pus on his penis in the last five days. PCR examination showed a positive result, whereas anti-HSV 1 IgM, anti-HSV 2 IgM, anti-HSV 2 IgG, VDRL, and TPHA were negative. The anti-HSV- 1 IgG result was reactive with a CD4 value of 122 cells/μL. The patient was given Acyclovir 3x400 mg for ten days and Co-amoxiclav 3x625 mg for seven days. Significant improvement was obtained, and the pain subsided. Conclusion: Clinical features of GH in infected HIV patients are often atypical and resemble other genital ulcers, thus requiring additional investigations. The serologic test may sometimes present a false negative, whereas PCR is much more sensitive and specific, nearing 100%. In patients with HIV infection, GH diagnosis at an early stage can shorten the course of the disease and prevent complications.
Co-Authors Adisasmito, Ayutika Saraswati Ahmad Yudianto Aldri Frinaldi Andi Yasmon Anggraini, Ika Anissa, Lidwina Aria Kekalih Arlha Aporia Debinta Benny Nelson Budi Iman Santoso Caroline Oktarina Christa Desire Gracia Djaja Surya Atmadja Efendi, Ida Effendi, Ida Emma Rusmayani Endi Novianto Erwinanto Evita Halim Effendi Evita Halim Effendi Fathan, Hafiza Fauziah, Siti Nurani Fourina, Peppy Githa Rahmayunita Gultom, Desy A. Hafiza Fathan Halim, Melissa Hanny Nilasari Harrina Erlianti Rahardjo, Harrina Erlianti Hartono Gunardi Haswinzky, Rose Amalia Heri Wibowo Herkutanto Hutabarat, Hernayati Ika Anggraini Indina Sastrini Inge Ade Krisanti Irawan, Yudo Irene Dorthy Santoso Jacoeb, Tjut N.A. Jhauharina Rizki Fadhilla Joedo Prihartono Kayika, I Putu Gede Kemal N. Siregar Krisanti, Inge Ade Krisanti, Roro Inge Ade Kuraga, Rahmaniar Desianti Kurniawan, Kristian Kusmarinah Bramono Larisa Paramitha Leonardo Lesmana, Elvira Lidwina Anissa Lili Legiawati Manalu, Patricsia Marissa, Melani Martinus Tarina Martinus, Martinus Mawardi, Prasetya Melani Marissa Melani Marissa Nelson, Benny Nur Azizah, Anggita Nurhadi Ibrahim Patricsia Manalu Peppy Fourina Pusponegoro, Erdina H.D. Rahadi Rihamadja Rahadi Rihatmadja Rahadi Rihatmadja Rahmaniar Desianti Kuraga Santoso, Irene Dorthy Sastrini, Indina Satya Wydya Yenny Shannaz Nadia Yusharyahya Sirait, Sondang P. Siti Nurani Fauziah Siti Setiati Sondang Pandjaitan Sirait Sri L. Menaldi Sugiharto, Ade Firmansyah Surahman Hakim Suyatna, Fransiscus Dhyanagiri Wahyu Widodo Widjajalaksmi Kusumaningsih, Widjajalaksmi Widya Artini Windy Keumala Budianti Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yeva Rosana Yudo Irawan Yudo Irawan Zainal Hakim