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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Majalah Kedokteran Gigi Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Padjadjaran Journal of Dentistry JFIOnline Journal of Food and Pharmaceutical Sciences Journal of Innovative and Creativity Indonesian Journal of Medical and Pharmaceutical Science
Suwaldi .
Faculty Of Pharmacy Universitas Gadjah Mada Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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The formation of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrine Isadiartuti, Dewi; ., Suwaldi
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.436 KB) | DOI: 10.14499/indonesianjpharm0iss0pp28-37

Abstract

Phenobarbital, a hypnotic and sedative agent, was found to form inclusion complex with hydroxypropyl-β-cyclodextrine at 1:1 molar ratio. The formation of inclusion complex in the solution was detected due to the increased solubility of phenobarbital and in the solid was confirmed by differential scanning calorimetry, X-Ray diffractometry, and infrared spectroscopy.In the solid, inclusion complex was prepared by freezed drying method. The inclusion complex formed was characterized, compared with phenobarbital, hydroxypropyl-β-cyclodextrine, and the physical mixture of phenobarbital and hydroxypropyl-β-cyclodextrine.Analyses using DSC and X-ray diffractometry showed that phenobarbital formed inclusion complex with hydroxypropyl-β-cyclodextrine.Key words : phenobarbital, hydroxypropyl-β-cyclodextrine, inclusion complex
The thermodynamics of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrin Martodihardjo, Suwaldi; Isadiartuti, Dewi
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.749 KB) | DOI: 10.14499/indonesianjpharm0iss0pp57-62

Abstract

Cyclodextrins are cyclic oligosaccharides which have been used extensively to improve the solubility in the formation of inclusion complex. The ability of cyclodextrin to form an inclusion complex has been attributed to factors including size of cyclodextrin cavity to the guest molecule and thermodynamics of their interactions.In this study, complex formation of phenobarbital and hidroxypropyl-β-cyclodextrin in the acetate buffer 0.01 M pH 4.4 and phosphate buffer 0.01 M pH 7.4 all with μ =0.10 and at temperatures of 32.o, 37.o, and 42o±0.5oC were determined.The results showed that phenobarbital formed inclusion complex with hidroxypropyl-β-cyclodextrin. The interaction shown a negative enthalphy (ΔH < 0 ), a spontaneous processes (ΔG < 0) and an increase in the entropy of the system (ΔS > 0).Key words : phenobarbital and hidroxypropyl-β-cyclodextrin, inclusion complex, thermodynamics
Co-Authors Achmad Fudholi Aditya Dwi Meilani Akhmad Kharis Nugroho Arwin , Annisa Rahmaliya Aryani, Ni Luh Dewi Aryani, Ni Luh Dewi Ayu Ariessanti, Ida Dewi Isadiartuti Endang Lukitaningsih Erna Prawita Setyowati Hapsari, Dina Catur Indriyati, Ajeng Mukti Indwiani Astuti Kusharwanti, Wara Lukman Hakim Munakhir Mudjosemedi Nur Rasdianah Nurjanah, Amilia Oktavia Eka Puspita, Oktavia Eka Pertiwi, Ratih Dyah Rahmatika, Anida Hasna Rahmatika, Anisa Hasna Rahmawati, Anna Ronny Martien Rurie Ratna Shantiningsih Siti Aminah Sugiyanti Sugiyanti Tri M. Andayani Wahyono Wahyono Widyaningsih, Sriatun Widyasari Putranti