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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) The Indonesian Biomedical Journal Jurnal Dinamika Pengabdian (JDP) Nusantara Medical Science Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) GHIDZA: Jurnal Gizi dan Kesehatan Majalah Patologi Indonesia Golden Age: Jurnal Ilmiah Tumbuh Kembang Anak Usia Dini Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Rina Masadah
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Obstetrics

 1 
Relationship of Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA Naeny Fajriah; Maisuri T Chalid; Lenny Lisal; Efendi Lukas; St. Nur Asni; Rina Masadah
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 2 September 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n2.289

Abstract

Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood.Method: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining.Result: 16 of 38 samples were acquired from mothers aged 26-30 years old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p = 1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p = 0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p = 0.082; p = 1.000).Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA.  Hubungan Ekspresi TLR-7 Plasenta dengan HBV DNA Tali Pusat dan HBV DNA Plasenta AbstrakTujuan: untuk melihat peran ekspresi TLR-7 terhadap transmisi vertikal intrauterina pada kehamilan melalui identifikasi marker serum hepatitis B pada darah ibu dan talipusar.Metode: Analisis ekspresi TLR dilakukan pada 38 sampel blok paraffin jaringan plasenta ibu yang menderita HBV dengan memakai pewarnaan imuhohistokimia TLR.Hasil: 16 dari 38 sampel berusia 26-30 tahun. Sebagian besar sampel merupakan kelompok primipara (52.6%). Penelitian ini tidak menemukan hubungan yang signifikan antara ekspresi TLR-7 di plasenta dan HBV DNA darah tali pusat (p = 1.000). Tapi, kami menemukan hubungan yang signifikan antara ekspresi TLR-7 plasenta dan HBV DNA ibu (p = 0,034). Sedangkan HBeAg dan HBV DNA plasenta tidak berhubungan dengan ekspresi TLR-7 plasenta (p = 0,082; p = 1.000).Kesimpulan: Tidak ada hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV di plasenta dan tali pusat, tetapi kami menemukan hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV ibu.  Kata kunci: toll-like receptor (TLR) 7, HBV DNA, tali pusat, plasenta, Hepatitis B, infeksi intrauterina
Co-Authors Abdul Muis Abdul Qadar Punagi Achmad, Djumadi Agusalim Bukhari Al atsari, Muhammad Azka Andi Alfian Zainuddin Andi Alfian Zainuddin Andi Asadul Islam Andi Weri Sompa Andira, Fiki Wahyu Budu - Budu Budu Bukhari, Agussalim Cahyono Kaelan, Cahyono Cangara, Husni Cangara, Muhammad H Chalid, Maisuri Tadjuddin Djumadi Achmad Achmad Efendi Lukas Eka Sunarwidhi Prasedya Febriani, Dwi Bahagia Gaffar, Masyita Gosal, Steffy Rebecca Ham, Jonathan Hamsu Kadriyan Hanifah, Rif’at Huswatun Hasanah Ibrahim Labeda Ilhamjaya Patellongi Ismail J Nelwan, Berti Kalatiku, Jane Magdalena Lenny Lisal Luthfi, Muhammad Madaeng, Andi Sitti Nur Fatimah Maharani, Risma Maharani, Risma Mahmud Ghaznawie Maisuri T Chalid Maisuri T. Chalid Makarim, Ahmad Rifaat Dzaki Manule, Yolanda Marcellus Simadibrata Mardiati Maricar, Nadra Maulana, Aries Mochammad Hatta Muh. Nasrum Massi Muhammad Amsyar Akil Muhiddin, Syurawasti Naeny Fajriah Nasser, Andi S.H.D. Nasser, Andi Sitti Halija Diawanti Nelwan, Berti J. Nelwan, Berti Julian Nour Hafifah, Andi Izza Nova Audrey Luetta Pieter Prihantono Prihantono Raden Tina Dewi Judistiani Raharja, Siska Putri Wulandari Ridha Wahyuni, Ridha Rinda Nariswati Risma Maharani Risma Maharani Romdhoni, Achmad Chusnu Rosdiana Natzir Sianipar, Kelvin Leonardo St. Nur Asni Sumardin, Khairul Miftah Syahrial, Andi Muhammad Abdu Fadil Syahril, Rizalinda Syahrul Rauf Syahrul Rauf Syahrul Rauf Tawali, Suryani Tjahjadi Robert Tedjasaputra Truly D Dasril Turyadi Turyadi, Turyadi Umar, Husaini Upik A Miskad UPIK ANDERIANI MISKAD, UPIK ANDERIANI Winny N Leiwakabessy Wulaa, Nurwapina Langga