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Journal : Narra J

Low-intensity aerobic cycle ergometer effects on lung function of myasthenia gravis patients: A randomized controlled trial Amalina, Nabila; Poerwandari, Dewi; Handajani, Noor I.; Sudibyo, Devi A.; Melaniani, Soenarnatalina
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.844

Abstract

Patients with generalized myasthenia gravis (MG) often show restrictive spirometry results. Although regular exercise and physical fitness are linked to better respiratory function, there is limited research assessing the effects of aerobic exercise on lung function in MG patients. The aim of this study was to analyze the effect of low-intensity aerobic exercise using a cycle ergometer on lung function parameters in MG patients. A randomized controlled trial with pre- and post-test was conducted at the Medical Rehabilitation Outpatient Clinic of Dr. Soetomo General Academic Hospital in Surabaya, Indonesia, in 2023. MG patients classified as I−IIb based on the Myasthenia Gravis Foundation of America (MGFA) classification were recruited and randomly divided into treatment and control groups. The treatment group was given low-intensity aerobic exercise using a cycle ergometer, education on lifestyle changes, and breathing exercises (deep and pursed lip breathing). Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and forced expiratory volume ratio (FEVR), were then measured. Measurements were conducted before and after eight weeks of low-intensity aerobic cycle ergometer exercise and compared with those of a control group. A total of 17 MG patients were included in this study. The results showed a significant increase in FVC in the treatment group (p=0.003), whereas no significant change in the control group (p=0.068). A significant increase in FEV1 was observed both in the treatment (p=0.029) and the control group (p=0.016). There was no improvement in FEVR in either group. After the intervention, significant differences were observed in FVC (p=0.009) and FEV1 (p=0.029) between the treatment and control groups. There was no significant difference in FEVR values after the intervention between both groups (p=0.491). In conclusion, eight weeks of low-intensity aerobic cycle ergometer exercise led to significant improvements in FVC and FEV1 among MG patients.
Adherence to iron supplementation and associated factors among pregnant women in Cambodia: Insights from the 2021–2022 Demographic and Health Survey Buanasita, Annas; Sumarmi, Sri; Mahmudiono, Trias; Melaniani, Soenarnatalina; Salim, Lutfi A.; Sokvy, Ma; Sari, Nur MW.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1659

Abstract

Iron deficiency is the leading cause of anemia during pregnancy, a major public health concern in many developing countries. To mitigate anemia, iron supplementation for at least 90 days is recommended for pregnant women. The aim of this study was to evaluate adherence to iron supplementation during pregnancy and to identify its key determinants in Cambodia. A cross-sectional study was conducted using secondary data from the 2021–2022 Cambodia National Demographic and Health Survey. Key variables assessed included maternal age, education level, ethnicity, wealth index, number of pregnancies, age at first pregnancy, prenatal care provider, timing of the first antenatal care (ANC) visit, and frequency of ANC visits. Multivariate logistic regression was employed to evaluate associations between adherence and independent variables. A total of 4,475 women aged 15–49 years who had been pregnant in the past five years were included in the analysis, with 91.2% adhering to iron supplementation for at least 90 days. Multivariate logistic regression showed that those with primary and higher education had greater odds of adherence (odds ratio (OR)=1.38; 95%CI: 1.00–1.90; OR=3.07; 95%CI: 1.39–6.79, respectively) compared to women with no education. There was a positive relationship between education level and adherence. Women who attended four or more ANC visits were more likely to adhere (OR=2.93; 95%CI: 2.27–3.77), and those who initiated ANC in the first trimester had higher adherence compared to those who started later (OR=1.78; 95%CI: 1.35–2.36). This study highlights that education level, frequency, and timing of ANC visits significantly influenced adherence to iron supplementation. Strengthening maternal education and promoting early and regular ANC follow-up should be prioritized to improve adherence and prevent anemia during pregnancy.
Co-Authors A.A. Ketut Agung Cahyawan W Ahsan Ahsan Ahsan Ahsan Alfadhila Khairil Sinatrya Andi Safutra Suraya Annas Buanasita Ardianah, Eva Arief Wibowo Arina Dery Puspitasari Asti Dewi Rahayu Fitrianingsih Badriawan, Muhammad Jefri Boerhan Hidayat, Boerhan Celine Masyita Desiana Chatarina Umbul Wahyuni Diah Indriani Dwi Oktavia Sri Asmoro Farisa Al Amin Avin Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Handajani, Noor I. Hanifah, Laili Hanindita, Meta Herdiana Hardian Bimanto Hardian Bimanto Hari Basuki Notobroto Hari Basuki Notobroto Imam Subadi Indah Handriani Indah Handriani, Indah KUNTORO Kuntoro Kuntoro Kuntoro Kuntoro Kusnanto Kusnanto Lilis Sulistyorini Lily Aina Lydia Arfianti Mahmudah Mahmudah Mahmudah Mahmudah Manihuruk, Surma Elisa Maulidiyatun Nafiisah Maya Fernandya Siahaan Melinda Putri Amelia Rachman Nabila Amalina Nanda Ardianto Nunik Puspitasari Nur Aisiyah Widjaja, Nur Aisiyah Nurfidaus, Yasmine Nursalam, Nursalam Pebriaini, Prisma Andita Poerwandari, Dewi Rachmah Indawati Rahmatika, Auni Renaldi Kurniawan Ria Puspitasari Roedi Irawan Rondhianto Rondhianto Rosly Zunaedi Rosyid, Alfian Nur Salim, Lutfi A. Santoso, Febrina Mustika Sari, Nur MW. Semedi, Bambang Pujo Sigit Ari Saputro SITI NURUL HIDAYATI Siti Rohmatun Ni'mah Soares, Ivo Da Costa Sokvy, Ma Sri Sumarmi Sudibyo, Devi A. Sulvy Dwi Anggraini Syahfitri Wulandari Syarifuddin Syarifuddin Tamara Nur Budiarti Teguh Prawono Sabat, Teguh Prawono Trias Mahmudiono Ulfa Al Uluf Utama Hutapea, Johannes Diandra Indra Wahyul Anis Windhu Purnomo Wisoedhanie Widi Anugrahanti Yuly Sulistyorini