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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Muara Medika dan Psikologi Klinis Jurnal MedScientiae Cermin Dunia Kedokteran
Sri L. Menaldi
Department Of Dermatology And Venereology Faculty Of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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DIAGNOSIS DAN TATA LAKSANA KEKAMBUHAN KUSTA Caroline Oktarina; Melani Marissa; Wresti Indriatmi; Sri Linuwih Menaldi
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.340

Abstract

Leprosy relapse is defined as the reappearance of leprosy’s signs and symptoms following completion of adequate Multidrug Therapy (MDT) regimen. Indonesia is the third biggest contributor for leprosy relapse with 284 cases in 2018. Several factors contribute to the occurrence of relapse, which include presence of persisters, history of inadequate therapy, drug resistance, history of irregular treatment, history of dapsone monotherapy, high initial bacteriological index, high number of skin and nerve lesions, negative lepromin test, history of antireaction therapy, human immunodeficiency virus (HIV) infection, and pregnancy. Diagnosis of relapse can be established based on clinical, bacteriological, and therapeutic criteria, also histopathological and serological criteria, if possible. With those criteria, it should be easier to differentiate relapse from reaction, resistance, reactivation, and reinfection. The principal management for leprosy relapse is re-administration of MDT according to the type of relapse; however, therapy should be modified if there are any evidences of drug resistance. Things which are important to be taken into account during relapse treatment are leprosy type, past medication history, and the possibility of drug resistance. With proper knowledge and diagnostic algorithm, it is expected that the treatment can be administered immediately in order to prevent disability and transmission of infection.
Epidemiology of Leprosy in Indonesia: a Retrospective Study Lubis, Ramona Sari; Anum, Qaira; Argentina, Fifa; Menaldi, Sri Linuwih; Gunawan, Hendra; Yuniati, Renni; Mulianto, Nur Rachmat; Siswati, Agnes Sri; Widasmara, Dhelya; Rusyati, Luh Made Mas; Mamuaja, Enricco Hendra; Muchtar, Vitayani; Cita Rosita Sigit Prakoeswa; Agusni, Regitta Indira; Bagus Haryo Kusumaputra; Medhi Denisa Alinda; Listiawan, Muhammad Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.29-35

Abstract

Background: According to WHO data, the number of new cases of leprosy has decreased in 2019. However, Indonesia continues to provide a significant number of cases. According to statistics, India, Brazil, and Indonesia account for 79 percent of all instances. Purpose: This study aims to describe the profile of leprosy patients, and involves all Dermatology and Venereology Academic Hospitals in Indonesia. Methods: This study was a retrospective study of 2461 patients from Dermatology and Venereology Outpatient Clinic at 13 Academic Hospitals in Indonesia between January 2018 and December 2020. Result: Subjects in this study were dominated by males (66.8%) and aged > 14 years (95.3%). The most common type of leprosy was multibacillary (MB) (86.2%), and erythema nodosum leprosum (ENL) was the most leprosy reaction (20.3%). Majority of the subjects experienced disability in the hands (26.6%), in grade 1. Conclusion: Leprosy cases in Indonesia are mostly experienced by adult males. The most common type of leprosy is MB, with ENL being the most common leprosy reaction. Grade 1 disability is the most prevalent, therefore proper education is necessary to keep patients from progressing to grade 2 disability.
Inhibitor Transient Receptor Potential Vanilloid Type 1: Penggunaan Topikal pada Berbagai Dermatosis Muhammad, Parikesit; Paramitha Wibawa, Larisa; Keumala Budianti, Windy; Legiawati, Lili; Menaldi, Sri Linuwih; Rosdiana, Dewi Selvina
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3179

Abstract

Transient receptor potential vanilloid type 1 (TRPV1) plays an important role in the pathophysiology of pruritus and pain. TRPV1 inhibitors can reduce the sensation of itching and pain by blocking nociceptive signals from peripheral nerve fibers to the central nervous system. Topical TRPV1 inhibitors is also thought to improve skin barrier function. Therefore, TRPV1 inhibitors are considered as potential therapy in various dermatoses. Topical TRPV1 inhibitors that are currently being studied are asivatrep for atopic dermatitis and trans-4-tert-butylcyclohexanol for various dermatoses associated with sensitive skin. Further studies with better quality and longer duration are needed to assess the efficacy and safety profile of TRPV1 inhibitors.
PERAN TERAPI ANTIOKSIDAN PADA MELASMA Diahtantri, Riyanti Astrid; Mughni, Fadhli Aulia; Menaldi, Sri Linuwih
Jurnal Muara Medika dan Psikologi Klinis Vol. 4 No. 1 (2024): Jurnal Muara Medika dan Psikologi Klinis
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmmpk.v4i1.34338

Abstract

Melasma adalah penyakit hiperpigmentasi pada kulit yang terpajan sinar matahari dan dapat bersifat kronik rekuren. Penyebab pasti melasma belum diketahui akan tetapi spesies oksigen reaktif (ROS) akibat pajanan sinar ultraviolet (UV) diduga berperan dalam patogenesis melasma. Mekanisme pertahanan terhadap toksisitas ROS mencakup antioksidan enzimatik, yang terdiri atas katalase, superoksida dismutase (SOD), dan glutation peroksidase, serta antioksidan non-enzimatik. Dalam tulisan ini akan dijelaskan jenis-jenis ROS, antioksidan, dan stres oksidatif serta pengobatan melasma yang berhubungan dengan penggunaan antioksidan untuk menetralisir efek stres oksidatif.
Patogenesis Melasma Diahtantri, Riyantia Astrid; Menaldi, Sri Linuwih; Mughni, Fadhli Aulia
Cermin Dunia Kedokteran Vol 51 No 9 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i9.1514

Abstract

Melasma is a chronic skin pigmentation disorder caused by sunlight exposure. Melasma is a multifactorial disease with various pathways that can induce hyperpigmentation. Exposure to ultraviolet (UV) light as a source of reactive oxygen species (ROS) and free radicals plays a role in the pathogenesis of melasma. Another mechanism is the role of ROS on melanogenesis and melanocyte cells as well as the signaling pathway for melanin synthesis. Concentration of antioxidants as a skin defense against ROS, namely superoxide dismutase (SOD), catalase, and glutathione peroxidase, also influences the occurrence of melasma.
Co-Authors Agnes Sri Siswati Ahmad Fuady Aldri Frinaldi Alida Widiawaty Anum, Qaira Aria Kekalih Augustine D. Sukarlan Bagus Haryo Kusumaputra Bani, Anna Puspitasari Caroline Oktarina Chairista, Inadia Putri Cita Rosita Sigit Prakoeswa Dewi Matindas Dewi Sumaryani Soemarko Dharmayati B. Utoyo Dhelya Widasmara Diahtantri, Riyanti Astrid Diahtantri, Riyantia Astrid Emmy Soedarmi Sjamsoe Emmy Soedarmi Sjamsoe-Daili Erika Zoulba Evita H. Effendi Fifa Argentina Fifinela Raissa Fitri Octaviana Githa Rahmayunita Hansen Angkasa Herqutanto - Hirzi Zulkarnain Irawan, Yudo Irawati, Yunia Iwan Dwiprahasto Jayawarsa, A.A. Ketut Joanne Natasha Keumala Budianti, Windy Kurniawardhani, Dewinta Retno Kusmarinah Bramono Larisa Paramitha Lidwina Anissa Lili Legiawati Lim, Henry W Lim, Henry W. Lubis, Ramona Sari Luh Karunia Wahyuni, Luh Karunia Luh Made Mas Rusyati M. Yulianto Listiawan Mamuaja, Enricco Hendra Marissa, Melani Martinus, Martinus Medhi Denisa Alinda, Medhi Denisa Melani Marissa Melani Marissa Miranda, Eliza Muchtar, Vitayani Mughni, Fadhli Aulia Muhammad, Parikesit Mulianto, Nur Rachmat Olivia, Taruli Ova Emilia Rahadi Rihatmadja Regitta Indira Agusni Renni Yuniati Rizka Farah Hilma Rizky, Luddwi Achmad Rosdiana, Dewi Selvina Saleha Sungkar Sali Rahadi Asih Sandra Widaty SD, Emmy Soedarmi Sirait, Sondang Pandjaitan Siskawati, Yulia Siskawati, Yulia Sjamsoe, Emmy Soedarmi Sjamsoe-Daili, Emmy Soedarmi Surya, Denny Taruli Olivia Triana Agustin Victor Santawi Widiawaty, Alida Wresti Indriatmi B. Makes Yayi S. Prabandari Yeni Dwi Lestari Yudo Irawan Zoulba, Erika