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All Journal Jurnal NERS Indonesian Journal of Cancer JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Majalah Obstetri dan Ginekologi Syntax Literate: Jurnal Ilmiah Indonesia The Southeast Asian Journal of Midwifery Pediomaternal Nursing Journal Indonesian Journal of Anesthesiology and Reanimation (IJAR) INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL International Journal of Midwifery Research Indonesian Journal of Cancer Folia Medica Indonesiana

PUNGKY MULAWARDHANA, PUNGKY

Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Airlangga, Dr Soetomo Hospital, Surabaya

Author-ID : 3195546

Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 25 Documents Claim Missing Document

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RELATIONSHIP OF RISK FACTORS WITH HISTOPATHOLOGICAL TYPES IN CERVICAL CANCER PATIENTS IN DR SOETOMO HOSPITAL Anggray Puspasari; Pungky Mulawardhana; ,Nila Kurniasari
SEAJOM: The Southeast Asia Journal of Midwifery Vol 7 No 1 (2021): SEAJOM: The Southeast Asia Journal of Midwifery
Publisher : AIPKIND (Asosiasi Pendidikan Kebidanan Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36749/seajom.v7i1.108

Cervical cancer is a process of changing into malignancy in the cervix. Based on studies and previous research, cervical cancer is the third female cancer in terms of incidence (527,600 new cases) and mortality (265,700 deaths) in the world. Cervical cancer has histotopathological types in the form of squamous cell carcinoma, adenocarcinoma, and other types. This study aimed to analyze the relationship of risk factors with histopathological types in cervical cancer patients in Dr. Soetomo Hospital. Method: This analytical descriptive study used a cross sectional research design. The number of samples were 300 patients collected by total sampling. Independent variables were risk factors including age, marital age, parity, smoking, oral contraceptives, and education while dependent variables were histopathological types including squamous cell carcinoma, adenocarcinoma, and other types. Instruments used documentation. Data analysis used chi square, fisher and contingency coefficient tests. Results: There was a relationship of cervical cancer risk factors of age to histopathological type (p= 0.000 and contingency coefficient = 0.170) and no relationship of risk factors to number of parity (p= 0.321 and contingency coefficient = 1000 0.064 ), marriage age (p = 0.720 and contingency cofience = 0.038), smoking (p = 0.711 and contingency cofience = 0.036), oral contraceptive (p = 0.655 and contingency comfience = 0.042), education (p = 0.744 and contingency co-efficiency = 0.089) to histopathological type. Conclusion: There is a relationship between risk factors and histopathological types in cervical cancer patients at Oncology Polyclinic at Dr Soetomo Hospital of Surabaya.

The Relationship of Knowledge, Attitude and Behavior Early Detection of Cervic Cancer In Midwifes In Puskesmas Surabaya Fransisca Wiga Alda Maretha; Reny Iâ€™tishom; Pungky Mulawardhana
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Background: Cervical cancer is the second most common type of cancer after breast cancer. Cervical cancer is a special concern of the government to support the success of the SDGs (Sustainable Development Goals). The government established a cervical cancer prevention program for 2015-2019 in collaboration with public health centers and local governments in detecting cervical cancer early in the community. Midwives have an important role in tackling cervical cancer, but there are still few studies in Indonesia that discuss the relationship between knowledge of midwives in attitudes and behavior to carry out early detection of cervical cancer for themselves. The purpose of this study was to determine the relationship between knowledge, attitudes, and behavior of early detection of cervical cancer in midwives at Puskesmas Surabaya. Methods: This research method is observational analytic with the cross-sectional approach. The number of samples is 94 with the random sampling technique. The independent variables are knowledge and attitudes and the dependent variable is behavior. The instrument used is a questionnaire. Using chi-square and fisher test. Results: There were 72 people (78.7%) who had good knowledge at the Surabaya Public Health Center, 52 people (55.3%) with a good attitude, and 49 people (52.1%). The results of the statistical test of knowledge with behavior p = 0.221 (p> 0.05), knowledge with attitude p = 0.039 (p <0.05), and behavior with attitude p = 0.042 (p <0.05). Conclusion: There is a relationship between knowledge of cervical cancer and attitudes towards early detection of cervical cancer, there is a relationship between attitudes towards early detection of cervical cancer and behavior for early detection of cervical cancer and there is no relationship between knowledge of cervical cancer and behavior of early detection of cervical cancer.

RISK FACTORS FOR ESTROGEN EXPOSURE IN VARIOUS GRADES OF ENDOMETRIOID CARINOMA Ma’rifatu Ulfa Hidayati; Pungky Mulawardhana; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 4 No. 1 (2020): Indonesian Midwifery and Health Sciences Journal, January 2020
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v4i1.2020.40-50

AbstractBackground: Incidence endometrial cancer in Southeast Asia it is estimated that 41% of new cases emerge. The incidence of endometrial cancer in Dr. Soetomo General Hospital has increased every year. In 2016 there were 119 new cases of endometrial cancer and in 2017 there were 160 cases. 75%-80% is type I endometrial cancer (endometrioid carcinoma). Risk factors for estrogen exposure (early menarche, parity, obesity) are risk factors for endometrial cancer. The prognosis of endometrial cancer depends on the grade. This study aims to determine differences in risk factors for estrogen exposure in various grades of type I endometrial cancer (endometrioid carcinoma) in the Poli Onkologi Satu Atap Dr. Soetomo General Hospital Surabaya. Methods: the research method was analytic observational with cross-sectional design. Sample size of 40 medical records was taken by total sampling technique. Research variables include age of menarche, parity, BMI, and grade of endometrial cancer. The instrument used was a data collection sheet and medical records. Data analysis using chi-square test. Results: The results showed 52% patients were grade 1-2, there were 95% of menarche patients in the age range of 12-14 years, 62.5% patients had parity of 1-2 and 52% patients, BMI was underweight-normal category. Test results based on early menarche did not show significant differences between grades 1-2 and grade 3 in endometrioid carcinoma (p = 0.168). Likewise, parity in various grades of endometrial cancer type I (endometrioid carcinoma) there was no significant difference (p = 0.220) and BMI also no significant difference (p = 0.987). Conclusions: risk factors for estrogen exposure which include menarche, parity, obesity do not make a significant differences to the grades of endometrioid carcinoma.

RELATIONSHIP OF AGE, MENOPAUSE STATUS, AND BMI WITH THE EVENT OF BACTERIAL VAGINOSIS IN NEW PATIENTS OF PELVIC ORGAN PROLAPSE Atmi Marmiati; Pungky Mulawardhana; Zakiyatul Faizah
Indonesian Midwifery and Health Sciences Journal Vol. 4 No. 2 (2020): Indonesian Midwifery and Health Sciences Journal, April 2020
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v4i2.2020.109-120

AbstractBackground and Purpose : The prevalence of Bacterial Vaginosis (BV) among Asian women in India and Indonesia is 32% while in the case of BV in 2018 the obstetric clinic of Dr. Soetomo Regional Hospital is 181 BV sufferers. The impact of BV on Pelvic Organ Prolapse (POP) patients, namely the delay in POP treatment such as BV pessaries can be influenced by age, menopausal status, and BMI. This study aims to analyze the relationship of age, menopausal status, and BMI with the incidence of BV in POP patients. Methods: This study used observational analytics with a retrospective and cross sectional approach. The number of samples used was 86 patients. Samoel taking technique with total sampling. The independent variable is the incidence of BV, while the dependent variable is age, menopause status, BMI. Bivariate data analysis using chi square, fisher's exact test and multivariate test using multiple logistic regression tests. Results: The results showed a positive BV prevalence of 76.7% with the majority of patients aged over 60 years at 44.2%, having menopause at 81.4%, and having a BMI of 18.5-24.5 at 47.7%. Fisher's exact test analysis test showed p value of maternal age = 0.003 (RR = 6.398) and p value of BMI = 0.767 (p> 0.005). Chi square analysis test showed p value of menopause status = 0.009 (RR = 4.833). The multiple logistic regression analysis test showed that maternal age was the most dominant factor with a value of p = 0.006 (OR = 6.398 (1,711-23,929)). Conclusion: There is a relationship between age and menopausal status with the incidence of BV. Age is the most dominant independent factor in the incidence of BV.

THE RELATIONSHIP BETWEEN BSE KNOWLEDGE AND BREAST TUMOR SIZE DURING SURGICAL CENTER VISIT AT UNAIR HOSPITAL Eva Silvia Yahya; Pungky Mulawardhana; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 6 No. 1 (2022): Indonesian Midwifery and Health Sciences Journal, January 2022
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v6i1.2022.66-73

AbstractBackground: Breast tumor is a group of abnormal cells and continue growing multiply in the breast. In Indonesia, it is known that 8,1% of 38.749 women have tumor in the breast. One way to detect it early is to do the Breast Self Examination (SADARI). The purpose of the research was to know the correlation of SADARI knowledge with the size of the breast tumor at admission to surgery outpatient clinic. Methods: This type of research is observational analytic, cross sectional design. The sample were 36 tumor patients. The sampling technique was a convenient sampling. The independent variable was the knowledge SADARI and the dependent variable was the size of the breast tumor. The secondary data was taken in the form of USG and the primary data was a questionnaire. The data was tested with Spearman Rank. Results: The results of the bivariate analysis showed 0,328 (p>0,05) probability score (p value) and 0,168 R score which meant the correlation was very weak. Conclusion : there is no correlation of SADARI knowledge with the size of breast tumor at admission of surgery outpatient clinic. Keywords: Knowledge, SADARI, The size of breast tumor at admission

MIDWIFE KNOWLEDGE IN EARLY DETECTION OF CERVICAL CANCER USING VISUAL INSPECTION WITH ACETIC ACID METHOD Deviati Juwita Sari; Pudji Lestari; Pungky Mulawardhana
International Journal of Midwifery Research Vol. 1 No. 3 (2022): International Journal of Midwifery Research
Publisher : Department of Midwifery, Faculty of Nursing and Midwifery, Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/ijmr.v1i3.15

Knowledge of a midwife in to do VIA examination will influence achievement VIA examination. Study this aim for knowing connection Among education and training status with knowledge midwife in detection early cancer cervix use method Visual inspection with acetic acid (VIA) in Banjarmasin City. Research design this is cross-sectional in 26 Puskesmas in Banjarmasin City March – November 2020 with amount sample as many as 172 respondents, retrieval technique sample use non-probability sampling technique is purposive sampling . Instrument study in the form of questionnaires and reports from the Department of Health. Data analysis is carried out by computerization. A total of 172 respondents obtained part big respondents who have P2B and D3 Midwifery education have knowledge not enough by 61.6% and the majority respondents who have not once follow training have knowledge not enough as much as 67.9%. Statistical test results show no there is connection Among education (p = 0,171) and training status (p = 0,001) with knowledge midwife in detection early cancer cervix with use VIA method. Research results show no there is connection Among education and there connection between training status with knowledge midwife in detection early cancer cervix use VIA method in Banjarmasin City. Training is one the step that becomes consideration in increase performance midwife in detection cancer cervical .

Comparison Between HE4, CA-125, and Combination of Both HE4 and CA-125 as Tumor Markers for Epithelial Ovarian Carcinoma Patients PUNGKY MULAWARDHANA; BRAHMANA ASKANDAR; SOEHATNO -
Indonesian Journal of Cancer Vol 6, No 2 (2012): Apr - Jun 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i2.166

Tujuan: Mengetahui dan membandingkan sensitivitas, spesifisitas, Positive Predictive Value, dan Negative Predictive Value antara HE4, CA-125, serta kombinasi HE4 dan CA-125 sebagai tumor marker pada pasien kanker ovarium tipe epitel. Mengetahui adanya korelasi antara kadar HE4 dengan kadar CA-125 serum pada pasien tumor ovarium.Metode penelitian dan tempat: Penelitian ini merupakan studi observasional analitik dengan cross-sectional, dilaksanakan di poli, ruang kandungan, dan Laboratorium Patologi Klinik RSU dr. Soetomo, sert laboratorium Prodia. Sampel dan alur penelitian: Terdapat 53 pasien dengan tumor ovarium yang dioperasi di RSU dr. Soetomo antara Februari sampai Mei 2011 yang memenuhi kriteria inklusi dan ekslusi. Terhadap masing-masing pasien dilakukan pemeriksaan HE4 dan CA-125 pada 1 hari sebelum operasi. Setelah hasil PA selesai, didapatkan 11 pasien yang mengalami drop out, 42 pasien lainnya kami masukkan dalam analisa penelitian dengan rincian 17 pasien kanker ovarium tipe epitel dan 25 pasien dengan tumor jinak ovarium. Peneliti berusaha mengetahui dan membandingkan sensitivitas, spesifisitas, Positive Predictive Value, dan Negative Predictive Value antara HE4, CA-125, serta kombinasi HE4 dan CA-125 sebagai tumor marker pasien kanker ovarium tipe epitel.Hasil penelitian: Analisis statistik Mc Nemar menunjukan kadar CA-125 serum memiliki perbedaan yang bermakna dengan hasil PA (p = 0,004), sedangkan kadar HE4 serum (p = 1,000) dan kombinasi kadar HE4 & CA-125 serum (p = 0,344) tidak memiliki perbedaan yang bermakna dengan hasil PA dalam menentukan diagnosis kanker ovarium. Spesifisitas kombinasi HE4 dan CA-125 (88,00%) lebih baik dari HE4 (80,00%) maupun CA-125 (20,00%). Sensitivitas HE4 (76,47%) lebih baik dari CA-125 (70,59%) maupun kombinasi HE4 dan CA-125 (58,82%). Positive predictive value kombinasi HE4 dan CA-125 (76,92%) lebih baik dari HE4 (72,22%) maupun CA-125 (37,50%). Negative predictive value HE4 (83,33%) lebih baik dari kombinasi HE4 dan CA-125 (75,86%) maupun CA-125 (50,00%). Uji korelasi dari Pearson menilai semua pasien sampel tumor ovarium mendapatkan adanya korelasi kadar HE4 serum dengan CA-125 serum, nilai r = 0,453 (p = 0,003).Kesimpulan: Kombinasi HE4 dan CA-125 memiliki nilai diagnostik lebih tinggi dibandingkan dengan HE4 tunggal dan CA-125 tunggal sebagai tumor marker kanker ovarium tipe epitel. Terdapat korelasi antara kadar CA-125 serum dengan kadar HE4 serum pada pasien tumor ovarium, walaupun tidak ada hubungan patofisiologi antara kedua tumor marker tersebut.Kata kunci: HE4, CA-125, sensitivitas, spesifisitas, positive predictive value, negative predictive value, kanker ovarium tipe epitel, tumor jinak ovarium

Ekspresi CD44 (Penanda Sel Punca Kanker) sebagai Faktor Prognostik Kekambuhan pada Kanker Ovarium Tipe Epitel Stadium III PUNGKY MULAWARDHANA; INDRA YULIATI; KETUT SUDIANA
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Epithelial ovarian cancer is a deadly cancer, cancer recurrence and resistance post surgical staging and chemotherapy are major problems which will eventually occur in most advanced stage ovarian cancer. Recent investigations have unravelled the role of CSC/ Cancer Stem Cell in the cancer recurrence and therapy resistance, CD44 has been reported as a CSC marker in ovarian cancer, investigator wanted to analyse CD44 expression as recurrence prognostic factor in stage III epithelial ovarian cancer. Purpose: to analyse the role of CD44 expression as recurrence prognostic factor in stage III epithelial ovarian cancer. Metode: Hystorical Cohort, ICH CD44 examination was performed on the pathological ovarian cancer sample which diagnosed with platinum resistant recurrence (study sample) and platinum sensitive recurrence (control sample). CD44 expression was measured, the role as recurrence prognostic factor evaluated, influence of CD44 expression increasetowards earlier recurrence analysed, and the CD44 expression differences between 2 groups based on grade; pathological type; and stadium were measured and analysed. Results: 40 research subjects were involved in the research, with 20 among them were platinum resistant and the other 20 were platinum sensitive. Mean CD44 expression in the platinum resistant group was 36,80+29,54; while in the resistant platinum was 7,05+9,58. There was a significant difference of CD44 expression between 2 groups (p=0,000). There was a strong correlation between CD44 expression with the timing of recurrence (p=0,894). With the cut off of12,5; 85% platinum resistant subject had CD44>12,5; 85% platinum sensitive subject had CD44<12,5; with 85% sensitivity and 85% specificity as a good recurrence prognostic factor. Relative Risk (RR) of CD44 Expression is 5,667, RRof tumor residue post surgical staging is 2,513. Through logistic regression analysis, it was concluded that high expression of CD44 and tumor residue are risk factors for recurrences, patient with CD44 expression of ≥ 12,50 has possibility of earlier recurrence (< 6 months) 48,487 times compared with patient with CD44 expression of < 12,50 and patient with tumor residue of < 1cm has possibility of earlier recurrence 13,013 times compared with patient without macroscopic residue.Conclusion: This research found that CD44 expression can be used as recurrence prognostic factor in stage III epithelial ovarian cancer, CD44 expression was significantly higher in the platinum resistant group, there was negative correlationbetween CD44 expression with the timing of recurrence. CD44 expression as recurrence prognostic factor was not influenced with grade and pathologic type, but influenced by stage. Expression of CD44 and tumor residue post surgical staging are good predictors for recurrence timing.ABSTRAKKanker ovarium tipe epitel adalah suatu kanker yang mematikan. Kekambuhan dan resistansi kanker pasca-surgical staging dan kemoterapi merupakan masalah utama yang akan terjadi pada sebagian besar kanker ovarium stadium lanjut. Penelitian-penelitian terbaru mengemukakan peran CSC (Cancer Stem Cell) dalam proses kekambuhan dan resistansi terapi. CD44 telah dilaporkan sebagai marker CSC pada kanker ovarium. Peneliti ingin meneliti ekspresi CD44 sebagai faktor prognostik kekambuhan kanker ovarium tipe epitel stadium III. Penelitian ini bertujuan menganalisis peran ekspresi CD44 sebagai faktor prognostik kekambuhan pada kanker ovarium tipe epitel stadium III. Metode yang digunakan dalam penelitian ini adalah hystorical cohort, di mana dilakukan pemeriksaan IHC CD44 pada sampel PA pasien kanker ovarium yang mengalami kekambuhan resistan platinum (sampel studi) dan sensitif platinum (sampel pembanding). Ekspresi CD44 diukur, peran sebagai faktor prognostik kekambuhan dievaluasi, pengaruh peningkatan ekspresi CD44 pada kekambuhan yang lebih dini dianalisis, dan perbedaan ekspresi CD44 dinilai pada 2 kelompok berdasarkan grade, tipe PA, dan stadium. Sebanyak 40 subjek penelitian dengan rincian 20 kelompok resistan platinum dan 20 kelompok sensitif platinum diikutkan dalam penelitian ini. Rerata ekspresi CD44 pada kelompok resistan adalah 36,80+29,54 dan kelompok sensitif platinum 7,05+9,58. Didapatkan perbedaan signifikan ekspresi CD44 di antara dua kelompok (p=0,000). Didapatkan pula hubungan yang kuat antara ekspresi CD44 dengan waktu kekambuhan (p=0,894). Dengan cut off 12,5; 85% sampel resistan platinum memiliki CD44>12,5 dan 85% sampel sensitif platinum memiliki CD44<12,5 dengan sensitivitas 85% dan spesifisitas 85% sebagai faktor prognostik kekambuhan yang baik. Didapatkan RR ekspresi CD44 sebesar 5,667, RR residu tumor pasca-surgical staging sebesar 2,513. Melalui analisis regresi logistik, didapatkan bahwa ekspresi CD44 yang tinggi dan adanya residu merupakan faktor risiko kekambuhan. Penderita dengan ekspresi CD44 ≥ 12,50 berisiko kambuh <6 bulan sebesar 48,487 kali penderita dengan ekspresi CD44 < 12,50; dan penderita dengan residu < 1 cm berisiko kambuh <6 bulan sebesar 13,013 kali penderita tanpa residu makroskopik. Penelitian ini menyimpulkan bahwa ekspresi CD44 dapat dipakai sebagai faktor prognostik kekambuhan pada kanker ovarium tipe epitel stadium III, ekspresi CD44 secara signifikan lebih tinggi pada kelompok resistan platinum, serta ada hubungan negatif antara ekspresi CD44 dengan waktu terjadinya kekambuhan. Ekspresi CD44 sebagai faktor prognostik tidak dipengaruhi oleh grade dan tipe PA, tetapi dipengaruhi oleh stadium kanker. Ekspresi CD44 dan residu tumor pasca-surgical staging merupakan indikator prediktif yang baik untuk kecepatan kekambuhan.

The performance of midwives in early detection of cervical cancer using visual inspection test with acetic acid Deviati Juwita Sari; Pudji Lestari; Pungky Mulawardhana
Majalah Obstetri & Ginekologi Vol. 30 No. 2 (2022): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I22022.52-57

HIGHLIGHTS 1. Visual Inspection with Acetic Acid (VIA) method is used in midwifery for early detection of cervical cancer.2. Service period, knowledge, and attitudes are factors that affect a midwife's performance in using VIA method for cervical cancer detection. ABSTRACT Objective: This study examined the association between service period, knowledge, and attitudes toward the performance of midwives in the early detection of cervical cancer using the Visual Inspection with Acetic Acid (VIA) method in Banjarmasin, Indonesia. Materials and Methods: This is a cross-sectional study done in 26 Public Health Centers in Banjarmasin, Indonesia, from March to November 2020 involving 172 respondents. Samples were purposively selected using a non-probability sampling technique. Data collection instruments were questionnaire and Health Service reports. Data analysis was done computerized. Results: Out of 172 respondents, 67.4% of which had > 10 years of service period, 67.4% had inadequate knowledge and 86% showed a positive attitude about early detection of cervical cancer using the IVA method, and 79.9% had poor performance in conducting early detection of cervical cancer using the IVA method. Results of Chi-square test showed the associations between the service period (p = 0.005), knowledge (p = 0.0001), and attitude (p = 0.005) with the performance of midwives in early detection of cervical cancer using the VIA method. Conclusion: Service period, knowledge, and attitudes were associated with the performance of midwives in the early detection of cervical cancer using the VIA method in Banjarmasin, Indonesia. Professional training programs should be taken into consideration in improving the performance of midwives in cervical cancer detection.

RELATIONSHIP BETWEEN KNOWLEDGE AND ATTITUDES TOWARDS ADHERENCE IN DETECTION OF CERVICAL CANCER Fadhilah Sari; Pungky Mulawardhana; Lestari Sudaryanti
Indonesian Midwifery and Health Sciences Journal Vol. 7 No. 3 (2023): Indonesian Midwifery and Health Sciences Journal, July 2023
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v7i3.2023.258-266

Background: Cervical cancer is an uncontrolled cell growth that occurs in the cervix caused by the Human Papilloma Virus (HPV) virus. Early detection programs for cervical cancer can be done in several ways, including Visual Inspection of Acetic Acid (IVA), pap smear, colposcopy, cervicography, and pap net. This method has been shown to reduce the incidence of invasive cervical cancer by the amount and mortality of cervical cancer. The purpose of this study was to determine the relationship between knowledge and attitudes towards Women of Childbearing Age (WCA) compliance in early detection of cervical cancer at the Ulak Karang Health Center in Padang City. Method: Cross Sectional. The population in this study was all WCA mothers (19-69 years old) in the working area of the Ulak Karang Health Center in Padang City as many as 2,916 people with a total sample of 97 people taken using quota sampling. This research was carried out in the working area of the Ulak Karang Health Center, Padang City in May-July 2023. The variables in this study are knowledge, attitudes and compliance with IVA examination. Data were analyzed univariately, bivariately (chi square) and multivariate. Results: There was a significant association between knowledge and WCA compliance in early detection of cervical cancer (p value 0.000). There was a significant relationship between attitude and WCA compliance in early detection of cervical cancer (p value 0.000). The relationship between knowledge and attitudes towards adherence is that there is a significant relationship between knowledge and attitudes towards WCA adherence in early detection of cervical cancer (p value 0.000). Conclusion: There is a relationship of knowledge and attitudes towards WCA compliance in early detection of cervical cancer.

Co-Authors , Ernawati Aldika Akbar, Muhammad Ilham Alifina Izza Anak Agung Istri Sri Wiadnyani Anas, Jimmy Yanuar Anggray Puspasari Anna Febriani Anny Setijo Rahaju, Anny Setijo Askandar Tjokroprawiro Atmi Marmiati Bachnas, Muhammad Adrianes Budi Utomo Deviati Juwita Sari Deviati Juwita Sari Dyah Erawati, Dyah Ecccita Raheestyningtyas Eccita Rahestyningtyas Ernawati Ernawati Eva Silvia Yahya Fadhilah Sari Faizah, Zakiyatul Ferdinandus, Euvanggelia Dwilda Firda Azizah Firmanto, Neissya Nastiti Fitria Khusnul Khotimah Fitriati, Mariza Fransisca Wiga Alda Maretha Hermanto Tri Joewono INDRA YULIATI, INDRA Jeremia Alvian Wiranata Jimmy Yanuar Anas Khanisyah Erza Gumilar Laksana, Muhammad Ardian Cahya Maulydia Ma’rifatu Ulfa Hidayati Mega Lestari Muhammad Adrianes Bachnas Muhammad Hafiz Nila Kurniasari Pudji Lestari Purwanto , Bambang Raheestyningtyas, Ecccita Reny Iâ€™tishom Reza Wangsanagara S.Pd. M Kes I Ketut Sudiana . Samantha, Ines Samsriyaningsih Handayani Sari, Deviati Juwita SOEHATNO - SOEHATNO -, SOEHATNO Sudaryanti, Lestari Tomy Lesmana Tri Wulanhandarini Tsalitsa Fajrina Jauhari Umi Choviva, Farida Vicky Sumarki Wardhana, Manggala Pasca Widati Fatmaningrum Willy Sandhika WITA SARASWATI, WITA Yuliana, Baiq Ade Herna Yuski Amin

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