Article Per Year (5 Year)
p-Index From 2021 - 2026
1.431
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Nexus Kedokteran Klinik Biomedika MNJ (Malang Neurology Journal) Indonesian Journal of Medicine Prosiding University Research Colloquium Magna Neurologica
Diah Kurnia Mirawati
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
Hubungan Frekuensi Bangkitan dengan Skor Kualitas Hidup pada Penderita Epilepsi Umum di RSUD Dr. Moewardi Fillisita Chandramalina Dewayani; Diah Kurnia Mirawati; Endang Sutisna Sulaeman
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.044 KB)

Abstract

Background: Epilepsy is a chronic neurology disease. When epilepsy was not well-controlled, it could cause so many effects such as decreasing quality of life score. The aim of this study was to find out the relation between seizure frequency and quality of life score of general epileptic patients in Dr. Moewardi hospital. Methods: This was an observational study with analytic cross-sectional approach conducted from July to August 2012 at Neurology Department of Dr. Moewardi hospital. Samples were taken by purposive sampling after selected based on inclusion and exclusion criteria. The frequency of seizure was recorded by medical record. The quality of life was assessed by QOLIE-31 questionnaire. Score of seizure frequency and quality of life were analyzed with one-way ANOVA models by SPSS 17.0 for Windows. Results: There were 30 samples consist of 13 women and 17 men. The average of quality of life total score in high seizure frequency was 59.56 4.71, medium seizure frequency was 78.32 2.20, and seizure free was 83.40 2.34. There was a negative relationship between seizure frequency and quality of life score on patients with general epilepsy. Analysis by one-way ANOVA/Kruskal Wallis showed a statistically significant relationship (p < 0.05) for total score component and the other seven components. Conclusion: Patients with higher seizure frequency had lower quality of life score. Keywords: seizure frequency, quality of life score, general epilepsy
Hubungan antara Kecemasan dengan Frekuensi Bangkitan pada Penderita Epilepsi Parsial di RSUD Dr. Moewardi Lucia Pancani Anggraeni; Diah Kurnia Mirawati; Endang Sutisna Sulaeman
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.044 KB)

Abstract

Background : Anxiety is a psychological disorder that involves dysregulation of the nervous system Therefore, anxiety could affected seizures threshold in people with epilepsy indirectly. The aim of this study was to know an association between anxiety and seizure frequency of partial epileptic patients in hospitals Dr. Moewardi. Methods: This was an observational study with analytic cross sectional approach. Samples were taken by purposive sampling after selected based on inclusion and exclusion criteria. The data were obtained by using of TMAS anxiety scale, interviewed seizures frequency in last one month, and the patient's medical record. Analysis of anxiety and seizures frequencys score used linear regression models by SPSS 17.0 for windows Results: There were 31 samples consisted of 10 women and 21 men. Result showed a significant positive relation between anxiety and seizure frequency of partial epileptic patients in hospitals Dr. Moewardi (p < 0.05, CI 95% = 0.06 - 0.037). Linear regression analysis test showed an equation that Y= a + bX = -1.174 + 0.218 X. It meaned that the seizure frequency would rise -1.174 + 0.218 X unit for every inrcreasing of anxiety level. Conclusion: Patients with higher level of anxiety have had more often seizure attack. Keywords: Partial epileptic patients, anxiety, frequency of seizure
Coronavirus disease 2019 (COVID-19) related stroke incidence: a case series Prabaningtyas, Hanindia Riani; Hapsari, Maria Yosita Ayu; Putra, Stefanus Erdana; Hafizhan, Muhammad; Mirawati, Diah Kurnia; Budianto, Pepi; Subandi, Subandi; Danuaji, Rivan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202307

Abstract

Coronavirus disease 2019 (COVID-19) can cause systemic and respiratory symptoms. Acute respiratory distress syndrome (ARDS), anemia, acute heart injury, secondary infection, and stroke are the complications of COVID-19. Age, oxidative stress, endothelial dysfunction, inflammatory status, vascular risk factors, and hypoxemia are risk factors for stroke associated with COVID-19. In this case report, two cases of COVID-19 complicated by stroke and other thromboembolic diseases were discussed. Case 1: a 46-year-old man presented with right extremities weakness, dysarthria, cough, colds, chest pain radiating to left upper extremity. He was diagnosed with moderate COVID-19, with complication of embolic stroke and myocardial infarction. After administration of IV furosemid and recombinant tissue plasminogen activator (rTPA), his condition improved, and he was discharged from our facility. Case 2: a 54-year-old woman presented with a decreased level of consciousness, skin discoloration, tenderness on her left calf, cough, fever, and shortness of breath. She was diagnosed with moderate COVID-19 with a complication of thrombotic stoke and deep vein thrombosis (DVT). She was treated with rTPA, IV citicoline, and fondaparinux for 5 days. In conclusion, COVID-19 carries a risk of thromboembolic complication. COVID-19 patients have a higher risk of bleeding, therefore, medications, particularly anticoagulant, should be administered with more caution.
ANGIOPLASTIC STENOSIS IN SPONTANEOUS BILATERAL CAROTIC ARTERY DISSECTION: A CASE REPORT Subandi, Subandi; Danuaji, Rivan; Suroto, Suroto; Mirawati, Diah Kurnia; Budianto, Pepi; Hambarsari, Yetty; Hamidi, Baarid Luqman; Prabaningtyas, Hanindia Riani; Hutabarat, Ervina Arta Jayanti; Ristinawati, Ira; Tejomukti, Teddy; Tedjo, Raden Andi Ario; Santosa, Novian Anindito; Putra, Stefanus Erdana; Hafizhan, Muhammad
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.20

Abstract

Case: A 28-years-old woman presented with sudden right extremities weakness, right sided facial droop, and not being able to speak. On examination, the patient had upper motor neuron (UMN) hemiplegia and motor aphasia. On blood laboratory, we found D-dimer level of 1068 ng/dl. A non-contrast head CT-scan and CT-angiography showed left cerebral hemisphere infarction, and bilateral carotid artery stenosis. Further investigation with transcranial Doppler demonstrated partial stenosis of internal carotid artery (ICA). On cerebral digital subtraction angiography (DSA), we observed pseudoaneurysm on the right ICA and flame-shaped appearance on the left ICA, both are common radiological finding of ICA dissection. Then we performed stenting angioplasty on bilateral ICA to provide recanalization, and aspirin 80mg q.d. and clopidogrel 75mg q.d. was initiated. Conclusion: Spontaneous dissection of the carotid artery can occur on young adults. DSA is considered as the gold standard for vascular examination, and stenting with angioplasty was performed for recanalization to prevent the progression to severe stroke.
A 21-Years-Old Man with Mesial Temporal Lobe Epilepsy and Dystonia: A Rare Case Report Putri, Puspita Sari Sugiyarto; Mirawati, Diah Kurnia; Hutabarat, Ervina Arta Jayanti
Magna Neurologica Vol. 2 No. 2 (2024): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v2i2.934

Abstract

Background: Mesial temporal lobe epilepsy (MTLE) with dystonia is a rare case. Seizures and movement disorders have almost the same phenomenology, so it is often difficult to distinguish them. In this study, we report a unique case of MTLE and co-occurring dystonia. Case: A 21 years old male with complaints of seizures since 4 years ago. Seizures of one body jerking and drooling with a duration of less than 5 minutes. Prior to the seizure the patient was nauseous then vomited and followed by an empty mind, after the seizure the patient was confused. The patient also complained of unconscious movements in his right hand since 8 years ago. The movements disappeared when the patient slept. Physical examination revealed dystonic movement with a sensory trick on the right hand. Magnetic resonance imaging (MRI) of the brain with contrast showed bilateral hippocampal atrophy accompanied by left hippocampal sclerosis. Blood laboratory results, electroencephalography, and neurobehavior examination were within normal limits.. Discussion: MTLE can be caused by mutations in SCN1A, VPS13A, C90RF72, or TDP 43. Dystonia can be caused by mutations in SCN1A, TUBB4A, TOR1A, THAP1, or GNAL. SCN1A causes an increase in sodium influx, causing depolarization which causes clinical manifestations in the form of seizures and dystonia. For some disorders, although genetic causes have been identified, the molecular pathophysiology remains largely unknown, requiring further research. Conclusion: For some disorders, although genetic causes have been identified, the molecular pathophysiology remains largely unknown, requiring further research.
Correlation of electrolytes with falling risk, cognitive function, and functional outcome in acute ischemic stroke patient Mirawati, Diah Kurnia; Ristinawati, Ira; Prabaningtyas, Hanindia Riani; Tedjo, Raden Andi Ario; Putra, Stefanus Erdana; Hafizhan, Muhammad; Ilhamsyah, Rudi
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23839

Abstract

Stroke outcome is determined on multiple factors. However, there are limited studies discussing the impact of electrolyte imbalance on stroke outcome. In this study, we analyzed sodium, calcium, and potassium level in acute ischemic stroke, and compare their risk of falling, cognitive function, and functional outcome. This was a cross-sectional study in Dr. Moewardi General Hospital, Indonesia between January and June 2023. Patient with acute ischemic stroke were enrolled in this study. Cognitive function was assessed with mini mental state examination (MMSE) and the Indonesian version of montreal cognitive assessment (MoCA-Ina). National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (MRS) and Morse Fall Score (MFS) were used to assessed stroke severity, disability, and risk of falling, respectively. Pearson correlation was then performed to evaluate the correlation of electrolytes level with MMSE, MoCA-Ina, NIHSS, MRS, and MFS. Furthermore, we also analyzed the odds ratio of increasing risk of falling, cognitive function deterioration, and worse functional outcome. A p-value of <0.05 is considered statistically significant. On univariate analysis, natrium is correlated with MMSE (r=0.174; p=0.042), NIHSS (r=-0.412; p=0.011), MRS (r=-0.174; p=0.042), and MFS (r=-0.304; p=0.042). Potassium is correlated with MMSE (r=0.344; p=0.044), MoCA-INA (r=0.341; p=0.048), NIHSS (r=-0.572; p=0.019), (MRS r=-0.376; p=0.017), and MFS (r=-0.612; p=0.031). Calcium is correlated with NIHSS r=-0.348 (p=0.018), MRS r=-0.256 (p=0.036). On odds ratio analysis, low natrium level increased the risk of deteriorating cognitive function, and low level of potassium increased the risk of falling. Electrolyte imbalances correlates with risk of falling and deteriorating cognitive function.
Quality of life in epilepsy: comparison between Indonesian version of QOLIE-10 and QOLIE-31 Mirawati, Diah Kurnia; Handayani, Lestari; Subandi, Subandi; Hafizhan, Muhammad; Putra, Stefanus Erdana
International Journal of Public Health Science (IJPHS) Vol 12, No 3: September 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i3.23043

Abstract

Quality of Life in Epilepsy Inventory 10 (QOLIE-10) and QOLIE-31 is used to measure patient’s quality of life. While longer version of QOLIE-31 is thought to have higher validity and reliability, QOLIE-10 is shorter and more practical to use in clinical setting. This study aimed to compare Indonesian version of QOLIE-10 and QOLIE-31. This was a cross sectional study conducted at Dr. Moewardi General Hospital, Surakarta, Indonesia. Participant were asked to complete the Indonesian version of QOLIE-10 and QOLIE-31, and data obtained then analysed to find the correlation between QOLIE-10 and QOLIE-31. A total of 51 epilepsy patients were included on this study. We observed correlation of 0.41 to 0.84 (p<0.05) for each item of QOLIE-10 with their respective QOLIE-31 subscale. We also found correlation value of 0.898 (p=.000) between total score of QOLIE-10 and QOLIE-31 showing strong positive correlation of two questionnaire. Independent T-sample test on QOLIE-10 and QOLIE-31 T-score result of p=.361, showing no statistical difference between two questionnaires. Frequency of seizure is correlated with patients’ quality of life. QOLIE-10 has strong positive correlation to QOLIE-31, which make it a useful tool to assess epilepsy patients’ quality of life.
COMPARISON OF EFFICACY BETWEEN EDARAVONE AND RILUZOLE COMBINATION THERAPY FOR PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS Budianto, Pepi; Mirawati, Diah Kurnia; B, Benedictus; Tan, Kenneth; Hafizhan, Muhammad; Putra, Stefanus Erdana
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.13

Abstract

Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neuromuscular disease with a survival period of less than 5 years. Although the past decade has shown a major growth of interest in Edaravone research due to its superior efficacy, a growing number of research done on Riluzole combinations for ALS therapy. Objective: A systematic review is needed to compare the patient outcomes as shown in the ALS functional rating scale (ALSFRS-R) of Edaravone and Riluzole combinations. Methods: This research is a systematic review from PubMed, ProQuest, and Science Direct. The studies included were randomized controlled trials (RCT) and post-hoc analysis of RCT published from 2012 to 2023. This research included 16 studies (11 RCT studies and 5 post-hoc studies of RCT). The studies discussed the patient population, side effects, and ALSFRS-R scores. Results: Edaravone showed better efficacy than Riluzole combination in maintaining ALSFRS-R score with mean difference between Edaravone (MD=2.19, 95% CI: 0.42-3.96, p=0.02) and Riluzole (MD=1.67, 95% CI: -0.19-3.52, p=0.08). The meta-analysis showed heterogeneity in both Edaravone (I2=90%, p<0.00001) and Riluzole (I2=77%, p=0.004) studies. Conclusion: The results conclusively showed that Edaravone was more efficacious than the explored Riluzole combinations so far. Nevertheless, Riluzole-Masitinib showed promising results to be further explored.
Association between vaspin rs2236242 gene polymorphism and atherosclerosis in ischemic stroke patients with diabetes mellitus in the Indonesian population Danuaji, Rivan; Suroto; Purwanto, Bambang; Indarto, Dono; Muhammad, Faizal; Mirawati, Diah Kurnia; Widyaningsih, Vitri; Soetrisno; Subandi; Budianto, Pepi; Hambarsari, Yetty; Hamidi, Baarid Luqman; Prabaningtyas, Hanindia Riani; Hutabarat, Ervina Arta Jayanti; Ristinawati, Ira; Tejomukti, Teddy; Tedjo, Raden Andi Ario
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247566

Abstract

BACKGROUND Stroke is the third leading cause of morbidity and second in mortality worldwide. Diabetes mellitus (DM) is a risk factor for stroke. Vaspin and single nucleotide polymorphism (SNP) rs2236242 involved DM pathogenesis. This study aimed to explore the correlation between SNP rs2236242, serum vaspin levels, and atherosclerosis in patients with ischemic stroke and DM. METHODS This study was conducted in Dr. Moewardi Hospital from 2022 to 2023. The case group included patients with ischemic stroke and DM, while the controls were those with ischemic stroke only. Tetra-primer amplification refractory mutation system-polymerase chain reaction was used to determine the genotypes. RESULTS There were 31 cases and 33 control. SNP rs2236242 showed that odds ratio (OR) (95% confidence interval [CI]) for AA-TT was 0.273 (0.241–0.305) and for TA-TT was 0.315 (0.298–0.341). The OR (95% CI) for allele A to T was 0.789 (0.373−1.669). The mean (standard deviation) serum vaspin level in the case group compared to the control was 1,570 (2,108) ng/ml versus 1,630 (1,428) ng/ml (p = 0.064). Higher vaspin levels were found in T allele of the TT (1,523 [2,269] ng/ml, p = 0.021) and TA (1,760 [1,349] ng/ml, p = 0.004) genotype groups than the A allele of the AA genotype group (0.914 [0.329] ng/ml). CONCLUSIONS Vaspin gene polymorphism AA genotype or A allele significantly reduces vaspin levels in patients with ischemic stroke with DM.
Study on the Effectiveness of Multimodal Interventions (TEKEN program) to Improve Cognitive Function of the Elderly Untari, Ida; Subijanto, Achmad Arman; Mirawati, Diah Kurnia
Prosiding University Research Colloquium Proceeding of The 14th University Research Colloquium 2021: Bidang Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Multimodal dan single modal menunjukkan efek sederhana dalam memperlambat perkembangan demensia. Tujuan kami adalah menilai dampak intervensi multimodal pada fungsi kognitif lansia dibandingkan dengan modal tunggal. Metode: Multistage random sampling di Surakarta, Indonesia. Intervensi multimodal terdiri dari kombinasi pelatihan kognitif dan senam yang dikemas dengan istilah program TEKEN (Telaten, Eling, Kekancan, Etung, seNeng) dan modal tunggal meliputi pelatihan kogitif, senam dan pendidikan kesehatan. Pelaksanaan 2 kali seminggu selama 24 kali pertemuan. Pengukuran fungsi kognitif menggunakan The Mini Mental State Exam (MMSE) dan The Montreal of Cognitive Assasement (MoCA) versi Indonesia dilakukan di awal dan akhir (3 bulan). Analisis menggunakan effect size/ES (d), regresi logistik, korelasi Kendall Tau Test. Hasil: 188 yang masuk dalam analisis akhir, terbagi 61 kelompok dengan program TEKEN, pelatihan kognitif: 40, senam: 49 dan pendidikan kesehatan: 38. Program TEKEN mempunyai ES (d) cukup besar (0,46) lebih kecil dari program pelatihan kognitif dan lebih kecil dari program senam pada pengukuran MMSE, sedangkan pada MoCA-Ina, program TEKEN mempunyai ES (d) kecil (0,19) namun lebih besar dari program kognitif dan lebih pula dari program senam. Nilai ES pada MoCA-Ina dapat menjadi nilai standar awal pada penelitian berikutnya. Kesimpulan: Multi modal dan single modal dapat meningkatkan fungsi kognitif pada lansia namun multi modal tidak mempunyai efek lebih bermakna secara keseluruhan dari modal tunggal (pelatihan kognitif, senam dan pendidikan kesehatan).
Co-Authors . Suroto Achmad Arman Subijanto, Achmad Arman Apriyanto, Arif B, Benedictus Bagus Dwi Prasetyo Bambang Purwanto Budianto, Pepi Damayanti, Elok Dewi, Endang Kusuma Dono Indarto Endang Sutisna Sulaeman Endang Sutisna Sulaeman Fillisita Chandramalina Dewayani Gia Noor Pratami Hafizhan, Muhammad Hambarsari, Yetty Hamidi, Baarid Lukman Hamidi, Baarid Luqman Hapsari, Maria Yosita Ayu Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Untari Ilhamsyah, Rudi Lestari Handayani Lucia Pancani Anggraeni Muhammad, Faizal Novian Anindito Santosa Prabaningtyas, Hanindia Riani Prabaningtyas, Hanindya Prabaningtyas, Hanindya Riani Putri, Puspita Sari Sugiyarto Rakhma, Titian Ristinawati, Ira Rivan Danuaji Soetrisno Stefanus Erdana Putra Subandi Subandi Sulistyani Sulistyani SUROTO Suroto . Suroto Suroto Susilo, Wahyu Agung Tan, Kenneth Tedjo, Raden Andi Ario Tejomukti, Teddy Vitri Widyaningsih Widhianingsih, Nella Lusti