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IIN INDAWATI
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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FORMULASI DAN UJI SIFAT FISIK LILIN AROMA JERUK BERGAMOT (Citrus bergamia) SEBAGAI AROMATERAPI : FORMULATION AND PHYSICAL PROPERTIES TESTS OF BERGAMOT ORANGE (Citrus bergamia) AROMA CANDLE AS AROMATHERAPY Ayu Gita Hamdani; Iin Indawati; Tomi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.781

Abstract

Aromaterapi ialah teknik yang dipakai untuk terapi aromatik, dan untuk melindungi serta menambah kesehatan fisik dan mental, termasuk dengan gangguan depresi dan stres. Lilin aromaterapi ialah salah satu aplikasi aromaterapi dengan cara dihirup (inhalasi) yaitu dengan menghirup uap aromatik yang didapatkan dari beberapa tetes minyak essensial pada tempat berisi air panas, dan salah satu minyak essensial yang telah digunakan untuk mengatasi kecemasan adalah jeruk bergamot (Citrus bergamia). Penelitian ini dilakukan untuk memformulasikan dan menguji sifat fisik pada lilin aromaterapi jeruk bergamot (Citrus bergamia). Soy wax dilelehkan diatas waterbath kemudian tambahkan minyak essensial jeruk bergamot (Citrus bergamia) sesuai dengan konsentrasi pada masing-masing formula. Lilin aromaterapi pada formula I menunjukkan konsentrasi minyak essensial terbaik dibandingkan dengan formula II dan formula III. Hal ini dikarenakan kadar minyak essensial tinggi akan berpengaruh pada sifat fisik lilin, yaitu titik lelehnya yang rendah dan waktu pembakaran lebih cepat sehingga membuat lilin cepat habis terbakar. Lilin aromaterapi pada formula III dengan  konsentrasi 6% minyak atsiri jeruk bergamot (Citrus bergamia) menunjukkan lilin aromaterapi yang paling banyak disukai responden. Kata kunci : Lilin Aromaterapi, Minyak Essensial Jeruk Bergamot, Uji Sifat Fisik Lilin
PHYTOCHEMICALS SCREENING AND ANTIOXIDANT ACTIVITY TEST OF ETHYL ACETATE FRACTION OF CHINESE BETLE LEAVES (Peperomia pellucida L.) Naida Rahma Almira; Didin Ahidin; Iin Indawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.823

Abstract

Peperomia pellucida (Chinese betel) is considered as a plant with antioxidant activity for  inhibiting oxidation reactions. This study aims to determine the yield of secondary metabolites, total flavonoid levels, and antioxidant activity. Dried leaves of Chinese betel were macerated using 70% ethanol as solvent. The extract was partitioned until the n-hexane and ethyl acetate fractions were obtained. A phytochemical screening test was followed by determining total flavonoid levels and antioxidant activity using UV-Vis spectrophotometry. Phytochemical screening results containing an ethanolic extract of Chinese betel leaves (ECBL) showed positive results on alkaloid, flavonoid, saponin, and tannin. Meanwhile, the ethyl acetate (EAF) and n-hexane (HF) fractions showed positive results only for flavonoid presence. The total flavonoid contents of ECBL, EAF, and HF were 3.30%, 2.54%, and 2.03%, respectively. The IC50 values of  ECBL, EAF, and HF were 7.51 ppm, 8.02 ppm, and 8.04 ppm, respectively. The highest flavonoid content was found in ECBL. Antioxidant activity test of Peperomia pellucida ethanolic extract, ethyl acetate fraction, and n-hexane fraction showed potent antioxidant activity.  Keywords: Antioxidant, Peperomia pellucida , DPPH
REVIEW: THE USE OF TOFU RESIDUE IN THE PHARMACEUTICS Ine Suharyani; Iin Indawati; Encu Asep Setiadi; Maisya Mauliana Insani; Ibnu Mas'ud
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1096

Abstract

Tofu is a processed soy product consisting of soft solids made by clumping soy protein extracts. The residual result of tofu processing is called the tofu dredging waste. In Indonesia, tofu waste remains an unsolved problem. Many people argue that the waste from tofu processing (tofu residue waste) does not have high economic value and is only used as feed for livestock and is even thrown carelessly into the river, which causes damage to the ecosystem. Tofu pulp has high nutritional content, such as protein (26.6%), fat (18.3%), carbohydrates (41.3%), phosphorus (0.29%), calcium (0.19%), iron (0.04%), and water (0.09%). The purpose of this journal review is to determine the use of tofu residue waste and solve the problem of tofu residue waste in the community. The method used was collecting various research journals through the Google Scholar website with keywords for the use of tofu residue in the pharmaceutical field. Based on the 7 journals reviewed, tofu pulp can be used as an anti-aging, adsorbent, anti-diabetes, anti-inflammatory, bioethanol, and excipient in tablet production. Keywords: Tofu, tofu residue, pharmaceutical
IDENTIFICATION OF MEDICINAL COMPOUND IN URIC ACID JAMU BY THIN LAYER CHROMATOGRAPHY METHOD Muhammad Yani Zamzam; Iin Indawati; Nina Karlina; Elsa Tiakomala; Windah Widia Ningrum; Aulia Nurkahfi; Andriana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1120

Abstract

Jamu is one of the traditional medicines derived from natural ingredients distributing in Indonesia. In accordance with Permenkes No. 007 of 2012, Medicinal Compound (MC) are prohibited from being added to jamu products. Previous research has found that some of the products in public contain MC. The aim of this study is to determine the presence or absence of allopurinol, piroxicam, and dexamethasone in uric acid jamu.  This research used 5 (five) samples of uric acid jamu, both those with and without distribution permits from The Indonesian Food and Drug Authority, randomly selected in Kedawung District, Cirebon Regency, West java, Indonesia. The identification method used in this study is Thin Layer Chromatography (TLC) with the stationary phase being silica gel GF 254. For the identification of allopurinol, the mobile phase is n-butanol: ammonium hydroxide: ethanol; for piroxicam identification, it is ethyl acetate-methanol-ammonia (6:3:1); and for dexamethasone identification, it is chloroform: acetone (1:4). Spot detection is done using ultraviolet (UV) light at 254 nm. The applied solutions are the test solution (A), the test solution with added allopurinol, piroxicam, or dexamethasone (B), and the reference standard solution (C). The research results from the 5 (five) samples of uric acid jamu identified one positive samples containing allopurinol, and all positive samples contained piroxicam and dexamethasone. Keywords: Jamu,  thin-layer chromatography, allopurinol, piroxicam, dexamethasone
PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT OF BASIL LEAVES (Ocimum sanctum L.) AGAINST Propionibacterium acne BACTERIA Didin Ahidin; Didi Rohadi; Iin Indawati; Muh Yani Zamzam; Rinto Susilo; Nurcholisah; Andriana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1227

Abstract

Acne is a skin disease often experienced by teenagers and young adults. Basil leaves (Ocimum sanctum L.) could be used as an alternative treatment for acne. This study aimed to determine the secondary metabolite content and antibacterial activity of Ocimum sanctum ethanol extract against Propionibacterium acne. Simplicia was extracted from basil leaves by maceration with 96% ethanol solvent. The extracts were tested for parameters, phytochemical screening, and antibacterial activity using the disc diffusion method. Ocimum sanctum ethanol extract was used at concentrations of 20%, 30%, and 40%. Ocimum sanctum ethanol extract has a brownish-black color with a distinctive aromatic aroma and a bitter, slightly sour taste, with a moisture content of 5.6%, ash content of 7.71%, and drying shrinkage of 7.1%. Ocimum sanctum ethanol extract contains flavonoids, tannins, steroids, and saponins. Antibacterial activity of clindamycin 0.01% and Ocimum sanctum ethanol extract concentration of 20%, 30%, and 40% could inhibit Propionibacterium acne bacteria as much as 11.95 mm, 4.47 mm, 4.91 mm, and 6.30 mm. The antibacterial activity of the Ocimum sanctum ethanol extract was 20%. The 30% and 40% treatments differed significantly from the positive controls. The ethanol extract of basil leaves has antibacterial activity against Propionibacterium acne bacteria with the best antibacterial activity at a concentration of 40% as much as 6.30 mm. Keywords: Basil leaf (Ocimum sanctum L.), phytochemical screening, antibacterial activity
SPRAY ANTI NYAMUK ( REPELLENT) INFUS KULIT BUAH JERUK NIPIS SEBAGAI ALTERNATIF PENCEGAHAN DEMAM BERDARAH DI MASYARAKAT Iin Indawati; Khofifah Khofifah; Vanessa Michelle
BAKTIMU : Jurnal Pengabdian Kepada Masyarakat Vol 1 No 1 (2021)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/bm.v1i1.202

Abstract

ABSTRAKPenyakit Demam Berdarah Dengue (DBD) merupakan salah satu masalah kesehatan masyarakat yang utama di Indonesia hingga saat ini. Diketahui bahwa di Kabupaten Cirebon hingga minggu kedua bulan Juni 2020 jumlah kasus penderita DBD tercatat sebanyak 463 orang dengan 11 orang meninggal. Disimpulkan bahwa perlu dan pentingnya sosialisasi mengenai pencegahan DBD pada masyarakat Kabupaten Cirebon, salah satu pencegahan dimasyarakat dengan memanfaatkan bahan yang terdapat dirumah melalui edukasi pemanfaatan Kulit Buah Jeruk Nipis sebagai spray anti nyamuk (Repellant). Sasaran kegiatan pengabdian masyarakat ini adalah masyarakat Kabupaten Cirebon. Kegiatan pengabdian kepada masyarakat ini menggunakan metode webinar dengan menyampaikan informasi dengan kegiatan edukasi tentang bahaya DBD dan cara pencegahan. Cara penggunaan serta pembuatan spray infus kulit buah jeruk nipis sebagai anti nyamuk (Repellant). Kegiatan sosialisasi pencegahan dan penggunaan Spray Infus Kulit Buah Jeruk Nipis berjalan dengan lancar. Hal ini ditandai dengan hasil uji hedonic sediaan yang mendapatkan skor rata-rata 3, artinya responden suka dengan sediaan Spray Infus Kulit Buah Jeruk Nipis.Kata Kunci: Demam berdarah, kulit buah jeruk nipis, anti nyamuk
EVALUASI PENGGUNAAN ANTIBIOTIK YANG RASIONAL PADA PASIEN PNEUMONIA RAWAT INAP DI RS X KOTA CIREBON Nurhaini, Rahmi; Tomi, Tomi; Faradhila, Afifah; Indawati, Iin
CERATA Jurnal Ilmu Farmasi Vol 14 No 2 (2023): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v14i2.815

Abstract

Antibiotics are the main therapy for pneumonia caused by bacteria. Inappropriate use of antibiotics leads to resistance. The purpose of this study was to describe the charateristics (gender, age, and payment status), the rationale for the use of antibiotics including the parameters of the right indication, the right patient, the right dose, and the right route of drug which refers to Permenkes number 28 of 2021 in pneumonia patients in the inpatient installation of RS X Kota Cirebon. This research is an observational study with retrospective data collection techniques through medical records. Sampling was done done by purposive sampling. The sample in this study was the medical recorsd of patients diagnosed with pneumonia who received antibiotic therapy and met the inclusion criteria of 97 medical records. The guidelines used are Permenkes number 28 of 2021 concercing guidelines for the use of antibiotics. Data analysis was carried out descriptively using Microsoft Excel 2019 presented in the form of tables, diagrams and percentages accompanied by explanations. The results of the study showed that the suitability of using antibiotics based on guidelines obtained right indication of 100%, right drug 34%, right dose 50,5%, and right route of drug administration 100%. Data on the number of patients who used antibiotics in pneumonia patients rationally was 23,7% and irrational use was 76,3%.
STUDY ON THE OPTIMIZATION OF MULBERRY LEAF EXTRACT BY MACERATING ETHANOL AND MICROWAVE ASSISTED EXTRACTION METHOD (MAE) WITH NATURAL DEEP EUTECTIC SOLVENTS (NADES) Kunaedi, Aan; Indawati, Iin; Karlina, Nina; Fadhillah, Zakie; Cantika, Citra Dhea; Khulfiah, Ade Ayu
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7915

Abstract

Ethanol extract from the leaves of Morus alba, an herb, has been widely used for medicine, including commercial formulations. This study aims to compare the characteristics of NADES extract using the MAE method and the maceration method. Mulberry leaf simplicia (Morus alba. L) ethanol extract was made with various ethanol concentrations of 50%, 60%, 70%, 80%, and 90%, and NADES (Natural Deep Eutectic Solvents) extract with a solvent ratio of 1:20 and 1: 30 on the MAE (Microwave Assisted Extraction) method with a time of 5 and 10 minutes. Measurement of total flavonoid content and total phenolic content was carried out by UV-vis spectrophotometry with quercetin and gallic acid as reference standards. The results showed that the ethanol extract with ethanol concentrations of 50%, 60%, 70%, 80%, and 90% had an average total flavonoid content; and total phenolic: 0.73%, 0.9%, 1.32%, 1.18%, 0.77%; total phenolic 96.789 mg/g, 71.262 mg/g, 126.465 mg/g, 116.643 mg/g, 93.366 mg/g. NADES extract with a solvent ratio of 1:20 at MAE 5" and 10" minutes obtained flavonoid levels of 0.36%, 0.4%, and total phenolic levels of 36.099 mg/g; 75.621 mg/g. While a ratio of 1:30 with an MAE time of 5" and 10" minutes, the flavonoid content was 0.44%; 0.48%, and the total phenolic content of 61.884 mg/g; 121.237 mg/g. Results of water-soluble essence of ethanol extract; NADES is 26%–31%; 21–24%. Result of ethanol soluble extract content of ethanol extract; NADES is in the range of 36%–42%; 85%–86%. Result of the specific gravity of ethanol extract; NADES is in the range of 0.82 g/mL–0.95 g/mL; 1.08 g/mL–1.18 g/mL. The ethanol extract pH test results were; NADES in the range 6.90–7.01; 7.59–7.89.
Identification of Medicinal Chemicals in Herbal Medicine for Shortness of Breath in Cirebon Using Thin-Layer Chromatography Method Indawati, Iin; Bagus Prayogo, Iqbal; Zamzam, Muh Yani
Jurnal Medisci Vol 1 No 6 (2024): Vol 1 No 6 June 2024
Publisher : Ann Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62885/medisci.v1i6.318

Abstract

Herbal medicine is prohibited from adding Medicinal Chemicals (BKO), both isolated and synthetic, by Permenkes No. 007 of 2012 Article 7. However, several previous studies found herbal medicine containing BKO; the addition of BKO is indicated so that products from the manufacturer feel faster and have instant efficacy. However, the addition of BKO to herbal medicine has side effects on the organs of the consumer. In 2014 – 2022, BPOM released 12 herbal products that were proven to contain BKO. This study aims to identify the existence of BKO in shortness-of-breath herbal medicine and to find out what BKO is contained in the herbal medicine. Using the purposive sampling method, this study tested six herbal medicine samples with shortness of breath circulating in Cirebon. The techniques used in the identification were thin-layer chromatography (KLT) with the silent phase of GF 254 silica gel, the motion phase of Chloroform, Methanol, and Aquabidest with a ratio of 2: 7: 1. Spot detection through 254 nm UV light. The controlled solution is the test solution (A), the positive control solution (B), and the comparator raw solution (C). Based on the study's results, 5 out of 6 herbal samples containing BKO, Samples 1 and 3 contained CTM and Ephedrine Hcl. Samples 2, 5, and 6 contained Ephedrine HCl only. Sample 4 does not contain BKO.
Narrative Review: The Potential Of Morus Alba And Morus Nigra As Anti-Inflammatory And Antioxidant Indawati, Iin; Kintoko
Jurnal Medisci Vol 2 No 1 (2024): Vol 2 No 1 August 2024
Publisher : Ann Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62885/medisci.v2i1.400

Abstract

Introduction: Oxidative stress causes various diseases. Inflammation is the body's response to tissue infections and injuries. Mulberry is a multifunctional plant with bioactive components that have potent antioxidant and anti-inflammatory activities. This study aims to determine the activity of antioxidants, anti-inflations, extraction processes, active compounds, and methods used for antioxidant and anti-inflammatory testing. Methods: Narrative review using a literature search using Google Scholar and PubMed. Results: The results of Morus alba and Morus nigra have antioxidant activity, the plant parts used by leaves, fruits, and roots. Various methods were used to determine antioxidant activity, including DPPH, reducing power assay, β-carotene bleaching, and Hydroxyl radical scavenger capacity. Conclusion: Anti-inflammatory mechanism of mulberry bioactive compounds by inhibiting several cytokines and inflammatory mediators such as IL-1β, IL-6, IL-8, IL-9, IL-10, IL-23a, IFN-ɣ, TNF-ɑ, MMP-3, MMP-9, TLR, COX-2, NF-kB and iNOS. Testing of antioxidant activity by DPPH, ABTS, FRAP, reducing power assay, β-carotene bleaching, and Hydroxyl radical scavenger capacity
Co-Authors Aan Kunaedi Achelia, Elvanka Putri Agus Khurniawan Alvionita, Elina Andriana Angellin Sephia Wulandari Ani Fathonah Ani Fatonah Anis Selawati Arwanto Aulia Nurkahfi Aulia Oktaviani Awaliya Agustin Ayu Gita Hamdani Bagus Prayogo, Iqbal bayu pamungkas Cantika, Citra Dhea Chaniago, Adhilla Kristina Dea Martelinda Della Nur Nadya Deni Firmansyah Devi Siti Noer Faufiyah Didi Rohadi Didin Ahidin Elina Alvionita Elisa Nurhidayah Elsa Safitri Elsa Tiakomala Elva Angela Encu Asep Setiadi Evi Sinta Fadhillah, Zakie Faradhila, Afifah Fatihatul Rizki Lusiana Fatonah, Ani Firda Rahmawati Ibnu Mas'ud Intan Singgih Khofifah Khofifah Khulfiah, Ade Ayu Khurniawan, Agus Kintoko Kurniawati Lela Sulastri, Lela Lilis Listiyani Luthfiah Khairunnisa M. Yani Zamzam Maisya Mauliana Insani Mareetha Zahra S Muh Yani Zamzam Muh. Yani Zamzam MUHAMMAD AMIR Muhammad Firli Gifari Muhimatul Umur Nabila, Syakira Putri Nadya Aulia Rahmah Naida Rahma Almira Nina Karlina Nina Karlina Nok Endang Ayu Prihatini Novita Sari Nur Rahmi Hidayati, Nur Rahmi Nurcholisah Nusikho Rahmi Nurhaini, Rahmi Renny Amelia Safirany, Mareetha Zahra Setyaningsih, Indah Sidik Lingga Kusuma Sidik Lingga Kusuma Siti Pandanwangi TW Suci Nurlia Suharyani, Ine Sulistiorini Indriaty Susilo, Rinto Syakira Putri Nabila Syema Aufa Omahoa Taufik Al Fazri Tomi . Tomi, Tomi Umi Fatchyatul Wahidah Umur, Muhimatul Umurdin Syafrandy Tuanany Uswatun Khasanah Vanessa Michelle Windah Widia Ningrum Yusnita, Afis Oni Zamzam, M. Yani Zamzam, Muh Yani Zamzam, Muhammad Yani