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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Kefarmasian Indonesia Community Empowerment Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Abdi Masyarakat Kita Sciences of Pharmacy Warta LPM Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Medimuh : Jurnal Kesehatan Muhammadiyah
Yayan Rizikiyan
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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IN VITRO ANTIBACTERIAL ACTIVITY OF CARICA PAPAYA LEAF EXTRACT-LOADED ACNE PATCHES AGAINST Propionibacterium acnes Indriaty, Sulistiorini; Rizikiyan, Yayan; Gianto, Vinie Regina Putri; Karlina, Nina; Hidayati, Nur Rahmi; Sulastri, Lela; Firmansyah, Deni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1673

Abstract

Acne vulgaris is a prevalent skin condition that is characterized by inflammatory lesions. Propionibacterium acnes is a key bacterium implicated in its pathogenesis. This study aimed to investigate the antibacterial potential of Carica papaya leaf extract against P. acnes and its efficacy when formulated into acne patches. Ethanolic extracts of C. papaya leaves were prepared at concentrations of 20%, 25%, and 30%. These extracts were incorporated into acne patch formulations and evaluated for antibacterial activity using the paper disc diffusion method. Clindamycin 1% was used as a positive control and 70% ethanol was used as a negative control. The results demonstrated that all concentrations of the C. papaya leaf extract exhibited significant antibacterial activity against P. acnes. The 30% concentration demonstrated the largest zone of inhibition, which was comparable to that of the positive control. These findings suggest that C. papaya leaf extract-based acne patches are promising natural alternatives for the treatment of acne vulgaris. Keywords: Papaya leaves (Carica papaya L), Propionibacterium acne, Acne patch, Inhibitory power
FORMULATION AND ANTIOXIDANT ACTIVITY FACE TONER BUTTERFLY PEA FLOWER KOMBUCHA (Clitoria ternatea L.) WITH DPPH METHOD Rizikiyan, Yayan; Hidayat, Salsabila Aulia; Suharyani, Ine; Sulastri, Lela; Indriaty, Sulistiorini; Karlina, Nina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1686

Abstract

Antioxidants can be given to the skin through cosmetics such as face toners. One source of antioxidants is obtained through the fermentation of butterfly pea flower kombucha (Clitoria ternatea L.), which has been proven to have better antioxidant activity than butterfly pea flower extract alone. This study aimed to determine the metabolite compounds in butterfly pea flower kombucha and create a facial toner formulation with good antioxidant activity. The butterfly pea flower kombucha was fermented for 6 days at room temperature. Facial toners were made with concentrations of 5%, 7,5% and 10%. Evaluation of the face toner includes organoleptic, homogeneity, pH, specific gravity, and viscosity tests. The antioxidant activity test used the DPPH (1,1-diphenyl-2-pycrilhydrazil) method, with vitamin C as a positive control. The results showed that there were alkaloids, flavonoids, saponins, and terpenoid compounds in butterfly pea flower kombucha. Face toners with concentrations of 5%, 7.5%, and 10% could be prepared and met all evaluations (organoleptic tests, homogeneity, pH, specific gravity, and viscosity). Antioxidant test results on formula 1 IC50 50,21±SD 0,01 (strong), formula 2 IC50 44,32±SD 0,02 (very strong) and formula 3 IC50 38,62±SD 0,03 (very strong). The higher the concentration of butterfly pea flower kombucha, the higher the antioxidant activity. Butterfly pea flower kombucha (Clitoria ternatea L.) which is formulated as a face toner preparation has strong to very strong antioxidants, and the increasing concentration of active ingredients had an effect on antioxidant activity.  Keywords: face toner, butterfly pea flower kombucha, DPPH method, antioxidant activity
Nanostructured lipid carrier (NLC) in topical preparations: a narrative review of components, manufacturing methods, characteristics and activities Rizikiyan, Yayan; Sugihartini, Nining; Rais, Ichwan Ridwan
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1643

Abstract

Nanostructured Lipid Carries NLCs have gained attention in formulation science and nanotechnology due to their biocompatible material and ability to enhance skin penetration. The goal is to create products that can effectively deliver active compounds to desired skin layers with minimal side effects. This review focuses on the use of functionalized NLCs in dermocosmetics, specifically looking at their composition, manufacturing method, characteristics, and role in delivering active compounds. The review obtained articles from databases such as Scopus, Pubmed, and Google Scholar, covering the years 2014-2024. Data search was conducted in May 2024. The search used keywords such as "NLC OR formulation OR dermal OR activity”. By considering factors such as NLC composition, manufacturing method, and impact on compound delivery, researchers aim to optimize NLCs for use in topical preparations. This research contributes to the development of dermocosmetics that can address various skin problems more effectively. The search results from 32 articles gave an overview of the widely used NLC components: solid lipids: glycerol monostearate, compitrol 888 ATO, and tristearin; liquid lipids: myglyol, transcutol, and oleic acid; surfactants: poysorbat 80 and polysorbate 20. The widely used methods were ultrasonication and high pressure homogenization. Frequently performed characterizations include particle size, polydispersity index (PDI), zeta potential, and Entrapment Efficiency (EE). The pharmacological activity of active components loaded into NLCs increased than without NLCs. The active ingredient formulated in NLC can produce better activity compared to the active substance formulated directly in the conventional preparation. The application of nanostructured lipid carrier (NLC) nanoparticles on the skin is very beneficial. These nano systems have shown promising results and more commercial formulations, so it is expected to be done in further research.
Co-Authors . Darmono . Syamsudin Adiibah, Siti Ahadi, Ghany Alifia, Fathia Putri Alya Najmatul Laila Ani Fatonah Ani Fatonah Anna S. Ranti Arifka, Mia Ayu Mulyani Ayu Mulyani ayunda Azzahra, Siti Cabellon-Semense, Daisy Jane Deni Firmansyah Desy Wulan Dari Didi Rohadi Elinawati Ernawati Ernawati Ewit Lestari Ewit Lestari Falya, Yuniarti Farhan Zulfa Madani Farhan Zulfa Madani Fariz, Rizal Miftah Fitriani, Vina Nurul Gianto, Vinie Regina Putri Hidayat, Salsabila Aulia Ichwan Ridwan Rais Inayatul Fajriyah Iqbal Bagus Prayogo Islamiyyah Nur Aini Ohorella Islamiyyah Nur Aini Ohorella Khofifah Lela Sulastri, Lela Lestari, Trisna Maryam, Diana Dwi Maryanto, Naida Ajeng mutmainah, iin Nasrul Wathoni Nina Karlina Nina Karlina Nina Karlina Nining Sugihartini Noviani, Lusy Nur Rahmi Hidayati, Nur Rahmi Nurhidayah, Sri Opi Nurholipah P. Simanjuntak Pratama, Reza Rahmasari, Yuni Ranti, Anna S. Renny Amelia Renny Amelia Renny Amelia Rima Yulia Senja, Rima Yulia Rizal Miftah Fariz Rizki Nurbaeti Rury Dwi Lestari Setyaningsih, Indah Shadrina, Ghesani Nur Simanjuntak, P. Sopiah, Sopi Siti Suci Naluriah Suci Riyanti Suhandi, Cecep Suharyani, Ine Sulistiani Sulistiorini Indriaty Suryaman, Ine Suharyani Tresna Lestari, Tresna Trisna Lestari Tussadiyah, Halimah Widia Ningsih, Widia Winda Sari Winda Sari Yadi Supriyadi Yasmin Yasmin Zamzam, Muhammad Yani