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FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI FACE MIST EKSTRAK NADES KULIT BAWANG MERAH (Allium cepa L.) TEHADAP BAKTERI Propionibacterium acnes: FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI FACE MIST EKSTRAK NADES KULIT BAWANG MERAH (Allium cepa L.) TEHADAP BAKTERI Propionibacterium acnes Yayan Rizikiyan; Farhan Zulfa Madani; Ine Suharyani; Sulistiorini Indriaty; Ani Fatonah; Ayu Mulyani
Medimuh : Jurnal Kesehatan Muhammadiyah Vol 5 No 1 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/mh.v5i1.1326

Kulit bawang merah (Allium cepa L.) telah lama digunakan sebagai obat tradisional karena mempunyai daya hambat pertumbuhan bakteri jerawat seperti Propionibacterium acnes. Oleh karena itu, kulit bawang merah berpotensi digunakan dalam industri makanan dan farmasi. Penelitian mengenai sediaan face mist dari ekstrak NADES kulit bawang merah belum pernah dilakukan sebelumnya. Penelitian ini dilakukan untuk memformulasikan sediaan face mist dengan bahan aktif ekstrak kulit bawang merah (Allium cepa L.) dengan konsentrasi 3%,6%,9% dan untuk mengetahui aktivitas antibakteri face mist tersebut terhadap bakteri Propionibacterium acnes. Kulit bawang merah (Allium cepa L.) diekstrasi menggunakan metode MAE (Microwave Assisted Extraction) dengan pelarut NADES (Natural Deep Eutectic Solvents) yaitu chaoline chloride dan urea perbandingan rasio molar 1:2 selanjutnya dimasukan kedalam microwave dengan waktu 120 menit suhu 60°C, daya yang digunakan 850 watt. Pengujian daya hambat face mist terhadap bakteri Propionibacterium acnes menggunakan metode sumuran. Adanya daya hambat ditunjukan dengan terbentuknya zona bening di sekitar sumur pada media agar. Diameter hambat diukur menggunakan jangka sorong. Hasil evaluasi face mist ekstrak NADES kulit bawang merah konsentrasi 3%, 6% dan 9% organoleptis, homogenitas, pH, viskositas, bobot jenis, uji waktu kering semuanya memenuhi persyaratan. Hasil pengujian aktivitas antibakteri dari face mist ekstrak NADES kulit bawang merah konsentrasi 3%, 6% dan 9% masing masing sebesar 5,91mm, 7,20mm, dan 9,60mm, ketiganya dapat dikatakan memiliki daya hambat dalam kategori sedang. Kata kunci: face mist, kulit bawang merah, Propionibacterium acnes, MAE

Nanostructured lipid carrier (NLC) in topical preparations: a narrative review of components, manufacturing methods, characteristics and activities Rizikiyan, Yayan; Sugihartini, Nining; Rais, Ichwan Ridwan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1643

Nanostructured Lipid Carries NLCs have gained attention in formulation science and nanotechnology due to their biocompatible material and ability to enhance skin penetration. The goal is to create products that can effectively deliver active compounds to desired skin layers with minimal side effects. This review focuses on the use of functionalized NLCs in dermocosmetics, specifically looking at their composition, manufacturing method, characteristics, and role in delivering active compounds. The review obtained articles from databases such as Scopus, Pubmed, and Google Scholar, covering the years 2014-2024. Data search was conducted in May 2024. The search used keywords such as "NLC OR formulation OR dermal OR activity”. By considering factors such as NLC composition, manufacturing method, and impact on compound delivery, researchers aim to optimize NLCs for use in topical preparations. This research contributes to the development of dermocosmetics that can address various skin problems more effectively. The search results from 32 articles gave an overview of the widely used NLC components: solid lipids: glycerol monostearate, compitrol 888 ATO, and tristearin; liquid lipids: myglyol, transcutol, and oleic acid; surfactants: poysorbat 80 and polysorbate 20. The widely used methods were ultrasonication and high pressure homogenization. Frequently performed characterizations include particle size, polydispersity index (PDI), zeta potential, and Entrapment Efficiency (EE). The pharmacological activity of active components loaded into NLCs increased than without NLCs. The active ingredient formulated in NLC can produce better activity compared to the active substance formulated directly in the conventional preparation. The application of nanostructured lipid carrier (NLC) nanoparticles on the skin is very beneficial. These nano systems have shown promising results and more commercial formulations, so it is expected to be done in further research.

FORMULASI KRIM BODY SCRUB BERAS KETAN HITAM DAN SARI LABU KUNING SEBAGAI ZAT AKTIF Indriaty, Sulistiorini; Ine Suharyani; Nur Rahmi Hidayati; Yayan Rizikiyan; Nina Karlina; Desy Wulan Dari
Medimuh : Jurnal Kesehatan Muhammadiyah Vol 5 No 2 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/mh.v5i2.1680

Body scrub adalah sediaan farmasi dalam bentuk produk perawatan kulit berbutir kasar. Beras ketan hitam dan sari buah labu kuning dapat dimanfaatkan sebagai zat aktif pada sediaan body scrub, karena beras ketan hitam dan sari labu kuning mengandung komponen antioksidan yaitu beta karoten dan vitamin C, yang membantu menjaga kesehatan kulit dan membantu kulit nampak lebih cerah.Penelitian ini bertujuan untuk mengetahui apakan beras ketan hitam konsentrasi 7% dan sari labu kuning konsentrasi 10%, 15% dan 20% dapat diformulasikan sebagai krim body scrub dan bagaimana hasil evaluasi sediaan tersebut. Krim body scrub beras ketan hitam konsentrasi 7% dan sari labu kuning di buat menjadi tiga formula dengan variasi konsentrasi sari labu kuning formula I 10%, formula II 15% dan formula III 20% pengamatan dilakukan pada hari ke-0, dengan parameter pengujian meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar dan uji tipe emulsi. Hasil yang diperoleh menunjukkan bahwa formula I berwarna krem, formula II berwarna coklat dan formula III berwarna coklat tua, untuk pH formula I yaitu 6,84, formula II yaitu 6,87, formula III yaitu 6,88. Daya sebar semistiff karna kurang dari <5. Sehingga dapat disimpulkan bahwa beras ketan hitam konsentrasi 7% dan sari labu kuning konsentrasi 10%, 15%, dan 20% dapat diformulasikan sebagai krim body scrub dengan formula tersebut dan hasil evaluasi sediaan body scrub beras ketan hitam dan sari labu kuning dengan variasi konsentrasi sari labu kuning 10%, 15%, dan 20% serta konsentrasi beras ketan hitam 7% dilihat dari uji organoleptis, uji homogenitas, uji daya sebar dan uji tipe krim menunjukkan hasil bahwa sediaan basis dan formula body scrub memenuhi persyaratan evaluasi sediaan yang baik. Kata kunci : Beras ketan hitam, sari labu kuning, body scrub.

ANALISIS INTERAKSI OBAT PADA PASIEN COVID-19 DENGAN PENYAKIT STROKE DI INSTALASI RAWAT INAP RSD GUNUNG JATI CIREBON Rizki Nurbaeti; Nur Rahmi Hidayati; Trisna Lestari; Sulistiorini Indriaty; Nina Karlina; Lela Sulastri; Yayan Rizikiyan
Medimuh : Jurnal Kesehatan Muhammadiyah Vol 5 No 2 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/mh.v5i2.1681

Interaksi obat covid-19 dengan penyakit stroke harus mendapatkan perhatian khusus karena pasien membutuhkan berbagai macam obat. Penelitian ini bertujuan untuk mengetahui karakteristik pasien, potensi interaksi obat, tingkat keparahan interaksi obat, gambaran jenis obat dan jumlah obat yang berinteraksi, serta hubungan antara karakteristik pasien dengan interaksi obat pada pasien. Penelitian ini merupakan penelitian non eksperimental dengan pengambilan data secara retrospektif. Sampel dalam penelitian ini adalah rekam medik pasien terdiagnosa covid-19 dengan penyakit stroke yang memenuhi kriteria inklusi. Terdapat 71 pasien terdiagnosa covid-19 dengan penyakit stroke, sebanyak 43 pasien berpotensi interaksi obat, karakteristik pasien paling banyak dialami oleh perempuan (63,38%), berdasarkan usia 45-59 tahun (33,80%), dan tingkat keparahan tahapan Monitor ketat (61,73%). Obat yang paling banyak interaksi yaitu aspirin + vitamin C (5,56%). Hubungan jumlah obat yang digunakan dan yaitu pasien dengan jumlah obat >5 obat lebih banyak terjadi interaksi sebesar (52,11%). Pasien terdiagnosa covid-19 dengan penyakit stroke beresiko tinggi mengalami interaksi obat karena adanya penyakit penyerta pada pasien sehingga terapi obat lebih banyak. Kata kunci: interaksi obat, covid-19, stroke, rekam medik

FORMULASI KRIM BODY SCRUB BERAS KETAN HITAM DAN SARI LABU KUNING SEBAGAI ZAT AKTIF Indriaty, Sulistiorini; Ine Suharyani; Nur Rahmi Hidayati; Yayan Rizikiyan; Nina Karlina; Desy Wulan Dari
Medimuh : Jurnal Kesehatan Muhammadiyah Vol 5 No 2 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/mh.v5i2.1680

Body scrub adalah sediaan farmasi dalam bentuk produk perawatan kulit berbutir kasar. Beras ketan hitam dan sari buah labu kuning dapat dimanfaatkan sebagai zat aktif pada sediaan body scrub, karena beras ketan hitam dan sari labu kuning mengandung komponen antioksidan yaitu beta karoten dan vitamin C, yang membantu menjaga kesehatan kulit dan membantu kulit nampak lebih cerah.Penelitian ini bertujuan untuk mengetahui apakan beras ketan hitam konsentrasi 7% dan sari labu kuning konsentrasi 10%, 15% dan 20% dapat diformulasikan sebagai krim body scrub dan bagaimana hasil evaluasi sediaan tersebut. Krim body scrub beras ketan hitam konsentrasi 7% dan sari labu kuning di buat menjadi tiga formula dengan variasi konsentrasi sari labu kuning formula I 10%, formula II 15% dan formula III 20% pengamatan dilakukan pada hari ke-0, dengan parameter pengujian meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar dan uji tipe emulsi. Hasil yang diperoleh menunjukkan bahwa formula I berwarna krem, formula II berwarna coklat dan formula III berwarna coklat tua, untuk pH formula I yaitu 6,84, formula II yaitu 6,87, formula III yaitu 6,88. Daya sebar semistiff karna kurang dari <5. Sehingga dapat disimpulkan bahwa beras ketan hitam konsentrasi 7% dan sari labu kuning konsentrasi 10%, 15%, dan 20% dapat diformulasikan sebagai krim body scrub dengan formula tersebut dan hasil evaluasi sediaan body scrub beras ketan hitam dan sari labu kuning dengan variasi konsentrasi sari labu kuning 10%, 15%, dan 20% serta konsentrasi beras ketan hitam 7% dilihat dari uji organoleptis, uji homogenitas, uji daya sebar dan uji tipe krim menunjukkan hasil bahwa sediaan basis dan formula body scrub memenuhi persyaratan evaluasi sediaan yang baik. Kata kunci : Beras ketan hitam, sari labu kuning, body scrub.

ANALISIS INTERAKSI OBAT PADA PASIEN COVID-19 DENGAN PENYAKIT STROKE DI INSTALASI RAWAT INAP RSD GUNUNG JATI CIREBON Rizki Nurbaeti; Nur Rahmi Hidayati; Trisna Lestari; Sulistiorini Indriaty; Nina Karlina; Lela Sulastri; Yayan Rizikiyan
Medimuh : Jurnal Kesehatan Muhammadiyah Vol 5 No 2 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/mh.v5i2.1681

Interaksi obat covid-19 dengan penyakit stroke harus mendapatkan perhatian khusus karena pasien membutuhkan berbagai macam obat. Penelitian ini bertujuan untuk mengetahui karakteristik pasien, potensi interaksi obat, tingkat keparahan interaksi obat, gambaran jenis obat dan jumlah obat yang berinteraksi, serta hubungan antara karakteristik pasien dengan interaksi obat pada pasien. Penelitian ini merupakan penelitian non eksperimental dengan pengambilan data secara retrospektif. Sampel dalam penelitian ini adalah rekam medik pasien terdiagnosa covid-19 dengan penyakit stroke yang memenuhi kriteria inklusi. Terdapat 71 pasien terdiagnosa covid-19 dengan penyakit stroke, sebanyak 43 pasien berpotensi interaksi obat, karakteristik pasien paling banyak dialami oleh perempuan (63,38%), berdasarkan usia 45-59 tahun (33,80%), dan tingkat keparahan tahapan Monitor ketat (61,73%). Obat yang paling banyak interaksi yaitu aspirin + vitamin C (5,56%). Hubungan jumlah obat yang digunakan dan yaitu pasien dengan jumlah obat >5 obat lebih banyak terjadi interaksi sebesar (52,11%). Pasien terdiagnosa covid-19 dengan penyakit stroke beresiko tinggi mengalami interaksi obat karena adanya penyakit penyerta pada pasien sehingga terapi obat lebih banyak. Kata kunci: interaksi obat, covid-19, stroke, rekam medik

Pemanfaatan Bunga Telang (Clitoria Ternatea) untuk Pembuatan Cendol di Desa Sindanglaut, Lemahabang, Kabupaten Cirebon Suharyani, Ine; Renny Amelia; Setyaningsih, Indah; Lestari, Tresna; Rizikiyan, Yayan; Falya, Yuniarti; Ayunda; Ahadi, Ghany; Fitriani, Vina Nurul; Maryanto, Naida Ajeng; Alifia, Fathia Putri; Tussadiyah, Halimah
Warta LPM WARTA LPM, Vol. 28, No. 1, Maret 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/warta.v27i1.7225

Cendol was known as a popular cold drink in Indonesia. To make cendol, synthetic color often used to get attractive color, but in other side this dye may have a serious problem for health. To address this issue, this program was done to practice the making of cendol by using natural dye such as butterfly pea flower which has blue-purple color. The use of natural dyes not only provides an attractive color but also offers health benefits as a natural antioxidant. In this program, we educate and practice the PKK members of Sindanglaut Village about the utilization of butterfly pea flower member in making cendol ice. The activity held on July-August 2024, involved 16 participants. The methods used in this program consisting of presentation, demonstration, and practice. The assesment about the improvement of their knowledge were done by pre- and post-tests. The results showed an increase in knowledge of participants about the benefits of butterfly pea flowers and the techniques for making cendol. In addition, the participants' enthusiasm for the training is very high, although some challenges, such as a decline in participants' motivation, were addressed with interventions like cheers and door prizes. This socialization is expected to motivate the PKK members to continue developing innovations in food and beverage preparation, as well as to promote the use of natural ingredients that are beneficial for health. In addition, this counseling can be an idea for utilizing materials available around the house to make food or drinks that can be sold, thereby increasing community income.

Local food-based education: Utilization of moringa leaves (Moringa oleifera, l.) for stunting prevention Amelia, Renny; Suharyani, Ine; Rizikiyan, Yayan; Lestari, Trisna; Sulastri, Lela; Supriyadi, Yadi; Azzahra, Siti; Ningsih, Widia; Mutmainah, Iin; Maryam, Diana Dwi; Shadrina, Ghesani Nur; Yasmin, Yasmin; Nurhidayah, Sri; Adiibah, Siti
Community Empowerment Vol 10 No 4 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12302

Stunting, a condition of impaired growth in children due to chronic malnutrition, is a significant public health problem. This community service aimed to increase the knowledge of the community, particularly pregnant women, regarding the potential of Moringa oleifera leaves as a healthy snack alternative in stunting prevention. This activity employed a pre-test post-test design with an intervention of counseling and training on making chicken nuggets fortified with Moringa oleifera leaves. The target participants were pregnant women with low upper arm circumference and mothers with stunted children. Evaluation of participants' understanding of stunting and the benefits of Moringa oleifera leaves was conducted before and after the intervention. The evaluation results showed an increase in participants' understanding of stunting and the benefits of Moringa oleifera leaves, as indicated by an increase in the average score of correct answers in the post-test compared to the pre-test. A hedonic test on the chicken nuggets fortified with Moringa oleifera leaves showed a very high level of liking for taste and color, and a high level of liking for aroma and appearance. The texture of the nuggets was identified as an aspect requiring further improvement.

The Development of Nano-mist Spray Propolis as Antioxidant Suryaman, Ine Suharyani; Sulastri, Lela; Rizikiyan, Yayan; Wathoni, Nasrul; Suhandi, Cecep; Noviani, Lusy; Rahmasari, Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.52433

Propolis is a lipid-based compound from honeybees composed of plant wax, resin, and pollen. Due to its poor water solubility, its application is limited to lipid-based formulations with low bioavailability. This study aimed to develop a water-based propolis nano-mist spray with improved dispersion and evaluate its antioxidant activity. The nano-mist formulation was prepared using soy lecithin and Tween 80 in a phosphate buffer base. Evaluations included organoleptic characteristics, pH, particle size, zeta potential, and antioxidant activity by DPPH method. The propolis extract contained flavonoids, alkaloids, and tannins. The resulting spray showed a light brown color, a pH of 6.87 ± 0.03, particle size of 272.13 ± 4.25 nm, and zeta potential of -0.433 ± 0.35 mV. Antioxidant testing revealed moderate activity with an IC₅₀ value of 83.63 ± 11.88 ppm. This study supports the potential of nano-mist spray as a promising delivery system for propolis with antioxidant properties suitable for cosmetic and pharmaceutical applications.

NLP Analysis of Mannan-Based Drug Delivery Trends Pratama, Reza; Cabellon-Semense, Daisy Jane; Sulastri, Lela; Arifka, Mia; Rizikiyan, Yayan
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403339

Mannan, a polysaccharide derived from various sources, has gained attention for its biocompatibility and potential in targeted drug delivery. Since its initial use in 1911 as an ointment base, mannan has been applied in cancer therapy, vaccine development, and as an antimicrobial agent. However, research is still largely dominated by in vitro and preclinical studies, with few clinical trials conducted to date. This study aims to provide an overview of mannan's advancements, its uses in drug delivery, the mechanisms involved, the research gaps, and the underexplored areas with significant potential. This study analyzed 321 peer-reviewed articles selected from Scopus (2000-2024), employing natural language (NLP) and bibliometric mapping to identify key materials, application areas, and research trends. Mannan’s flexible molecular structure allows for copolymerization with polymers such as chitosan, alginate, polyacrylate, and polycaprolactione, enabling improved targeting, mucoadhesion, and controlled drug release. Chitosan emerged as the most frequently used co-polymer, particularly in nanogel formulations for cancer and inflammatory diseases. Keyword impact analysis also revealed growing interest in mannans role in post-COVID-19 cytokine storm mitigation and vaccine enhancement, despite limited representation in clinical pipelines. Optimization of polymer ratios, crosslinker use and formulation strategies, remains essential to improving translational outcomes. Future research should also focus on clinical trials to demonstrate its effectiveness. In conclusion, this study underscores mannans role as promising biomaterial for next-generation drug delivery systems, while identifying gaps in clinical validation, mechanistic insight, methodological consistency. To advance toward commercial and clinical applications, future research should integrate machine learning models for predicting formulation parameters and drug release profiles. This findings offer a roadmap for the design, standardization, and eventual commercialization of mannan-based delivery platforms.

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