Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal Journal of Epidemiology and Public Health Oto Rhino Laryngologica Indonesiana Sumatera Medical Journal International Journal of Nasopharyngeal Carcinoma Narra J
Delfitri Munir
Faculty Of Medicine Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Factors Affecting Presbycusis on Audiogram Overview at H. Adam Malik General Hospital Medan Manullang, Frenky Sorimuda; Adnan, Adlin; Munir, Delfitri
Journal of Epidemiology and Public Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2021.06.01.02

Abstract

Background: Presbycusis incidence is thought to have a relationship with hereditary factors, metabolism, atherosclerosis, noise and lifestyle. The presbycusis classification consists of Sensory (outer hair-cell), neural (ganglion-cell), metabolic (strial atrophy), and conductive cochlea (stiffness of the basilar membrane). Factors that influence presbycusis include age, gender, genetics, hypertension, gout, diabetes mellitus, hypercholesterolemia, noise exposure, and smoking. This study aims to determine the factors that influence presbycusis on the audiogram image at H. Adam Malik Hospital Medan. Subjects and Method: This study was an analytical study with a cross sectional design in elderly patients at the polyclinic. The study was conducted in November to December 2019. The dependent variable was the incidence of presbycusis. The independent variables were uric acid levels, blood sugar levels, smoking habits, hypercholesterolemia, and hypertension. Data were analyzed by using chi square test. Results: The prevalence of presbycusis in the 45-59 years age group was 39 people (54.2%) and the 60-74 years age group was 33 people (45.8%). In this study, it shows that male respondents are more than female respondents, where the number of men is 58 people (80.6%) and women are 14 people (19.4%). Based on presbycusis type, there were 33 (45.9%) people (normal), 18 (25%) people (strrial type), 7 (7.9%) people (neural type), 7 (7.9%) people (sensory type), 7 (7.9%) people (cochlear type). High sugar content (OR= 3.33; 95% CI= 1.81 to 6.13; p <0.001), uric acid levels (OR= 2.36; 95% CI= 1.19 to 4.70; p= 0.005), total cholesterol levels (OR= 3.33; 95% CI= 1.81 to 6.13; p <0.001), and smoking (OR= 1.90; 95% CI = 1.21 to 2.97; p= 0.016) increased the risk of presbycusis. Conclusion: High sugar levels, uric acid levels, total cholesterol levels, and smoking habits increase the risk of presbycusis.
Therapeutic potential of thymoquinone in regulating p63, claudin, and periostin in chronic rhinosinusitis with nasal polyps: An animal model study Ulfa, Loriana; Munir, Delfitri; Rambe, Andrina YM.; Farhat, Farhat; Wardani, Retno S.; Amin, Mustafa M.; Zahara, Devira; Ardinata, Dedi
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1728

Abstract

High recurrence rate and the necessity for repeated surgical interventions contribute to the chronicity and treatment-resistant nature of chronic rhinosinusitis with nasal polyps (CRSwNP). Thymoquinone, known for its protective effects on epithelial integrity, has not been previously explored in CRSwNP. The aim of this study was to investigate the therapeutic potential of thymoquinone to restore epithelial integrity by assessing p63 transcription factor and claudin protein expressions, as well as periostin mRNA expression in an animal model. An in vivo study using post-test-only control group design was conducted in which male Wistar rats were randomly assigned to three groups, each consisting of 10 animals: healthy group, CRSwNP group, and thymoquinone-treated group for three weeks. Immunohistochemistry was used to analyze the p63 and claudin protein expressions, while periostin mRNA expression was quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR). This study found that thymoquinone significantly reduced p63 transcription factor expression compared to the untreated CRSwNP group (p=0.009). Claudin protein expression was significantly higher in thymoquinone-treated group compared to CRSwNP group (p=0.007), indicating improved epithelial barrier function. Periostin mRNA expression showed no significant difference between healthy and thymoquinone-treated groups (p=0.564), but a significant decrease was observed in CRSwNP group compared to thymoquinone-treated group (p=0.000) and between the healthy and CRSwNP groups (p=0.002), suggesting attenuation of tissue remodeling and inflammation. In conclusion, thymoquinone could enhance sinonasal epithelial barrier integrity in CRSwNP by downregulating p63 transcription factor, upregulating claudin protein expression, and reducing periostin mRNA expression. These findings emphasize the potential of thymoquinone as a therapeutic agent to mitigate inflammation and tissue remodeling in CRSwNP, warranting further investigation as a novel treatment option.
Level of Knowledge, Attitude, and Behavior of Students at SMA Negeri 13 Medan on Prevention of Sexually Transmitted Infections Elisabeth; Magdalena Simatupang, Maria; Munir, Delfitri; Rasiyanti Siregar, Olga
Sumatera Medical Journal Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i1.12045

Abstract

Background: Sexually Transmitted Infection (STI) is a contagious disease that has been a health problem around people all over the world because the incidence rate of sexually transmitted diseases (STDs) tends to increase. Objective: This research objects to know the level of knowledge, attitudes and behavior of SMA Negeri 13 Medan students regarding STI prevention. Methods: This is descriptive research with cross-sectional design. The sampling technique is done by stratified random sampling with questionnaire as data collection tool and the data analysis was carried out using descriptive statistics. Results: The results showed that the knowledge level of SMA Negeri 13 Medan students about preventing STI was mostly in the good category (54.2%), attitudes were in the good category (93.7%), and behaviors were in the moderate category (47.9%). Conclusion: Most of students have a good knowledge level, good attitude level, and moderate behavior level towards STI prevention.
Co-Authors -, Fadhlia Adlin Adnan Agung Putra Amin, Mustafa M. Andrina Yunita Murni Rambe Ardinata, Dedi - Arlinda Sari Wahyuni Asnir, Rizalina Arwinati Chrestella, Jessy Darlan, Dewi M. Dolly Irfandy Elisabeth Erna Mutiara Evita Mayasari Farhat, Farhat Farhat, Farhat Ginting, Andi R. Haryuna, Tengku Siti Hajar Hasibuan, Mangain Hendradewi, Sarwastuti Ibrahim Irsan Nasution Kusuma Dewi, Anna Mailasari Magdalena Simatupang, Maria Magdi, Yoan Levia Manullang, Frenky Sorimuda Nurdiansah, Firman Pardede, Sujahn Anto Putri Chairani Eyanoer, Putri Chairani Rambe, Andriana Yunita Murni Rambe, Andrina Y.M Rambe, Andrina YM. Rambe, Andrina Yunita Murni Ramsi Lutan Rasiyanti Siregar, Olga Restimulia, Lia Rina Yunita Rozi, Muhammad F. Rusda, Muhammad sagala, irwan pernandi Sagala, Irwan Pernandi Silvia, S Simanjuntak, Amran Sinta Sari Ratunanda Siska Indriany Sorimuda Sarumpaet Sutikno, Budi Taufik Ashar Ulfa, Loriana Wardani, Retno S. Wardani, Retno Sulistyo Zahara, Devira Zakiah, Azmi Mir’ah