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All Journal Journal of Food and Pharmaceutical Science EKSAKTA: Journal of Sciences and Data Analysis Journal Pharmaceutical Science and Application (JPSA) Jurnal Tumbuhan Obat Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Dental Journal (Majalah Kedokteran Gigi) Majalah Farmaseutik Proceeding Biology Education Conference Journal of Pharmaceutical and Sciences. Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Yosi Bayu Murti
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Hypoglycemic Activity and Pancreas Protection of Combination Juice of Mengkudu (Morinda citrifolia Linn.) Juice and Temulawak (Curcuma xanthorrhiza Roxb.) Juice on Streptozotocin-Induced Diabetic Rats Santoso, Bilal Subchan Agus; Sudarsono, Sudarsono; Nugroho, Agung Endro; Murti, Yosi Bayu
Indonesian Journal of Pharmacy Vol 29 No 1, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1451.748 KB) | DOI: 10.14499/indonesianjpharm29iss1pp16

Abstract

Mengkudu fruit contains scopoletin and temulawak rhizome contains curcumin have been observed because they have strong antioxidant activity and they were used traditionally as antidiabetic. This research aimed to evaluate effect of antihyperglycemic and pancreas protection of juice combination of mengkudu fruit juice (MFJ) and temulawak rhizome juice (TRJ) on diabetes rats which were inducted with streptozotocin (STZ). Rats were grouped into 7 groups, each of group consisting 5 rats. Each of group was treated accordingly for 28 days except for a normal group of rats. Rats taken blood from the plexus retroorbitalis for examination of blood glucose levels every week. On the last day, rats blood was examined for malondialdehyde (MDA) levels. After that the rats were turned off for examination of pancreatic morphological conditions. The results showed that diabetic rats given MFJ-TRJ combination juice experienced a significant decrease in blood glucose levels, a significant decrease in MDA levels and improvement pancreas morphology when compared with the negative control group. The conclusion of this research was giving combination juice of MFJ-TRJ juice can decreased blood glucose level, decreased MDA level and can improved pancreas morphology condition.
PROTECTIVE EFFECT ETHANOLIC EXTRACT OF Boesenbergia pandurata (ROXB.) Schlecht. AGAINST UVB-INDUCED DNA DAMAGES IN BALB/C MICE Shanti Listyawati; Sismindari Sismindari; Sofia Mubarika; Yosi Bayu Murti
Indonesian Journal of Pharmacy Vol 26 No 2, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.14 KB) | DOI: 10.14499/indonesianjpharm26iss2pp108

Abstract

Boesenbergia pandurata (Roxb.) Schlecht. contains bioactive compounds that have a number healthy effect including anti-oxidant and anti-carcinogenic activity. This research was carried out to examine the protective effect of B. pandurata extract against expression of cyclobutane pyrimidine dimers (CPDs) as marker of UVB-induced DNA damage in Balb/c mice. Dried powder of B. pandurata rhizomes was extracted by maceration method using 96% ethanol. The extract was quantified with pinostrobin as active marker using TLC scanner. Ethanolic extract of B. pandurata (EEBP) was given orally at 14 days before UV exposure with a variety doses, 0 (vehicle), 20, 40 and 60mg/kgBW/day and continuing until termination of the experiment. Following the UVB irradiation (1.4J/m2), mice were sacrificed at different time points (2, 24, 48, and 72h after UVB exposure). The back skin samples were collected to analyze CPDs expression by immunohistochemical method. The result showed that EEBP (contained 5% pinostrobin) dose was 40 and 60mg/kgBW/day had protective activity against UV-induced DNA damage as indicated by the decrease of CPDs expression.   Key words:  Boesenbergia pandurata (Roxb.) Schlecht., UVB, DNA damage, CPDs.
CONSTRUCTION OF IN SILICO STRUCTURE-BASED SCREENING TOOLS TO STUDY THE OXIDATIVE METABOLITES FORMATION OF CURCUMIN BY HUMAN CYTOCHROME 450 3A4 Dewi Setyaningsih; Muhammad Radifar; Yosi Bayu Murti; Enade Perdana Istyastono
Indonesian Journal of Pharmacy Vol 24 No 2, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.033 KB) | DOI: 10.14499/indonesianjpharm24iss2pp75-85

Abstract

Cytochrome P450 3A4 (CYP3A4) is a phase 1 metabolism enzyme which is responsible for the metabolism of about 3040% drug in the market. This CYP3A4 is the most abundant CYP450 expressed in human body and also the one who is responsible for the biotransformation of most drugs. The competitive inhibition of curcumin (a yellow bioactive pigment discovered in Curcuma sp.) towards human CYP3A4 indicates that curcumin can be a substrate for the enzyme. In this study, in silico approaches employing molecular docking and interaction fingerprinting were used to predict the binding mode and the site of metabolism (SOM) of curcumin. Together with the SOMs retrieved previously and the list of possible reactions catalyzed by CYP3A4, the docking and fingerprinting results indicate that the most probable metabolite of curcumin metabolism by human CYP3A4 is an oxidative metabolite 1-(3,4-dihydroxyphenyl)-5hydroxy-7-(4-hydroxy-3-methoxy-phenyl)hepta-1,4,6-trien-3one.Key words: site of metabolism (SOM), curcumin, biotransformation, in silico, molecular docking, protein-ligand interaction fingerprinting
Co-Authors Agung Endro Nugroho Akhmad Kharis Nugroho Damiana Nitya Kanistri Damiana Nitya Kanistri Desi Riza Pratiwi Dewi Setyaningsih Dian Mayasari Dina Aryani Dina Aryani, Dina Dyaningtyas Dewi Putri Pamungkas Ema Damayanti Enade Perdana Istyastono Erwin Nur Indiarto Gani, Andayana Puspitasari Hari Purnomo Harsini Harsini Illian, Didi Nurhadi Indah Purwantini Indrawan Kurnia Dwinatari Indrawan Kurnia Dwinatari, Indrawan Kurnia Izatunnafis, Izatunnafis Kuswandi Kuswandi Kuswandi Kuswandi Lalita Lisprayatna Lalita Lisprayatna, Lalita Mahfud Alkarim Mahfud Alkarim, Mahfud mufrod mufrod Mufrod Mufrod Muhammad Radifar Mutiara Annisa Priyasana, I Putu Rafika Sari Rahmawati, Arini Nur Yunia Puspitaningrum Ramadhani, Novia Putri Ratih Anggar Kusumaningtyas Respati Tri Swasono Retno Murwanti Ropiqa, Meri Sanan, Antonius Oenunu Santoso, Bilal Subchan Agus Sekararum Diah Kartikasari Sekararum Diah Kartikasari, Sekararum Diah Shanti Listyawati Sindu Nuranto Sisca Devi Sisca Devi Sismindari Sismindari Siswanto, Soni Siti Sunarintyas Sofa Farida Sofia Mubarika Haryana Sri Budi Barunawati Sudarmanto, B.S. Ari Sudarsono Sudarsono Sudarsono, Sudarsono Suparyono Saleh Sylvia Utami Tunjung Pratiwi T. Nanda Saifullah Sulaiman T. Nanda Saifullah Sulaiman, T. Nanda Saifullah Tamhid, Hady Anshory Tatang Irianti Tivanie, Riza Ayu TN. Saifullah Sulaiman TN. Saifullah Sulaiman, TN. Saifullah Tri Rini Nuringtyas Triana Hertiani Wayan Tunas Artama Yekti Asih Purwestri