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All Journal Journal of Tropical Biodiversity and Biotechnology Jurnal Dinamika Pengabdian (JDP) Indonesia Chimica Acta Indonesian Journal of Chemistry Communications in Science and Technology SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Chemistry Indonesian Journal of Chemical Research Jurnal Pengabdian Masyarakat Borneo Abdimas Galuh : Jurnal Pengabdian Kepada Masyarakat Indobiosains Molekul: Jurnal Ilmiah Kimia
Hasnah Natsir
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Jl. Perintis Kemerdekaan Km 10 Tamalanrea, Makassar 90245, South Sulawesi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Toxicity and Cytotoxicity Test of Anticancer Peptides Isolated from Symbiotic Bacteria Asmi, Nur; Ahmad, Ahyar; Natsir, Hasnah; Karim, Harningsih; Muhakim, Ali; Khairunnur, Siti
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Vol. 18 No. 1 (2025): Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.43925

Abstract

The purpose of this research was to evaluate the toxicity and cytotoxicity of the fragment peptide from symbiotic bacteria in the lung cancer LK-2 cell line, compared normal M5S cell line. Protein hydrolyzates were separated using Molecular Weight Cut Off (MWCO) to isolate peptide fragments. Fragments were categorized as ≤ 5 kDa, > 5-10 kDa, and > 10 kDa to evaluate their toxicity through the Brine Shrimp Lethality Test (BSLT) method and to study cytotoxicity effects and proliferation in LK-2 lung cancer cells against normal M5S cells. MTT assay was used to analyze the percentage of living cells and cell growth. The Selectivity Index (SI) equation was applied to determine selectivity. Findings indicated that the peptide fragment ≤ 5 kDa had the highest toxicity, with an LC50 of 8.15 µg/ml. The number of LK-2 cells that died increased when exposed to peptide fragments of sizes ≤ 5 kDa, > 5-10 kDa, and > 10 kDa over 16 hours. Moreover, cell growth in LK-2 cells decreased after 16 hours, while there was no significant decline (P < 0.05) in M5S cells compared to the controls. The peptide fragments with molecular weights ≤ 5 kDa and > 5-10 kDa demonstrated the highest selectivity, resulting in an SI value of 3. These results suggest that the selected peptide fragments may serve effectively as anticancer agents. This study highlights the potential of peptides from symbiotic bacteria as possible treatments for cancer, particularly lung cancer.
Pemberdayaan Masyarakat Melalui Pelatihan Pengolahan Air Kelapa Menjadi Nata De Coco Terfortifikasi Kitosan di Kelurahan Tiroang, Kabupaten Pinrang, Sulawesi Selatan Natsir, Hasnah; Arif, Abdur Rahman; Arfah, Rugaiyah A; Budi, Prastawa; Zakir, Muhammad; Karim, Abdul; Fauziah, St; Mardianti, Riska; Nadir, Muhammad
Jurnal Pengabdian Masyarakat Borneo Vol 8, No 3 (2024)
Publisher : Universitas Borneo Tarakan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35334/jpmb.v8i3.3485

Abstract

Coconut, particularly coconut water, serves many purposes in people's lives. Coconut water is generally consumed with the young fruit, but old coconut water is frequently discarded into the environment. Therefore, integrating coconut water into a product has a high economic value. The aims of this community service is to process coconut water into nata de coco by empowering the community through training for PKK members. This program's methodology included partner problem analysis and the available problem-solving strategy, which consists of counselling, training, and collecting data. The implementation of this activity resulted in numerous benefits, particularly increased public understanding of the role of coconut water in daily life, such as its nutritional value, processed products such as nata de coco, and other advantages. Based on the data collected, it is known that all participants have differing levels of knowledge about nata de coco products, namely 10% of participants know very well, 30% of participants know, and 12% of participants know little. However, 58% of participants were totally ignorant that coconut water is the starting material in nata de coco. Following the training, all participants understood that coconut water was the raw material in nata de coco. On the other hands, 75% of the participants were very understanding, 20% were quite understanding, and only 5% had a basic understanding of how to make nata de coco. These findings indicate that the solution of the activities carried out is extremely effective in increasing the participants' understanding and interest in making nata de coco, which can encourage the creation of "home industry" based jobs in the community, particularly in Tiroang Village. 
Edukasi pemanfaatan limbah cangkang rajungan menjadi pengawet alami pada kelompok nelayan "Mappedeceng" Natsir, Hasnah; Arfah, Rugaiyah A.; Karim, Muh. Yusri; Raya, Indah; Ahmad, Ahyar; Zakir, Masculine; Nadir, Muhammad; Mardiyanti, Riska; Rasyid, Herlina; Erviani, Andi Evi; Aziz, Fitriani; Anita, Anita; Rauf, Wahyudin; Gita, Gita; Khotimah, Husnul; Alam, Muh. Nur
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 5 (2025): September (In Progress)
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i5.34094

Abstract

Abstrak Limbah cangkang rajungan yang mencapai 40-60% dari total bobot rajungan selama ini hanya dibuang ke lingkungan sehingga menimbulkan pencemaran di daerah pesisir. Kegiatan pengabdian masyarakat ini bertujuan memberikan edukasi dan pelatihan kepada kelompok nelayan "Mappedeceng" di Desa Lasitae, Kecamatan Tanete Rilau, Kabupaten Barru tentang pemanfaatan limbah cangkang rajungan menjadi kitosan sebagai pengawet alami. Metode pelaksanaan terdiri dari tiga tahapan yaitu persiapan, pelaksanaan (penyuluhan, pelatihan teknologi pengolahan, dan praktik langsung), serta evaluasi melalui pre-post test. Kegiatan dilaksanakan pada 9 Agustus 2025 dengan melibatkan 40 peserta. Hasil evaluasi menunjukkan peningkatan pengetahuan peserta sebesar 38,75% berdasarkan perbandingan skor pre-test (rata-rata 10,575) dan post-test (rata-rata 18,325). Kegiatan praktik pembuatan pengawet alami menunjukkan antusiasme tinggi dari peserta, dengan mayoritas merasa percaya diri menerapkan teknologi ini di rumah. Kitosan yang dihasilkan terbukti dapat memperpanjang masa simpan produk perikanan hingga 2-3 kali lipat dan memiliki nilai ekonomi tinggi sekitar Rp 75.000-100.000 per kilogram. Program ini berhasil meningkatkan kesadaran nelayan tentang pentingnya ekonomi sirkular dalam perikanan dan memberikan solusi berkelanjutan untuk mengatasi masalah limbah cangkang rajungan sekaligus menciptakan peluang ekonomi baru bagi masyarakat pesisir. Kata kunci: limbah cangkang rajungan; kitosan; pengawet alami; pemberdayaan nelayan; teknologi pengolahan limbah. Abstract Crab shell waste, which accounts for 40-60% of the total weight of crabs, is often dumped into the environment, causing pollution in coastal areas. This community service activity aims to provide education and training to the "Mappedeceng" fishing group in Lasitae Village, Tanete Rilau District, Barru Regency, on the utilization of crab shell waste into chitosan as a natural preservative. The implementation method consists of three stages: preparation, implementation (counseling, processing technology training, and direct practice), and evaluation through a pre-post test. The activity was carried out on August 9, 2025, involving 40 participants. The evaluation results showed an increase in participant knowledge of 38.75% based on a comparison of pre-test scores (average 10.575) and post-test (average 18.325). The practical activity of making natural preservatives showed high enthusiasm from the participants, with the majority feeling confident in applying this technology at home. The resulting chitosan has been proven to extend the shelf life of fishery products by two to three times and has a high economic value of around IDR 75,000-100,000 per kilogram. This program has successfully raised awareness among fishermen about the importance of a circular economy in fisheries and provided a sustainable solution to address the problem of crab shell waste while creating new economic opportunities for coastal communities. Keywords: crab shell waste; chitosan; natural preservative; fishermen empowerment; waste processing technology.
Co-Authors A Arfah, Rugaiyah Abdul Karim Abdur Rahman Arif, Abdur Rahman Ahyar Ahmad Alam, Muh. Nur Ali Muhakim Andi Evi Erviani Anggriani, Dhea Faraditha Anita Anita Arfah, Rugaiyah Arfah, Rugaiyah A Arfah, Rugaiyah A. Aziz, Fitriani Djabal Nur Basir dwyana, Zarsawaty Fauziah, St Gita, Gita Harningsih Karim Husnul Khotimah Indah Raya Irfandi, Rizal Karimah, Aulia Khairunnur, Siti Mardianti, Riska Mardiyanti, Riska Maswati Baharuddin Muh. Yusri Karim Muhammad Nadir Muhammad Zakir Munandar, Nurharis Musa, Bulkis Nur Asmi Nur Haedar Paulina Taba Permatasari, Nur Umriani Prastawa Budi Ramadani, Ananda Rasyid, Herlina Rauf, Wahyudin Riskawati Riskawati, Riskawati Sarlan, Sarlan Sarni Sarni Sartika Sartika Seniwati Dali SITI HALIMAH LAREKENG, SITI HALIMAH Situmorang, Sarah Victoria Octovianni Solly Aryza St Fauziah, St Fauziah Sukmawaty, Eka Suriati Eka Putri Syaharuddin Kasim Yunita, Vivi Alfi Yusafir Hala Zakir, Masculine