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All Journal journal of internal medicine Jurnal Kesehatan Andalas Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Care : Jurnal Ilmiah Ilmu Kesehatan JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Narra J Journal of Scientech Research and Development The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Scientica: Jurnal Ilmiah Sains dan Teknologi
Ulfa Kholili
Division Of Gastroentero-hepatology, Department Of Internal Medicine, Faculty Of Medicine, Airlangga University/Dr. Soetomo General Hospital, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Perbedaan Profil Abses Hati Pyogenic dengan Amoebic pada Pasien Abses Hati Rawat Inap di RSUD Dr Soetomo Tahun 2016-2019 Paramitha, Annisya Dinda; Kholili, Ulfa; Setyoboedi, Bagus
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1391

Abstract

Abses hati dibagi menjadi dua berdasarkan penyebab, yaitu bakteri pyogenik dan amoebik. Abses hati yang terjadi pada Dr. Soetomo masih belum diketahui, tetapi protozoa atau bakteri yang menyebabkan abses hati ditemukan banyak di Indonesia. Tujuan: Menentukan perbedaan profil klinis pasien dengan abses hati amoebik dan pyogenik di RSUD Dr. Soetomo pada periode 2016 sampai 2019.  Metode: Studi ini adalah analitik observasional menggunakan pendekatan cross-sectional pada rekam medis, dengan kriteria inklusi tes seroamoeba dan USG. Data dianalisis menggunakan uji Chi-square untuk skala nominal, t-test dan Man-Whitney untuk skala interval. Hasil: Ada 58 pasien dengan abses hati, masing-masing terdiri dari 29 pasien pada kedua jenis abses hati. Abses hati terjadi lebih dari 85% pada pria dengan usia rata- rata 42 hingga 45 tahun. Manifestasi klinis yang paling umum adalah nyeri RUQ (Kuadran Kanan Atas) (93,1%), hepatomegali (70%), dan demam (69%). Hasil pemeriksaan USG adalah abses tunggal di lobus kanan. Tinjauan terapi menggunakan drainase perkutan lebih dari operasi. Komplikasi yang paling umum adalah efusi pleura (37,9%) dan sepsis (34,5%). Kematian hanya terjadi pada abses hati pyogenik sebesar 13,8%, sedangkan pada amoebik 0%. Dan rata-rata lama durasi abses hati (LOS) adalah 15 (sekitar 7 hari). Simpulan: Terdapat perbedaan karakteristik, gambaran klinis, dan angka kematian antara pasien abses hati amoebik dan pyogenik, dan terbukti secara statistika pada mortalitas.Kata kunci: abses hati amoebic, abses hati pyogenic, rawat inap
Increased Levels of TNF-α, IL-6, and IL-10 are Associated with The Degree of Liver Fibrosis in Chronic Hepatitis B Patients with NUC Therapy Maimunah, Ummi; Kholili, Ulfa; Putra, Rheza Rahmadika; Brimantyo, Dio; Wirantara, Hendy
The Indonesian Biomedical Journal Vol 16, No 1 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i1.2848

Abstract

BACKGROUND: Liver fibrosis in chronic hepatitis B (CHB) involves the host immune responses mainly T-lymphocyte regulatory cells and cytokines production. Tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 have been reported to play a crucial role in the development of liver fibrosis. However, their association with liver fibrosis in treated CHB patients remains unclear. Therefore, this study was conducted to investigate the association between TNF-α, IL-6, and IL-10 with the degree of liver fibrosis in treated CHB patients.METHODS: This was a cross-sectional prospective study including 101 treated chronic hepatitis B subjects. TNF-α, IL-6, and IL-10 serum levels were measured with quantitative sandwich enzyme-linked immunosorbent assay (ELISA) kit. Transient elastography result was classified according to METAVIR score. Data was analyzed by the Spearman correlation test with a p<0.05 was considered statistically significant.RESULTS: From 101 subjects, there were significant differences were seen in TNF-α, IL-6, and IL-10 between patients with mild, significant and advance fibrosis. TNF-α (r=0.292; p<0.05), IL-6 (r=0.221; p<0.05), and IL-10 (r=0.208; p<0.05) were significantly correlated with the degree of fibrosis. After multivariate analysis, TNF-α was the only one cytokine parameter which significantly correlated with the degree of fibrosis.CONCLUSION: Levels of TNF-α, IL-6 and IL-10 are associated with the degree of liver fibrosis. These parameters may potentially be used to evaluate the development of liver fibrosis in treated CHB patients.KEYWORDS: chronic hepatitis B, liver fibrosis, cytokines, transient elastography
PROFIL RASIO NEUTROFIL TERHADAP LIMFOSIT PADA PASIEN DENGAN DUGAAN DEMAM TIFOID DI RSUD DR. SOETOMO SURABAYA Nurhidayah, Meiwinda Rizky; Arfijanto, Muhammad Vitanata; Widodo, Agung Dwi Wahyu; Kholili, Ulfa
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 1 (2021): EDITION MARCH 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i1.2042

Abstract

Demam tifoid merupakan penyakit multisistem akut yang disebabkan oleh Salmonella typhi dan bersifat endemis. Rendahnya sensitivitas alat diagnostik menyebabkan under diagnosed maupun over diagnosed. Beberapa studi menggunakan rasio neutrofil limfosit sebagai parameter status inflamasi. Studi ini untuk mengetahui gambaran rasio neutrofil limfosit pada pasien dengan dugaan demam tifoid. Sebuah studi deskriptif observasional dengan desain lintang potong menggunakan data sekunder dari rekam medis di Rumah Sakit Umum Daerah Dr. Soetomo Surabaya tahun 2016-2018. Teknik pengambilan sampel adalah total sampling dan diperoleh 64 sampel. Jumlah pasien dengan jenis kelamin laki-laki sebanyak 53,1% dan perempuan sebanyak 46,9% Perbandingan pasien laki-laki dan perempuan 1,3:1 dengan rentang usia terbanyak 17-25 tahun. Gambaran klinis rerata lama demam yaitu 6,95 hari dengan rentang lama demam terbanyak 1-7 hari. Demam ditunjukkan pada semua pasien (100%). Pemeriksaan hematologi kadar hemoglobin, leukosit dan trombosit dalam batas normal. Hasil neutrofil dan limfosit dalam batas normal. Gambaran rasio neutrofil limfosit memiliki median 3,97 dengan rentang nilai dalam batas normal.
Electrolyte and acid-base imbalances and kidney function in children with acute diarrhea: A study from Dr. Soetomo General Academic Hospital 2021–2023 Hamzah, Arshq Mirza; Fardah Athiyyah, Alpha; Kholili, Ulfa; Sulistiawati, Sulistiwati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.27973

Abstract

Diarrhea is the third leading cause of death in children under five, causing nutritional deficits that hinder growth, cognitive, and academic performance. Each episode before the age of 2 years increases the risk of stunting by 5%. Systematic data, such as sociodemographic, clinical characteristics, and laboratory characteristics, are important for prevention. This descriptive observational study used a retrospective design based on medical records of children with acute diarrhea treated at Dr. Soetomo General Hospital, Surabaya, from 2021 to 2023. A total of 461 subjects met the criteria; 429 underwent electrolyte imbalance testing, 198 were assessed for urea and creatinine levels, and 68 had their acid-base balance evaluated. A total of 288 subjects (62.5%) were male children; 262 patients (75%) were 0-12 months old; 253 (61%) had good nutritional status; 339 (73.5%) underwent therapy for less than 1 week; and 402 patients (65%) recovered. A total of 40% experienced mild-moderate and severe dehydration with neurologic (16.4%) and respiration comorbidities (16.2%). Electrolyte disturbances included hyponatremia (33.1%), hypokalemia (12.1%), hyperchloremia (50.2%), increased urea (28.3%), abnormal creatinine (35.4%), hypobicarbonate (75%), and acidosis (63.2%). Therefore, early detection and appropriate management are essential to mitigate further complications and improve recovery outcomes.
The Dominant Personality Type In Gastroesophageal Reflux Disease (GERD) Patients At Dr. Soetomo General Hospital Surabaya Viorelina, Angela Romauli; Abdurachman; Ulfa Kholili; Izzatul Fithriyah; Delwi Novita; Anita Zara Weinheimer
Jurnal Psikiatri Surabaya Vol. 15 No. 1 (2026): May
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Gastroesophageal Reflux Disease (GERD) is a disorder of reflux of gastric contents into the esophagus, which can cause symptoms and complications. The global prevalence of GERD is 25% in adults, 20% in Western countries, and 3–5% in Asia, and it continues to increase. Physical therapy has been widely used, ranging from diet, exercise, and medication to surgery. Meanwhile, non-physical therapy, such as personality changes, has not been developed much. The Big Five Personality is a personality theory that consists of five dimensions, namely openness, conscientiousness, extraversion, agreeableness, and neuroticism, with each dimension representing different aspects of personality and related to health. This research aims to identify the dominant personality traits of GERD patients based on the Big Five personality model. Methods: This research used secondary data from medical records of GERD patients at RS Dr. Soetomo Surabaya and primary data from the Big Five Personality questionnaire interview using the descriptive cross-sectional method. Results: A total of 51 GERD patients at Dr. Soetomo Surabaya; it was found that the mean age of patients was 34.23 (SD 9.526) years, and there were 26 female patients (51%) and 25 male patients (49%). The interview results revealed that agreeableness was the dominant personality type. Conclusion: According to the Big Five Personality Theory, the dominant personality type in GERD patients at Dr. Soetomo General Hospital Surabaya is agreeableness.
Distribution of Hepatitis B Virus Genotypes Among Patients at Internal Medicine Unit, Dr. Soetomo General Hospital, Surabaya Citrawati Dyah Kencono Wungu; Mochamad Amin; Ulfa Kholili; Gwenny Ichsan Prabowo; Poernomo Boedi Setiawan; Soetjipto Soetjipto; Retno Handajani
WMJ (Warmadewa Medical Journal) Vol 4 No 1 (2019): May 2019
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.4.1.1032.6-13

Abstract

Background: Hepatitis B virus (HBV) infection is a major health problem worldwide, especially in developing countries. The study of HBV genotypes is important to find out the diversity of HBV genotypes related to the severity of the disease, response to therapy, and clinical symptoms. Objective: This study was aimed to detect HBV genotypes in patients at Hepatology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Methods: This study was conducted on new patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya in one month. Nested PCR was performed by targetting HBV surface genes. Samples with positive HBV DNA were sequenced and analysed further. Results: In this study, a total of 27 samples were obtained. The prevalence of HBV infection shown by positive HBsAg in patients with symptoms of liver disease was 55.55% (15/27 patients). Based on the results of electrophoresis from PCR products, positive HBV DNA was obtained in these 15 patients (100%). After sequencing samples with positive HBV DNA, genotype B of Indonesian strain was found to be predominant genotype (100%). Subgenotype analysis showed that 7/15 samples had B3 subgenotype (46.67%). Conclusion: In patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya, the prevalence of HBV infection was high (55.55%) and genotype B was predominant. In Surabaya, HBV genotype infection still remained like the previous pattern, although in Indonesia there have been many inter-island and ethnic migration. Further similar studies are needed to obtain the diversity of other HBV genotypes.
Co-Authors Abdurachman Adaninggar PN Agung Dwi Wahyu Widodo Alshawsh, Mohammed A. Alvin Hartanto Kurniawan Alvin Hartanto Kurniawan Amie Vidyani Andreas Novaldi Watang Anita Zara Weinheimer Annisa Zahra Mufida Annisya Dinda Paramitha Aryati Aryati Bagus Setyoboedi Benedictus Hanjaya Suwandi Brimantyo, Dio Budi W Budi Widodo Budi Widodo Delwi Novita Denada Aisyah Syalini Denny Vianto Diah Rizki Rahma Dini Dwicahya, Fatrian Erlina, Rina Fardah Athiyyah, Alpha Fauziah Diayu Retnaningtyas Ghaniyya, Willandra Fitriyanri Hamzah, Arshq Mirza Herry Purbayu Humairah, Ira Isna Mahmudah Iswan A Nusi Iswan A Nusi Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Maria Inge Lusida MOCHAMAD AMIN Mochamad Amin Muhammad Miftahussurur Muhammad Rivai Muhammad Vitanata Arfijanto, Muhammad Vitanata Nasronudin Nasronudin Novira Widajanti, Novira Nurhidayah, Meiwinda Rizky Pangestu Adi Paramitha, Annisya Dinda PN, Adaninggar Poernomo B Setiawan Poernomo Boedi Setiawan Poernomoboedi Setiawan Prabowo, Gwenny Ichsan Priyo Budi Purwono Puspa Wardhani Puspitasari, Yessy Putra, Rheza Rahmadika Retno Handajan Retno Handajani Rina Erlina Ruslan, S. Eriaty N. Setiawan, Poernomo B Setiawati, Rosy Shahnaz Azzahra SOETJIPTO SOETJIPTO . Soetjipto Soetjipto Sulistiawati, Sulistiwati Syalini, Denada Aisyah Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tri Yanti Ummi Maimunah Vania Azalia Gunawan Viorelina, Angela Romauli Wessels, Firda I. Widodo, Budi Wirantara, Hendy Wungu, Citrawati Dyah Kencono Yanti, Tri