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Nurul Qiyaam, Nurul
Universitas Muhammadiyah Mataram
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Analisis Efektivitas Biaya (Cost Effectiveness Analysis) Penggunaan Amitryptiline Dibandingkan Carbamazepine pada Pasien Nyeri Neuropatik (Studi Kasus Di Klinik Saraf Rumkital. Dr. Ramelan Surabaya) Nurul Qiyaam; Abdul Rahem; Dian Maria Pia; Lestiono Lestiono
Jurnal Pharmascience Vol 2, No 2 (2015): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i2.5822

Abstract

ABSTRAK Nyeri neuropatik merupakan penyakit kronis yang memerlukan penanganan optimal, sehingga perlu memperhatikan aspek efektivitas dan biaya terapi. Efektivitas amitryptiline dan  carbamazepine untuk pengobatan nyeri neuropatik telah dibuktikan, tetapi belum  diketahui mana yang paling cost-effective. Penelitian ini dilakukan untuk menganalisis efektivitas biaya (cost-effectiveness) amitryptiline dan carbamazepine pada pasien nyeri neuropatik di klinik Saraf Rumkital dr. Ramelan Surabaya. Pengumpulan data dilakukan selama Februari-Mei 2014 didapatkan sebanyak 62 pasien. Metode penelitian Randomized Controlled Trial (RCT)  kemudian dilakukan analisis efektivitas biaya dengan menghitung nilai Average Cost-Effectiveness Ratio (ACER) masing-masing terapi. Pengukuran efektifitas terapi dilihat dari penurunan intensitas nyeri menggunakan Numerical Rating Scale (NRS) sebelum dan 4 minggu sesudah terapi. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa terdapat perbedaan intensitas nyeri pre dan post pada terapi amitryptiline dan carbamazepine,akan tetapi tidak terdapat perbedaan efektifitas terapi dan nilai ACER antara amitryptiline dan carbamazepine. Biaya terapi amitryptilin (Rp.41.695) lebih murah dibandingkan carbamazepine (Rp.47.380) sehingga amitryptiline lebih menghemat biaya dari carbamazepine dengan efektivitas setara. Perbedaan biaya terapi hanya pada harga obat saja sehingga penelitian ini juga sesuai dengan metode Cost Minimation Analysis (CMA). Disarankan penelitian lebih lanjut cost-effectiveness menggunakan sampel yang lebih spesifik terkait penyebab nyeri neuropatik. Kata kunci :   nyeri neuropatik, amitryptiline, carbamazepine, cost-  effectiveness ABSTRACTNeuropathic pain is a chronic disease that requires optimum handling, so it needs to consider the aspects of the effectiveness and cost of treatment. Carbamazepine’s and amitryptiline’s effectiveness for the treatment of neuropathic pain has been demonstrated, but there were no data available regarding the cost-effectiveness between those medications. This study was conducted to analyze the cost-effectiveness  of amitryptiline and carbamazepine in patients with neuropathic pain in the Neurology Clinic in dr.Ramelan Navy Hospital  Surabaya. Data collection was conducted during February until May 2014, it was found as many as 62 patients. Randomized Controlled Trial studies (RCT) then was conducted to make a cost effectiveness analysis by the calculation of the value of Average Cost-Effectiveness Ratio (ACER) for each therapy.  Measurement of the effectiveness of therapy was obtained from a decrease in pain intensity using a Numerical Rating Scale (NRS) before and 4 weeks after therapy. Based on these results, it can be concluded that there was a difference in decreasing rate of pain intensity between pre and post amitryptiline and carbamazepine therapy, but there were no difference in therapeutic effectiveness and value of ACER between amitryptiline and carbamazepine. Cost of Amitryptiline therapy (Rp.41.695) was cheaper than Carbamazepine (Rp.47.380), so amitryptiline more cost- saving  than  carbamazepine with equal effectiveness. The difference is on the cost of the drug therapy alone so this study was also in accordance with the Cost Minimation Analysis (CMA). Further research suggested cost-effectiveness using a sample that is more specifically related to the causes of neuropathic pain. Keywords: neuropathic pain, amitryptiline, carbamazepine, cost-effectiveness
Kepatuhan Penggunaan Obat Antihipertensi di Puskesmas Pagesangan Mataram Wirawan Adikusuma; Nurul Qiyaam; Fita Yuliana
Jurnal Pharmascience Vol 2, No 2 (2015): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i2.5823

Abstract

ABSTRAK Keberhasilan suatu pengobatan tidak hanya dipengaruhi oleh kualitas pelayanan kesehatan, sikap, dan keterampilan petugasnya, tetapi juga dipengaruhi oleh kepatuhan pasien. Penelitian ini bertujuan untuk mengetahui kepatuhan penggunaan obat hipertensi dan beberapa variabel karakteristik pasien yang berpengaruh terhadap kepatuhan pasien hipertensi di Puskesmas Pagesangan, Mataram. Penelitian ini dilakukan dengan metode observasional crossectional dengan mengambil data secara prospektif selama periode Februari – Maret 2015. Pengukuran kepatuhan dilakukan dengan menggunakan kuesioner MMAS (Morisky Medication Adherence Scale) yang berisi 8 pertanyaan. Persentase tingkat kepatuhan berdasarkan kuesioner MMAS adalah kepatuhan tinggi 75 % dan kepatuhan rendah 25 %. Berdasarkan analisis Chi Square tidak ada karakteristik subyek penelitian yang berpengaruh terhadap kepatuhan (P>0,05).Kata kunci: Hipertensi, kepatuhan, MMAS ABSTRACTThe success of a treatment is not only influenced by the quality of health services, attitudes and skills of its health workes, but also influenced by patient adherence. This research is aimed to measure adherence to antihypertensive therapy in hypertensive patients at primary health center Mataram, and to investigate patient’s characteristic associated with such adherence. This research was carried out by observational cross-sectional design with prospective data collection during February – March  2015. The measurement of adherence is done by using a questionnaire MMAS (Morisky Medication Adherence Scale) which contains 8 questions. The percentage of the level of adherence by questionnaire MMAS is a high adherence 75% and 25% lower adherence. Based on the analysis of Chi-Square no characteristic of the study subjects that affect adherence (P>0,05).Key word : Hipertensive, Adherence, MMAS
Co-Authors Abdul Rahem Abdul Rahem, Abdul Abdul Rahman Wahid Affandi, Rizal Alvi Kusuma Wardani Alvi Kusuma Wardani Ana Pujianti Harahap Anak Agung Gede Sugianthara Anisa Anisa Anjeli Amalia Anna Pradiningsih Anna Pradiningsih Arif Rahman Atis Anggraini Aulia Amini Ayu Fatmala Ayu Febriyanti Ayu Febriyanti, Ayu Baiq Leny Nopitasari Baiq Leny Nopitasari Baiq Lenysia Pupita Anjani Baiq Lenysia Puspita Anjani Baiq Lenysia Puspita Anjani, Baiq Lenysia Puspita Baiq Nurbaety Bimantika, Fara Mutia Cyntiya Rahmawati Damayanti, Elok Dara Junia Hartanti Dian Maria Pia Dian Maria Pia, Dian Maria Dzun Haryadi Ittiqo Eko Satria Putra Erwinayanti, Gusti Ayu Puti Sri Fita Yuliana Fita Yuliana, Fita Furqani, Nur Furqani, Nur Furqoni, Nur Hapsari, Yunita Hariati Hariati Hariati, Hariati Hartanti, Intan Sri Igayatni, Rahayu Irmatika Hendriyani Isnaini, Marlinda Ittiqo, Dzun Haryadi Lestiono Lestiono Lestiono Lestiono, Lestiono Mahacita Andanalusia Maharani, Anggina Putri Nabila Mardiyah WD, Siti Mayada, Silhiyatun Melati Permata Hati Muhammad Faisal Mutmainah, Umul Ni Wayan Ari Adiputri Nopitasari, Baiq Leny Novianti Novianti Nur Furqani Nur Furqani Nur Furqoni Ocktaviana Saputri, Legis Partini, Tien Pradiningsih, Anna Purnama Supyan Assauri Puspita Anjani, Baiq Lenysia Puspita Putra, Eko Satria Rahmawati, Cyntiya Rendy Alya Praja Rihhadatul Aisy Risma Widia Ningsih Rosdiawati, Rosdiawati Rozali Bayu Sugarda Safitri, Santi Safwan Safwan Safwan Safwan Saptahadi, Lalu Iman Saputra, Yoga Dwi Shah Iqbal Ikraman Akbar Sierly, Nadia Tien Partini Tri Murti Andayani Wahid, Abdul Rahman Widayatul Khairi Wiratama, I Ketut Wisnu Arya Wirawan Adikusuma Yuli Fitriana Zulyadaen Zulyadaen