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All Journal International Journal of Electrical and Computer Engineering IAES International Journal of Robotics and Automation (IJRA) IAES International Journal of Artificial Intelligence (IJ-AI) International Journal of Reconfigurable and Embedded Systems (IJRES) International Journal of Advances in Applied Sciences ComEngApp : Computer Engineering and Applications Journal Jupiter Jurnal Simetris TELKOMNIKA (Telecommunication Computing Electronics and Control) Bulletin of Electrical Engineering and Informatics JSI: Jurnal Sistem Informasi (E-Journal) Jurnal Ilmu Komputer dan Agri-Informatika Indonesian Journal of Electrical Engineering and Informatics (IJEEI) Scientific Journal of Informatics ICON-CSE Annual Research Seminar Proceeding of the Electrical Engineering Computer Science and Informatics Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Jurnal Ilmiah Matrik JURNAL TEKNIK INFORMATIKA DAN SISTEM INFORMASI Jurnal Sisfokom (Sistem Informasi dan Komputer) Jurnal Plastik Rekonstruksi Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Electrical Engineering and Computer Science Jurnal Generic Bioscientia Medicina : Journal of Biomedicine and Translational Research Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Penelitian Pendidikan
Siti Nurmaini
University Of Sriwijaya
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Jurnal Simetris

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Cervical Intraepithelial Neoplasia Classification Based on Deep Neural Network with Hybrid Features Fusion Suhandono, Nugroho; Nurmaini, Siti
Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer Vol. 17 No. 1 (2026): JURNAL SIMETRIS VOLUME 17 NO 1 TAHUN 2026
Publisher : Fakultas Teknik Universitas Muria Kudus

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Abstract

Cervical cancer remains one of the leading causes of cancer-related mortality among women worldwide, particularly in low- and middle-income countries where access to trained specialists and advanced diagnostic infrastructure is severely limited. Cervical Intraepithelial Neoplasia (CIN), the precancerous lesion preceding cervical malignancy, exists across a spectrum of severity — CIN1, CIN2, and CIN3 — each requiring distinct clinical management. Accurate and timely differentiation of these stages through colposcopy is critical; however, the subjective nature of visual interpretation, high inter-observer variability, and the scarcity of experienced colposcopists in resource-constrained settings frequently lead to misclassification, delayed treatment, or unnecessary interventions. These diagnostic limitations underscore an urgent need for automated, objective, and reliable computer-aided diagnosis (CAD) tools capable of supporting clinicians in multiclass cervical lesion grading. To address this challenge, this study proposes a hybrid CAD framework for multiclass cervical lesion classification using colposcopy images. The proposed method integrates handcrafted texture and color features — specifically Color Moments and Gray Level Run Length Matrix (GLRLM) — with deep semantic features extracted from pretrained EfficientNetB3 and MobileNetV3 networks. Classification is performed by a fully connected Deep Neural Network (DNN) operating on the aggregated feature representations to categorize images into four classes: Normal, CIN1, CIN2, and CIN3. Experiments were conducted on an IARC colposcopy dataset comprising 200 cases, employing stratified 5-fold cross-validation to ensure robust evaluation. The proposed methodology achieved an average accuracy of 82.67% ± 3.65% and a Cohen's Kappa of 0.7466 ± 0.0634, with a peak accuracy of 86.22% on the best-performing fold. Results demonstrate strong recognition performance for Normal and CIN3 classes, while intermediate stages remain more challenging due to overlapping visual characteristics. Overall, the hybrid feature fusion strategy enhances classification robustness and shows promise for supporting reliable cervical precancer screening in resource-limited healthcare environments.
Co-Authors A. Darmawahyuni A. I. Sapitri Ade Iriani Sapitri Ade Iriani Sapitri Ade Iriani Sapitri Ade Silvia Ade Silvia Ade Silvia Handayani Aditya Aditya Aditya, Aditya Agung Juli Anda Agus Triadi Agus Triadi Agus Triadi Ahmad Zarkasi Ahmad Zarkasi Ahmad Zarkasi Ahmad Zarkasih Akhiar Wista Arum Andre Herviant Juliano Anggun Islami Anggun Islami Annisa Darmawahyuni Ardy Hidayat Arief Cahyo Utomo Armansyah, Risky Arnaldo, Muhammad Arum, Akhiar Wista Arum, Akhiar Wista Arum Aulia Rahman Thoharsin B. Tutuko Bambang Tutuko Bambang Tutuko Bayu Wijaya Putra Benedictus Wicaksono Widodo Bhakti Yudho Suprapto Bhakti Yudho Suprapto Bhakti Yudho Suprapto Cindy Kesty Darmawahyuni, Annisa Darmawahyuni, Annisa Deris Stiawan Dewi, Kemala Dewi, Tresna Dian Palupi Rini Dian Palupi Rini Dian Palupi Rini Dimas Budianto Dinda Lestarini Dodo Zaenal Abidin Dwi Mei Rita Sari Ekawati Prihatini Erliza Yuniarti Fachrudin Abdau Fahreza, Irvan Falah Yuridho Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus, Firdaus Firsandaya Malik, Reza Ganesha Ogi GITA FADILA FITRIANA Hadipurnawan Satria Hanif Habibie Supriansyah Huda Ubaya Huda Ubaya Huda Ubaya Husnawati Husnawati Husnawati Husnawati Husnawati Husni, Nyayu Latifah Husni, Nyayu Latifah Irfannuddin Irfannuddin Irsyadi Yani Irvan Fahreza Iryadi Yani Iryadi Yani, Iryadi Isdwanta, Rendy Islami, Anggun Jasmir Jasmir Jasmir Jasmir Jordan Marcelino Kemala Dewi Khairunnisa, Cholidah Zuhroh Krisna Murti Kurniawan, Anggy Tias Kurniawan, Anggy Tyas Legiran Legiran M. Hashim, Siti Zaiton M. N. Rachmatullah M. Naufal Rachmatullah Maharani, Masayu Nadila Marcelino, Jordan Masayu Nadila Maharani Mira Afrina Muhamad Akbar Muhammad Afif Muhammad Anshori Muhammad Arnaldo Muhammad Fachrurrozi Muhammad Fachrurrozi Muhammad Irham Rizki Fauzi Muhammad Naufal Rachmatullah Muhammad Naufal, Muhammad Muhammad Roriz Muhammad Taufik Roseno, Muhammad Taufik Muzakkie, Mufida Nabilah, Aini Nadia Ayu Oktabella, nadia ayu oktabella Novi Yusliani Nuswil Bernolian Nuswil Bernolian Nuswil Bernolian Nyayu Latifah Husni Nyayu Latifah Husni, Nyayu Latifah Oky Budiyarti Osvari Arsalan Passa, Rahma Satila Patiyus Agustiansyah PATIYUS AGUSTIANSYAH, PATIYUS Pola Risma PP Aditya, PP, Aditya, PP Pratama, Jimiria Putri Mirani Rachmamtullah, Muhammad Naufal Radiyati Umi Partan Radiyati Umi Partan Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rahma Satila Passa Rendy Isdwanta Renny Amalia Pratiwi Reza Firsandaya Malik Reza Firsandaya Malik Ria Nova Ricy Firnando Ricy Firnando Ricy Firnando Rizal Sanif Rizki Kurniati Rossi Passarella Sahat Pangidoan Samsuryadi Samsuryadi Saparudin Saparudin Saparudin, Saparudin Sapitri, Ade Iriani Saputra, Tommy Sari, Dwi Mei Rita Sarifah Putri Raflesia Sarifah Putri Raflesia, Sarifah Putri Sastradinata, Irawan Sigit Prasetyo Noprianto Siti Zaiton Siti Zaiton M. Hashim Soedjana, Hardi Siswo Sri Desy Siswanti Suci Dwi Lestari Suci Dwi Lestari Suhandono, Nugroho Sukemi Sukemi Sukemi Sukemi Sukemi Sukman Tulus Putra Sutarno Sutarno Syamsul Arifin Syaputra, Hadi Tio Artha Nugraha Tresna Dewi Tresna Dewi Tri Undari Triadi, Agus Triadi, Agus Varindo Ockta Keneddi Putra Velia Yuliza Winda Kurnia Sari Wisnu Adi Putra Yani, Iryadi Yesi Novaria Kunang Yurni Oktarina Zaqqi Yamani