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All Journal Jurnal Ilmu Pertanian Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences METAMORFOSA Journal of Biological Sciences Jurnal Biologi Udayana El-Hayah : Jurnal Biologi Jurnal Sains Peternakan Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Pharmasipha JURNAL ILMIAH PETERNAKAN TERPADU Journal of Dedicators Community Biota Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) JSMARTech : Journal of Smart Bioprospecting and Technology J-PEN Borneo : Jurnal Ilmu Pertanian Jurnal Sains Alami (Known Nature) Berkala Penelitian Hayati Jurnal Riset Perikanan dan Kelautan Jurnal Sains Alami (Known Nature) KOPEMAS Exhibition and Seminar on Science and Creative Technology – Al Azhar Proceeding Genbinesia Journal of Biology
Nurul Jadid Mubarokati
Universitas Islam Malang
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Journal : Jurnal Sains Alami (Known Nature)

 1 
Pengaruh Pemberian Daun Pepaya (Carica papaya) Terhadap Endoparasit dan Hasil Panen Susu Sapi Perah (Bos taurus) sebagai Antihelmintik Alami di Balai Besar Pelatihan Peternakan (BBPP) Batu Nia Novita Nurrohmah; Nour Athiroh AS; Nurul Jadid Mubarakati
Jurnal SAINS ALAMI (Known Nature) Vol 3, No 2 (2021)
Publisher : FMIPA UNISMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/j.sa.v3i2.7428

Abstract

Helmintiasis is a worm disease that often occurs in cows so that it can reduce milk harvesting. One prevention that can be done  with natural ingredients in the form of papaya leaf (Carica papaya). Papaya leaves contain alkaloids, enzyme papain, saponin, flavonoid, and tannin. The purpose of this experiment was to analyze the effect of papaya leaf (Carica papaya) on endoparasites and milk harvesting. This is an experimental research used a pre-test post-test control group design on five dairy cows with one treatment, specifically 70% basal green feed and 30% papaya leaves and one positive control (Albendazole). Method of identification use the qualitative method is, native method (direct slide) and the flotation method (Flotation method). The obtained data were analyzed with a Anova test, it showed that result is (p<0,05). That are able to suppress the growth of endoparasites in cow 1, 2, 3, 4, 5 by 60%, 58%, 50%, 45% , and 34% respectively in the native method and the floating method are 75%, 63%, 56%, 45%, and 34%. Increased harvesting milk for 3 weeks is 2-4 liters.  It was conluded that there was an influence between papaya leaves (Carica papaya) on endoparasites in dairy cows (Bos taurus) as a natural antihelmintic. Keywords: Helmintiasis, Papaya Leaf (Carica papaya), Endoparasite, Cows (Bos taurus), Milk Harvesting ResultABSTRAKHelmintiasis adalah penyakit cacingan yang sering terjadi pada sapi sehingga dapat menurunkan hasil panen susu. Salah satu pencegahan alami yang dapat dilakukan yakni dengan memberikan daun pepaya (Carica papaya) sebagai pengobatan alami. Daun pepaya merupakan bahan alami yang mengandung senyawa aktif berupa alkaloid, flavonoid, enzim papain, saponin, dan tanin yang memiliki efek antihelmintik pada sapi perah (Bos taurus). Tujuan dari penelitian ini adalah untuk menganalisa efek daun pepaya (Carica papaya) terhadap endoparasit dan hasil panen susu. Penelitian ini merupakan penelitian eksperimental, menggunakan rancangan penelitian pre test post test control group design pada 5 ekor sapi perah dengan 1 perlakuan yaitu pemberian pakan hijau basal 70% dan daun pepaya 30% dan 1 kontrol positif (Albendazole). Metode pelaksanaan penelitian menggunakan uji feses metode kualitatif yaitu metode natif (Direct slide) dan metode apung (Flotation method). Data yang diperoleh dianalisis dengan uji statistika (Anova) dengan hasil (p<0,05). Hasil penelitian ini menunjukkan bahwa sapi 1, 2, 3, 4, 5 mengalami penurunan endoparasit sebesar 60%, 58%, 50%, 45%, dan 34% secara berturut-turut pada metode natif dan metode apung sebesar 75%, 63%, 56%, 45%, dan 34%. Pemberian daun pepaya pada sapi perah selama 3 minggu dapat meningkatkan panen susu sebesar 2-4 per hari. Sehingga dapat disimpulkan bahwa terdapat pengaruh antara daun pepaya  (Carica papaya) terhadap endoparasit pada sapi perah (Bos taurus) dan hasil panen susu.Kata kunci: Helmintiasis, Daun Pepaya (Carica papaya), Endoparasit, Sapi (Bos taurus),  Hasil panen susu
Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari Tengku Anggun Lestari; Nour Athiroh; Nurul Jadid Mubarakati
Jurnal SAINS ALAMI (Known Nature) Vol 3, No 1 (2020)
Publisher : FMIPA UNISMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/j.sa.v3i1.6621

Abstract

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus
Gambaran Histopatologi Otak Pada Tikus Hipertensi (DOCA-Garam) yang Dipapar Ekstrak Metanolik Kombinasi Benalu Teh dan Benalu Mangga Model Preventif Dyan Aprillia Susanti; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarokati
Jurnal SAINS ALAMI (Known Nature) Vol 5, No 1 (2022)
Publisher : FMIPA UNISMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/j.sa.v5i1.15541

Abstract

Hypertension is an increase in blood pressure that exceeds normal limits. In patients with hypertension, systolic blood pressure is 140 mmHg and diastolic blood pressure is 90 mmHg and comes from a complex and interconnected environment. Hypertension is a non-communicable disease that can cause death in humans and is closely related to cardiovascular disease. Hypertension is considered the main cause of 9.4 million deaths that occur in the world's population every year. Disorders of blood vessels around the brain due to hypertension can cause death. The purpose of this study was to determine the effectiveness of the methanolic extract of the combination of Mango Mistletoe and Mistletoe Tea (EMKBTBM) given to rats with hypertension model on the histopathological features of the brain in hypertensive rats (DOCA-salt) preventive model. The method used in this study was the true experimental method and the RAL research design on 25 male wistar rats with 3 treatments (PI, PII, PIII), (K-) group without any treatment (without administration of DOCA Salt and EMKBTBM) and (K+) using DOCA-Salt induction without giving EMKBTBM, and 5 times replication. The EMKBTBM was given with a ratio of mango mistletoe: tea mistletoe which was 3:1 and then given at a dose of 50, 100, 200 mg/KgBB in the treatment of PI, PII, PIII. Data analysis was carried out by using ANOVA statistical test using the JAMOVI application. Based on the results of the study, it was shown that giving EMKBTBM to rats had the effect of reducing the amount of damage (necrosis) in the white matter area of the brain. The administration of EMBTBM at a dose of 50 mg/KgBW was the most optimum dose in reducing the amount of white matter cell necrosis in the male wistar rat brain.Keywords:3 Brain Necrosis, Hypertension, Mango Mistletoe, Tea MistletoeABSTRAKHipertensi merupakan bertambahnya tekanan darah melebihi batas normal. Pada penderita hipertensi, tekanan darah sistolik 140 mmHg dan tekanan darah diastolik  90 mmHg serta berasal dari lingkungan yang kompleks dan saling berhubungan. Hipertensi ialah penyakit tidak menular yang dapat mengakibatkan kematian pada manusia dan berkaitan erat dengan penyakit kardiovaskular. Hipertensi dianggap sebagai sebab utama 9,4 juta kematian yang terjadi pada penduduk dunia pada setiap tahunnya. Gangguan pembuluh darah disekitar otak akibat hipertensi dapat menebabkan kematian. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas Ekstrak Metanolik Kombinasi Benalu Mangga dan Benalu Teh (EMKBTBM) yang diberikan pada tikus model hipertensi terhadap gambaran histopatologi otak pada tikus hipertensi (DOCA-garam) model preventif. Metode yang digunakan dalam penelitian ini menggunakan metode true eksperimental serta desain penelitian RAL pada 25 ekor tikus wistar jantan dengan 3 perlakuan (PI, PII, PIII), (K-) kelompok tanpa perlakuan apapun (tanpa pemberian DOCA Garam dan EMKBTBM) dan (K+) menggunakan induksi DOCA-Garam tanpa pemberian EMKBTBM, serta 5x ulangan. Pemberian EMKBTBM dengan perbandingan benalu mangga : benalu teh yaitu 3:1 kemudian diberikan dengan dosis 50, 100, 200 mg/KgBB pada perlakuan PI, PII, PIII. Analisis data dilakukan dengan uji statistic ANOVA menggunakan aplikasi JAMOVI. Berdasarkan hasil penelitian menunjukkan pemberian EMKBTBM pada tikus mempunyai efek yaitu dapat mengurangi jumlah kerusakan (nekrosis) di area white matter otak. Pemberian EMBTBM dengan dosis 50 mg/KgBB merupakan dosis paling optimum dalam menurunkan jumlah nekrosis sel white matter otak tikus wistar jantan.Kata kunci: Benalu Teh, Benalu Mangga, Hipertensi, Nekrosis Otak
Gambaran Histopatologi Otak Pada Tikus Hipertensi (DOCA-Garam) yang Dipapar Ekstrak Metanolik Kombinasi Benalu Teh dan Benalu Mangga Model Preventif Dyan Aprillia Susanti; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarokati
Jurnal SAINS ALAMI (Known Nature) Vol. 5 No. 1 (2022)
Publisher : FMIPA UNISMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/j.sa.v5i1.15541

Abstract

Hypertension is an increase in blood pressure that exceeds normal limits. In patients with hypertension, systolic blood pressure is 140 mmHg and diastolic blood pressure is 90 mmHg and comes from a complex and interconnected environment. Hypertension is a non-communicable disease that can cause death in humans and is closely related to cardiovascular disease. Hypertension is considered the main cause of 9.4 million deaths that occur in the world's population every year. Disorders of blood vessels around the brain due to hypertension can cause death. The purpose of this study was to determine the effectiveness of the methanolic extract of the combination of Mango Mistletoe and Mistletoe Tea (EMKBTBM) given to rats with hypertension model on the histopathological features of the brain in hypertensive rats (DOCA-salt) preventive model. The method used in this study was the true experimental method and the RAL research design on 25 male wistar rats with 3 treatments (PI, PII, PIII), (K-) group without any treatment (without administration of DOCA Salt and EMKBTBM) and (K+) using DOCA-Salt induction without giving EMKBTBM, and 5 times replication. The EMKBTBM was given with a ratio of mango mistletoe: tea mistletoe which was 3:1 and then given at a dose of 50, 100, 200 mg/KgBB in the treatment of PI, PII, PIII. Data analysis was carried out by using ANOVA statistical test using the JAMOVI application. Based on the results of the study, it was shown that giving EMKBTBM to rats had the effect of reducing the amount of damage (necrosis) in the white matter area of the brain. The administration of EMBTBM at a dose of 50 mg/KgBW was the most optimum dose in reducing the amount of white matter cell necrosis in the male wistar rat brain.Keywords:3 Brain Necrosis, Hypertension, Mango Mistletoe, Tea MistletoeABSTRAKHipertensi merupakan bertambahnya tekanan darah melebihi batas normal. Pada penderita hipertensi, tekanan darah sistolik 140 mmHg dan tekanan darah diastolik  90 mmHg serta berasal dari lingkungan yang kompleks dan saling berhubungan. Hipertensi ialah penyakit tidak menular yang dapat mengakibatkan kematian pada manusia dan berkaitan erat dengan penyakit kardiovaskular. Hipertensi dianggap sebagai sebab utama 9,4 juta kematian yang terjadi pada penduduk dunia pada setiap tahunnya. Gangguan pembuluh darah disekitar otak akibat hipertensi dapat menebabkan kematian. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas Ekstrak Metanolik Kombinasi Benalu Mangga dan Benalu Teh (EMKBTBM) yang diberikan pada tikus model hipertensi terhadap gambaran histopatologi otak pada tikus hipertensi (DOCA-garam) model preventif. Metode yang digunakan dalam penelitian ini menggunakan metode true eksperimental serta desain penelitian RAL pada 25 ekor tikus wistar jantan dengan 3 perlakuan (PI, PII, PIII), (K-) kelompok tanpa perlakuan apapun (tanpa pemberian DOCA Garam dan EMKBTBM) dan (K+) menggunakan induksi DOCA-Garam tanpa pemberian EMKBTBM, serta 5x ulangan. Pemberian EMKBTBM dengan perbandingan benalu mangga : benalu teh yaitu 3:1 kemudian diberikan dengan dosis 50, 100, 200 mg/KgBB pada perlakuan PI, PII, PIII. Analisis data dilakukan dengan uji statistic ANOVA menggunakan aplikasi JAMOVI. Berdasarkan hasil penelitian menunjukkan pemberian EMKBTBM pada tikus mempunyai efek yaitu dapat mengurangi jumlah kerusakan (nekrosis) di area white matter otak. Pemberian EMBTBM dengan dosis 50 mg/KgBB merupakan dosis paling optimum dalam menurunkan jumlah nekrosis sel white matter otak tikus wistar jantan.Kata kunci: Benalu Teh, Benalu Mangga, Hipertensi, Nekrosis Otak
Co-Authors Abdul Hamid A. Toha Adi Sofyan Ansori, Muhammad Agus Mohammad Hikam Ahmad Taufiq Alik Maulidiyah Annisatul Anis Hakimah Ari Hayati Ari Hayati Arifiati, Shinta Arina Roikhana Asari, Devi Indrayani Fitri Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Azis Mawardi Azis Mawardi Chintya Ayu Pertiwi Della Aljanna Savita Dewi Qurrot &#039;Aini Dewi, Atikah Nur Shabrina Razan Dyan Aprillia Susanti Eka Kumalasari Fradina, IntanTrixi Gatot Ciptadi Gatra Ervi Jayanti Gatra Ervi Jayanti Hakimah, Annisatul Anis Hasan Zayadi Hatif Khusnin Nida' Hikam, Agus Mohammad Husain Latuconsina Islami, Darajatun Islamya, Nur Afni Auli Ismatud Diniyah Istirochah Pujiwati Januarista, Terra Kamilah, Nahdhiyatun Kharisma, Viol Dhea Kurniasari, Yulia Lestari, Tengku Anggun M. Abdul Qodir Jailani Ma'ruf, Muhammad Maghfiroh, Faldha Laili Malia Anjani Moch Mustakim Moch Mustakim Muhammad Dailami, Muhammad Musaffak, Taufik Ridwan Muzayyan, Abdullah Rozzen Nabilah Miftachul Khoiriyah Nafisa Nafisa Nia Novita Nurrohmah Nour Athiroh Abdoes Sjakoer Nur Cahya Kartika Slamet Nur Laily Azizah Nur Mufida Nur Mufida Nurrohmah, Nia Novita Nurul Humaidah Oktavia Rahayu Puspitarini Oktaviana, Nimas Ajeng Pinanti, Honesty Nurizza Pratiwi, Radita Intan Aisyah Radita Intan Aisyah Pratiwi Rafsanjani, Ramizard Rahayu Dwi Lestari Ramadhan, Majida Rasyadan Taufiq Probojati Rossa Martha Wulandari Rossa Martha Wulandari Saimul Laili Sama’ Iradat Tito Saputri, Syntia Diyah Hayu Ria Silvia, Putri Azizatul Siti Khoirun Ni’mah Siti Qurrotul Aini Sulis Setiawati Suroyya, Mariyam Sutiman B. Sumitro Sutiman Bambang Sumitro Syaiful Arifin Tengku Anggun Lestari Thiya Fathiyatul Fauziyah Tintrim Rahayu, Tintrim Ula, Erfa Navadiatul Umu Intan Kinasih Vikriansyah, Muchammad Faruq Vina Fitria Wulandari Waliyyul Ahdi Alhikami Widyananda, Muhammad Hermawan Yunani, Silvi