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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences METAMORFOSA Journal of Biological Sciences Jurnal Biologi Udayana El-Hayah : Jurnal Biologi Jurnal Sains Peternakan Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Pharmasipha JURNAL ILMIAH PETERNAKAN TERPADU Journal of Dedicators Community Biota Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) JSMARTech : Journal of Smart Bioprospecting and Technology J-PEN Borneo : Jurnal Ilmu Pertanian Jurnal Sains Alami (Known Nature) Berkala Penelitian Hayati Jurnal Riset Perikanan dan Kelautan Jurnal Sains Alami (Known Nature) KOPEMAS Exhibition and Seminar on Science and Creative Technology – Al Azhar Proceeding Genbinesia Journal of Biology
Nurul Jadid Mubarokati
Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Journal : METAMORFOSA Journal of Biological Sciences

 1 
INVESTIGASI BAHAN AKTIF PEGAGAN BERDASARKAN JEJARING DENGAN PROTEIN TARGET : STUDI PENCARIAN OBAT ALZHEIMER SECARA IN SILICO Moch Mustakim; Vina Fitria Wulandari; Nabilah Miftachul Khoiriyah; Azis Mawardi; Rossa Martha Wulandari; Thiya Fathiyatul Fauziyah; Nurul Jadid Mubarakati
Metamorfosa: Journal of Biological Sciences Vol 9 No 1 (2022)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2022.v09.i01.p12

Abstract

INTISARI Penyakit Alzheimer merupakan penyakit neurodegeneratif yang mematikan peringkat 10 teratas berdasarkan WHO tahun 2019. Alzheimer ditandai dengan adanya penurunan aktifitas Choline Acetytransferase (ChAt) yakni zat yang berperan dalam pembentukan enzim asetikolin sebagai enzim. Salah satu bahan alam yang diketahui berperan dalam meningkatan daya ingat yaitu Pegagan. Untuk mengetahui jalur mekanisme senyawa aktif pegagan dalam pengobatan Alzheimer, penelitian ini menggunakan pendekatan in silico dengan menganalisis protein target dan senyawa aktif pegagan dalam suatu jejaring interaksi protein-senyawa. Penelitian ini menggunakan 12 senyawa uji dan molekul reseptor ChAt yang digunakan yaitu 5 TPG dan 4 KMD. Desain jejaring interaksi protein-senyawa dilakukan menggunakan sea target dan STRING database. Hasil interaksi lalu divisualisasikan di perangkat cytoscape. Hasil penelitian ini ditemukan terdapat 8 senyawa uji yang memiliki interaksi dengan reseptor ChAt sedangkan protein target yang berhubungan langsung dengan reseptor ChAt yaitu Tryptophan 5-hydroxylase 1 dan Zinc finger protein GLI. Jadi, senyawa aktif pegagan yang paling banyak berperan berdasarkan protein targetnya adalah senyawa Asiatic Acid, Brahmic Acid, -Humulene, -Caryophyllene, Bicyclogermacrene, Germacrene B, - Pinene, Caryophyllene. Kata kunci: penyakit Alzheimer, Choline Acetytransferase (ChAt), Pegagan, in silico, Jejaring interaksi
Profil Metabolit Daun Kesambi (Schleichera oleosa) Berdasarkan Analisis Histokimia dan In Silico Tintrim Rahayu; Radita Intan Aisyah Pratiwi; Nurul Jadid Mubarakati
Metamorfosa: Journal of Biological Sciences Vol 8 No 1 (2021)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2021.v08.i01.p17

Abstract

Kesambi (Schleichera oleosa) merupakan tumbuhan golongan familia Sapindaceae. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder pada daun kesambi melalui analisis histokimiadan in silico. Metode penelitian secara deskriptif eksperimental menggunakan sampel tumbuhan kesambi yang tumbuh di pulau Madura. Analisis histokimia dilakukan dengan preparasi daun segar melalui sayatan bawah daun dengan cara ditetesi reagen pendeteksi metabolit sekunder (CuSO4, FeCl3, Wagner, Sudan III, AlCl3 & FeCl3+NaCO3) kemudian diamati perubahan warnanya secara mikroskopis. Sedangkan pengujian in silico bertujuan untuk mengetahui interaksi senyawa aktif dengan ER? sebagai target terapi kanker payudara ER+ melalui molecular docking analysis. Web server pendukung yang digunakan yaitu KNApSAcK, Pubchem, Pass Online dan PDB ID serta software yaitu PyRx, PyMol dan Chimera 1.14. Hasil penelitian analisis histokimia menunjukkan bahwa daun kesambi mengandung senyawa metabolit sekunder yaitu terpenoid, flavonoid, alkaloid, tanin, lipofil dan fenol. Hal ini dikonfirmasi dengan analisis in silico yaitu didapatkan senyawa aktif seperti scopoletin yang merupakan turunan dari fenol, (-)-beta-sitosterol, betulin, betulinic acid, lupeol, lupeol asetat, schleicheol 1&2, schleicherastatin 1-7 yang merupakan turunan dari terpenoid. Berdasarkan hasil molecular docking terdapat interaksi senyawa aktif dengan protein 3ERT, senyawa yang memberikan hasil paling efektif sebagai kandidat obat kanker payudara yaitu lupeol asetat dengan nilai Root Mean Square Deviation (RMSD) paling baik yaitu l.b 1.588 Å dan u.b 2.219 Å. Senyawa lupeol asetat diprediksi memiliki aktivitas sebagai inhibitor ER? terhadap kanker payudara ER+. Kata Kunci : Kesambi (Schleichera oleosa), histokimia, molecular docking dan ER?
Kadar Superoksida Dismutase (SOD ) Pada Paru-Paru Tikus Hipertensi Doca-Garam Yang Dipapar Ekstrak Metanolik Benalu Teh Dan Benalu Mangga Siti Qurrotul Aini; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
Metamorfosa: Journal of Biological Sciences Vol 8 No 2 (2021)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2021.v08.i02.p13

Abstract

Hypertension is a condition caused by the pressure of blood against the artery walls when the blood is Hypertension is a condition caused by the pressure of blood against the artery walls when the blood is pumped from the heart to the tissues. In hypertension, it can stimulate the formation of reactive oxygen species (ROS) compounds. The use of exogenous antioxidants in preventing oxidative stress can alternatively use herbal plants. For example, herbal plants such as tea parasites and mango parasites can increase the activity of superoxide dismutase (SOD) and reduce the concentration of malondialdehyde (MDA). This study aims to further examine the role of methanolic extracts from the combination of tea parasite and mango parasite (EMBTBM) on superoxide dismutase (SOD) in hypertensive rats exposed to DOCA-salt using experimental methods. Using 25 male Wistar rats, consisted of 5 treatments, namely control (-), control (+), the treatment group for the combination of tea parasites and mango parasites with doses of 50, 100, and 200 mg / KgBB respectively with five repetitions. The results of this study indicate that the level of increased SOD with the combination of EMBTBM in the control group (+) was very significantly different from the control group (-), treatment 1, 2, and 3. This very significant difference was due to the p-value = <0.001 (< 0.05). The benefit of this study is that it can be used as a reference for the role of the combination of tea parasites and mango parasites on superoxide dismutase (SOD) in hypertensive rats exposed to DOCA-salt. Keywords: Hypertension, EMBTBM, SOD.
Profil Histopatologi Otot Jantung pada Tikus Hipertensi (Doca-Garam) yang Dipapar Kombinasi Ekstrak Metanolik Benalu Teh Dan Benalu Mangga (EMBTBM) Annisatul Anis Hakimah; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
Metamorfosa: Journal of Biological Sciences Vol 8 No 2 (2021)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2021.v08.i02.p20

Abstract

Some herbs from the parasite group and the Loranthaceae family also act as antihypertensives. This study aims to look at the histopathological profile of the heart in hypertensive rats (DOCA-Salt) exposed to the combination of Methanolic Extract of Benalu Tea and Mango Benalu (EMBTBM) for 14 days using true experimental design method with completely randomized design on 50 rats, divided into 5 controls -), control (+), treatment 1 dose 50 mg / KgBB, treatment 2 doses 100 mg / KgBB and treatment 3 doses 200 mg / KgBB. Each treatment had 5 replications. In analyzing the data used the ANOVA test, one of the methods is JAMOVI with version 1.1.9.0. As for the calculation of cell diameter using the IMAGE J application. The results showed that the histopathological profile of the heart in hypertensive rats (DOCA-Salt) exposed to EMBTBM for 14 days on heart cell necrosis showed very real evidence between the control (+) and control (- ), treatment 1, 2, and 3. This is evidenced by the results of the analysis p-value <0.05, namely 0.002, so it is denied that EMBTBM has an effect on the average number of necrosis of cardiac cells. There is also a significant difference in the number of heart cell diameter of hypertensive rats between the control (+) and control (-) groups, treatment 1, 2, and 3. This is evidenced by the results of the analysis showing a p-value <0.05, namely 0.021, so that it can it is denied that EMBTBM can shrink the diameter of cells in the heart organ. Keywords: Hypertension, Heart, Left Ventricle, Anatomical Histopathology, EMBTBM.
Co-Authors Abdul Hamid A. Toha Abdullah Rozzen Muzayyan Adi Sofyan Ansori, Muhammad Agus Mohammad Hikam Ahmad Taufiq Alik Maulidiyah Annisatul Anis Hakimah Ari Hayati Arifiati, Shinta Arina Roikhana Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Azis Mawardi Azis Mawardi Chintya Ayu Pertiwi Della Aljanna Savita Devi Indrayani Fitri Asari Dewi Qurrot &#039;Aini Dewi, Atikah Nur Shabrina Razan Dyan Aprillia Susanti Eka Kumalasari Fradina, IntanTrixi Gatot Ciptadi Gatra Ervi Jayanti Gatra Ervi Jayanti Hakimah, Annisatul Anis Hasan Zayadi Hatif Khusnin Nida' Hikam, Agus Mohammad Husain Latuconsina Islami, Darajatun Islamya, Nur Afni Auli Ismatud Diniyah Istirochah Pujiwati Januarista, Terra Kamilah, Nahdhiyatun Kharisma, Viol Dhea Kurniasari, Yulia Lestari, Tengku Anggun M. Abdul Qodir Jailani Ma'ruf, Muhammad Maghfiroh, Faldha Laili Malia Anjani Moch Mustakim Moch Mustakim Muchammad Faruq Vikriansyah Muhammad Dailami, Muhammad Musaffak, Taufik Ridwan Nabilah Miftachul Khoiriyah Nafisa Nafisa Nia Novita Nurrohmah Nour Athiroh Abdoes Sjakoer Nur Cahya Kartika Slamet Nur Laily Azizah Nur Mufida Nur Mufida Nurrohmah, Nia Novita Nurul Humaidah Oktavia Rahayu Puspitarini Oktaviana, Nimas Ajeng Pinanti, Honesty Nurizza Pratiwi, Radita Intan Aisyah Radita Intan Aisyah Pratiwi Rahayu Dwi Lestari Ramadhan, Majida Ramizard Rafsanjani Rasyadan Taufiq Probojati Rossa Martha Wulandari Rossa Martha Wulandari Saimul Laili Sama’ Iradat Tito Saputri, Syntia Diyah Hayu Ria Silvia, Putri Azizatul Siti Khoirun Ni’mah Siti Qurrotul Aini Sulis Setiawati Suroyya, Mariyam Sutiman B. Sumitro Sutiman Bambang Sumitro Syaiful Arifin Tengku Anggun Lestari Thiya Fathiyatul Fauziyah Tintrim Rahayu, Tintrim Ula, Erfa Navadiatul Umu Intan Kinasih Vina Fitria Wulandari Waliyyul Ahdi Alhikami Widyananda, Muhammad Hermawan Yunani, Silvi