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All Journal Sari Pediatri Paediatrica Indonesiana Jurnal Plastik Rekonstruksi Medica Hospitalia ASEAN Journal of Community Engagement Jurnal Sosial dan Teknologi Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Luh Karunia Wahyuni, Luh Karunia
Departemen Ilmu Kesehatan Fakultas Kedokteran Universitas Indonesia Anak/Rumah Sakit Cipto Mangunkusumo, Jakarta
Humanities Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Platelet-Rich Plasma as a Pharmacopuncture Agent in Cervical Myofascial Pain Nareswari, Irma; Kamal, Achmad Fauzi; Mihardja, Hasan; Yunus, Reyhan Eddy; Jusuf, Ahmad Aulia; Harahap, Alida Roswita; Wahyuni, Luh Karunia; Werdhani, Retno Asti; Handayani, Selfi; Rukmindar, Dion
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.310

Abstract

Chronic cervical myofascial pain (CMP) is a prevalent musculoskeletal disorder characterized by persistent neck pain, inflammation, functional impairment, and altered pain processing. Conventional treatments, including pharmacological therapy and physical rehabilitation, often provide limited and temporary relief. Increasing evidence suggests that chronic CMP involves not only peripheral nociceptive input but also nociplastic pain mechanisms driven by sustained neuroimmune dysregulation and central sensitization. Pharmacopuncture, combining acupuncture point stimulation with localized injection of therapeutic agents, has evolved with the introduction of regenerative biologics such as platelet-rich plasma (PRP). PRP contains concentrated platelets and bioactive growth factors, including VEGF, PDGF, and TGF-β, which exert anti-inflammatory and tissue-reparative effects. Emerging data indicate that PRP pharmacopuncture may reduce pro-inflammatory cytokines (e.g., IL-1β and TNF-α), modulate regulated cell death pathways (e.g., apoptosis and pyroptosis), and promote the restoration of myofascial tissue homeostasis. These mechanisms may contribute to both peripheral tissue repair and attenuation of nociplastic pain processing. This narrative review synthesizes current clinical and experimental evidence on the biological mechanisms and therapeutic potential of PRP pharmacopuncture in chronic CMP. Available studies report meaningful improvements in pain intensity and functional outcomes compared with conventional acupuncture or pharmacotherapy alone. However, substantial methodological heterogeneity may arise from PRP preparation protocols, acupoint selection, and outcome measures, limiting the ability to draw definitive conclusions. High-quality randomized controlled trials incorporating standardized protocols and mechanistic biomarkers are required to establish PRP pharmacopuncture as an evidence-based integrative treatment for chronic CMP.
Co-Authors ., Dadun Achmad Fauzi Kamal Adrian Prasetya Sudjono Agatha Geraldyne Ahmad Aulia Aldri Frinaldi Alwin, Wanarani Andayani, Gitalisa Aria Kekalih Aryono Hendarto Bangun, Kristaninta Bani, Anna Puspitasari Boya Nugraha Budiati Laksmitasari Clements Clements Damayanti Rusli Syarif Daniel, Hisar Dini Prima Utami Djoenaedi, Intania Dwiranti, Astari Edbert Wreksoatmojo Elfrida Ratnawati Febrina Rahmayanti Fitriana, Anis fitriana, ika Grace Wangge, Grace Harahap, Alida Roswita Harini, Melinda Hasan Mihardja Hidemi, Octaviany Hikari Ambara Sjakti, Hikari Ambara Ida Ruwaida, Ida Ika Fitriana Indri Wijayanti Inez Ayuwibowo Sangwidjojo Irawan Mangunatmadja Irawan Mangunatmadja Irawati, Yunia Kreshanti, Prasetyanugraheni Kurniawardhani, Dewinta Retno Lindrawati Tjuatja lmral Chair Luzanil, Sonny Tirta Made Susiyanti Matsurah, Qaishum Melinda Harini Melinda Harini Melinda Harini Melinda Harini Mellisya Ramadhany Menaldi, Adhityawarman Menaldi, Sri Linuwih SW Nareswari, Irma Nugraha, Boya Octaviany Hidemi Peggy Sunarjo Prasandhya Astagiri Yusuf Primo Parmato Priscilia, Florentina Putra, Johanes Rachmawati, Elvie Zulka Kautzia Ramadhany, Mellisya Retno Asti Werdhani Reyhan Eddy Yunus Rico Kurniawan Risma Kerina Kaban Risma Kerina Kaban Rizky Kusuma Wardhani Rukmindar, Dion Sahid, Muhammad Hidayat Sari, Vania Aramita Satyanaya Widyaningrum Selfi Handayani Siti Handayani Skolastika Mitzy Benedicta Sri L. Menaldi Sri Linuwih Susetyo Wardhani, Sri Linuwih Susetyo Steven Setiono Sunarjo, Peggy Tedjasukmana, Deddy Tirza Z Tamin Tirza Z Tamin Tirza Z Tamin Tri Rahayu Victor Prasetyo Poernomo Wardhani, Rizky Kusuma Wardhani, Rizky Kusuma  Wicaksono, Gunawan Widjajalaksmi Kusumaningsih, Widjajalaksmi Wijayanti, Indri Yeni Dwi Lestari