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All Journal SANITAS: Jurnal Teknologi dan Seni Kesehatan Jurnal Peduli Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara MEDIC MEdical Dedication Studium: Jurnal Pengabdian Kepada Masyarakat Sinteza Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Indonesian Journal of Cosmetics Bencoolen Journal of Pharmacy
Puspa Dwi Pratiwi
Faculty of Dentistry, University of Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Sinteza

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Bahan Tambahan dalam Sediaan Tablet: Review Pratiwi, Puspa Dwi; Citrariana, Shesanthi; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.17472

Abstract

Tablets are solid pharmaceutical dosage form without or with suitable excipients by press or compression manufacturing process. The excipient chosen can influence the product performance (physical properties and stability) and bioavailability. All excipients must be optimally selected to get the optimal formula of tablet dosage form. This article review aims to overview of excipient in tablet dosage form and their role in formulating tablet dosage form. this review article was written based on literature studies from electronic databases such as PubMed, ScienceDirect, and Google Scholar which contain related information using keyword in Indonesian or English use article published in 2013-2023. excipients in tablet dosage form are fillers or diluents, disintegrants, lubricants, preservatives, flavors, sweeteners, coloring, and coating agents. These excipients added to tablet dosage form to facilitating the process of manufacture tablet dosage form, increasing stability and effectiveness of active pharmaceutical ingredients in tablet. The conclusion of this review, there are many classification of tablet excipients which is different function to get compendial requirements of tablet dosage form.
Aplikasi Simplex Lattice Design untuk Optimasi Emulgator dalam Krim Minyak Atsiri Kulit Jeruk Manis Pratiwi, Puspa Dwi; Arnas, Deah Lestiana
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26539

Abstract

In order to obtain a perfect emulsified and stable preparation, choosing the right composition emulsifier is crucial. Formula optimization is needed to determine the best combination of ingredients in formulation process based on evaluation responses. Simplex Lattice Design (SLD) is an experimental design method for mixing materials with the proportion of the total number of materials 1 or 100%. This research was aims to obtained the optimal cream formula using tween 80 and span 80 as emulsifiers and determined their effect on the physical properties of cream preparation. SLD method was used as optimization method with tween 80 and span 80 as independent variables and pH, viscosity, spreadability, and stickiness as responses. The minimum limit for tween 80 and span 80 is 1% (w/v) and the maximum is 9% (w/v) with total 10%. The optimal formula was obtained from consideration of the response by entering the target value to obtain a formula with desirability value close to 1. There are 5 formulas based on SLD recommendations, with a concentration ratio of tween 80 and span 80 9:1 (run 1); 7:3 (run 2); 1:9 (run 3); 5:5 (run 4); and 3:7 (run 5). The relationship between concentration and response value can be explained based on the significance of the model and equations obtained. The optimal formula was the concentration ratio of tween 80 and span 80 8.6:1.34 with a desirability value of 0.953. The conclusion of this research was that SLD can be used to optimize the emulsifier with response predictions close to the results obtained.
Co-Authors Amalia Rani, Amalia Angraini, Resti Indah Arnas, Deah Lestiana Baiq Maylinda Gemantari Citrariana, Shesanthi Damayani, Mira Ovita Diah Riski Gusti Dominica, Dwi Elisma Elisma Faradina Aghadiati Fitrianingsih Fitrianingsih Hayaza, Azzam Hafid M. Rifqi Efendi Maharini , Indri Maharini, Indri Muhammad Syukri Muhlisun Azim Neldi, Vina Novia Tri Astuti Novia, Ria Pondawinata, Marizki Puspawan Hariadi Rizki, Nanda Putri Sadli, Nurul Kamilah Sani K, Fathnur Santi Perawati, Santi Sitanggang, Sarah Dianora Sulastri, Novi Syamsurizal - - Uce Lestari Utami, Diah Tri Yuliawati Yuliawati , Yuliawati