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All Journal MEDIA MEDIKA INDONESIANA Journal of Nutrition and Health JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College WMJ (Warmadewa Medical Journal) Sari Pediatri Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Riset Kesehatan Poltekkes Depkes Bandung Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Diponegoro International Medical Journal (DIMJ) Bioscientia Medicina : Journal of Biomedicine and Translational Research
Niken Puruhita
Clinical Nutrition Specialist Program, Faculty Of Medicine, Diponegoro University
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengaruh pendidikan gizi terhadap pengetahuan dan sikap tentang gizi anak Sekolah Dasar Nuryanto, Nuryanto; Pramono, Adriyan; Puruhita, Niken; Muis, Siti Fatimah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 1 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.257 KB) | DOI: 10.14710/jgi.3.1.121-125

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Background: Nutrition education is one method to change the knowledge and attittude of nutrition on school children.The study aimed to see the effect of nutrition education on knowledge and attitude of nutrition among school children.Methods: The study was one group pre-post test design of a quasi experimental design. Subjects were 99 schoolchildren randomly selected through multi stage sampling method among the 4th, 5th, and 6th graders. They were givennutrition education using posters and pocket books in children meeting for three months. The data of knowledge andattitude were collected through interview using structure questionares. The differences in knowledge attitude andpractice of of nutrition among school children were tested by wilcoxon test.Results: The mean of knowledge about nutrition among school children before nutrition education is 66,45±9,6%increasing to 71,61±9,3% after nutrition education. Median of attitude before nutrition education is 70,31% increasingto 75% after nutrition education. The result showed that there was an effect of nutrition education on knowledge andattitude of school children.Conclusion: Nutrition education can improve knowledge and attitude of school children.
Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum Damayanti, Kusmadewi Eka; Wijayahadi, Noor; Puruhita, Niken
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 1 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.446 KB) | DOI: 10.14710/jgi.4.1.63-66

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Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats. Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day. Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05).Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats. 
Pengaruh pemberian klorofilin berbagai dosis terhadap indeks fagositosis makrofag dan kadar nitric oxide mencit BALB/c yang diinfeksi dengan Salmonella typhimurium Arum, Puspito; Suromo, Lisyani B; Puruhita, Niken
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.322 KB) | DOI: 10.14710/jgi.2.2.78-82

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Background: Immune responses to eliminate Salmonella infection are by activating macrophage and by producing NO. Chlorophyllin is a chlorophyll derivate that has immunomodulator properties. Objective: The aim of this study was to prove effect of chlorophyllin in macrophage phagocytosis index and NO level. Methods: A post test only controlled group design was conducted in 5 groups Balb/c mice (negative control, positive control, dosage 100 µg/200 g BW, dosage 200 µg/200 g BW and dosage 380 µg/200 g BW). Macrophage phagocytosis index was measured by counting cells that phagocyte latexs particles. NO level was measured by Griess method. Macrophage phagocytosis index difference was analyzed by one way anova and NO level deference was analyzed by Kruskall-Wallis test (α 0,05).Results: Means of macrophage phagocytosis index were 0,7(±0,80), 1,8(±0,80), 2(±0,22), 2,5(±0,43) and 3,2(±0,68) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was a significant difference of macrophage phagocytosis index between group (p 0,000). Mean of NO level were 0,4 µM(±0,10), 0,6 µM(±0,60), 0,8 µM(±0,64), 0,6 µM(±0,67) and 0,4 µM(±0,26) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was no difference of  NO level between group (p 0,813).Conclusion: There was a significant difference of macrophage phagocytosis index between chlorophyllin administered group and control. The higher chlorophyllin dosage, the higher macrophage phagocytosis index. Therewas no difference of  NO level between chlorophyllin administered group and control.
PERBEDAAN KADAR KOLESTEROL LDL DARAH TIKUS SPRAGUE DAWLEY PADA PEMBERIAN KOPI FILTER DAN TANPA FILTER Sari, Raysa Tanjung; Puruhita, Niken
Journal of Nutrition College Vol 1, No 1 (2012): Oktober 2012
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.969 KB) | DOI: 10.14710/jnc.v1i1.403

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Background : Coffee contains cafestol and kahweol which can increase LDL cholesterol levels. Effect of cafestol and kahweol with chlorogenic acids are antagonist in coffee. Chlorogenic acids is strong antioxidant in coffee. Unfiltered coffee contains more chlorogenic acids and cafestol than filtered coffee. The study aims to determine the differences of LDL cholesterol levels of Sprague Dawley rats in giving filtered and unfiltered coffee. Methods : a laboratory experimental study, with randomized pre-post test control group design, with a simple random sampling to 28 Sprague Dawley rats were divided into 3 groups. The first treatment was given unfiltered coffee 4x2.7 ml, the second treatment was given filtered coffee 4x2.7 ml and the control was given water 4x2.7 ml for 28 days. LDL cholesterol levels were determined by the homogenous enzyme method. Data were analyzed by paired t-test and Oneway ANOVA test at 95% confident level. Results : Changes levels of LDL cholesterol in filtered coffee (0.85 mg/dl) are higher than unfiltered coffee (0.15 mg/dl). However statistical test shows there is no significant difference of LDL cholesterol in filtered and unfiltered coffee (p>0.05). Conclusion : There is no significant difference of LDL cholesterol levels of Sprague Dawley rats in filtered and unfiltered coffee.
PERBEDAAN KADAR KOLESTEROL LDL DAN HDL ANTARA WANITA VEGETARIAN TIPE VEGAN DAN NON-VEGAN Edyanto, Ermia; Puruhita, Niken
Journal of Nutrition College Vol 1, No 1 (2012): Oktober 2012
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.686 KB) | DOI: 10.14710/jnc.v1i1.433

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ABSTRACTBackground: Studies which investigated different risk for cardiovascular disease in vegetarian reported that each vegetarian diet type had different lipid serum level. Elevated LDL cholesterol level and reduced HDL cholesterol level are independent risk factors for coronary heart disease. This study was aimed to compare levels on LDL and HDL cholesterol between vegetarian vegan and non-vegan.Methods: Two groups of vegetarian women, 23 people in each group of vegan and non-vegan, participated in this cross-sectional study. The data taken of each subject were nutrient intakes (total fat, PUFA, MUFA, SFA, cholesterol, and total fiber), physical activity, body weight, height, LDL and HDL cholesterol serum levels. Data were analyzed by Shapiro-Wilk test, independent-t test, Mann-Whitney test and ANACOVA test.Results: There were no significant differences on LDL and HDL cholesterol serum levels between vegetarian vegan and non-vegan, both before and after variables i.e age, physical activity, body mass index (BMI), amount of total fat, PUFA, MUFA, SFA, cholesterol, and total fiber adjusted (p > 0,05). LDL cholesterol levels for vegetarian vegan and non-vegan were respectively: 97,8 ± 54,87 mg/dl and 112,6 ± 36,03 mg/dl, while for HDL cholesterol, those levels were 54,9 ± 11,15 mg/dl and 55,2 ± 10,82 mg/dl. In multivariant analysis, the most influential variables on LDL cholesterol serum level were age (p = 0,001) and physical activity (p = 0,010), while for HDL serum cholesterol were BMI (p = 0,010) and total fat (p = 0,012). This study also found the significant difference of BMI between vegetarian vegan and non-vegan (p = 0,011), whose for each of groups’ BMI, were respectively: 20,9 ± 3,08 kg/m2 and 23,5 ± 3,53 kg/m2. Conclusion: LDL and HDL cholesterol serum levels are not different between vegetarian vegan and non-vegan. BMI of both groups is different. Age and physical activity affect on LDL serum cholesterol level, while BMI and total fat affect on HDL serum cholesterol level. LDL cholesterol serum level and BMI in vegetarian vegan  are lower than non-vegan. Key words: Vegetarian diet, vegan, non-vegan, LDL cholesterol, HDL cholesterol
Pengaruh Pemberian Tambahan Putih Telur pada Diet Tinggi Kalori dan Protein terhadap Kadar Albumin Darah Penderita Keganasan Kepala Leher dengan Hipoalbuminemia Dian Ruspita; Suprihati -; Amriyatun -; Niken Puruhita
Medica Hospitalia : Journal of Clinical Medicine Vol. 1 No. 3 (2013): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.926 KB) | DOI: 10.36408/mhjcm.v1i3.64

Abstract

Latar belakang : Penderita keganasan kepala leher sering mengalami hipoalbuminemia karena asupan makanan yang menurun akibat terjadi gangguan saluran cerna, nyeri, depresi, konstipasi, malabsorbsi, efek samping pengobatan. Salah satu syarat kemoterapi adalah kadar albumin yang cukup. Putih telur adalah salah satu sumber asam amino yang dapat membentuk albumin bila dikonsumsi secara proporsional. Tujuan penelitian ini adalah membuktikan pemberian tambahan putih telur pada diet tinggi kalori dan protein dapat meningkatkan kadar albumin d a r a h p e n d e r i t a ke g a n a s a n ke p a l a l e h e r d e n g a n hipoalbuminemia. Metode : Penelitian intervensi dengan control trial pretest–post test design di bangsal RSUP Dr Kariadi Semarang, sejak Desember 2010 – Mei 2011. Sampel adalah pasien keganasan kepala leher yang dirawat untuk mendapatkan kemoterapi yang memenuhi kriteria inklusi. Jumlah sampel minimal yang dibutuhkan adalah 11 subyek untuk tiap kelompok. Kelompok penelitian adalah kelompok A yaitu kelompok diet putih telur, B yaitu kelompok diet tanpa telur dan C yaitu kelompok diet tambahan putih telur. Setelah pemberian diet putih telur ayam 5 hari kemudian dianalisis selisih kadar albumin pada hari ke–21 dan sebelum perlakuan. Analisis data menggunakan SPSS for Windows 17.0. Hasil : Empat puluh lima kasus hipoalbuminemia memenuhi kriteria inklusi dan 40 subyek yang dapat dianalisis. Selisih albumin kelompok A (0,18±0,51), B (0,02±0,61), C (0,02±0,41). Tidak didapatkan perbedaan bermakna selisih kadar albumin setelah dan sebelum perlakuan berdasarkan hasil uji one way anova (p=0,656). Simpulan : Tambahan putih telur pada diet tinggi kalori dan protein dapat meningkatkan kadar albumin darah penderita keganasan kepala leher dengan hipoalbuminemia pada hari ke-21 namun secara statistik tidak bermakna. Kata kunci: putih telur, keganasan kepala leher, hipoalbuminemia, kadar albumin.
Problema Malnutrisi di Rumah Sakit Hertanto Subagio; Niken Puruhita; Annta Kern
Medica Hospitalia : Journal of Clinical Medicine Vol. 3 No. 3 (2016): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.364 KB) | DOI: 10.36408/mhjcm.v3i3.225

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Malnutrisi di rumah sakit merupakan hal penting yang seringkali terlewatkan pada penanganan pasien. Prevalensi yang sangat tinggi, komplikasi yang bervariasi tingginya mortalitas dan biaya yang harus ditanggung akibat malnutrisi mengharuskan penanganan yang bersifat multidisiplin dan terintegrasi pada pasien dengan malnutrisi atau berisiko malnutrisi. Kendala yang dihadapi pada penatalaksanaan pasien malnutrisi di rumah sakit adalah belum tersedianya protokol atau kurangnya komunikasi antar pengelola pasien baik dokter termasuk dokter spesialis gizi, ahli gizi, perawat maupun ahli farmasi. Pembentukan tim terapi gizi diharapkan dapat mengatasi masalah gizi di rumah sakit dan mendukung terapi medis dokter penanggung jawab pasien.
Modifikasi Tekstur Makanan dan Minuman Pasien Disfagia Niken Puruhita
Medica Hospitalia : Journal of Clinical Medicine Vol. 3 No. 3 (2016): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.484 KB) | DOI: 10.36408/mhjcm.v3i3.237

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Disfagia adalah terhambatnya proses perpindahan makanan dan cairan dari mulut ke lambung. Komplikasi disfagia antara lain malnutrisi, dehidrasi, pneumonia aspirasi dan bahkan kematian. Pasien disfagia biasanya mengalami kesulitan mengkonsumsi makanan reguler dengan konsistensi bervariasi. Perubahan tekstur makanan yang sesuai dapat menurunkan risiko pneumonia aspirasi, meningkatkan asupan dan status gizi pasien disfagia. Modifikasi tekstur makanan secara bertahap disesuaikan dengan perkembangan kondisi pasien. Kemampuan menelan pasien diuji berkala sebelum diberikan makanan yang lebih padat konsistensinya. Modifikasi tekstur makanan hendaknya dilakukan tanpa mengubah warna dan cita rasa untuk meningkatkan selera makan pasien. Bentuk dan tekstur makanan yang tersedia di RSUP Dr. Kariadi meliputi makanan biasa, makanan lunak, makanan saring, dan makanan blenderized. Minuman encer berisiko menyebabkan aspirasi pada pasien disfagia. Modifikasi minuman dengan menambahkan pengental akan lebih mudah ditoleransi. Pengental minuman ini belum tersedia di Indonesia, sehingga RSUP Dr Kariadi menggunakan jeli sebagai pengental. Metode yang banyak dipakai untuk mengukur kosistensi makanan untuk pasien disfagia antara lain adalah line spread test dan fork test.
Early nutrition approach in critically ill COVID-19 patients Niken Puruhita
World Nutrition Journal Vol. 4 No. S3 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.S3.0003

Abstract

This presentation is aimed to describe several guidelines available indicating nutritional therapy in critically ill COVID-19 patients. Data from our ICU in dr. Kariadi General Hospital will be presented.
Energy target achievement and its determinants in critically ill COVID-19 patients in Indonesia Niken Puruhita; Febe Christianto; Luciana Sutanto; Banundari Rachmawati; Sofyan Harahap; Muchlis Ahsan Udji Sofro; Retnaningsih -; Riwanto; Hertanto Wahyu Subagio
World Nutrition Journal Vol. 4 No. 2 (2021): Volume 04 Issue 2, August 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i2.0006

Abstract

Introduction. Achievement of energy target in critically ill Covid-19 patients in Intensive Care Unit (ICU) is challenging. This study was aimed to depict the possibility of achieving energy target and its determinants in critically ill Covid-19 patients. Methods. A cross sectional study was conducted in ICU of dr. Kariadi Hospital Semarang, Indonesia. Secondary data were obtained from Covid-19 patients who were in ICU for minimum 3 days, from March to December 2020. Data collected included age, sex, Body Mass Index (BMI), comorbidities, Modified Nutrition Risk in Critically Ill (mNUTRIC) score, energy intake, route of nutrition delivery (enteral or combination of enteral and parenteral nutrition), lactate status, ICU length of stay (LOS), duration of mechanical ventilator and mortality. Risk Prevalence calculations were conducted to measure risks. Variables with significant associations and p< 0.25 were included in multiple logistic regression. Results. A total of 188 subjects were included in the analysis. Most patients were male (62.8%) and obese (61.8%). As much as 56.9% patients were able to achieve energy target of 20 kcal/kgBW on day 3 of ICU stay. Those with low risk mNUTRIC score and nutrition delivery was through enteral and parenteral route were more likely to achieve target energy of 20 kcal/kgBW in the first 3 days in the ICU. Conclusions. Achieving energy target of 20 kcal on day 3 of ICU stay for critically ill Covid-19 patients is feasible. Low mNutric score and nutrition delivery through enteral and parenteral route were two determinants for the achievement.
Co-Authors Adriyan Pramono Ahmad Syauqy Alfadila, Tsania Izza Aliva Nabila Farinisa Amalia Sukmadianti Amalia Sukmadianti Amriyatun - Annta Kern Annta Kern Nugrohowati Aryu Candra Asep Iwan Purnawan Asri Purwanti Banundari Rachmawati Budi Santosa Christianto, Febe Della Ayuning Priastiti Dewi, Suci Noviya Dian Ruspita Eiyta Ardinasari Enny Probosari Enny Probosari Ermia Edyanto Etika Ratna Noer Etisa Adi Murbawani Febe Christianto Febe Christianto FILLAH FITHRA DIENNY Gina Amalia Hagnyonowati Hagnyonowati Handayani, Endah Nur Hani Purnamasari Hartanto, Okky Heidi Listya Heri-Nugroho Heri-Nugroho Hermina Sukmaningtyas Hertanto Subagio Hertanto Wahyu Subagio Hertanto Wahyu Subagyo Hertanto WS JC Susanto Jennifer Setiawan Khairuddin - Kusmadewi Eka Damayanti Lilis Banowati Lisyani B Suromo Luciana Sutanto MARTHA ARDIARIA Martha Irene Kartasurya Minidian Fasitasari Muchlis Ahsan Udji Sofro Muhammad Sulchan Muhammad Sulchan Nadia Savitri Nathalia Safitri Noor Wijayahadi Noverita Rochsitasari Novitasari, Anggi Nugraheni Nugraheni Nurjanah, Ayu Nuryanto Nuryanto Puspito Arum Ratha, Putu Prayoga Raysa Tanjung Sari Retnaningsih - Riwanto Rizkita, Maura Sania Rosa Kristiansen Saldi Fitra Setiawan, Felix SIGIT ADIANTO Siska Indah Septiana, Siska Indah Siti Fatimah Muis Siti Fatimah Muis Siti Fatimah Muis Sofyan Harahap Sukma Paramita R, Sukma Suprihati - Tania Wijayanti Yan Wisnu Prajoko Yekti Wirawanni Yudomurti Yudomurti Yuniari, Dwi Zega Yudama Archilona