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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Science and Technology Indonesia Jurnal Penelitian Sains IJEMS (Indonesian Journal of Environmental Management and Sustainability) QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Berkala Penelitian Hayati Sriwijaya Bioscientia Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat BIOVALENTIA: Biological Research Journal Jurnal Pepadu Jurnal Manusia dan Lingkungan Jurnal Medika: Medika

Elisa Nurnawati

Biology Department, Faculty Of Mathematics And Natural Sciences, Sriwijaya University, Indonesia

Author-ID : 3516002

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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POTENCY AND ACTIVITY OF SECONDARY METABOLITE OF Trichoderma harzianum AC1(b) J2 INHIBITOR GROWTH Colletotrichum capsici IPBCC 13.1098 Nurkayah, Nurkayah; Nurnawati, Elisa; Widjajanti, Hary
BIOVALENTIA: Biological Research Journal Vol. 5 No. 1 (2019)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Trichoderma harzianum is a fungus that can produce secondary metabolites which able to inhibit the growth of Colletotrichum capsici. a pathogenic fungus causing anthracnose in plants. the Aims of this research were to obtain and analyze the ability of secondary metabolites of Trichoderma harzianum AC1 (b) J2 isolated from Scleria poaeformis. to inhibit the growth of Colletotrichum capsici IPBCC13.1098. The secondary metabolite eluat of Trichoderma harzianum were tested for the antifungal activity toward Colletotrichum capsici IPBCC 13.1098. Fractionation was carried out by Column Chromatography and produced 31 eluat. The secondary metabolite eluat of Trichoderma harzianum with the highest inhibition zone diameter was eluat 1 with 8.4 mm in diameter. The secondary metabolite eluat with the highest value of inhibition zone was carried out by MIC test and thin layer chromatography (TLC). Based on the MIC results, the minimum inhibitory concentration of the secondary metabolite of Trichoderma harzianum to fungus Colletotrichum capsici was 250 ppm with inhibition zone diameter was 0.10 mm. The results of TLC showed orange spots on the TLC plate that indicated alkaloite compounds.

EXPLORATION OF ENDOPHYTIC FUNGI OF DRAGON SCALEâ€™S FERN (Pyrrosia piloselloides (L.) M.G. Price) AS AN ANTIBACTERIAL SOURCES Asiandu, Angga Puja; Widjajanti, Hary; Nurnawati, Elisa
BIOVALENTIA: Biological Research Journal Vol. 5 No. 2 (2019)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Endophytic fungi are fungi which live inside the host plant tissue and have been undergone a horizontal gene transfer process. Endophytic fungi are able to synthesize the same bioactive compounds which synthesized by their host plants. The host plant used in this research was dragonâ€™s scales fern (Pyrrosia piloselloides (L.) M.G. Price). Dragonâ€™s scales fern produces various of bioactive compounds which used as antibacterial agents such as polyphenols. This research was aimed to obtain endophytic fungi isolates from trophophyll fronds and sporophyll fronds of dragonâ€™s scales fern, to determine the antibacterial activity of the secondary metabolite extracts of endophytic fungi, to determine the Minimum Inhibitory Concentration (MIC), to determine the characteristics of the endophytic fungi isolates which potentially as antibacterial source. Based on the research, 13 endophytic fungi isolates were obtained from dragonâ€™s scales fern fronds consist of 5 isolates from trophophyll fronds and 8 isolates from sporophyll fronds. The antibacterial activity test showed that the extract of secondary metabolites of the isolate DTP2 had the highest inhibition zone diameter against E.coli 14.82 Â± 4.05 mm, DTP4 against S.aureus 8.80 Â± 0.03 mm and DSP4 against S.dysentriae 10.15 Â± 0.36 mm. MIC of ethyl acetate extracts of secondary metabolites of isolate DTP2 against E.coli was 125 Âµg/mL, DTP4 against S.aureus was 125 Âµg/mL and DSP4 against S.dysentriae was 31.25 Âµg/mL. The endophytic fungi isolate DTP2 identified as Aureobasidium melanogenum, DTP4 identified as Penicillium alliisativi and DSP4 identified as Aspergillus flocculosus.

POTENCY OF ENDOPHYTIC FUNGI ISOLATED FROM Muntingia calabura AS ANTIFUNGAL SUBSTANCES AGAINST Candida parapsilosis Agung Bimantara; Hary Widjajanti; Elisa Nurnawati
BIOVALENTIA: Biological Research Journal Vol. 8 No. 2 (2022)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.8.2.2022.226

Alternative is needed to overcome the problem of dandruff caused by C. parapsilosis. Endophytic fungi isolated from plants are capable of synthesizing compounds to produce various secondary metabolites. This study aimed to obtain the most active endophytic fungal isolates, determine the class of compounds, and determine the antifungal activity of the endophytic fungi (M. calabura) against C. parapsilosis. Fifteen isolates of endophytic fungi isolated from M. calabura were coded FDK1-FDK15. There was a color change in the media after 30 days of cultivation isolates of fungi. FDK4 and FDK13 have potential as antifungals. FDK13 fungal extract had the highest inhibition zone diameter of 20.00 mm. 20 eluates were obtained from the isolation of com-pounds (Thin Layer Chromatography), FDK 131, 1314, 1317, and 1320 eluates are compounds of the terpenoid group and FDK1316 eluates are phenol group compounds that are active in inhibiting yeast growth. FDK1317 was the most active compound isolate in inhibiting the growth of C. parapsilosis with an inhibition zone diameter of 12.5 mm.

POTENTIAL OF ACTIVE COMPOUNDS LEAVES OF MANGO PARASITE (Dendrophthoe pentandra (L). Miq) AS ANTIFUNGAL M.Ridha Mauludi; Harry Widjajanti; Elisa Nurnawati
BIOVALENTIA: Biological Research Journal Vol. 8 No. 1 (2022)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Infection is a disease that is easily found in tropical areas such as Indonesia. The causes of infection that are easily found include infections due to fungi. One of the fungi that causes many infections is the Candida fungus. Tropical drugs commonly used to treat cutaneous candidiasis include nystatin, clotrimazole, miconazole, ketoconazole and other azoles. However, antifungal drugs have limitations, such as severe side effects, poor penetration into certain tissues, and the emergence of resistance. To overcome the negative effects caused by these synthetic antifungal drugs, it is necessary to explore natural antifungal drugs. One of the plants that has the potential as a medicinal plant is the mango parasite plant (Dendrophthoe pentandra (L.) Miq) which is a parasitic plant that attaches to the host which has the potential as herbal medicine. Research on the potential of active compounds in the leaves of mango parasite (Dendrophthoe pentandra (L). Miq) as antifungals has been carried out from November 2020 to June 2021 at the Genetics and Biotechnology Laboratory, Biology Department, FMIPA Sriwijaya University. The purpose of this study was to obtain fractions that had antifungal activity, to obtain isolates that had antifungal activity, what active compounds were present in the leaves of the mango parasite as antifungal, and to determine the minimum inhibitory concentration of the fungus Candida albicans. Based on research that has been carried out with methanol, n-hexane and ethyl acetate extracts that are active as antifungals, namely n-hexane and ethyl acetate extracts with an n-hexane inhibition zone diameter of 12 mm while ethyl acetate is 10 mm. Then purification of the n-hexane and ethyl acetate fractions was carried out using gravity column chromatography and the n-hexane fraction obtained two pure compounds that were active as antifungals, namely isolate N-1 with a diameter of 12 mm and N-4 with a diameter of 10 mm. Two pure acetate fractions were obtained which were active as antifungals, namely isolates E-1 with a diameter of 10 mm and E 5 with a diameter of 12 mm. Furthermore, the results of the eluate were tested by MIC and thin layer chromatography (TLC). The MIC results on isolates N-1, N-4, and E-1 were able to inhibit at a concentration of 500 ppm and were classified as strong. Meanwhile, isolate E-5 was able to inhibit at a concentration of 1000 ppm which was classified as moderate. The TLC results showed color spots on isolate N-1 which were blue, namely terpenoids, while in isolate N-4 which was orange in color were alkaloids, while in isolate E-1, the color was phenolic yellow, while in isolate E-5, which was purple, it was group terpenoids. The results of the bioautography of isolate N-1 with R¦ value: 0.9, isolate N-4 with R¦: 0.6, isolate E-1 with R¦ value: 0.8, and isolate E-5 with R¦ value: 0,9.

CELLULASE ACTIVITY OF RIZOSFER BACTERIA OF KETAPANG PLANTS (Terminalia catappa L.) Rosmania, Rosmania; Widjajanti, Hary; Nurnawati, Elisa
BIOVALENTIA: Biological Research Journal Vol. 9 No. 2 (2023)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.9.2.2023.403

Cellulose, a natural biopolymer produced by plants, undergoes enzymatic breakdown by cellulase, cleaving the monomer's β-1,4 glycosidic bonds. Cellulolytic bacteria, producers of cellulase, can be isolated from plant rhizospheres, like Ketapang (Terminalia catappa L.), abundantly found in the Biology Department at Universitas Sriwijaya, South Sumatra, Indonesia. This study aimed to isolate cellulolytic bacteria from Ketapang rhizosphere soil and assess their cellulase activity. The spread plate method on selective Carboxy Methyl Cellulose Agar (CMC agar) was used for bacterial isolation, and cellulase activity was measured using the DNS method (3.5-dinitro salicylic acid). Results yielded 22 isolates of cellulolytic bacteria capable of growth on selective CMC agar. Thirteen isolates, identified through a screening test, produced cellulase, forming clear zones post-addition of 0.1% Congo Red and 1 M NaCl. Cellulolytic activity indices for these isolates ranged from 0.02 to 2.6 mm. The highest indices (IAS) and cellulase activities were observed in BS10, BS4, and BS22, with IAS values of 2.64, 2.12, and 1.71, and cellulase activities of 354.99 U/ml, 9.42 U/ml, and 9 U/ml, respectively. Identification results suggested that isolate BS10 bore similarities to the genus Zoogloea, while isolates BS4 and BS22 showed similarities to the genus Bacillus.

Co-Authors Ady Mara, Ady Afreni Hamidah Agung Bimantara Alfarado, Daniel Ali Djamhuri Andika Puspita Dewi Asiandu, Angga Puja Christina Vivid Handayani Daniel Alfarado Desnelli Desnelli Desnelli Desnelli Eca Desriana Zahwa Eka Amelia Elfita Elfita Endro Setyo Cahyono, Endro Setyo Erni Martani Erni Martani Erni Martani Evi Yuliza Evi Yuliza, Evi Fatma Ferlinahayati Ferlinahayati Fitri Maya Puspita Fitri Maya Puspita Fitrya Fitrya Harmida Harmida Harmida Harmida Harry Widjajanti Harvianti, Yuniar Hary Widjajanti Hary Widjajanti Hary Widjajanti Hary Widjajanti Heni Yohandini Heni Yohandini Indrawati Indrawati Indrawati Indrawati Jurnal Pepadu Laila Hanum LANGKAH SEMBIRING Langkah Sembiring M.Ridha Mauludi Mardiyanto Mardiyanto Maulida Harwati Mega Tiara Muhammad Said MUHAMMAD SAID Muharni Muharni Muharni, . Mustafa Kamal Mustafa Kamal Niko Erlangga Nina Tanzerina Nita Aminasih Nurkayah, Nurkayah Poedji Loekitowati Hariani Putra Bahtera Jaya Bangun Putra Bahtera Jaya Bangun, Putra Bahtera Jaya Putri, Hanindita Alifia Rizkiani, Delisa Robinson Sitepu Rosmania, Rosmania Salni Salni Sarno Sarno Sarto Sarto Sarto Sebastian Margino Sebastian Margino Sebastian Margino Sisca Octarina Siti Alharzsa Suheyanto Suheryanto Sutandar, Vivi Hendra Umi Kalsum Widjajanti, Haryati Ahda Yadi Oktariansyah

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