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All Journal Alchemy : Journal of Chemistry Jurnal Fitofarmaka Indonesia Jurnal Kartika Kimia Jurnal Farmasi Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) International Journal Mathla'ul Anwar of Halal Issues International Journal of Medicine and Health Jurnal Pengabdian Pada Masyarakat Pharmacon: Jurnal Farmasi Indonesia Journal of Pharmascience
Arini Khaerunnisa
Universitas Mathla'ul Anwar
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Aktivitas Antioksidan Ekstrak dan Antihiperpigmentasi Serum Biji Alpukat (Persea americana Mill.) sebagai Inhibitor Enzim Tirosinase Fatimah Zahra; Arini Khaerunnisa; Dhyneu Dwi Jayantie; Eva Vauziah; Irfan Iryana
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.21458

Abstract

Melanin merupakan pigmen utama yang memiliki fungsi melindungi kulit dari kerusakan akibat paparan sinar ultraviolet. Sintesis melanin berlebih dapat menyebabkan terjadinya hiperpigmentasi. Kandungan utama dalam biji alpukat (Persea americana Mill) adalah katekin yang berpotensi sebagai inhibitor enzim tirosinase. Tujuan dalam penelitian ini adalah untuk membuat formulasi sediaan serum ekstrak biji P.americana Mill dan mengetahui bagaimana aktivitas penghambat enzim tirosinase. Sampel Biji P.americana di maserasi dengan etanol 70%. Diformulasi dengan tiga formula yaitu F0 sebagai basis, F1 formula dengan 50x nilai antioksidan, dan F2 formula dengan 100x nilai antioksidan. Uji stabilitas sediaan dilakukan selama 28 hari uji stabilitas sediaan meliputi uji organoleptis, viskositas, pH, daya sebar, dan homogenitas. Hasil penelitian menunjukkan %rendemen ekstrak sebesar 13,168%. Hasil skrining fitokimia ekstrak Biji P. americana mengandung flavonoid, tanin, saponin, steroid dan alkaloid. Ekstrak biji P. americana memiliki nilai IC50 sebesar 22,26 ppm. Pengujian stabilitas sediaan serum ekstrak biji P. americana memiliki stabilitas yang baik. Aktivitas inhibisi enzim tirosinase F0, F1, F2 dan serum komersial memiliki nilai IC50 masing-masing sebesar 3274, 3585, 2809 dan 2165 ppm. Aktivitas inhibisi enzim tirosinase sediaan serum ekstrak biji P. americana mempunyai nilai IC50 yang paling baik berada pada sediaan serum dengan formula 100x nilai antioksidan. Kata Kunci: Alpukat, Antioksidan, Hiperpigmentasi, Serum, Tirosinase  Melanin is the main pigment that has the main function of protecting the skin from damage due to ultraviolet exposure, excess melanin synthesis can lead to the occurrence of hyperpigmentation. The main ingredients in Avocado Seeds (Persea americana Mill) are catechins which have potential as tyrosinase enzyme inhibitors. The aim in this study was to create a formulation of P. americana Mill seed extract serum preparation and to find out how tyrosinase enzyme inhibitor activity in P. americana seed extract serum preparations. A sample of P. americana seed was macerated with 70% ethanol. It is then formulated with three formulas namely F0 as the base, F1 formula with 50x the antioxidant value, and F2 formula with 100x the antioxidant value. A preparation stability test was performed over a 28-day preparation stability test covering organoleptic, viscosity, pH, dispersibility, and homogeneity assays. The tyrosinase enzyme inhibition assay was analyzed in vitro. Results of phytochemical screening of P. americana seed extract contain flavonoid group compounds, tannins, saponins, steroids and alkaloids. P. americana Seed Extract has an IC50 value of 22.26 ppm. Stability testing of serum preparation P. americana Seed extract has good stability. The inhibitory activity of tyrosinase enzyme F0, F1, F2 and commercial serum had IC50 values of 3274, 3585, 2809 and 2165 ppm respectively. The inhibitory activity of tyrosinase enzyme of serum preparation of P. americana seed extract had the best IC50 value in serum preparation with formula 100x antioxidant value.
Aktivitas Penghambatan α-Glukosidase secara in vitro dan in silico serta Penurunan Glukosa Darah pada Mencit dari Ekstrak Etanol Biji Gandaria (Bouea macrophylla) Tarso Rudiana; Eneng Elda Ernawati; Ayu Sunayah; Nuzulia Romadlotun Nikmah; Hasanah Hasanah; Siti Sawalia; Lia Permatasari; Arini Khaerunnisa; Dimas Danang Indriatmoko; Swastika Oktavia; Siti Nurbayti; Muhammad Ihda Hamlu Liwatu Zein
Jurnal Kartika Kimia Vol 9 No 1 (2026): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v9i1.1054

Abstract

Gandaria (Bouea macrophylla) merupakan tumbuhan topis mengandung senyawa golongan fenolik dan flavonoid yang dapat dimanfaatkan sebagai antidiabetes. Penelitian ini bertujuan untuk mengidentifikasi senyawa metabolit sekunder pada ekstrak etanol biji B. macrophylla, menentukan potensi antidiabetes melalui inhibisi enzim α-glukosidase secara in vitro dan in silico serta menentukan penurunan kadar gula darah secara in vivo. Ekstrak etanol biji B. macrophylla memiliki % rendemen sebesar 31,74% dengan kandungan metabolit sekunder seperti flavonoid, fenolik, alkaloid, saponin dan triterpenoid. Hasil analisis UPLCMS/MS ekstrak etanol biji B. macrophylla mengandung senyawa asam 3,4-dihidroksimandelat, larisitrin dan L-(-)-fenilalanin serta dapat menginhibisi enzim α-glukosidase dengan nilai IC50 sebesar 22,5627 µg/mL. Secara in silico senyawa L-(-)-fenilalanin dan larisitrin memiliki nilai energi bebas dan Konstanta inhibisi terbaik pada inhibisi enzim α-glukosidase (PDB ID: 3L4Y). Studi in vivo ekstrak etanol biji B. macrophylla dapat menurunkan kadar gula darah pada mencit Mus muscullus yang diinduksi aloksan sebesar 63,0 % pada dosis 500 mg/kg BB. Senyawa golongan fenolik dan flavonoid diduga berperan dalam menginhibisi enzim α-glukosidase secara in vitro dan in silico serta dalam menurunkan kadar gula darah mecit.
Antimicrobial Activity of Ethanol Extract of Walang Leaves against Salmonella typhi and Candida tropicalis Swastika Oktavia; Ayu Febi Lestari; Arini Khaerunnisa
International Journal of Medicine and Health Vol. 4 No. 3 (2025): September : International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v4i3.5931

Abstract

Leaves of Etlingera walang (Blume) RMSm have been empirically used in traditional medicine to relieve stomach disorders and are known to contain secondary metabolites with potential antimicrobial properties. Salmonella typhi infection can cause typhoid fever with symptoms such as diarrhea and abdominal pain, while Candida tropicalis is a fungus that can infect the gastrointestinal tract and lead to digestive disturbances. This study aimed to evaluate the antibacterial and antifungal activities of the ethanolic extract of E. walang leaves against S. typhi and C. tropicalis. The antimicrobial assay was carried out using the disk diffusion method at extract concentrations of 25%, 50%, and 100%, with chloramphenicol and ketoconazole as positive controls, and DMSO as the negative control. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and tannins. However, the results showed that the extract did not produce inhibition zones against either test microorganism. Extract evaluation indicated a moisture content of 12.23%, total ash 13.39% (above the standard), acid-insoluble ash 1.25%, total plate count 1.8 × 10 ⁴ , and mold and yeast count 1.0 × 10 ³. The findings suggest that although the ethanolic extract of E. walang leaves contains secondary metabolites and is traditionally used for stomach ailments, it does not exhibit antimicrobial activity against S. typhi or C. tropicalis.
Stimulant Activity of White Pepper (Piperis albi Fructus) Ethanol Extract In Vivo Arini Khaerunnisa; Dhyneu Dwi Jayantie; Sutihat Sutihat; Nurul Hida; Nani Suryani
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 1 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i1.2411

Abstract

Caffeine is a stimulant substances that can stimulate the central nervous system (CNS) increasing concentration, and reducing drowsiness. The use of caffeine generally comes from coffee plants which can increase gastrin secretion. Long-term use of caffeine can cause side effects such as feelings of anxiety, irritability, insomnia and faster heart rate. An alternative stimulant that has limited side effects is needed. White pepper (Piperis albi fructus) is potential as stimulant. The extract of White pepper contained piperine compound. Piperine can potentially be a stimulant because it can stimulate the formation of energy in the body. The purpose of this study was to determine the in vivo stimulant activity of ethanol extract White pepper in male white mice. The method used in this research is Natatory exhaustion. 25 test animals were divided into 5 groups. The doses used are white pepper extract 0.32; 0.65 and 1.3 mg/20 g BW, caffeine 0.26 mg/20 g BW and 0.5% CMC-Na. Data analysis with SPSS 16 with the Kruskal-Wallis test and the Mann-Withney test. The results of the stimulant activity test of white pepper ethanol extract at a dose of 0.32; 0.65 and 1.3 mg/20 g BW for male white mice with the DDY strain with an average % increase in stamina of 63.92; 120.81 and 179.31%,mean while in the positive control of caffeine by 232.55% and the negative control of CMC-Na by 21.10%. White pepper ethanol extract dose of 1.3 mg/20 g BW has stimulant activity which is not significantly different from caffeine positive control.
Co-Authors Agus Setiawan Ayu Febi Lestari Ayu Sunayah Candra Junaedi Cory Novi Dhyneu Dwi Jayantie Dhyneu Dwi Jayantie Dhyneu Dwi Jayantie Dimas Danang Indriatmoko Dimas Danang Indriatmoko Dimas Danang Indriatmoko Djamil, Ratna Dwi Marwati Juli Siswanti Eka Yulli Kartika Eneng Elda Ernawati Eneng Elda Ernawati Eva Vauziah Fatimah Zahra Gina Siti Nurhayati Hadi Susilo hasanah hasanah Indriatmoko, Dimas Danang Irfan Iryana Iryana, Irfan Jayantie, Dhyneu Dwi Kartika, Eka Yulli Komalasari Komalasari Lia Permatasari Lilik Sulastri Muhammad Ihda Hamlu Liwatu Zein Nani Suryani Nani Suryani Nani Suryani Nurhayati, Ghina Siti Nurul Hida Nuzulia Romadlotun Nikmah Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Parwaz Setaviani Ratna Djamil Ratna Djamil Renaldy, Renaldy Siswanti, Dwi Marwati Juli Siti Amaliya Siti Nurbayti Siti Sawalia Sulistriyani, Sulistriyani Sutihat Sutihat Swastika Oktavia Swastika Oktavia Tarso Rudiana Tarso Rudiana, Tarso Vauziah, Eva Zahra Khaerul Kamila