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Aktivitas Antibakteri Formulasi Sediaan Lotion Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) Terhadap Bakteri Propionibacterium acnes Dg. Majid, Viranty; ahwan, ahwan; Qonitah, Fadilah
Jurnal Farmasi Sains dan Teknologi Vol. 2 No. 02 (2024): Jurnal Farmasi Sains dan Teknologi
Publisher : PC Ikatan Apoteker Indonesia (IAI) Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65117/7x8s9g35

Abstract

Penyebab dari jerawat yang dialami oleh 85% remaja perempuan Indonesia yaitu salah satunya bakteri Propionibacterium acnes. Tanaman daun salam (Syzygium polyanthum (Wight) Walp.) diketahui memiliki zat aktif alkaloid, saponin, flavonoid dan tanin yang bersifat antibakteri. Tujuan dari penelitian ini yaitu untuk mengetahui formulasi lotion ekstrak etanol daun salam memenuhi persyaratan uji sifat fisik sediaan yang baik dan untuk mengetahui sediaan lotion ekstrak etanol daun salam memiliki daya hambat terhadap pertumbuhan bakteri Propionibacterium acnes. Pengujian sifat fisik meliputi uji organoleptis, uji homogenitas, uji pH, uji daya lekat, uji daya sebar dan uji viskositas. Pengujian aktivitas antibakteri menggunakan metode Kirby Bauer. Sediaan lotion ekstrak etanol daun salam dibuat dengan konsentrasi 1,5%, 3%, 4,5%, kontrol negatif (Basis lotion) dan kontrol positif (Acnol lotion). Data hasil uji sifat fisik dan aktivitas antibakteri dianalisis statistik dengan uji One Way Anova. Hasil penelitian menunjukkan bahwa sediaan lotion ekstrak etanol daun salam memenuhi persyaratan uji sifat fisik sediaan yang baik. Sediaan lotion ekstrak etanol daun salam juga memiliki daya hambat terhadap bakteri Propionibacterium acnes dengan rata-rata nilai diameter zona hambat kontrol negatif (0%) (0±0,00) tidak ada, F1 (4,5%) (5,30±0,52 mm) daya hambat sedang, F2 (3%) (7,96±0,61 mm) daya hambat sedang, F3 (4,5%) (10,56±0,61 mm) daya hambat kuat dan kontrol positif (12,70±0,87 mm) daya hambat kuat. Hasil analisis data One Way Anova dan uji Post Hoc menunjukkan nilai p-value <0,05 yang berarti ada perbedaan antar formula. Berdasarkan hasil penelitian dapat disimpulkan bahwa sediaan lotion ekstrak etanol daun salam mempunyai kualitas fisik yang baik dan mempunyai aktivitas antibakteri
Perbandingan Efektivitas Analgesik Dua Sediaan Tablet Paracetamol Generik Dan Tablet Asam Mefenamat Generik Terhadap Mencit Putih Jantan (Mus Musculus) dengan Menggunakan Metode Geliat ahwan, ahwan; Qonitah, Fadilah
Jurnal Farmasi Sains dan Teknologi Vol. 2 No. 02 (2024): Jurnal Farmasi Sains dan Teknologi
Publisher : PC Ikatan Apoteker Indonesia (IAI) Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65117/7jdq3w09

Abstract

Paracetamol dan asam mefenamat merupakan obat analgesik-antipiretik paling banyak dikonsumsi masyarakat dan digunakan dalam swamedikasi nyeri. Paracetamol dan asam mefenamat bentuk sediaan tablet berjenis generik dan bermerek. Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas analgesik pada sediaan tablet paracetamol generik, asam mefenamat generik, dan kombinasi paracetamol dan asam mefenamat generik. Tujuan dari penelitian ini adalah untuk membandingkan efektivitas analgesik antara tablet paracetamol generik, asam mefenamat generik, dan kombinasi paracetamol dan asam mefenamat generik. Penelitian ini dilakukan dengan menggunakan metode geliat, sebanyak 20 mencit putih jantan (Mus musculus) dilakukan dalam penelitian ini dan dibagi menjadi 4 kelompok. Kelompok I kontrol negatif, kelompok II (paracetamol generik), kelompok III (asam mefenamat generik), dan kelompok IV (kombinasi paracetamol dan asam mefenamat generik). Setelah 15 menit pemberian perlakuan, mencit diinduksi dengan larutan asam asetat 1% secara intraperitonial. Data yang digunakan adalah jumlah geliat komulatif mencit setiap 5 menit selama 1 jam, kemudian digunakan untuk menghitung presentase daya analgesik. Daya analgesik paracetamol generik (46,29%), asam mefenamat generik (55,13%), dan kombinasi paracetamol dan asam mefenamat generik (53,98%). Hasil tersebut menunjukan bahwa daya analgesik terbesar adalah asam mefenamat (55,13%). Berdasarkan dari hasil uji SPPS Kruskal Wallis menunjukkan terdapat perbedaan bermakna dari efektivitas analgesik paracetamol generik, asam mefenamat generik, dan kombinasi paracetamol dan asam mefenamat generik (p<0,05).
UJI SIFAT FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN SIRIH CINA Paperomia pellucida L Zulaika, Laili nur; Qonitah, Fadilah; Ariastuti, Reni
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 1 No. 02 (2023): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/69wa9r92

Abstract

Bakteri Propionibacterium acnes merupakan salah satu bakteri penyebab jerawat. Masker gel peel-off merupakan salah satu sediaan yang dapat digunakan untuk menjaga kesehatan kulit dari jerawat. Daun sirih cina (Paperomia pellucida L) mengandung senyawa alkaloid, flavonoid saponin dan tanin yang merupakan tanaman yang efektif terhadap bakteri penyebab jerawat (P. acnes). Penelitian ini bertujuan untuk menformulasikan sediaan masker gel peel-off ekstrak etanol daun sirih cina. Sediaan masker gel peel-off dibuat 4 formula dengan konsentrasi daun sirih cina sebesar 0%, 10%, 15% dan 20%. Uji sifat fisik yang diamati adalah organoleptis, pH, homogenitas, daya sebar, daya lekat, viskositas dan uji waktu  mengering. Hasil penelitian diperoleh bahwa sediaan masker gel pell-off ekstrak etanol daun sirih cina pada formula 0,1,2,3 mempunyai sifat fisik yang baik, memenuhi standar sifat fisik yang ditetapkan. Penelitian ini dapat disimpulkan bahwa masker gel peel-off ekstrak etanol daun sirih cina memiliki sifat fisik yang baik, memenuhi standar sifat fisik yang ditetapkan untuk sediaan masker gel peel-off.                                                                                                                                                                                                                                                                        
EVALUASI SIFAT FISIK SEDIAAN FACIAL WASH  EKSTRAK ETANOL DAUN SIRIH CINA (Paperomia pellucidaL.)SEDIAAN FACIAL WASH  EKSTRAK ETANOL DAUN SIRIH CINA (Paperomia pellucidaL.) Santika, Maria; Qonitah, Fadilah; Ariastuti, Reni
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 2 No. 02 (2024): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/0s6vh950

Abstract

If dirt on the face is not cleaned over time, it will accumulate into blackheads and pimples. Acne can also occur due to underlying blockage and inflammation, usually caused by the bacteria Propionibacterium acnes. Ethanol extract of Chinese betel leaves contains alkaloids, tannins, lipids and essential oils which have antibacterial properties. The aim of this research is to find out whether the facial wash formulation can meet the requirements for a good physical properties test and to find out whether the Chinese betel leaf extract (Paperomia pellucida L. Kunth) facial wash preparation has inhibitory power against P.acnes. This research is experimental research. Physical property tests carried out include organoleptic, pH, foamability and viscosity tests. Antibacterial activity testing was carried out using the diffusion method. Facial wash preparations from Chinese betel leaf extract (Paperomia pellucida L. Kunth) are made with concentrations of 0% (F0), 10% (F1), 15% (F2), 20% (F3). The results of the antibacterial activity test were tested using one way anova statistics. The research results showed that the facial wash preparation met the requirements for a good physical properties test and there was no significant difference between the formulas. The average results of the positive control antibacterial activity test for clindamycin had an inhibitory power of 19.53 ± 0.38 mm (strong), the facial wash preparation of Chinese betel leaf ethanol extract with a concentration of 10% was 8.90 ± 0.97 mm ( moderate), 15% concentration 12.00 ± 0.24 mm (strong), 20% concentration 13.33 ± 0.38 mm (strong), and negative control 0 ± 0 (not inhibiting. This study can be concluded that facial wash ethanol extract of Chinese betel leaves can inhibit antibacterial activity and the significant value is 0.000 <0.05, which means there is a difference in each concentration with the positive control
PENERAPAN REAKTOR BIOGAS FIXED DOME DALAM PENGOLAHAN LIMBAH PETERNAKAN MENJADI SUMBER ENERGI TERBARUKAN DI DESA BRAJAN, BOYOLALI Ariastuti, Reni; Qonitah, Fadilah; Indriastiningsih, Erna; Widagdo, Arisena; Nabila, Jihan
Kumawula: Jurnal Pengabdian Kepada Masyarakat Vol 8, No 2 (2025): Kumawula: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kumawula.v8i2.57988

Abstract

The potential natural resources of Brajan Village, Mojosongo, Boyolali include the availability of fertile rice fields covering an area of 166.651 hectares, almost 60% of the total area. Residents utilize this potential for farming and animal husbandry. These activities produce various kinds of waste, including post-harvest waste and livestock manure. The waste produced is generally unused or disposed of by residents. Starting from the large amount of existing potential, Sahid University Surakarta held community service activities aimed at reducing environmental pollution caused by untreated waste, as well as making the waste more useful and economically valuable. This activity was carried out by constructing a fixed dome biogas reactor and continued with training on the application of using the reactor to process livestock manure into biogas and organic compost from bio-slurry. In this service activity, the team provided a biogas reactor installation to one of the Brajan Village residents as a grant recipient. In addition, support in the form of chopping machines and agricultural tools was also provided to Gapoktan members as farming and composting equipment. Training activities were also conducted to increase the knowledge of Brajan Village residents regarding biogas and compost. This community service activity was considered successful and well-targeted because, after participating in the training, the residents' knowledge level regarding biogas and compost, which was initially classified as fair, improved to a very good level. Moreover, agricultural and livestock waste that was previously discarded now has higher economic value because it can be processed into biogas and compost. Potensi sumber daya alam Desa Brajan, Mojosongo, Boyolali berupa ketersediaan lahan persawahan subur seluas 166,651 Hektar, hampir 60% dari luas total wilayah. Potensi tersebut dimanfaatkan warga untuk bertani dan berternak, dari aktivitas tersebut menghasilkan berbagai macam limbah, diantaranya limbah pasca panen dan kotoran ternak. Limbah yang dihasilkan pada umumnya tidak dimanfaatkan/dibuang oleh warga. Berawal dari banyaknya potensi yang ada, Universitas Sahid Surakarta mengadakan kegiatan pengabdian yang bertujuan untuk mengurangi pencemaran lingkungan akibat limbah yang tidak tertangani, serta menjadikan limbah lebih bermanfaat dan bernilai ekonomis. Kegiatan ini dilakukan dengan pembuatan reaktor biogas teknologi fixed dome dan dilanjutkan pelatihan aplikasi penggunaan reaktor dalam mengolah kotoran ternak menjadi biogas dan komos organik dari bio-slurry. Pada kegiatan pengabdian ini, tim pengabdi memberikan instalasi reaktor biogas kepada salah satu warga Desa Brajan sebagai penerima hibah. Selain itu bantuan berupa mesin pencacah dan alat pertanian juga diberikan kepada anggota gapoktan sebagai sarana bertani dan membuat kompos. Kegiatan pelatihan juga dilakukan untuk meningkatkan pengetahuan warga Desa Brajan terkait biogas dan kompos. Kegiatan pengabdian ini dinilai  berhasil dan tepat sasaran karena setelah mengikuti pelatihan tigkat pengetahuan warga terkait biogas dan kompos yang awalnya tergolong cukup menjadi sangat baik. Di samping itu, limbah pertanian dan peternakan yang dibuang begitu saja sekarang menjadi lebih bernilai ekonomis karena mampu diolah menjadi biogas dan kompos.
Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Demam Di Desa Bumi Dipasena Abadi Lampung Hasna Fadlu Rahma; Sakti Pambudi, Risma; Qonitah, Fadilah
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 3 No. 01 (2025): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/nz6x2x57

Abstract

Self-medication is one of the most general treatments for minor illnesses such as fever. Self-medication in Indonesian society is quite high, but health workers do not provide complete information about the correct use of drugs. The study aims to determine the correlation between the level of knowledge and self-medication behavior for fever at Bumi Dipasena Abadi Village in Lampung. The research is an analytical correlational study using a cross-sectional approach. The sample amounted to 100 respondents. The research instrument used a questionnaire that had passed the validity and reliability test. The results show that the level of knowledge about fever is high at 91%, moderate at 8%, and 1% is categorized as the low category. Self-medication behavior is categorized as 96% in the good category, 3% in the sufficient category, and 1% in the poor category. Data analysis implemented univariate and bivariate analysis using the chi-square test and obtained a p-value of 0.002 (P<0.05). It shows that there is a significant correlation between the level of knowledge and self-medication behavior for fever.
Uji Aktivitas Tabir Surya Gel Ekstrak Etanol Daun Jeruk Purut (Citrus hystrix DC) qonitah, fadilah; Ariastuti, Reni; Maharani, Pratiwi
FASKES : Jurnal Farmasi, Kesehatan, dan Sains Vol. 3 No. 1 (2025): Bulan Juli 2025, FASKES : Jurnal Farmasi, Kesehatan, dan Sains
Publisher : Program Studi Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/faskes.v3i1.5218

Abstract

Latar belakang: Tabir Surya adalah produk kosmetik yang memiliki kemampuan untuk melindungi kulit dari sinar ultraviolet matahari. Daun jeruk purut mengandung senyawa flavonoid yang diduga mampu berfungsi sebagai pelindung dari sinar matahari. Tujuan: Penelitian ini dilakukan untuk mengevaluasi apakah gel ekstrak etanol dari daun jeruk purut dapat memberikan perlindungan terhadap sinar matahari, yang diukur melalui nilai SPF (Sun Protection Factor), persentase transmisi eritema, dan pigmentasi kulit. Empat formula gel dibuat dengan konsentrasi sebesar 0% (FI), 0,5% (FII), 1% (FIII), dan 1,5% (FIV). Metode: Efektivitas tabir surya dalam gel diuji secara in vitro menggunakan spektrofotometer UV Vis. Data dianalisis dengan metode analisis one-way ANOVA. Hasil: Hasil menunjukkan bahwa nilai SPF rata-rata dari formula gel I hingga IV adalah 0,67±0,01 (tanpa perlindungan), 6,32±0,05 (perlindungan ekstra), 12,94±0,05 (perlindungan maksimal), dan 16,20±0,01 (perlindungan ultra). Nilai persentase eritema adalah 0,92±0,002, 0,42±0,002, 0,18±0,000, 0,11±0,000 (sunblock), sementara nilai transmisi pigmentasi adalah 0,94±0,002, 0,54±0,001, 0,36±0,000, 0,23±0,000 (sunblock). Hasil menunjukkan bahwa formula II, III, dan IV memiliki aktivitas perlindungan terhadap sinar matahari, dengan SPF tertinggi terdapat pada formula IV. Simpulan dan saran: Ada perbedaan aktivitas tabir surya yang signifikan antara setiap formula yang diuji (nilai p-value <0,05)
FORMULASI DAN UJI ANTIBAKTERI SEDIAAN SABUN CAIR EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L) DENGAN BASIS MINYAK KELAPA TERHADAP BAKTERI Staphylococcus aureus tohir, fauzha muftia; ahwan, ahwan; Qonitah, Fadilah
Jurnal Farmasi Sains dan Teknologi Vol. 3 No. 01 (2025): Jurnal Farmasi Sains dan Teknologi
Publisher : PC Ikatan Apoteker Indonesia (IAI) Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65117/x33p6m60

Abstract

The use of extracts from medicinal plants in the community is used to prevent diseases, maintain body freshness and treat diseases. Guava leaves (Psidium guajava L) contain active compounds such as tannins, triterpenoids, flavonoids, saponins, alkaloids, and essential oils that have antibacterial effects. This study aims to determine the antibacterial activity of liquid soap ethanol extract of guava leaves against Staphylococcus aureus bacteria. The liquid soap formula of guava leaf extract (Psidium guajava L) is made into 4 formulas F0 (0%), F1(5%), F2(10%), and F3(15%). Antibacterial activity is seen from the antibacterial activity test using the diffusion method. Physical testing of guava leaf ethanol extract liquid soap includes organoleptic, pH, foam height, homogeneity, and viscosity. The results of the study showed that the entire formula qualified for good physical properties and could inhibit the growth of Staphylococcus aureus. The results of the antibacterial activity test showed that guava leaf extract soap (Psidium guajava L) had an inhibition in the formula F0 of 0.00±0.00 mm (no antibacterial activity), F1 of 4.60±0.46 mm (weak antibacterial activity), F2 of 5.27±0.06 mm (moderate antibacterial activity), F3 of 5.93±0.32 mm of moderate antibacterial activity) and a positive control of 11.77±1.46 mm (strong antibacterial activity). Based on the results of the study, it was concluded that the liquid soap formula of guava leaf extract (Psidium guajava L) has good physical properties and shows antibacterial activity against Staphylococcus aureus, and does not differ significantly (p<0.05). 
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI MARKISA UNGU (Passiflora edulis Sims) TERHADAP Propionibacterium acnes: ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF PURPLE PASSION FRUIT SEEDS (Passiflora edulis Sims) AGAINST Propionibacterium acnes Rifani, Inesta; Ariastuti, Reni; Qonitah, Fadilah
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/3413qz27

Abstract

Inflammation of the hair follicles and sebaceous glands causes acne, a common skin disorder often triggered by bacterial infections such as Propionibacterium acnes. This study aims to determine the antibacterial activity of an ethanolic extract of purple passion fruit seeds against Propionibacterium acnes. The extraction process was carried out by maceration using 96% ethanol. The antibacterial activity of the extract was tested using the disk diffusion method (Kirby-Bauer) at concentrations of 10%, 20%, and 30%, with positive control (clindamycin) and negative control (1% DMSO) for comparison. Antibacterial activity was measured based on the inhibition zone diameter. The data obtained were then statistically analyzed using a one-way ANOVA test with a 95% confidence level. The extract yield was 5.78% and contained chemical compounds such as flavonoids, alkaloids, tannins, saponins, and terpenoids. The antibacterial test results showed inhibition zones for the 10%, 20%, and 30% extract concentrations and the positive control (clindamycin) of (6.45 ± 1.86) mm (moderate activity), (10.38 ± 0.29) mm (strong activity), (12.21 ± 1.21) mm (strong activity), and (17.78 ± 0.55) mm, respectively. Statistically, there was a significant difference in antibacterial activity between the samples (p-value < 0.05). In conclusion, the ethanolic extract of passion fruit seeds possesses antibacterial properties effective against Propionibacterium acnes..   Keywords: antibacterial, seed, Passiflora edulis Sims, Kirby_bauer, acne
POTENSI HAND SANITIZER EKSTRAK ETANOL BUNGA GLETANG (TRIDAX PROCUMBENS.L) SEBAGAI ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS Qonitah, Fadilah; Valerie Novia Ramadhani, Feby; Ahwan
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 3 No. 02 (2025): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/c4wphx13

Abstract

The gletang flower is a plant with potential for development as a hand sanitizer. The gletang flower contains compounds such as flavonoids, alkaloids, saponins, tannins, and phenols, which have been shown to inhibit the growth of Staphylococcus aureus bacteria. This study aims to determine the statistical data and antibacterial effects of hand sanitizers made from gletan flower ethanol extract on the growth of Staphylococcus aureus bacteria. The hand sanitizer was prepared with gletan flower ethanol extract in four formulas: Formula 0, Formula 1, Formula 2, and Formula 3. Testing of the physical properties of the hand sanitizer included organoleptic testing, homogeneity, pH, viscosity, and spreadability. The antibacterial activity was tested using the disc test method, and the data was analyzed using the Kruskal-Wallis test. The results of the study show that all formulations exhibit good physical properties and antibacterial activity. The antibacterial activity of the positive control was measured with an average inhibition zone of 9.8 ± 0.52 mm. Formula 1 yielded an average inhibition zone of 9.2 ± 0.05 mm, followed by Formula 2 with 12.06 ± 0.07 mm and Formula 3 with 14.25 ± 0.31 mm. The negative control showed no inhibition zone of 0 ± 0.00 mm. The conclusion of this study is that all three formulas of the hand sanitizer made from gletang flower ethanol extract exhibit good physical properties and have been shown to have antibacterial activity against Staphylococcus aureus, with significant differences.