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All Journal Althea Medical Journal Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry Jurnal Kesehatan Vokasional Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Science Midwifery Medicra (Journal of Medical Laboratory Science/Technology) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Junior Medical Journal Advance Sustainable Science, Engineering and Technology (ASSET)
Nunung Ainur Rahmah
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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In Vivo Study of Telang Cream on Interleukin (IL)-6, Epidermal Growth Factor (EGF), and Wound Reepithelialization Pratiwi, Nike; Irwandi, Nurmayani; Hadi, Restu Syamsul; Thamrin, Nabila Pyrenina; Damayanti, Ndaru Andri; Juniarti, Juniarti; Rahmah, Nunung Ainur
Jurnal Kesehatan Vokasional Vol 10, No 2 (2025): May
Publisher : Sekolah Vokasi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkesvo.106084

Abstract

Background: Povidone iodine is widely used in wound healing, but it can cause irritation and cellular toxicity. Clitoria ternatea L. has the potential to contain compounds such as rutin, quercetin 3-O-rhamnoside, ternatin, and anthocyanins as natural alternatives in wound healing. In this study, the extract used contains anthocyanins.Objective: The study aimed to evaluate the effects of Clitoria ternatea L. extract cream on the expression of Interleukin-6, Epidermal Growth Factor, and re-epithelialization in Sprague Dawley rat incision wounds.Methods: An in-vivo study with a post-test only control design was conducted on five treatment groups, including a control group without wounds (healthy), povidone iodine, and Clitoria ternatea L. extract cream (5%, 10%, 15%). IL-6 and EGF were analyzed using immunohistochemistry, while re-epithelialization was assessed using hematoxylin-eosin staining.Results: Clitoria ternatea L. extract increased IL-6 and EGF expression, with the highest expression at a 10% concentration. Re-epithelialization was faster in the treatment groups compared to both the positive and negative controls.Conclusion: The 10% Clitoria ternatea L. extract cream demonstrated efficacy comparable to povidone iodine in incision wound healing.
Pengaruh Daun Teh Hijau Terhadap Organ Tikus Galur Wistar Setelah Paparan Asap Rokok Juniarti, Juniarti; Rahmah, Nunung Ainur; Janah, Lulu Ah; Dinda, Salsabila Chyllia; Patrisha, Milaviza; Agustin, Rika Alivia; Susmiarsih, Tripanjiasih
Majalah Sainstekes Vol. 12 No. 1 (2025): JUNI 2025
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v12i1.3654

Abstract

Paparan asap rokok dapat menimbulkan berbagai macam penyakit yang berujung pada kematian. Banyak penelitian mengenai dampak merokok aktif terhadap kesehatan dan efek toksik keseluruhan, tetapi efek perokok pasif terhadap kesehatan tidak sepenuhnya dipahami. Asap rokok mengandung radikal bebas yang menyebabkan peningkatan stres oksidatif dan kerusakan organ. Salah satu bahan herbal, yaitu ekstrak daun teh hijau dapat menangani stress oksidatif sebab memiliki aktivitas antioksidan. Tujuan penelitian ini mengetahui pengaruh daun teh hijau terhadap kerusakan organ paru, hepar, dan ginjal akibat paparan pasif asap rokok dengan menggunakan model tikus jantan galur Wistar.Jenis penelitian adalah eksperimen. Sampel berupa tikus putih (Rattus norvegicus) galur Wistar selama 30 hari diberi paparan pasif asap rokok kretek tanpa filter dengan dosis 1 batang sehari dan ekstrak methanol daun teh hijau dengan dosis 100mg/kgBB. Setelah dilakukan pembedahan organ paru, hepar, dan ginjal, kemudian dilakukan pemeriksaan histopatologi dengan pewarnaan Hematoksilin-Eosin. Data diuji secara statistik mengunakan uji Wilcoxon. Hasil penelitian menunjukkan paparan pasif asap rokok pada tikus menyebabkan kerusakan pada organ bermakna secara statistik, pada paru (113,93%, p=0,000), hepar (59%, p=0,003), dan ginjal (89,82%, p=0,001). Pemberian ekstrak daun teh hijau pada tikus yang diberikan paparan pasif asap rokok dapat menurunkan kerusakan organ akibat paparan pasif asap rokok pada paru sebesar (49,04%, p=0,001), hepar sebesar (10,94%, p=0,132), dan ginjal sebesar (40,38%, p=0,003). Disimpulkan bahwa ekstrak daun teh hijau dapat memperbaiki kerusakan organ paru, hepar, dan ginjal akibat paparan pasif asap rokok.
Optimizing Image Preprocessing for AI-Driven Cervical Cancer Diagnosis Chandra Prasetyo Utomo; Neng Suhaeni; Nashuha Insani; Elan Suherlan; Nunung Ainur Rahmah; Ahmad Rusdan Utomo; Indra Kusuma; Muhamad Fathurachman; Dewa Nyoman Murti Adyaksa
Advance Sustainable Science Engineering and Technology Vol. 7 No. 1 (2025): November-January
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v7i1.1128

Abstract

Cervical cancer ranks among the top causes of cancer-related deaths in women globally. Early detection is vital for improving patient survival rates. The multiclass classification of cervical cell images presents challenges primarily due to the notable variations in cell sizes across different classes. Conventional AI methods for diagnosing cervical cancer often rely on image-resizing techniques that overlook crucial features like relative cell dimensions, which impairs the models' ability to distinguish between classes effectively. This paper presents a novel AI-driven approach that employs constant padding to maintain the natural size differences among cells. Our method utilizes deep learning for both feature extraction and multiclass classification. We assessed the method using the publicly accessible SIPaKMeD dataset. Experimental findings indicate that our approach surpasses traditional image-resizing methods, especially in classes that are more challenging to predict. This strategy highlights AI's potential to improve cervical cancer diagnosis, offering a more precise and dependable tool for early detection. A reliable and precise AI model for diagnosing cervical cancer is crucial for promoting widespread screening and ensuring timely and effective treatment, which can ultimately lower mortality rates. By aiding early and accurate diagnosis, this approach aligns with global health efforts to alleviate the burden of cancer and other diseases, especially in areas with limited access to advanced healthcare services facilities.
Effect of Vitamin D Supplementation on Irisin, Telomerase, Klotho, and Tumor Necrosis Factor-alpha (TNF-α) in Elderly: A Quasi-Experimental Study Mukhtar, Diniwati; Rahmah, Nunung Ainur; Wuryanti, Sri; Marsiati, Himmi; Haddad, Desi Ariyani; Manik, Sabarina Elfrida; Weni, Linda; Nursabur, Bistamy Muhammad; Hutabarat, Andrea Ivana Allicia; Puspita, Switania Putri
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4286

Abstract

Background: Vitamin D plays a crucial role in aging by regulating mitochondrial function, inflammation, oxidative stress, and telomere stability. Vitamin D deficiency is common among the elderly and is linked to accelerated aging. Biomarkers such as irisin, telomerase, klotho, and tumor necrosis factor-alpha (TNF-α) are associated with aging processes. This study aimed to evaluate the effect of vitamin D supplementation on these biomarkers in elderly individuals.Methods: This quasi-experimental pretest-posttest study was conducted in Kadugadung Village, Banten, Indonesia from Maret to September 2024.  A total of 47 healthy elderly individuals (≥60 years) were recruited using purposive sampling. The treatment group (n=25) received 800 IU/day of vitamin D for 20 days, whereas the control group (n=22) received none. Blood samples were collected before and after the intervention to measure serum irisin, telomerase activity, klotho, and TNF-α. Baseline variables included body mass index (BMI), blood pressure, hemoglobin, hematocrit, blood glucose, cholesterol, and uric acid. Data were analyzed using paired and independent statistical tests.Results: Vitamin D supplementation significantly increased serum irisin levels (p=0.016), meanwhile no significant changes were observed in telomerase activity (p=0.128), klotho (p=0.819), or TNF-α (p=0.098). In the treatment group, blood glucose was correlated positively with TNF-α (r=0.423, α<0.05), whereas cholesterol was correlated negatively with TNF-α (r=-0.51, α<0.01). Furthermore, telomerase activity was correlated positively with irisin (r=0.348, α<0.05).Conclusion: Vitamin D supplementation at 800 IU/day significantly enhances serum irisin, but does not affect telomerase, klotho, or TNF-α. These findings suggest a potential role of vitamin D in modulating aging-related biomarkers.
Co-Authors Aan Royhan Agung Novianto, Agung Agustin, Rika Alivia Ahmad Rusdan Utomo Ari Fahrial Syam Arifandi, Firman Arrahmani, Betharie Cendera Batubara, Lilian Chandra Prasetyo Utomo Citra Fitri Agustina Damayanti, Ndaru Andri Darmawan Kartono David Handojo Muljono Dewa Nyoman Murti Adyaksa Diah Rini Handjari Diah Rini Handjari Dianti, Sry Vhina Dinda, Salsabila Chyllia Diniwati Mukhtar Elan Suherlan Ening Krisnuhoni Firman Arifandi Haddad, Desi Ariyani Hanna Sari Widya Kusuma, Hanna Sari Widya Hutabarat, Andrea Ivana Allicia INDRA KUSUMA Irfan Syarif, Irfan Irwandi, Nurmayani Janah, Lulu Ah Juniarti Juniarti Juniarti Linda Weni Manik, Sabarina Elfrida Marsiati, Himmi Muhamad Fathurachman Muhammad Achmad Yani Muhammad Arsyad Mustofa, Muhammad Samsul Nafik, Said Nashuha Insani Neng Suhaeni Nursabur, Bistamy Muhammad Patrisha, Milaviza Pendrianto Pendrianto, Pendrianto Pratiwi, Nike Puspita, Switania Putri Restu Syamsul Hadi Rostiana, Ajeng Nita Saffa Hasanah Sri Utami Sri Wuryanti Susi Endrini Susmiarsih, Tripanjiasih Syafruddin A. R. Lelosutan Taslim, Siti Ghadira Inayah Thamrin, Nabila Pyrenina Triana Intan Sari Vera Yuwono WAHYU WIDOWATI Wiji Purnamasari, Yulia Wirasmi Marwoto Wirasmi Marwoto Yulia Suciati Yusnidar, Amirah