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Optimasi Formula Granul Effervescent Ekstrak Rimpang Temu Putih (Curcuma zedoaria) dengan Variasi Pemanis Alami sebagai Antioksidan: Optimization and Antioxidant Evaluation of Effervescent Granules Containing White Turmeric (Curcuma zedoaria) Rhizome Extract with Natural Sweeteners Diki Zaelani; Ratu Siti Robiatul Awaliyah; Rahmat Santoso; Emma Emawati; Reza Pratama
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13193

Abstract

White turmeric (Curcuma zedoaria), a member of the Zingiberaceae family, contains bioactive compounds with antioxidant potential, but its utilization remains limited due to its bitter taste and less practical traditional preparations. This study aimed to optimize the formulation of effervescent granules containing white turmeric rhizome extract using different natural sweeteners and to evaluate their physical properties and antioxidant activity. The effervescent granules were prepared by the wet granulation method using stevia (F1, 17.5%), palm sugar (F2, 10%), and corn sugar (F3, 14.5%) as sweeteners. The granules were evaluated for physical characteristics (organoleptic properties, moisture content, flow rate, angle of repose, dissolution time, pH, foam height, and hedonic test) and antioxidant activity using the DPPH method both qualitatively and quantitatively. The results showed that all formulas met the standard physical requirements of effervescent granules. The best formulation was obtained from F3 (corn sugar) with the highest acceptance score in the hedonic test. The antioxidant activity of white turmeric extract exhibited an IC₅₀ value of 53.53 ppm, while the effervescent granules showed strong antioxidant activity with IC₅₀ values of 62.53 ppm (F1), 62.62 ppm (F2), and 62.79 ppm (F3). These findings indicate that variations in natural sweeteners influence the sensory characteristics without significantly reducing the antioxidant potency of the formulation. Keywords: Effervescent granules; Curcuma zedoaria; Natural sweeteners; Antioxidant, Formulation optimization.
Utilizing Breadfruit (Artocarpus altilis) Starch-Derived Maltodextrin as a Pharmaceutical Binder: Preparation and Evaluation in Paracetamol Formulations Diki Zaelani; Ari Wibowo; Rahmat Santoso
Indonesian Journal of Herbal Science and Innovation Vol. 1 No. 2 (2025): Indonesian Journal of Herbal Science and Innovation (IJHerbSI)
Publisher : PT CENDEKIA SCIENCE AND TECHNOLOGY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64673/ijherbsi.v1i2.8

Abstract

This study aimed to explore the potential of breadfruit (Artocarpus altilis) starch as a renewable source for pharmaceutical-grade maltodextrin through enzymatic modification. The modified starch produced maltodextrin with a dextrose equivalent (DE) value of 4.30, placing it within the low-DE range suitable for use as a binder in tablet formulations. The maltodextrin was then applied as a binding agent in the production of paracetamol tablets using the wet granulation method. The resulting tablets were evaluated for key quality parameters including organoleptic properties, weight uniformity, size uniformity, hardness, friability, and disintegration time. The findings showed that tablets formulated with maltodextrin at concentrations of 5%, 7%, 9%, and 11% successfully met all pharmacopeial quality requirements. These tablets exhibited smooth and uniform appearance, acceptable hardness and friability, and disintegration times appropriate for immediate-release dosage forms. Statistical analysis using one-way ANOVA demonstrated significant differences among formulations for weight uniformity, size uniformity, and hardness (p < 0.05), indicating that varying maltodextrin concentrations had a measurable effect on tablet performance. Despite these differences, all acceptable formulations remained within the required limits. Overall, the study confirms that enzymatically modified breadfruit starch can be transformed into maltodextrin suitable for use as an effective binder in paracetamol tablet production. Optimal binder performance was achieved at concentrations between 5% and 11%. These findings highlight the potential of breadfruit as a locally sourced, sustainable raw material for pharmaceutical excipients, contributing to the development of alternative natural binders in tablet manufacturing.
Yoghurt and Fennel Leaves Extract Based Liquid Soap Production Workshop at Al Ilyas Arjasari Boarding School In Bandung Ira Adiyati Rum; Agus Sulaeman; Rahmat Santoso; Yanni Dhiani; Lia Marliani; Deni Iskandar
Inaba of Community Services Journal Vol. 3 No. 2 (2024): Volume 3 No. 2, December 2024
Publisher : Universitas INABA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56956/inacos.v3i2.384

Abstract

The Boarding School partner has many students but the habit of washing their hands before eating is not accompanied by washing with soap. This is a concern because washing with soap ensures the disappearance of pathogenic microbes. Teaching the importance of washing hands with soap before meals aims to raise awareness about the benefits of maintaining hygiene and supplementary nutrition could improve health. We trained the pupils in the Boarding School to make liquid hand-washing soap and yoghurt to stimulate a hygienic lifestyle, provide in-house supplementary nutrition, and gain economic benefit from the products. The hygienic lifestyle knowledge was delivered through a presentation in an open-class setting, while soap and yoghurt production skills were taught by an in-hand workshop, followed by post-monitoring for both activities. The yoghurt was produced by fermentation, and the soap was made by formulating a macerate of fennel leaf extracted into hand-washing soap. The pupils’ knowledge of hygienic lifestyles improved with an average score of 68 to 90.
Formulasi dan evaluasi sediaan gel dari ekstrak daun Seledri (Apium graveolens L) dengan variasi konsentrasi Na-CMC M. Ramadhan Saputro; Rahmat Santoso; Susi Cahyani
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol. 10 No. 1 (2026): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51873/jhhs.v10i1.411

Abstract

Latar Belakang: Sediaan gel merupakan sediaan yang tidak berminyak, mudah menyerap, dan memberikan kenyamanan dalam penggunaan. Daun seledri (Apium graveolens L.) berpotensi dikembangkan dalam sediaan gel karena memiliki flavonoid dan fenolik yang berkhasiat sebagai antioksidan, antiinflamasi, dan antibakteri, sehingga. Tujuan: Memformulasikan dan mengevaluasi sediaan gel ekstrak daun seledri pada konsentrasi Na-CMC yang berbeda. Metode: Metode eksperimen dilakukan dengan memformulasikan gel dalam tiga variasi konsentrasi Na-CMC, yaitu 4% (F1), 5% (F2), dan 6% (F3). Evaluasi sediaan yang dilakukan meliputi uji organoleptik, pH, viskositas, daya sebar, dan daya lekat. Hasil: Seluruh formula memiliki bentuk kental, warna hijau muda, dan bau khas daun seledri. Nilai pH berada pada rentang 4,76–4,83. Perbedaan yang ditunjukan dari ketiga formula adalah viskositas, daya sebar, dan dan daya lekat. Semakin besar konsentrasi, viskositas sediaan meningkat, daya sebar sediaan menurun dan daya lekat sediaan meningkat. Simpulan: Berdasarkan hasil evaluasi, ketiga formula memenuhi persyaratan sediaan gel topikal. Namun demikian, formula 2 dengan konsentrasi Na-CMC 5% menunjukkan karakteristik viskositas, daya sebar, dan daya lekat yang paling optimal dari formula lainnya.
Kegiatan promotif-preventif kesehatan keluarga dan pemberdayaan masyarakat melalui optimalisasi pengelolaan sampah Agus Mi’raj Derajat; Rahmat Santoso; Yunisa Mega Pasha; Ina Sugiharti; Madinatul Munawaroh; Dewi Kurnia; Nadia Ushfuri Amini; Roganda Situmorang
JOURNAL of Public Health Concerns Vol. 6 No. 6 (2026): JOURNAL of Public Health Concerns
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerja sama dengan: Unit Penelitian dan Pengabdian Kep Akademi Keperawatan Baitul Hikmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/phc.v6i6.4419

Abstract

Background: Indonesia faces significant health challenges, ranging from the double burden of disease to issues regarding the distribution of medical facilities and personnel. Official data from the Indonesian Ministry of Health and Statistics Indonesia (BPS) indicate that the country is grappling with a double health burden: a high prevalence of infectious diseases alongside a surge in non-communicable diseases. Consequently, educational interventions are required to provide insights aimed at improving health outcomes. Purpose: To enhance public knowledge regarding the risks of stunting, adolescent early marriage, and hypertension, and to provide guided training on household waste management and the adoption of clean and healthy living behaviors. Method: This initiative consisted of interactive education and training interventions conducted in Mandalahaji Village, Pacet District, Bandung Regency. Forty-two residents participated in the program, which involved eight lecturers and twenty-six students. Participant knowledge and understanding were assessed using a one-group pretest-posttest design, utilizing questionnaires administered before (pretest) and after (posttest) the educational activities. Knowledge was evaluated by comparing pretest and posttest results, while participant skills were assessed through observations of waste sorting practices, health cadres conducting screening visits, and the implementation of clean and healthy living behaviors. These results were analyzed descriptively to provide an overview of healthy living behaviors implementation and to evaluate the success of the educational activities. Results: Evaluation showed an improvement in participants' knowledge and skills across the entire series of activities, with achievements approaching or exceeding the minimum target of 70% of the total program target. Post-test results indicated that the number of participants demonstrating a "good" level of knowledge was 38 (90.5%) for waste management; 40 (95.2%) for balanced nutrition and immunization; 38 (90.5%) for screening techniques and hypertension; and 42 (100.0%) for the prevention of early marriage. Additionally, 40 participants (95.2%) demonstrated a "good" level of knowledge regarding clean and healthy living behavior following the educational activities. Conclusion: The program successfully improved community knowledge and skills regarding household waste management, balanced nutrition, early detection of hypertension, adolescent reproductive health, and healthy living behavior, with outcomes approaching or meeting the minimum target of 70% of the program's objectives. Suggestion: Periodic follow-up support by health volunteers and waste bank administrators is necessary to ensure the sustainability of waste management and healthy living behaviors practices. Health volunteers need to continue monitoring changes in community behavioral patterns specifically waste sorting practices, screening visits, and healthy living behaviors implementation in the subsequent months to ensure the program's impact is sustained. Keywords: Community empowerment; Family health education; Healthy living behaviors; Household waste management Pendahuluan: Indonesia menghadapi berbagai tantangan besar di bidang kesehatan, mulai dari beban ganda penyakit hingga masalah penyebaran fasilitas dan tenaga medis. Data resmi dari Kementerian Kesehatan RI dan Badan Pusat Statistik menunjukkan Indonesia menghadapi beban ganda kesehatan, yaitu tingginya penyakit menular serta lonjakan penyakit tidak menular. Sehingga diperlukan intervensi edukasi untuk memberikan wawasan sebagai upaya perbaikan derajat kesehatan. Tujuan: Untuk meningkatkan pengetahuan masyarakat mengenai risiko stunting, pernikahan dini pada remaja, hipertensi, serta pelatihan dengan pendampingan pengelolaan sampah rumah tangga dan penerapan perilaku hidup bersih dan sehat (PHBS). Metode: Kegiatan ini merupakan edukasi interaktif dengan intervensi pelatihan yang dilaksanakan di Desa Mandalahaji, Kecamatan Pacet, Kabupaten Bandung. Kegiatan ini diikuti 42 warga untuk menjadi partisipan. Pelaksanaan kegiatan melibatkan 8 orang dosen serta 26 orang mahasiswa. Pengukuran tingkat pengetahuan dan pemahaman partisipan dilakukan dengan pendekatan one group pretest and posttest design menggunakan kuesioner yang diberikan sebelum (pretest) dan sesudah kegiatan edukasi (posttest). Evaluasi pengetahuan dilakukan dengan membandingkan hasil pretest dan posttest, sedangkan untuk tingkat kemampuan partisipan di evaluasi berdasarkan observasi ketika melakukan praktik pemilahan sampah, kader dalam melakukan kunjungan skrining, dan penerapan PHBS. Hasil evaluasi ini di analisa secara deskriptif untuk memberikan gambaran penerapan PHBS dan menilai keberhasilan kegiatan edukasi. Hasil: Evaluasi menunjukkan peningkatan pengetahuan dan keterampilan peserta pada seluruh rangkaian kegiatan, dengan capaian mendekati atau melampaui target minimal 70 persen dari total sasaran program. Berdasarkan posttest menunjukkan bahwa tingkat pengetahuan mengenai pengelolaan sampah dalam kategori baik menjadi sebanyak 38 partisipan (90.5%), untuk tingkat pengetahuan mengenai gizi seimbang dan imunisasi dalam kategori baik menjadi sebanyak 40 partisipan (95.2%), untuk tingkat pengetahuan mengenai teknik skrining dan hipertensi dalam kategori baik menjadi sebanyak 38 partisipan (90.5%), untuk tingkat pengetahuan mengenai pencegahan pernikahan dini dalam kategori baik menjadi sebanyak 42 partisipan (100.0%). Sedangkan untuk tingkat pengetahuan mengenai pola hidup bersih dan sehat (PHBS) dalam kategori baik menjadi sebanyak 40 partisipan (95.2%) setelah kegiatan edukasi. Simpulan: Program berhasil meningkatkan pengetahuan dan keterampilan masyarakat mengenai pengelolaan sampah rumah tangga, gizi seimbang, deteksi dini hipertensi, kesehatan reproduksi remaja, dan PHBS, dengan capaian mendekati atau memenuhi target minimal 70 persen dari sasaran program. Saran: Perlu dilakukan pendampingan lanjutan secara berkala oleh kader kesehatan dan pengurus bank sampah agar praktik pengelolaan sampah dan PHBS dapat berjalan berkelanjutan. Pemantauan perubahan pola perilaku masyarakat (praktik pemilahan sampah, kunjungan skrining, dan penerapan PHBS) perlu terus dilakukan oleh kader kesehatan pada bulan-bulan berikutnya untuk memastikan keberlanjutan dampak program.