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Journal : Respiratory Science

Association of Interleukin-2 (IL-2) Levels With Acid-Fast Bacillus (AFB) Sputum Conversion In Drug-Resistant Pulmonary Tuberculosis Patient Gede Sasmika Suwandi; Yani Jane Sugiri; Tri Wahju Astuti; Harun Al Rasyid
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.52

Abstract

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which can be found on multiple organs, but mostly infect the lung. AFB smear is used to diagnose and evaluate therapy response, to show bacterial burden and the patient’s infectious status. Combination of antituberculosis drugs for a long period of time could cause poor compliance and increased risk of resistance. Mtb infection induce immune response and release cytokines, one of which is interleukin-2 (IL-2) that regulate T lymphocyte cell. Higher IL-2 levels is found on patient with high bacterial burdern.  This study aims to see the assossciation between IL-2 levels before and 30 days after DR-TB treatment, to see pre and post-treatment IL-2 levels with conversion of AFB smear, and correlation between pre-treatment IL-2 levels and AFB smear. Method: This was a cohort prospective study at RSUD dr Saiful Anwar Malang. Thirty nine DR-TB patients underwent AFB smear before and 30 days after treatment, while IL-2 levels was also measured by Enzym-Linked Immunosorbent Assay (ELISA) technique. Results: The levels of IL-2 before treatment was significantly higher compared to 30 days after treatment (P<0.001). There was no significant IL-2 levels difference between conversion and non-conversion group (P=0.23), and a weak, not-significant correlation between IL-2 levels and AFB smear (r=0.28; P=0.06). Conclusion: The levels of IL-2 was significantly higher before than after treatment and it cannot be used to determine the positivity of acid-resistant bacilli smears in the sputum of patients with DR-TB. The limited timeframe and biomarker in this study raise the possibility to observe IL-2 as well as other biomarkers after intensive phase of TB treatment for future studies.
Co-Authors Achmad Chusairi Agus Tri Indah K agus tri indah, agus tri Amalia , Rizky Tri Anisa Ramadhani Kusumastiti Annisa Nurul Arofah Anungputri, Pramita Sari Aris Rosidah Armanu Thoyib Asih Trimurtini Asrul Asrul Azwa, Nor Azzahra, Azimah Badrul Munir, Badrul Baradatu, Karen Syafiyah Citra Cicilia Lihawa, Cicilia Dewangga Primananda Susanto Dewi Retno Sari Saputro, Dewi Retno DEWI SARTIKA Dewi, Rose Khasana Eky Indyanty Wuryaning Lestari Erdi Suroso Esa Ghanim Fadhallah Eviana Norahmawati Fiella Rachmatika Gede Sasmika Suwandi Hakim, Lukman Hani, Miftahul Khairunnisa Harahap, Nur Azizah Hardika, Arif Satria Herdiana, Novita Iin Noor Chozin Irwan Irwan Iskandar, Ferdi Ja'far, Ja'far Jamil, Ahmad Kenty Wantri Anita, Kenty Wantri Khaled, Naswan Abdo Kusumastiti, Anisa Ramadhani Lilik Zuhriyah Lukman Hakim Lukman Hakim lumban gaol, andy Luqiana, Jihan Nabila Machlusil Husna, Machlusil Marani, Ika Novitaria Mariyatul Khiptiyah Masruroh Rahayu, Masruroh Nadiya Elfira Bilqis, Nadiya Elfira Ngakan Putu Parsama Putra Ningsih, Agustin Setia Noermijati, Noermijati Nurul Fadhilah Otik Nawansih Panjaitan, Nurul Aisyah Salsabila Pinahayu, Griesinta Trianty Andria Prabowo, Edwin Damar Pratama, Arista Pratama, Erlan Anugrah Pratiwi, Suryanti Dwi Putra, Ngakan Putu Putri Dina Mardika Rahmad Rahmad Retnani, Diah Prabawati retnaningtyas, sri Rezkiah, Fahmy Riskawati, Yhusi Karina Rizky Rosita, Rizky Santony Santony Sasongko Adhi Nugroho Shahdevi Nandar Kurniawan, Shahdevi Nandar Siahaan, Sylvia Sagita Sidiq, Krisna Sri Budhi Rianawati, Sri Budhi Sriyanti, Rini Subeki Subeki Sugiri, Yani Jane Supiyan, Arif Dwi Suryanti Dwi Pratiwi Susanthy Djajalaksana Susanto, Dewangga Primananda Susilo, Hery Sutanto Sutanto Sutrasno Sutrasno Tae, Vidria Handayani Tanto Pratondo Utomo Teguh Rahayu Sartono Teguh Rahayu Sartono Tita Hariyanti Triwahju Astuti Umar Muhammad Noor Windasari, Eka Yani Jane Sugiri Yasep Setiakarnawijaya Yudha Rose Satiti, Yudha Rose Yulia Kartina Yuliandari, Puspita Zanemi, Fani