Article Per Year (5 Year)
p-Index From 2021 - 2026
2.012
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Applied Sciences Microbiology Indonesia Majalah Kedokteran Bandung BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Biosains Pascasarjana Jurnal Perikanan dan Kelautan Jurnal Riset Industri Jurnal Ilmiah Arena Tekstil The Indonesian Biomedical Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Ilmu dan Teknologi Kayu Tropis Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) International Journal of Health Science and Technology Jurnal Kajian Budaya dan Humaniora (JKBH)
Ratu Safitri
Faculty Of Mathematics And Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Narra J

 1 
Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model Khristian, Erick; Ghozali, Mohammad; Bashari, Muhammad H.; Purnama, Jeri N.; Irianto, Gunawan; Panigoro, Ramdan; Safitri, Ratu
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1003

Abstract

Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis. An experimental design with a post-test-only control group method was conducted using animal models. Fifty rats were used and divided into ten groups, nine received different intravenous doses of iron dextran: 10, 20, 30, 40, 50, 60, 80, 100, and 120 mg/kg body weight (BW) and a control group received no treatment. The results showed that intravenous iron dextran starting at a dose of 10 mg/kg BW caused significant changes in liver iron concentration while starting at 20 mg/kg BW significantly affected hepatocyte morphology, transferrin levels, unsaturated iron binding capacity, serum iron levels, and transferrin saturation. Intravenous iron dextran starting at 40 mg/kg BW resulted significant changes in the level of total iron binding capacity compared to control group. In conclusion, intravenous iron dextran significantly altered hepatocyte morphology, increased liver iron concentration, and modified the serum iron profile, reflecting changes that might be observed in patients with transfusion-dependent thalassemia.
Co-Authors Abun Abun Abun Hasbuna Padmadijaya Ahmad Yani Nelly Wahyuni Lia Destiarti Akeyla Tabina Tawangalun Alif Bagus Rakhimullah Ani Melani Maskoen Ani Melani Maskoen Ari Widiyantoro Arrizqiani, Tanendri Aufa Aulia Kanza Bambang Priadie Bashari, Muhammad H. Bashari, Muhammad Hasan BERTI HARIASIH HANDAYANI Candra Arumimaniyah Diana Indah Permatasari E. M. Soekartadiredja Edhyana Sahiratmadja Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Emma Rachmawati Erick Khristian Erick Khristian Erick Khristian Fakhira, Anisa Muthia Febby Hauwita Firdawati, Nurul Fitri Rahmi Fadhilah Gemilang Lara Utama Harlia Harlia Herman Susanto Ibnu Dwi Buwono Irianto, Gunawan Iskandar Iskandar Jeri Nobia Purnama Jeri Nobia Purnama Jeri Nobia Purnama Joko Kusmoro Kamisah, Yusof Kartiawati Alipin Khristian, Erick Marlinda Siahaan Maryati Maryati Mas Rizky A.A Syamsunarno Mas Rizky A.A. Syamsunarno Masahiko Kurabayasi Melanie, M Mia Miranti Mia Miranti Rustama Mohammad Ghozali Mohammad Ghozali Mohammad Ghozali, Mohammad Mutia, Theresia Nia Rossiana Nurullia Fitriani Poniah Andayaningsih Purnama, Jeri N. R. Ninda Naufal Utami Ramdan Panigoro Rifaida Eriningsih Rifaida Eriningsih Rifaida Eriningsih, Rifaida Rika Pura Berliyani ROFIQ SUNARYANTO Rufi'i Ruhyat Kartasudjana Rusdianto Rusdianto, Rusdianto Rymond Jusuf Rumampuk Salsabila, Nadhila Hasna Shinta Asarina Sri Rejeki Rahayuningsih Sukaya Sastrawibawa Sunendi, Sunendi Tanendri Arrizqiyani, Tanendri Tatsuya Iso Theresia Mutia Theresia Mutia Theresia Mutia, Theresia Titi Lahanda Susanti Tri Yuliana Unang Supratman Uni Gamayani Wibowo, Annisa Maharani Yasmi P. Kuntana, Yasmi P. Yasmi Purnamasari Kuntana Youngest, Racy Yuli Andriani Yulia, Tri Yusof Kamisah