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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Jurnal Ilmu dan Teknologi Kesehatan JKKP (Jurnal Kesejahteraan Keluarga dan Pendidikan) Majalah Patologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Cermin Dunia Kedokteran
Iris Rengganis
Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health

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Association between Food Specific IgG Antibodies with Clinical Activity of Disease in Patients with Inflammatory Bowel Disease Parhusip, Santi Sumihar Rumondang; Rengganis, Iris; Simadibrata, Marcellus; Abdullah, Murdani; Shatri, Hamzah; Yunihastuti, Evy; Wibowo, Heri
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202341-48

Abstract

Background: Inflammatory bowel disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile.Method: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo index and Crohn's disease activity index.Results: The highest proportion of dietary IgG in Crohn's disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347; p = 0.041) and chickpeas IgG (r = -0.473; p = 0.017) with clinical disease activity; while in Crohn's disease, a weak positive correlation with disease activity was seen in barley (r = 0.261; p = 0.042).Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Crohn's disease clinical activity. 
PENGAWASAN ORANG TUA DALAM INTENSITAS PENGGUNAAN MEDIA SOSIAL TERHADAP PROKRASTINASI AKADEMIK: Indonesia Iris Rengganis; Tarma; Rasha
JKKP (Jurnal Kesejahteraan Keluarga dan Pendidikan) Vol. 6 No. 02 (2019): JKKP (Jurnal Kesejahteraan Keluarga dan Pendidikan)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.638 KB) | DOI: 10.21009/JKKP.062.07

Abstract

This research aim is conducted to obtain description about the influence of parental control in the intensity of social media use on academic procrastination. The research was conducted in the SMP Putra 1 Jakarta. The method used in this quantitative assosiatif approach. The population in this research is VII, VII, IX grade students of SMP Putra 1 Jakarta, with the total sample of 83 respondents. Data was taken by using proportionate stratified random sampling. The prerequisite test in this study lilifoers normality test and rgresion linearity test, the result of the test that normal and linear. Result of correlation coefficient test are obtained -0,616 > 0,217. Result of t-test with significant level 0,05 obtained -7,04 > 1,99, it is explained that the are a negative correlation and significant correlation between parental control in the intensity of social media use on academic procrastination. Result of significant regression obtained 30,68 > 3,96, it is explained that there significant influence between parental control in the intensity of social media use on academic procrastination. Parental control in the intensity of social media use on academic procrastination of 37,9%, and the remaining 62,1% is determined by other factors which is not examined. Abstrak Penelitian ini bertujuan untuk memperoleh gambaran tentang pengaruh pengawasan orang tua dalam intensitas penggunaan media sosial terhadap prokrastinasi akademik. Penelitian ini dilaksanakan di SMP Putra 1 Jakarta. Jenis penelitian ini adalah kuantitatif asosiatif. Populasi pada penelitian ini adalah siswa/i SMP Putra 1 Jakarta kelas VII, VIII, dan IX, dengan jumlah sampel sebesar 83 responden. Teknik pengambilan data menggunakan proportionate stratified random sampling. Uji prasyarat pada penelitian ini menggunakan uji normalitas lilifoers dan uji linieritas regresi, diperoleh hasil bahwa data berdistribusi normal dan bersifat linear. Uji hipotesis data yang digunakan adalah korelasi koefisien product moment diperoleh -0,616 > 0,217. Hasil uji t dengan taraf signifikan 0,05 diperoleh 7,04 > 1,99, hal ini menjelaskan bahwa terdapat korelasi negatif dan hubungan yang signifikan antara pengawasan orang tua dalam intensitas penggunaan media sosial terhadap prokrastinasi akademik. Perhitungan uji signifikan regresi diperoleh 30,68 > 3,96, maka terdapat pengaruh yang signifikan antara pengawasan orang tua dalam intensitas penggunaan media sosial terhadap prokrastinasi akademik. Pengawasan orang tua dalam intensitas penggunaan media sosial memberikan sumbangan efektif terhadap prokrastinasi akademik sebesar 37,9%, sedangkan sisanya 62,1% ditentukan faktor lain yang tidak diteliti.
Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study Putranto, Rudi; Adhiatma, Kresna; Tarigan, Tri Juli Edi; Rumende, Cleopas Martin; Shatri, Hamzah; Rengganis, Iris; Nugroho, Pringgodigdo; Rinaldi, Ikhwan
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237005

Abstract

BACKGROUND The prevalence of type 2 diabetes mellitus (T2DM) is increasing and commonly accompanied by comorbidities, such as depression. Vitamin D levels have been associated with T2DM and depression although the mechanism is uncertain. This study aimed to compare vitamin D levels between patients with T2DM with and without depression in the Indonesian community, where such research is rare. METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital. The participants who met the inclusion criteria on an outpatient basis were screened for depression using the Beck Depression Inventory-II (BDI-II) questionnaire and then divided into 2 groups: patients with T2DM with (BDI-II ≥14) and without (BDI-II <14) depression. Both groups were examined for vitamin D levels using the ELISA method, and an analysis of the mean difference between both groups was performed. RESULTS Of 60 patients, 23 (38%) experienced depression. The median vitamin D levels were 21.8 ng/ml (IQR 14.9–26.6) in the depression group and 26.5 ng/ml (IQR 23.96–34.08) in the non-depression group (p = 0.001). After performing multivariate analysis with confounding variables, the adjusted OR of variables (sex, sun exposure score, and body mass index) was 1.123 (95% CI: 1.003–1.259; p = 0.045). CONCLUSIONS Vitamin D levels were significantly lower in patients with T2DM with depression. Future studies should be carried out to determine the benefits of vitamin D supplementation in patients with T2DM with depression and their pathophysiology.
Efficacy of fetal hemoglobin inducers in adult transfusion-dependent beta-thalassemia patients: a systematic review and meta-analysis Naufal, Muhammad Afif; Fauzi, Ahmad; Rengganis, Iris
Medical Journal of Indonesia Vol. 34 No. 4 (2025): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257796

Abstract

BACKGROUND Patients with transfusion-dependent beta-thalassemia (TDBT) face risks of iron overload, which also burdens national expenditures in Indonesia. Elevated fetal hemoglobin (HbF) expression is associated with reduced blood transfusion dependency. This study aimed to assess the efficacy and safety profile of HbF inducers as adjuvant therapy for adult patients with TDBT and appraise its feasibility for Indonesian patients. METHODS This study analyzed 7 trials of HbF inducers, such as hydroxyurea, thalidomide, butyrate, and decitabine, in 382 adult participants (mean age >16), including 28 patients with non-TDBT. Outcomes assessed included hemoglobin (Hb) levels, transfusion needs, and adverse events (AEs). Studies were sourced from PubMed, Cochrane, Embase, and individual searches. The standardized mean difference (SMD) was used as the primary effect size. The protocol was registered in PROSPERO (CRD4202454646368). RESULTS High heterogeneity was observed, with HbF inducers associated with a significant decrease in transfusion needs (SMD = −0.88; 95% confidence interval [CI] = −1.37 to −0.26); I2 = 79%, P✗2<0.01). No significant change in Hb levels was found (SMD = 0.11; 95% CI = −0.69 to 0.91; I2 = 90%, P✗2<0.01). The most common AEs were transaminitis and cytopenias, which were tolerable and alleviated upon dose cessation. CONCLUSIONS HbF induction agents can be used as adjuvant therapy for TDBT, considering their cost-effectiveness, efficacy, and safety profiles.
Ekstrak Teh Hijau Mengurangi Luas Area Fibrosis Paru Tikus Desdiani; Iris Rengganis; Samsuridjal Djauzi; Agus Setiyono; Mohammad Sadikin; Sri Widia A. Jusman; Nurjati Chairani Siregar; Suradi; Putri C. Eyanoer
Majalah Patologi Indonesia Vol. 29 No. 1, Januari 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.403

Abstract

BackgroundPulmonary fibrosis is often found in infectious diseases and chemical exposure in the work environment. Antifibrotic effects can befibropreventive and fibrolysis. Bleomycin can cause inflammation and pulmonary fibrosis. Catechin is proven can repair liverdamages due to alcohol induction. The aim of this study is to examine the effect of antifibrotic green tea catechin on reducing thearea of rat lung fibrotic.MethodsThis research was carried out in vivo experimentally in the Laboratory Animal Management Unit at Faculty of Veterinary MedicineIPB in 4 groups of rat experiments, consisting of 3 rats in the negative control group, 3 rats in the positive control group, 3 rats in thegroup of rats given bleomycin on the 8th day and 28thwith green tea extract every day from day 0 to 49 days (fibropreventive), 3groups of rats given bleomycin days 0 and 21 with green tea extract every day from day 15 to 49 (fibrolysis). Histopathologicalexamination was performe for all groups of rats.ResultsThis study showed that administration of green tea extract in fibropreventive groups and fibrolysis groups could reduce the fibrosisarea in rat lungs based on Aschroft's modified scale.ConclusionBased on the results of this study it was found that the anti-fibrotic activity of green tea extract was proven to be able to suppressthe development of pulmonary fibrosis both by fibropreventive and fibrolysis
Hubungan Antara Gangguan Depresi dengan Kualitas Hidup, Stresor Psikososial, dan Tingkat Kontrol Asma pada Pasien Asma di RSUPN Dr. Cipto Mangunkusumo Agung W Putro; Irmia Kusumadewi; Iris Rengganis; Feranindhya Agiananda
Majalah Kedokteran Indonesia Vol 68 No 8 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.8-2018-44

Abstract

Introduction : Poor asthma control level and the presence of comorbid disorders such as depression and psychosocial stress will affect the quality of life and increase the economic burden of asthmatic patients and their family. We investigated the correlation between depressive disorders, quality of life, psychosocial stressors, and level of asthma control in asthmatic patients. Methods : The study was cross-sectional descriptive-analytic in 37 asthmatic patients with depressive disorder and 37 asthmatic patients without depressive disorder in the Allergy and Immunology Clinic RSUPN Dr. Cipto Mangunkusumo using SCID-1, WHOQOL-BREF, Holmes and Rahepsychosocial stressors, and ACT questionnaires. Results : There is a relation between the presence of depressive disorders and lower quality of life scores based on physical health (p less-than 0,001), psychological health (p less than 0,001), social relations (p=0.023), environment (p=0.022), psychosocial stressors (OR 3.85; p=0.005), and the level of asthma control (p=0.001) in asthmatic patients. Conclusion: Asthmatic patients with depressive disorders tend to have lower quality of life score in all domains (physical health, psychological health, social relationships, and environment) and lower level of asthma control scores than asthmatic patients without depressive disorders. Asthmatic patients who have psychosocial stressors have 3.8 times higher risk to have depressive disorders.
Co-Authors -, Lisnawati -, Yudhistira Achmad Fariz Adhiatma, Kresna Adityo Susilo, Adityo Agiananda, Feranindhya Agung W Putro Agus Joko Susanto, Agus Joko Agus Setiyono Alida Roswita Harahap Alimuddin, Suriani Alimuddin, Suriani Aria Kakalih Aria Kekalih Aryati Aryati Asih Setiarini Cityta Putri Kwarta Cleopas M Rumende, Cleopas M Cleopas Martin Rumende Danny Rasjiid Garna Desdiani Dewi Wulandari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Estie Puspitasari Estie Puspitasari, Estie Evy Yunihastuti Fauzi Ahmad Muda Hanny Siti Nuraeni Herdiman Theodorus Pohan Heri Wibowo Heri Wibowo Ikhwan Rinaldi Indira Priya Darsini Indira Priya Darsini Irmia Kusumadewi Irmia Kusumadewi Joedo Prihartono Joedo Prihartono Kuntjoro Harimurti Kwarta, Cytyta Putri Lisnawati Rachmadi Lukman Edwar Marcellus Simadibrata K Mohammad Sadikin Murdani Abdullah Naufal, Muhammad Afif Ninik Sukartini Nuraeni, Hanny Siti Nurjati Chairani Siregar Parhusip, Santi Sumihar Rumondang Pringgodigdo Nugroho, Pringgodigdo Priya Darsini, Indira Putri C. Eyanoer Putro, Agung W R. Tedjo Sasmono Rambe, Dirga S. Rasha Roy Akur Pandapotan Roy Akur Pandapotan, Roy Akur Rudi Putranto Rumende, Cleopas M. Samsuridjal Djauzi Saptawati Bardosono Siti Setiati Sri Widia A.Jusman Suhendro Suhendro Suhendro Suwarto Suhendro Suwarto, Suhendro Suradi Susanto, Agus J. Suzanna Immanuel Suzanna Immanuel Suzanna Immanuel Tarma Tri Juli Edi Tarigan Yolanda Candra Yordan Khaedir Yudhistira Yudhistira -