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All Journal METAMORFOSA Journal of Biological Sciences INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Veteriner Jurnal e-Biomedik JURNAL BIOMEDIK Prosiding Seminar Nasional MIPA Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya WMJ (Warmadewa Medical Journal) Molecular and Cellular Biomedical Sciences (MCBS) Berkala Ilmiah Kedokteran Duta Wacana ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Kesehatan Pharmamedika Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Neurologico Spinale Medico Chirurgico Indonesian Journal of Global Health research IJAAM (Indonesian Journal of Anti-Aging Medicine) IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Indonesian Archives of Biomedical Research (InABR) Cermin Dunia Kedokteran Eduvest - Journal of Universal Studies Asian Journal of Social and Humanities Cermin Dunia Kedokteran
Wimpie I Pangkahila
Department Of Andrologi And Sexology, Faculty Of Medicine, Udayana University
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Correlation between TNF-α Serum Level and Andropause with Quality of Life on Elderly Trisna Yuliharti Tersinanda; RA Tuty Kuswardhani; Wimpie I Pangkahila
Indonesian Journal of Global Health Research Vol 2 No 3 (2020): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.045 KB) | DOI: 10.37287/ijghr.v2i3.186

Abstract

As the population of elderly increases, the number of andropause also increases. Andropause is characterized by the decrease of testosteron level which is accompanied by hypogonadism symptoms. Many studies mentioned that decreased testosterone level will contribute to inflammation state, one of the cytokine is TNF-α, which then lead to many chronic inflammation disorders and influence the quality of life. Understanding the significant correlation between androgen and inflammation allows accurate consideration making in using androgen replacement therapy, therefore the quality of life will be improved significantly.This research was an analytical cross-sectional study. Subjects were recruited through random sampling at Denpasar in 2019. TNF-α serum level was measured by human immunoassay method. Andropause was measured by ADAM questionnaire and confirmed by total decreased testosterone serum level. Quality of life was measured by WHOQOL-BREF questionnaire which was then continued by bivariate and multivariate analysis to control the confounding variables. It was considered statistically significant if P value is more than 0.05. There were 60 elderly involved as research subjects consisting of 43 andropause cases and 17 non andropause cases. There was significant correlation between TNF-α serum and quality of life. This study also found that there was significant difference in quality of life between andropause and non andropause group. This study shows that there was significant correlation between TNF-α serum level and andropause with quality of life in elderly.
Krim Ekstrak Bawang Hitam (Allium sativum Linn) Mencegah Peningkatan Ekspresi MMP-1 dan Penurunan Jumlah Kolagen Dermis Kulit Tikus (Rattus norvegicus) Wistar Jantan yang Dipapar Sinar UV-B Balqis Wasliati; Wimpie Pangkahila; A.A.G.P Wiraguna
Cermin Dunia Kedokteran Vol 46 No 8 (2019): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i8.420

Abstract

Pendahuluan: Bawang hitam berasal dari bawang putih (Allium sativum Linn) melalui proses pemanasan, sehingga terjadi peningkatan kandungan antioksidan: fenolik, flavonoid (quarcetin), dan DPPH (IC-50). Tujuan penelitian ini adalah membuktikan krim ekstrak bawang hitam (Allium sativum Linn) mencegah peningkatan ekspresi MMP-1 dan penurunan jumlah kolagen dermis pada kulit tikus (Rattus norvegicus) Wistar jantan yang dipapar sinar UV-B. Metode: Penelitan ini adalah penelitian eksperimental post-test only control group design. Sampel penelitian ini terdiri dari 36 ekor tikus (Rattus norvegicus) Wistar jantan, dibagi menjadi 2 kelompok perlakuan secara acak. Tikus diberi bahan dasar krim dan dipapar sinar UV-B disebut kelompok kontrol, tikus diberi krim ekstrak bawang hitam 15% dan dipapar sinar UV-B disebut kelompok perlakuan. Total dosis UV-B 840 mJ/cm2 selama 4 minggu. Setelah perlakuan, tikus dieuthanasia dengan ketamine-xylazine lalu ekspresi MMP-1 diperiksa secara imunohistokimia dan jumlah kolagen dermis kulitnya menggunakan pewarnaan Pico-Sirius-Red. Hasil: Rerata ekspresi MMP-1 kelompok kontrol 28,58% dan kelompok perlakuan 8,60%; p<0,001 (uji t independent); terdapat perbedaan bermakna ekspresi MMP-1 antara kelompok kontrol dan kelompok perlakuan. Rerata jumlah kolagen kelompok kontrol 57,53% dan kelompok perlakuan 83,80%; p<0,001 (uji t independent); terdapat perbedaan bermakna jumlah kolagen antara kelompok kontrol dan kelompok perlakuan. Simpulan: Krim ekstrak bawang hitam (Allium sativum Linn) 15% mencegah peningkatan ekspresi MMP-1 dan penurunan jumlah kolagen dermis kulit tikus (Rattus norvegicus) Wistar jantan yang dipapar sinar UV-B. Aim: Black garlic was produced from garlic (Allium sativum Linn) through the heating process to increase the antioxidant content: phenolic, flavonoid (quarcetin), and DPPH (IC-50). The aim of this study is to prove that black garlic extract cream (Allium sativum Linn) application prevents enhancement of MMP-1 expression and reduction of dermal collagen in male Wistar rat (Rattus norvegicus) skin which has been exposed to UV-B light. Method: An experimental research using post-test only control group design. Total samples of 36 male Wistar rats (Rattus norvegicus) were divided into 2 groups. Control group were given cream and UV-B exposure (P0), treatment group were given 15% black garlic cream extract and UV-B exposure (P1). The total dose of UV-B was mJ/cm2 for 4 weeks. The rats were euthanized with ketamine-xylazine after treatment; MMP1 expression was examined using immunohistochemistry and dermal collagen using Pico-Sirius-Red staining. Result: MMP-1 expression of control group 28.58% and of treatment group 8.60% (independent t test, p<0.001). Mean of collagen in control group 57.53% and in treatment group 83.8% (independent t test, p<0.001). Conclusion: Black garlic extract cream 15% prevents the enhancement of MMP-1 expression and the reduction of dermal collagen in male Wistar rat (Rattus norvegicus) skin which has been exposed to UV-B light.
Administration of Corosolic Acid Decreased MDA, HMG-CoA, Through Increased Leptin and GLP-1 Levels in Obese Male Rats Mochtar, Fransiska; Pangkahila, Wimpie I.; Dewi, I Gusti Ayu Sri Mahendra; Saraswati, Made Ratna; Azizah, Norma Nur Azizah
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.204

Abstract

Obesity is a condition where excessive fat is accumulated, which poses a health risk. Several treatments for obesity have been carried out, ranging from lifestyle adjustments to medication to surgery. Corrosolic acid (CA) is a natural compound that has the potential to act as an obesity agent through many mechanisms, including through reactive oxygen species (ROS). This study aims to prove that CA can reduce MDA levels and HMG-CoA reductase levels and increase leptin levels and GLP-1 levels in male Wistar rats with obesity. Wistar obese rats were orally treated with CA compound induction at a dose of 10 mg/Kg BW. MDA, HMG-CoA reductase, leptin and GLP-1 levels were examined using serum and plasma from mice in both groups of mice before and after treatment, using the ELISA method. CA to the treatment group can reduce the body weight of rat MDA levels significantly at p<0.0001, HMG-CoA reductase levels significantly at p<0.0001 and increase leptin and GLP-1 levels significantly at p<0.0001. CA's mechanism for treating obesity is through the ROS mechanism because CA has antioxidant levels that can capture free radicals in the body.CA has been proven to be an alternative drug in treating obesity by reducing body weight, MDA, and HMG-CoA levels and increasing leptin and GLP-1 levels in obese Wistar rats.
EFEKTIFITAS EKSTRAK DAUN GANDARUSA (Justicia gendarusa, Burm f.) MENGHAMBAT PROSES PENUAAN OVARIUM DAN MENGHAMBAT TERBENTUKNYA KISTA FUNGSIONAL PADA MARMUT (Cavia cobaya) Rusmiatik, Rusmiatik; Pangkahila, Wimpie
JURNAL KEDOKTERAN Vol. 5 No. 2 (2020)
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36679/kedokteran.v5i2.231

Abstract

Penuaan merupakan proses alamiah yang dilalui oleh setiap mahluk hidup bila mempunyai umur panjang, sekaligus sebagai proses yang sangat ditakuti oleh kebanyakan orang. Selama proses tersebut, terjadi perubahan anatomi dan penurunan fungsi organ tubuh. penerapan ilmu terkini dan teknologi-teknologi kedokteran untuk deteksi dini, pencegahan, pengobatan, dan pengembalian berbagai disfungsi yang berkaitan dengan usia dan penyakit. Tujuan penelitian ini adalah untuk mengetahui apakah pemberian ekstrak daun gandarusa (justicia gendarusa Burm .f) dapat mengurangi pembentukan kista fungsional dan mampu menghambat proses penuaan pada ovarium marmut. Rancangan penelitian ini adalah posttest only control group design, terdiri dari empat kelompok. Besar sampel 28 ekor marmut betina berusia 24 bulan, berat badan 600-650 gram. Pemilihan sampel secara random. Penelitian dilakukan selama 2 bulan dengan waktu perlakuan 28 hari. Kelompok kontrol diberikan 6 ml aquadest dan kelompok perlakuan masing – masing diberikan ekstrak daun gandarusa 6 ml peroral 2 kali sehari sesuai dosis. Sesudah perlakuan dilakukan pembedahan, pembuatan preparat histologi ovarium, dan pengamatan menggunakan mikroskop. Analisis data terdiri dari analisis deskriptif dan komparatif dengan bantuan komputer.Hasil penelitian menunjukkan peningkatan jumlah folikel skunder, dan mengurangi terbentuknya kista fungsional secara bermakna dengan nilai (p<0,05) pada kelompok perlakuan, disebabkan kemampuan ekstrak daun gandarusa sebagai fitoestrogen dan antioksidan alami menghambat terbentuknya radikal bebas, sehingga melindungi DNA dan sel dari kerusakan.Simpulan : ekstrak daun gandarusa meningkatkan jumlah folikel skunder, dan mengurangi terbentuknya jumlah kista fungsional. Saran: perlu penelitian lebih lama agar efek ekstrak daun gandarusa terhadap ovarium tampak lebih jelas.
Co-Authors ., Nuriyah ., Yulyani ., Zenitalia A. A. G. P. Wiraguna A.A. Gede Budhiarta A.A. Gede Budhiarta A.A. Gede Budhiarta A.A.G.P Wiraguna A.A.G.P. Wiraguna A.A.G.P. Wiraguna A.A.G.P. Wiraguna AAGP Wiraguna AAGP Wiraguna AAGP Wiraguna AAGP. Wiraguna Agung Wiwiek Indrayani Agus Eka Darwinata Akpriyanti, DG Ika Aman, I G M Anak Agung Ayu Ngurah Susraini Anak Agung Gde Budhiarta Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Gede Budhiarta Anak Agung Gede Budhiarta Anak Agung Gede Putra Wiraguna Andrew Lie Angelia Ongko Prabowo Anne Carolina Kencanawati Anshori, Ahmad M. Aprilany Stella peng Astried Haryanto Augus Venty Azizah, Norma Nur Azizah Bagus Komang Satriyasa Balqis Wasliati Balqis Wasliati Bissi Herliane Budhiarta, Anak A.G. Chandra, Aji B. Chynthia Friama Delly Dahlia Dessy Indriana Hatta Dewi, Dian Andriani Ratna Dian Andriani Dumaria, Corazon H. Dwindi Saptania Efrida Sumawati Erwin Sugito Eveline Margo Feily Sari Moelyono Fenni Liem Ferbian M. Siswanto, Ferbian M. Fiter, Joni Gde Ngurah Idraguna Pinatih Gina Septivani Hendrik Danico Heny Widiyowati S Hery Widijanto Huda, Siti M. N. I Gede Made Aman I Gede Widhiantara I Gusti Ayu Sri Mahendra Dewi I Gusti Made Aman I Ketut Suada I Ketut Tunas I Nyoman Adiputra I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Wayan Weta Ida Sri Iswari Indah Mira Tiaraputri Wijaya Ingrid Rotinsulu J. A. Pangkahila Junivan Lindra Kandy Rosa Ismalia Larasati, Veny Laura Indriana Liliana, Nize Lis Widodo Peni Liya Rosdiana Luh Putu Iin Indrayani Maker Made Ayu Mirah Wulandari Made Oka Negara MADE RATNA SARASWATI . Manus, Widya Christine Maulidha Suzi Annisa Maya Cesarya Simangunsong Meiny Linda Setiawan Meiyati Panambunan Melanie Maria Magdalena Ratulangi Mery Merysia Milhanah Milhanah Mochtar, Fransiska Muhammad Rahmatullah Ni Luh Putri Astini Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Sriwidyani Nina Marini Nining Triyana Darise Nurwiyanti, . Palumpun, Eva F. Periskila Abigail Phery Candres Putri Puspitasari R. A.T. Kuswardhani Rafiah Sirikit Saenong Riliani, Marisa Romy Kamaluddin Ronald Suryaprawira Rusmiatik, Rusmiatik Sabella Setia Wardani Siahaan, Eva R. Siahaan, Marintan S. Y. Sofiana, Rahmi Suarni . Sulaiman, Yogie Susianingsih Murni Hartati Syafii, Corry P. Tambor Tiur Marlina Tamon, Oktavian Tarnajaya, Karnia Thomas Eko Purwata Trisna Yuliharti Tersinanda Ursula Sulistiani Vany Novanty Vashti Saraswati Vitia Tandy Widhayanthi, Trisna A. Wiraguna AAGP Wiraguna, A A G P Wiraguna, A AGP Wiraguna, AAG Wiraguna, Anak A.G.P. Yuziana Yuziana