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All Journal METAMORFOSA Journal of Biological Sciences INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Veteriner Jurnal e-Biomedik JURNAL BIOMEDIK Prosiding Seminar Nasional MIPA Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya WMJ (Warmadewa Medical Journal) Molecular and Cellular Biomedical Sciences (MCBS) Berkala Ilmiah Kedokteran Duta Wacana ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Kesehatan Pharmamedika Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Neurologico Spinale Medico Chirurgico Indonesian Journal of Global Health research IJAAM (Indonesian Journal of Anti-Aging Medicine) IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Indonesian Archives of Biomedical Research (InABR) Cermin Dunia Kedokteran Eduvest - Journal of Universal Studies Asian Journal of Social and Humanities Cermin Dunia Kedokteran

Wimpie I Pangkahila

Department Of Andrologi And Sexology, Faculty Of Medicine, Udayana University

Author-ID : 3606750

Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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GAMBARAN PENURUNAN DORONGAN SEKSUAL PADA IBU HAMIL DI PUSKESMAS DENPASAR SELATAN II PADA TAHUN 2015 Vashti Saraswati; Wimpie Pangkahila
E-Jurnal Medika Udayana Vol 7 No 11 (2018): vol 7 no11 2018 E-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.645 KB)

Dorongan seksual merupakan komponen yang penting dalam kelangsungan aktivitas dan fungsi seksual pada manusia termasuk wanita. Pada wanita yang sedang hamil diketahui adanya perubahan fisiologis terutama pada hormonal wanita yang sangat berpengaruh terhadap fungsi seksualnya. Penelitian ini dilakukan untuk mengetahui adanya penurunan dorongan seksual pada ibu hamil di Puskesmas Denpasar Selatan II pada tahun 2015.Penelitian cross-sectional ini diikuti oleh 44 orang ibu hamil usia kehamilan trimester satu hingga tiga yang melakukan pemeriksaan di Puskesmas Denpasar Selatan II. Metode penelitian dilakukan dengan melakukan wawancara menggunakan kuisioner FSFI yang disertai dengan kuisioner untuk data demografi berupa usia ibu hamil, trimester kehamilan, tingkat pendidikan, agama, pekerjaan, jumlah paritas, riwayat merokok, riwayat minum alkohol, dan perencanaan kehamilan. Analisis data dilakukan dengan crosstab.Prevalensi penurunan dorongan seksual pada ibu hamil di Puskesmas Denpasar Selatan II adalah 43,2%. Berdasarkan trimester kehamilan, jumlah ibu yang mengalami penurunan dorongan seksual paling besar adalah ibu hamil pada trimester III. Berdasarkan tingkat pendidikan, penurunan dorongan seksual paling besarditemukan pada ibu hamil dengan pendidikan terakhir jenjang Sekolah Menengah Atas (SMA). 57,9% dari responden merupakan kehamilan nulipara.Ibu hamil memiliki kecenderungan untuk mengalami penurunan fungsi seksual, di antaranya yaitu dorongan seksual. Kata kunci : Penurunan dorongan seksual, disfungsi seksual, kehamilan

Fraksi Heksan dan Fraksi Metanol Ekstrak Biji Pepaya Muda Menghambat Spermatogonia Mencit (Mus Musculus) Jantan Bagus Komang Satriyasa; Wimpie I Pangkahila2
Jurnal Veteriner Vol 11 No 1 (2010)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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To avoid population booming, family planning program should be maintained in which menand woman have the same rights and obligations. However in execution of family planning the roleof men is still low. Studies about contraception in men are limited. Male contraception that isknown in society are condom and vasectomy. In the recent few years in particular, researcheshave been refocused on investigating traditional plants as anti fertility. In use researches manyplants have been studied, including papaya seed. Some researches on herbal anti fertility propertiesof papaya seed have been carried out including those on the active compounds of anti fertility, onapprolaki-lakite dosage of extract of carica papaya seed by animal experiments. Hexane fraction ofunripe papaya seed extract contains glycosides, alkaloid and triterpenoids, which is assumed hasan antifertility effect, so it can be used as a male contraceptive, although the mechanism of actionis not yet clear. Research is conducted at Animal Laboratory Unit Department of PharmacologyFaculty of Medicine University of Udayana, and Laboratorium Patologi Balai Penyidikan danPengujian Veterian (BPPV) Wilayah VI Denpasar Direktorat Jenderal Peternakan, DepartmentPertanian. This study used the pre-test and post-test control group design, using 30 male mice ofbalb C strain, aged 12 weeks, weight 20-22 gram, subsequently grouped by random into 3 groupseach consisting of 10 male mice. One control group (P0 = control group) was given double distilledwater, and two treatment groups (P1 = treatment group) was given fraction of the hexane extractof young Carica papaya seed 20 mg/20gram Body wieght/day, (P2 = treatment group) was givenfraction of the methanol extract of young Carica papaya seed 20 mg/20 gram/day). After 36 days oftreatment, evaluation of the testis, of the male mice was conducted. Data were analysed by normalitytest of Shapiro-will, homogeneity test, and Anova test. This study showed that cells of spermatogoniaA decreased significantly (p < 0,01). It is concluded that hexan fraction and methanol fraction ofunripe carica papaya seeds extract can decrease spermatogonia A cell of male mice (mus musculus).

Oral Administration of Caesalpinia bonducella Seeds Ethanolic Extract Decreased Post Prandial Blood Glucose Level and Prevented the Reduction of Fasting Insulin Level of Diabetic Male Albino Rats (Rattus norvegicus) Veny Larasati; Wimpie Pangkahila; Anak Agung Gde Budhiarta
JURNAL KEDOKTERAN DAN KESEHATAN Vol 3, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Caesalpinia bonducella contain flavonoid, tanin, saponin which has antidiabetic activity. The aim of this study was to determine that the Caesalpinia bonducella seed extract orally reduces post-prandial blood glucose level and prevent the reduction of fasting insulin level in diabetic male albino rats (Rattus norvegicus). This study was a true experimental with pre-test post-test control group design using 24 male albino rats. All samples were induced with streptozotocin which caused the destruction of ? cell and nicotinamide which protected the ? cell from destructions of that the pancreatic ?-cell was not destructed entirely. The selected samples were divided into three groups: the control negative group was given distilled water (P0), the control positive group was given glibenclamide (P1), and the treatment group was given ethanolic extracts of Caesalpinia bonducella seed 500mg/kg body weight (P2). Blood glucose and plasma insulin measurements were taken after 14 days of treatment. The result showed that the post-prandial blood glucose level of treatment group (P2) was decreased significantly, from 232,63±10,31 mg/dl to 185,50±16,00 mg/dl (P<0.001) whereas in P0 group, post-prandial blood glucose level was rising significantly from 223,75±17.03 mg/dl to 267,25±17,56 mg/dl (p<0.001). In P1 group, the reduction of post-prandial blood glucose level was bigger compare to P2 group, which was from 228,50±11,55 mg/dl to 115,88±10,23 mg/dl (p<0.001). Post test fasting insulin level of P2 group was significantly different compare to other group (p<0.05). The administration of Caesalpinia bonducella seed extract increased the fasting insulin level although did not significant statistically (p>0.05) whereas the other group showed the reduction of fasting insulin level (p<0.05). It can be concluded that the administration of Caesalpinia bonducella seed extract orally reduced post-prandial blood glucose level and prevent reduction of fasting plasma insulin level in diabetic male albino rats.

TERAPI TESTOSTERON DAN LH (Luteinizing Hormone) MENINGKATKAN JUMLAH SEL LEYDIG MENCIT (Mus musculus) YANG MENURUN AKIBAT PAPARAN ASAP ROKOK I Gede Widhiantara; Wimpie I Pangkahila; Alex J Pangkahila
Prosiding Seminar Nasional MIPA 2012: PROSIDING SEMINAR NASIONAL MIPA UNDIKSHA 2012
Publisher : Prosiding Seminar Nasional MIPA

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ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh asap rokok terhadap jumlah sel Leydig mencit dan terapi hormon testosteron serta LH dalam meningkatkan kembali jumlah sel Leydig yang menurun akibat paparan asap rokok.Penelitian ini merupakan penelitian eksperimental dengan rancangan randomized pretest - posttest control group design. Sampel dalam penelitian ini adalah mencit jantan dewasa strain Balb-C umur 2 – 3 bulan dengan kisaran berat badan 20-25 gram, sebanyak 54 ekor mencit dibagi tiga kelompok yaitu 18 ekor mencit kelompok kontrol (asap rokok dan terapi aquadest steril), 18 ekor mencit kelompok perlakuan 1 (asap rokok dan terapi testosteron secara intramuscular) dan 18 ekor mencit kelompok perlakuan 2 (asap rokok dan terapi LH secara intramuscular). Sebelum perlakuan, 6 ekor diambil dari setiap kelompok untuk pre-test dengan pembuatan preparat mikroskopis testis dan pemeriksaan jumlah sel Leydig. Sisanya sebanyak 12 ekor dipergunakan untuk post-test 1 yang diberi perlakuan asap rokok selama 35 hari dan post-test 2 yang diberi terapi selama 30 hari.Hasil penelitian menunjukkan terjadinya penurunan jumlah sel Leydig secara bermakna (p<0,05) pada kelompok yang diberi asap rokok. Setelah diberi terapi hormon testosteron serta LH menunjukkan terjadi peningkatan jumlah sel Leydig secara bermakna dibandingkan kelompok kontrol yang diterapi dengan aquadest steril (P<0,05). Peningkatan jumlah sel Leydig pada kelompok yang diterapi dengan LH lebih tinggi dibandingkan dengan kelompok yang diterapi dengan testosterone (P<0.05). Dari hasil penelitian ini dapat disimpulkan bahwa paparan asap rokok dapat menurunkan jumlah sel Leydig ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh asap rokok terhadap jumlah sel Leydig mencit dan terapi hormon testosteron serta LH dalam meningkatkan kembali jumlah sel Leydig yang menurun akibat paparan asap rokok.Penelitian ini merupakan penelitian eksperimental dengan rancangan randomized pretest - posttest control group design. Sampel dalam penelitian ini adalah mencit jantan dewasa strain Balb-C umur 2 – 3 bulan dengan kisaran berat badan 20-25 gram, sebanyak 54 ekor mencit dibagi tiga kelompok yaitu 18 ekor mencit kelompok kontrol (asap rokok dan terapi aquadest steril), 18 ekor mencit kelompok perlakuan 1 (asap rokok dan terapi testosteron secara intramuscular) dan 18 ekor mencit kelompok perlakuan 2 (asap rokok dan terapi LH secara intramuscular). Sebelum perlakuan, 6 ekor diambil dari setiap kelompok untuk pre-test dengan pembuatan preparat mikroskopis testis dan pemeriksaan jumlah sel Leydig. Sisanya sebanyak 12 ekor dipergunakan untuk post-test 1 yang diberi perlakuan asap rokok selama 35 hari dan post-test 2 yang diberi terapi selama 30 hari.Hasil penelitian menunjukkan terjadinya penurunan jumlah sel Leydig secara bermakna (p<0,05) pada kelompok yang diberi asap rokok. Setelah diberi terapi hormon testosteron serta LH menunjukkan terjadi peningkatan jumlah sel Leydig secara bermakna dibandingkan kelompok kontrol yang diterapi dengan aquadest steril (P<0,05). Peningkatan jumlah sel Leydig pada kelompok yang diterapi dengan LH lebih tinggi dibandingkan dengan kelompok yang diterapi dengan testosterone (P<0.05). Dari hasil penelitian ini dapat disimpulkan bahwa paparan asap rokok dapat menurunkan jumlah sel Leydig ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh asap rokok terhadap jumlah sel Leydig mencit dan terapi hormon testosteron serta LH dalam meningkatkan kembali jumlah sel Leydig yang menurun akibat paparan asap rokok.Penelitian ini merupakan penelitian eksperimental dengan rancangan randomized pretest - posttest control group design. Sampel dalam penelitian ini adalah mencit jantan dewasa strain Balb-C umur 2 – 3 bulan dengan kisaran berat badan 20-25 gram, sebanyak 54 ekor mencit dibagi tiga kelompok yaitu 18 ekor mencit kelompok kontrol (asap rokok dan terapi aquadest steril), 18 ekor mencit kelompok perlakuan 1 (asap rokok dan terapi testosteron secara intramuscular) dan 18 ekor mencit kelompok perlakuan 2 (asap rokok dan terapi LH secara intramuscular). Sebelum perlakuan, 6 ekor diambil dari setiap kelompok untuk pre-test dengan pembuatan preparat mikroskopis testis dan pemeriksaan jumlah sel Leydig. Sisanya sebanyak 12 ekor dipergunakan untuk post-test 1 yang diberi perlakuan asap rokok selama 35 hari dan post-test 2 yang diberi terapi selama 30 hari.Hasil penelitian menunjukkan terjadinya penurunan jumlah sel Leydig secara bermakna (p<0,05) pada kelompok yang diberi asap rokok. Setelah diberi terapi hormon testosteron serta LH menunjukkan terjadi peningkatan jumlah sel Leydig secara bermakna dibandingkan kelompok kontrol yang diterapi dengan aquadest steril (P<0,05). Peningkatan jumlah sel Leydig pada kelompok yang diterapi dengan LH lebih tinggi dibandingkan dengan kelompok yang diterapi dengan testosterone (P<0.05). Dari hasil penelitian ini dapat disimpulkan bahwa paparan asap rokok dapat menurunkan jumlah sel Leydig mencit dan keadaan ini dapat dipulihkan dengan terapi hormon testosteron serta LH.

The Correlation between TNF-α Serum Level and Andropause with Quality of Life on Elderly Trisna Yuliharti Tersinanda; RA Tuty Kuswardhani; Wimpie I Pangkahila
Indonesian Journal of Global Health Research Vol 2 No 3 (2020): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

As the population of elderly increases, the number of andropause also increases. Andropause is characterized by the decrease of testosteron level which is accompanied by hypogonadism symptoms. Many studies mentioned that decreased testosterone level will contribute to inflammation state, one of the cytokine is TNF-α, which then lead to many chronic inflammation disorders and influence the quality of life. Understanding the significant correlation between androgen and inflammation allows accurate consideration making in using androgen replacement therapy, therefore the quality of life will be improved significantly.This research was an analytical cross-sectional study. Subjects were recruited through random sampling at Denpasar in 2019. TNF-α serum level was measured by human immunoassay method. Andropause was measured by ADAM questionnaire and confirmed by total decreased testosterone serum level. Quality of life was measured by WHOQOL-BREF questionnaire which was then continued by bivariate and multivariate analysis to control the confounding variables. It was considered statistically significant if P value is more than 0.05. There were 60 elderly involved as research subjects consisting of 43 andropause cases and 17 non andropause cases. There was significant correlation between TNF-α serum and quality of life. This study also found that there was significant difference in quality of life between andropause and non andropause group. This study shows that there was significant correlation between TNF-α serum level and andropause with quality of life in elderly.

Gel of sandfish (Holothuria scabra) extract prevented melanin elevation in UVB-exposed guinea pig (Cavia porcellus) skin Dwindi Saptania; Wimpie Pangkahila; Anak Agung Gde Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 4 No 2 (2020): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v4i2.95

Introduction: Hyperpigmentation is a condition of increasing melanin production in the skin due to UV light exposure. Sandfish (Holothuria scabra) contains phenol, quercetin, saponins, tannins, flavonoids and antioxidants such as vitamin C and others that have the potential anti-melanogenesis effects. The purpose of this study was to prove that topical administration of 40% sandfish (Holothuria scabra) extract gel prevented melanin elevation in UVB-exposed guinea pig (Cavia porcellus) skin. Methods: This study used a randomized post-test only group design by using of 36 guinea pigs. Guinea pigs were then divided into two groups. The control group were 18 guinea pigs exposed to UVB rays and treated with placebo gel base (P0). The treatment group were 18 guinea pigs exposed to UVB rays and treated with 40% sandfish extract gel. The back skin exposed to UVB rays, was cleaned from fur and swabbed with 70% alcohol. After that a punch-biopsy was carried out in the area and histopathological preparations were made. The amount of melanin was examined using Masson-Fontana staining. Results: The results showed that the average amount of melanin in the control group was 18.11± 1.11%, while the average amount of melanin in the treatment group was 1.82 ± 0.72%. Comparative analysis using independent T- test showed that the value of p was <0.001 means that there were significant differences between the control group and the treatment group. Conclusion: The administration of 40% sandfish (Holothuria scabra) extract gel prevented melanin elevation in UVB-exposed guinea pig (Cavia porcellus) skin.

The relationship between the levels of adiponectin HMW and the metabolic syndrome component in menopausal women Melanie Maria Magdalena Ratulangi; Anak Agung Gede Budhiarta; Wimpie Pangkahila
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 2 No 1 (2018): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.068 KB)

Introduction: In menopausal women, there increasing evidence of adipocyte dysfunction which result in a decrease in adiponectin HMW. The decrease in adiponectin HMW causes various pathological conditions related to aging such as metabolic syndrome. Simple adiponectin HMW measurements can evaluate early insulin resistance, metabolic disorders, or vascular health. The purpose of this study was to prove the relationship between adiponectin HMW levels and metabolic syndrome components in menopausal women. Methods: In this study, 45 postmenopausal women were used who declared physically healthy, met the criteria of metabolic syndrome based on IDF (International Diabetes Federation), willing to participate in the study and willing to fill out research forms as research subjects. This research was conducted at Panti Werdha Theodora in Makassar while the examination of HMW Adiponectin, fasting blood glucose, triglycerides, and High Density Lipoprotein was carried out in Prodia Laboratory. Result: The results showed a strong correlation between adiponectin HMW and metabolic syndrome components which included waist circumference, HDL levels, triglyceride levels, systolic blood pressure, diastolic and fasting blood glucose (p <0.05). Conclusion: It can be concluded that there was a relationship between adiponectin HMW levels and the metabolic syndrome component in menopausal women. HDL and waist circumference were the most significant factors compared to other metabolic factors associated with Adiponectin HMW.

Cream jengkol seed extract 8% (Archidendron pauciflorum) inhibited the increase melanin amount in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet-B rays Rafiah Sirikit Saenong; Wimpie Pangkahila; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.85

Introduction: The exposure to UV rays on the skin causes hyperpigmentation and premature aging. Hyperpigmentation is caused by an increase of melanin count in the epidermal skin layer. The abundant natural resources that come from Indonesia and have the potential to be good antioxidants are jengkol seeds. The aim of this research was to prove that 8% jengkol seeds (Archidendron pauciflorum) extract cream could inhibit the increase of melanin count in the skin of guinea pig (Cavia porcellus) exposed to ultraviolet B rays. Method: This design of this research is an experimental research with the post-test only control group design. This research used 36 male guinea pigs (Cavia porcellus), local strains, aged 3 months with a body weight of 300-350mg, divided into 2 groups, each of which was 18. The research was conducted for 2 weeks, then a tissue biopsy was carried out as a histological preparation and then the Masson-Fontana staining was carried out. Results: The results showed that the mean value of melanin count for the base cream group was 20.851 ± 1.777%, whereas in the treatment group which applied with 8% jengkol seeds extract cream showed the mean value of 1.289 ± 0.391% (p <0,001). This indicated that the base cream group has a bigger melanin count than the jengkol seeds extract group. Conclusion: The 8% jengkol seeds (Archidendron pauciflorum) extract cream inhibited the increase of melanin

Administration of metformin cream prevented the increase of melanin amount in ultraviolet B exposed guinea pigs (Cavia porcellus) skin Vitia Tandy; Wimpie Pangkahila; A.A.G.P. Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.71

Introduction: Ultraviolet exposure has been known to be the most significant factor influencing skin pigmentation, includes in increasing melanin amount. It is caused by the effect of ultraviolet B radiation in increasing melanin synthesis. Topical administration of metformin can inhibit the melanogenesis process by decreasing the level of cAMP and inhibiting PKC-β activation. This research aimed to prove that administration of 0.5% metformin cream prevented the increase of melanin amount in ultraviolet B exposed guinea pigs (Cavia porcellus) skin. Methods: This study was a true experimental research using posttest only control group design. Thirty six male guinea pigs were divided into control and treatment group. Base cream was administered to the control group and 0.5% metformin cream was administered to the treatment group once daily. All of the guinea pigs were exposed to ultraviolet B radiation at 390 mJ/cm2 three times a week. Punch biopsy was conducted two weeks after treatment to obtain skin samples for histologic preparations. Thereafter, those samples were stained with Masson-Fontana to examine the melanin amount. Finally, the average melanin amount in both groups was compared. Results: All samples in both groups successfully made to the end of the research without drop out. This research found that the average amount of melanin in treatment group, which was 2.04 ± 0.62%, was significantly lower than control group, which was 18.57 ± 1.68% (p < 0.001). Conclusion: Administration of 0.5% metformin cream prevented the increase of melanin amount in ultraviolet B exposed guinea pigs (Cavia porcellus) skin.

Combination treatment of metformin and red fruit (Pandanus conoideus l.) extract increased pancreatic β cell density but had no effect toward fasting blood glucose and glycated albumin levels in diabetic male wistar rats (Rattus norvegicus) Ingrid Rotinsulu; Wimpie I. Pangkahila; A.A. Gede Budhiarta
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 3 No 2 (2019): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Background: Diabetes mellitus (DM) is a degenerative disease associated with premature aging characterized by hyperglycemia. Hyperglycemia in people with DM causes oxidative stress and increases Glycated Albumin level, which is the initial precursor to the formation of AGEs. In turn, AGEs will lead to pancreatic β cell damage and apoptosis. Red fruit (Pandanus conoideus L) contains phytochemicals with antioxidant that has the potential to reduce diabetic complications. Therefore, this study aimed to evaluate the effect of metformin and red fruit extract combination toward blood glucose, glycated albumin and pancreatic β cells density in diabetic rats (Rattus norvegicus). Methods: A post-test only control group study was conducted using 36 male Wistar rats as subject. All subjects were induced for type-2 DM with Streptozotocin and Nicotinamide. The diabetic rats were then divided into 2 groups: the positive control group treated with metformin + placebo and the treatment group treated with metformin + red fruit extract. Pancreatic β cell, fasting blood glucose and glycated albumin assessments were performed after 21 days of treatment. Results: The results showed the mean number of pancreatic β cells in the treatment group was higher than the control group (116.11±33.14 vs 83.20±23.94 cells/visual field; p=0.002). But the mean fasting blood glucose in the treatment group was not significantly different compared to the control group (107.67±14.93 vs. 113.67±11.19 mg/dl; p=0.181). The same result also found in the gycated albumin level (Treatment vs control: 6.97±3.63 vs 6.42±4.01 ng/ml; p=0.666). Conclusion: It can be concluded that the administration of red fruit extract increased the density of pancreatic β cell but did not reduce fasting blood glucose and glycated albumin levels in diabetic Wistar rats.

Co-Authors ., Nuriyah ., Yulyani ., Zenitalia A. A. G. P. Wiraguna A.A. Gede Budhiarta A.A. Gede Budhiarta A.A. Gede Budhiarta A.A.G.P Wiraguna A.A.G.P. Wiraguna A.A.G.P. Wiraguna A.A.G.P. Wiraguna AAGP Wiraguna AAGP Wiraguna AAGP Wiraguna AAGP. Wiraguna Agung Wiwiek Indrayani Agus Eka Darwinata Akpriyanti, DG Ika Aman, I G M Anak Agung Ayu Ngurah Susraini Anak Agung Gde Budhiarta Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Gede Budhiarta Anak Agung Gede Budhiarta Anak Agung Gede Putra Wiraguna Andrew Lie Angelia Ongko Prabowo Anne Carolina Kencanawati Anshori, Ahmad M. Aprilany Stella peng Astried Haryanto Augus Venty Azizah, Norma Nur Azizah Bagus Komang Satriyasa Balqis Wasliati Balqis Wasliati Bissi Herliane Budhiarta, Anak A.G. Chandra, Aji B. Chynthia Friama Delly Dahlia Dessy Indriana Hatta Dewi, Dian Andriani Ratna Dian Andriani Dumaria, Corazon H. Dwindi Saptania Efrida Sumawati Erwin Sugito Eveline Margo Feily Sari Moelyono Fenni Liem Ferbian M. Siswanto, Ferbian M. Fiter, Joni Gde Ngurah Idraguna Pinatih Gina Septivani Hendrik Danico Heny Widiyowati S Hery Widijanto Huda, Siti M. N. I Gede Made Aman I Gede Widhiantara I Gusti Ayu Sri Mahendra Dewi I Gusti Made Aman I Ketut Suada I Ketut Tunas I Nyoman Adiputra I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Wayan Weta Ida Sri Iswari Indah Mira Tiaraputri Wijaya Ingrid Rotinsulu J. A. Pangkahila Junivan Lindra Kandy Rosa Ismalia Larasati, Veny Laura Indriana Liliana, Nize Lis Widodo Peni Liya Rosdiana Luh Putu Iin Indrayani Maker Made Ayu Mirah Wulandari Made Oka Negara MADE RATNA SARASWATI . Manus, Widya Christine Maulidha Suzi Annisa Maya Cesarya Simangunsong Meiny Linda Setiawan Meiyati Panambunan Melanie Maria Magdalena Ratulangi Mery Merysia Milhanah Milhanah Mochtar, Fransiska Muhammad Rahmatullah Ni Luh Putri Astini Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Sriwidyani Nina Marini Nining Triyana Darise Nurwiyanti, . Palumpun, Eva F. Periskila Abigail Phery Candres Putri Puspitasari R. A.T. Kuswardhani Rafiah Sirikit Saenong Riliani, Marisa Romy Kamaluddin Ronald Suryaprawira Rusmiatik Rusmiatik Sabella Setia Wardani Siahaan, Eva R. Siahaan, Marintan S. Y. Sofiana, Rahmi Suarni . Sulaiman, Yogie Susianingsih Murni Hartati Syafii, Corry P. Tambor Tiur Marlina Tamon, Oktavian Tarnajaya, Karnia Thomas Eko Purwata Trisna Yuliharti Tersinanda Ursula Sulistiani Vany Novanty Vashti Saraswati Vitia Tandy Widhayanthi, Trisna A. Wiraguna AAGP Wiraguna, A A G P Wiraguna, A AGP Wiraguna, AAG Wiraguna, Anak A.G.P. Yuziana Yuziana

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