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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Indonesian Journal of Cancer Chemoprevention JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Dinamika Pengabdian (JDP) Panrita Abdi - Jurnal Pengabdian pada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Berkala Ilmiah Kimia Farmasi Riset Informasi Kesehatan JAMAS: Jurnal Abdi Masyarakat Camellia Borneo Journal of Pharmacy
Marcellino Rudyanto
Department Of Pharmaceutical Chemistry, Faculty Of Pharmacy, Airlangga University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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HUBUNGAN STRUKTUR TURUNAN N-KLOROBENZOILAMOKSISILIN DAN AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Kusumowati, Ika Trisharyanti Dian; Siswandono, .; Rudyanto, Marcellino
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 3 (2011)
Publisher : Indonesian Research Gateway

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Abstract

The aim of this research is to determine structure-activity relationship N-chlorobenzoylamoxicillin derivatives against Pseudomonas aeruginosa ATCC 27853. Antibacterial activities of the N-benzoylamoxicillin­ derivatives against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. The result showed that there was significance MIC of amoxycillin with N-benzoylamoxycillin, N-2-chlorobenzoylamoxycillin, and N-3-chlorobenzoylamoxycillin. Non linier regression between log MIC and lypophilic parameter N-chlorobenzoylamoxycillin derivatives showed -log KHM = 3,963 p2 - 3,001 p - 2,477, r = 0,906. To see more clearly quantitative strucuture-activity relationship of N-benzoylamoxicillin derivatives, further similar studies need to be done by increasing numbers of another N-benzoylamoxicillin derivative compounds.  ABSTRAK Penelitian ini bertujuan mengetahui hubungan struktur-aktivitas antibakteri senyawa-senyawa turunan N-kolorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853. Uji aktivitas antibakteri turunan senyawa N-klorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853 dilakukan dengan metode dilusi. Nilai KHM menunjukkan adanya perbedaan aktivitas yang bermakna antara amoksisilin dengan N-benzoilamoksisilin, N-2-klorobenzoilamoksisilin, dan N-3-klorobenzoilamoksisilin. Persamaan non linier log KHM dengan sifat lipofilik senyawa turunan N-klorobenzoilamoksisilin diperoleh -log KHM = 3,963 p2 - 3,001 p - 2,477, dengan harga r = 0,906.
HUBUNGAN STRUKTUR TURUNAN N-KLOROBENZOILAMOKSISILIN DAN AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Kusumowati, Ika Trisharyanti Dian; Siswandono, .; Rudyanto, Marcellino
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.49

Abstract

The aim of this research is to determine structure-activity relationship N-chlorobenzoylamoxicillin derivatives against Pseudomonas aeruginosa ATCC 27853. Antibacterial activities of the N-benzoylamoxicillin­ derivatives against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. The result showed that there was significance MIC of amoxycillin with N-benzoylamoxycillin, N-2-chlorobenzoylamoxycillin, and N-3-chlorobenzoylamoxycillin. Non linier regression between log MIC and lypophilic parameter N-chlorobenzoylamoxycillin derivatives showed -log KHM = 3,963 p2 - 3,001 p - 2,477, r = 0,906. To see more clearly quantitative strucuture-activity relationship of N-benzoylamoxicillin derivatives, further similar studies need to be done by increasing numbers of another N-benzoylamoxicillin derivative compounds.  ABSTRAK Penelitian ini bertujuan mengetahui hubungan struktur-aktivitas antibakteri senyawa-senyawa turunan N-kolorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853. Uji aktivitas antibakteri turunan senyawa N-klorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853 dilakukan dengan metode dilusi. Nilai KHM menunjukkan adanya perbedaan aktivitas yang bermakna antara amoksisilin dengan N-benzoilamoksisilin, N-2-klorobenzoilamoksisilin, dan N-3-klorobenzoilamoksisilin. Persamaan non linier log KHM dengan sifat lipofilik senyawa turunan N-klorobenzoilamoksisilin diperoleh -log KHM = 3,963 p2 - 3,001 p - 2,477, dengan harga r = 0,906.
Co-Authors Adam Hermawan Afandi, Ryan Ani Riani Hasana Anisa Tri Hutami Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Melani Hariyadi Dinda Monika Nusantara Ratri Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Setyawan Edy Meiyanto Edy Meiyanto Fauzia, Alfi Nur Hadi Poerwono I Nyoman Wijaya Idha Kusumawati Ika T. D. Kusumowati Siswandono, Ika T. D. Kusumowati Ika Trisharyanti Dian Kusumowati Isnaeni Juni Ekowati Kholis Amalia Nofianti Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Miatmoko, Andang Muhammad Agus Syamsur Rijal Noor Erma Nasution Noorma Rosita Nusandari, Ratna Retno Sari Rohana, Melissa Shigeru Sasaki Shigeru Sasaki Siammita, Dhea Anansya Siswandono, Siswandono Sudjarwo Sudjarwo Sugijanto Sukardiman Suzana Syahrani, Achmad Tristiana Erawati Tutiek Purwanti Tutuk Budiati Wibowo, Nadya Khadijah Widji Soeratri Wiwied Ekasari Yusuf, Helmy ZAINAL ABIDIN