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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biopropal Industri JRST (Jurnal Riset Sains dan Teknologi) Jurnal Ilmu Kefarmasian Indonesia Daengku: Journal of Humanities and Social Sciences Innovation Basic and Applied Nursing Research Journal Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Jurnal Pelayanan Pastoral (JPP) Sciences of Pharmacy Jurnal Kefarmasian Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
. Syamsudin
Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Efek Ekstrak Biji Leucaena leucocephala L. terhadap Profil Lipid Darah Tikus Diabetes Humairoh Hanan; Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 1 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The use of Leucaena leucochepala as an antidiabetic has already been known in society, but the support experiment was very rare. The purpose of this experiment is to know whether the extract of L. leucochepala semen have an effect to the blood lipid profile of a NIDDM rat which is streptozotocin (stz) induced. It is made in 6 groups, each group consist of 5 rats. Group 1: Normal control, group 2: Negative control (stz), group 3: Positive control (clorpropamid), group 4: Extract of Leucaena semen low dose (0.25 g/kg BW), group 5: Extract of Leucaena semen medium dose (0.5 g/kg BW) and group 6: Extract Leucaena semen high dose (1 g/kg BW). Rats are made hiperglycemia with iv induction of stz 50 mg/kg BW. Chlorpropamid and Leucaena semen extract are given orally. The experiment results of blood sugar level, total cholesterol, triglyceride, HDL and LDL are analyzed by ANOVA and continued with BNT test (p < 0.05). The result from the experiment is the high reduction of blood sugar level from the Leucaena semen extract high dose in amount of 65.30%. Results from the total cholesterol level of group 1:61.60 mg/dl, group 2: 91.60 mg/dl, group 3: 62.20 mg/dl, group 4: 76.00 mg/dl, group 5: 65.40 mg/dl and group 6: 55.80 mg/dl. Results from the triglyceride level of group 1: 83.40 mg/dl, group 2: 201.40 mg/dl, group 3: 133.40 mg/dl, group 4: 114.80 mg/dl, group 5: 93.20 mg/dl and group 6: 80.40 mg/dl. Results from the HDL level of group 1: 47.60 mg/dl, group 2: 26.40 mg/dl, group 3: 35.20 mg/dl, group 4: 43.40 mg/dl, group 5:58.40 mg/dl and group 6: 90.40 mg/dl. Results from the LDL level of group 1: -2.68 mg/dl, group 2:26.72 mg/dl, group 3: 0.32 mg/dl, group 4: 9.64 mg/dl, group 5:-11.64 mg/dl and group 6: -50.16 mg/dl.
Efek Antiplasmodium dari Ekstrak Etilasetat Kulit Batang Asam Kandis (Garcinia parvifolia) secara In Vitro Syamsudin Syamsudin; Budi Prasetyo; Antonius Antonius
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This research was carried out to assess the antiplasmodic activity of six fractions from the aethylacetate extract of the stem barks of Garcinia parfivolia. The result showed that fractions C, D, and G were IC50 < 10 µg/ml, fraction E: IC50 24,19 µg/ml, and fraction F and H: > 100 µg/ml against a chloroquine resistant strain of P. falciparum FCR-3.
Stres Oksidatif di dalam Model Kerja Obat Antimalaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Several antimalarial drugs may act by producing free radicals, anion superoxide through a redox cycling process with oxygen. The mode of action of chloroquine, primaquine, artemisinin, anthraquinone and xanthones as antimalarial drug is partly increasing the oxidative stress in the parasitized red blood cell.
Mekanisme Kerja Obat Antimalaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Malaria remains the most devastating infectious parasitic disease, inflicting both death and economic losses on at least half the world's population. Numerous attempts have been made to control the disease using vector control measures and/or chemoprophylaxis. Antimalarial drugs have a selective action on the different phases of the parasite life cycle. Mechanism of antimalarial drugs action will be discussed in this article.
Pemberdayaan kelompok masyarakat Desa Gunung Sari Kecamatan Pamijahan Kabupaten Bogor dalam pemanfaatan tanaman obat keluarga (TOGA) dan pembuatan jamu yang baik Greesty F Swandiny; Syamsudin Syamsudin; Riza Dharma Putra; Deni Rahmat
Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 4 (2022): Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat
Publisher : ARKA INSTITUTE

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Abstract

Tujuan kegiatan PKM membantu kelompok tani untuk dapat mengelola TOGA secara mandiri dengan melakukan pemberdayaan dalam memanfaatkan lahan pekarangan sebagai basis ekonomi lokal masyarakat kemudian tahapan berikutnya adalah upaya pembuatan jamu yang dapat diproduksi sehingga dapat membentuk unit usaha kecil masyarakat. Metode yang digunakan adalah membantu edukasi manfaat TOGA dengan memanfaatkan pekarangan rumah, pembuatan jamu kemudian dapat bermanfaat dan menambah nilai ekonomi masyarakat. Metode pendekatan yang digunakan adalah dengan brainstorming untuk membuka pola piker tentang pentingnya memiliki TOGA, menanamkan jiwa kewirausahaan masyarakat dengan memproduksi jamu yang baik yang tahapan paling penting dapat membentuk produk unggulan masyarakat dengan standar dan perizinan yang berlaku. Target dan capaian Kelompok masyarakat yang merupakan petani dan buruh tani dapat membuat kegiatan bermanfaat dengan mengelola TOGA, menanam tumbuhan berkhasiat obat yang dapat dimanfaatkan secara mandiri oleh masyarakat sekitar dan dapat membuat jamu secara mandiri. Luaran yang dihasilkan a) Luaran wajib : Terbentuknya kelompok tani yang mengelola TOGA yang dapat dikenal sebagai apotek hidup Desa Gunung Sari, terciptanya lahan pekarangan yang dimanfaatkan untuk menanam tanaman berkhasiat obat yang dapat dibuat sebagai bahan utama pembuatan jamu.b) Luaran tambahan : kegiatan diunggah pada youtube, pemberitaan di media massa dan satu artikel ilmiah yang dipublikasikan melalui Jurnal ber ISSN atau prosiding ber ISBN dari seminar nasional.
Risk Factor Analysis of Drug-Resistant Tuberculosis in Tuberculosis Patients at Level II Health Facilities in Depok City Anisa Rachmita Arianti; Syamsudin Syamsudin; Ros Sumarny; Lusi Nursilawati Syamsi
Daengku: Journal of Humanities and Social Sciences Innovation Vol. 4 No. 1 (2024)
Publisher : PT Mattawang Mediatama Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.daengku2224

Abstract

Based on Global Tuberculosis Report In 2022, Indonesia will be among the 10 countries contributing to the highest incidence of drug-resistant tuberculosis each year. There are 12,794 cases of drug-resistant tuberculosis in Indonesia with 7,884 cases starting treatment. The number of drug-resistant tuberculosis cases involves a variety of risk factors. This study aims to analyze the risk factors associated with drug-resistant tuberculosis. The research method is observational analytic design case control study. The research samples were patients with drug-resistant tuberculosis and drug-sensitive tuberculosis in Depok City Health Facilities for the period March 2022–May 2023. Data were collected using questionnaires and SITB (Tuberculosis Information System). Bivariate analysis using Chi Square, while multiple logistic regression multivariate analysis. The results of the study of 73 cases and 73 controls showed that the majority were aged 18 - 65 years, 89% of cases and 62% of controls, male gender was the most dominant, 64.4% of cases and 52% of controls, most of the respondents did not work 68.5 % of cases and 53.4% ​​of controls, most of them had low income, 82.8% of cases and 62% of controls. Most of the case group had a high level of education, namely 58.5%. Meanwhile, most of the control group had low education, 50.7%. Bivariately, risk factors associated with drug-resistant tuberculosis are HIV, history of previous treatment, adherence to taking medication and the role of drug swallowing supervisor (PMO). Based on multivariate analysis, the dominant variable associated with the incidence of drug-resistant tuberculosis is history of previous treatment (OR6.021 with CI 2.055-18.721) meaning that patients with a history of previous treatment have a 6 times risk of developing drug-resistant tuberculosis compared to patients without a history of previous treatment.
Aktivitas Antiinflamasi Crude Extract Fukoidan dari Sargassum crassifolium pada Sel RAW 264.7 yang Diinduksi LPS Hikariastri, Pangartika; Winarno, Hendig; Kusmardi, Kusmardi; Laksmitawati, Dian Ratih; Abdillah, Syamsudin
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1547

Abstract

Inflammation is known as the basic mechanism underlying various chronic diseases. Macrophage activation by inflammatory stimulus induces the release of inflammatory mediators, thus the mediators becoming a promising target of anti-inflammatory drug development. Previous studies indicated that fucoidan has anti-inflammatory activity by inhibiting the release of proinflammatory mediators. The aim of this study is determining anti-inflammatory activity of fucoidan crude extract form Sargassum crassifolium Garut waters by observing its effect on proinflammatory cytokines TNF-α, IL-1β, dan IL-6. Fucoidan is a polysaccharide substance which has various characteristics, depending on the source and the extraction method which is influencing its bioactivity. Sargassum crassifolium collected from Garut-West Java is extracted using diluted HCl 0,1 M and precipitated with ethanol to obtain fucoidan crude extract. The crude extract is tested on LPS-induced RAW 264.7 cells to evaluate its effect on TNF-α, IL-1β, and IL-6 level using ELISA method. The result showed that fucoidan crude extract decreased the level of TNF-α by the dose of 25 and 50 μg/ml, and decreased the level of IL-1β and IL-6 by the dose of 25 μg/ml. The dose of 50 μg/ml failed to inhibit IL-1β and IL-6 production. This study showed that fucoidan crude extract derived from S. crassifolium has anti-inflammatory activity to RAW 264.7 cells by the dose of 25 μg/ml.
Evaluation of Total Flavonoid Content, Xanthine Oxidase Inhibition, and Uric Acid Inhibitory Activity In Vitro and In Vivo of Ethanol Extract of Sida rhombifolia Aulena, Desi Nadya; Kumala, Shirly; Abdillah, Syamsudin; Rahmat, Deni; Sugiastuti, Fenty; Indarwati, Indarwati; Fitriyani, Dwi
Sciences of Pharmacy Volume 3 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0303255

Abstract

Secondary metabolites content in Sida rhombifolia L. (SR) are believed to inhibit the xanthine oxidase (XO) enzyme, which is responsible for converting hypoxanthine and xanthine into uric acid. This study aimed to compare flavonoid levels, XO inhibitory activity, and the reduction of uric acid levels of sidaguri herb, stem, leaves, and root extract both in vitro and in vivo. The research results showed that the highest total flavonoid content in SR was found in the leaves, at 21.29±0.08 mg/QE/g extract. The IC50 values were as follows: roots (EESRR 1096.07±1.07 ppm), stems (EESRS 561.62±7.01 ppm), leaves (EESRL 101.84±0.63 ppm), and herbs (EESRH 104.70±3.50 ppm). EESR can inhibit the XO enzyme and has potential as an anti-hyperuricemia agent. The best total flavonoid content and IC50 values were observed in EESRL, which are 21.29±0.08 mg/QE/g and 101.84±0.63 ppm, respectively. EESRL at a dose of 400 mg/kg BW has the equivalent ability to reduce blood uric acid levels in mice when compared to the positive control group. Based on these findings, it can be concluded that EESRL has significant potential as a natural XO inhibitor and can be considered a promising candidate for the development of anti-hyperuricemia treatments.
Study of Molecular Docking, Molecular Dynamics, Pharmacokinetics and Toxicity Prediction: Compounds from Nigella sativa Linn, Andrographis paniculata Nees, and Propolis as Inhibitors of Mycobacterium tuberculosis Growth Asarini; Abdillah, Syamsudin; Sani, Yulvian; Alam, Gemini
Basic and Applied Nursing Research Journal Vol 5 No 2 (2024): Basic and Applied Nursing Research Journal (BANRJ)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/banrj.05.02.02

Abstract

Background: Tuberculosis (TB) is caused by *Mycobacterium tuberculosis*, and Multiple Drug-Resistant Tuberculosis (MDR-TB) arises from resistance to first-line treatments like Rifampicin and Isoniazid. Since current TB medications have been used for over four decades, discovering new drug candidates is critical. This research focuses on herbal compounds—Black cumin (*Nigella sativa*), Sambiloto (*Andrographis paniculata*), and propolis—as potential inhibitors of *M. tuberculosis* by targeting DHFR. The objective of the study is to predict the activity of these herbal compounds prior to in vitro and in vivo testing. Methods: This study employed computational tools, including Molegro Virtual Docking (MVD) and Molecular Dynamics (MD), to assess the interactions of the herbal compounds with DHFR (PDB ID: 2CIG). Pharmacokinetic predictions were also conducted to evaluate the absorption and toxicity of the compounds. Results: Molecular docking and MD simulations indicated that Andrographolide, Thymoquinone, and Caffeic Acid Phenethyl Ester effectively inhibited the growth of *M. tuberculosis*. The analysis revealed favorable binding interactions and conformational changes in DHFR, with significant activity observed for Thymoquinone. Conclusion: This study suggests that Andrographolide, Thymoquinone, and Caffeic Acid Phenethyl Ester may serve as promising candidates for further development as anti-tuberculosis drugs. Subsequent in vitro and in vivo studies are warranted to validate their therapeutic potential.
Toxicity of Sida rhombifolia L. 96% ethanol extract based on LD50 and macropathological examination of mice's organs Aulena, Desi Nadya; Kumala, Shirly; Abdillah, Syamsudin; Rahmat, Deni; Zaidan, Sarah; Fitriyani, Dwi; Raihan, Dany
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1463

Abstract

The Indonesian people empirically use Sidaguri (Sida rhombifolia L.) in medicine, such as anti-hyperuricemia. Herbal-based treatment is currently much preferred. Drug metabolism, in general, mainly occurs in the liver, so the possibility of damage to this organ is high. This study aims to determine the acute toxicity category of 96% ethanol extract of sidaguri based on the LD50 value, changes in body weight, changes in organ weight, and macro pathology in the organs of male DDY mice in vivo. The method used in this research was experimental with a fixed dose design following the Indonesian Food and Drug Authority regulations regarding guidelines for in vivo non-clinical toxicity tests. The test group was divided into six dose groups (standard, 50, 300, 2000, 5000, and 15000 mg/kg Body of weight). Observations were made for 24 hours. Observations were continued for 14 days on death parameters, toxicity symptoms, body weight, and relative organ weights using five main organs (heart, lungs, liver, spleen, and kidneys, and pathological examination). The acute toxicity test results showed no death in all dose treatment groups. Macropathological analysis did not show abnormalities in organs in all groups of mice. LD50 value is more than 15000 mg/kg. Sidaguri 96% ethanol extract is safe and Practically non-toxic.
Co-Authors . Darmono A. Keban, Sesilia Anisa Rachmita Arianti Antonius Antonius Asarini Aulena, Desi Nadya Basilianus, Edward Budi Prasetyo Chandra Wiguna Brata Cyntia Cyntia Dacosta, Fransiska Deni Rahmat Dian Ratih Laksmitawati Diandy, M. Ivan Dwi Fitriyani, Dwi Dwiyanti, Luvty S.L. Fatty Nurhasanah Fetri Charya Munarsih Ganiswarna S Gemini Alam Gracia Sakristi, Maria Antonia Greesty Finotory Swandiny Haryo Haryo Hendig Winarno Hermawati, Ema Hikariastri, Pangartika Humairoh Hanan I. W.T. Wibawan Indarwati Indarwati Irma L. M. Kartiningsih Kartiningsih Kokadir, Sucipto Kusmardi Kusmardi Lilik Sulastri Lusi Nursilawati Syamsi MANUEL HUTAPEA, MANUEL Natadidjaja, Ronald Irwanto Nur Rahmi Hidayati, Nur Rahmi Partomuan Simanjuntak Partomuan Simanjuntak Putra, Fahreza Pratama Putri, Vinessa Gracia RAHMAT, DENI Raihan, Dany Riza Darma Putra Ros Sumarny ROS SUMARNY Sadikin M Sesilia A. Keban Shirly Kumala Sugiastuti, Fenty Suyatna FD Swandiny, Greesty Finotory Syafawi, M. Irfan Yayan Rizikiyan Yohanes Subasno Yulvian Sani Zaidan, Sarah