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All Journal Sosiohumaniora Dentika Dental Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Scientific Dental Journal B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi MDJ (Makassar Dental Journal) Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal of Syiah Kuala Dentistry Society

Tenny Setiani Dewi

Universitas Padjadjaran

Author-ID : 376563

Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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MANAGEMENT OF SEVERE XEROSTOMIA AND ORAL CANDIDIASIS IN PATIENT WITH VALVULAR HEART DISEASE: A CASE REPORT Helen Christine; Tenny Setiani Dewi; Wahyu Hidayat
Dentino : Jurnal Kedokteran Gigi Vol 6, No 2 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i2.12008

Background: Valvular heart disease is a heart valve disorder that needs complex multiple medications by administering certain drugs that cannot be replaced with other drugs because of different mechanisms of action. Beta-blockers and Angiotensin-Converting Enzyme inhibitors are drugs of choice for valvular heart disease, with diuretics and antipsychotics can cause xerostomia. Valvular heart disease patient who has a severe infection or sepsis needs long-term antibiotic treatment. Xerostomia and long-term antibiotic treatment are predisposing factors for oral candidiasis. Objective: to discuss oral candidiasis and severe xerostomia because of multiple medications in valvular heart disease patients. Case: A 58-year-old male was referred from Cardiology and Vascular Medicine Department with a chief complaint of sore tongue and pain at swallowing since 3 days ago with dry sensation of the mouth. Extraoral examination revealed dry and exfoliative lips, intraoral examination revealed fissured and lobulated tongue and white plaques could be scraped off leaving erythematous area oropharynx and tongue. The diagnoses were oropharyngeal candidiasis and severe xerostomia score of 8 according to the Chalacombe scale. Case Management: Patient was treated with nystatin, chlorine dioxide, 0.12 % chlorhexidine digluconate mouthwash, and vaseline album. Oral candidiasis was disappeared on the 22nd day of treatment. Conclusion: Xerostomia and oral candidiasis in patients with valvular heart disease require appropriate therapy, more intensive monitoring by considering the patient's general condition, and interprofessional team collaboration in the therapy of the main disease. Keywords: Oral candidiasis, Valvular heart disease, Xerostomia

Correlation between salivary zinc levels and salivary volume on taste disorders in elderly patients Dewi Kania Intan Permatasari; Tenny Setiani Dewi; Dewi Marhaeni Diah Herawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 1 (2021): March 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i1.p31-34

Background: Taste disorders often occur in the elderly, which can have serious consequences on their health status. Zinc and saliva volume have a role in maintaining taste acuity, especially in the elderly. Purpose: This study was to determine the correlation between salivary zinc levels, salivary volume, and taste disorders in elderly patients. Methods: This was a cross-sectional research. Elderly patients with and without taste disorders were included in this study. Salivary zinc levels were measured using the Atomic Absorption Spectrometry (AAS) method. Salivary volume was measured using the spitting method. The correlation between salivary zinc levels, salivary volume, and taste disorders was analysed using the chi-square test. Multivariate analysis was performed to control for confounding variables with logistic regression. Results: Based on our findings, no significant correlation was determined between the levels of zinc in saliva and taste disorders. However, there was a significant correlation between salivary volume and taste disorders. Salivary volume and smoking were determined to be associated with taste disorders. Conclusion: This research showed that salivary zinc levels were not correlated with taste disorders; on the contrary, salivary volume was correlated with taste disorders. Smoking was determined to be a confounding variable on taste disorders in elderly patients.

Temuan susuk pada gambaran radiografi seorang wanita dengan nyeri orofasialThe radiographic finding of charm needles in a woman with orofacial pain Etis Duhita Rahayuningtyas; Tenny Setiani Dewi
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 2 (2020): Agustus 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i2.23831

Pendahuluan: Susuk merupakan struktur mirip jarum logam yang disematkan ke dalam jaringan lunak. Nyeri orofasial pada pengguna susuk, dapat diakibatkan karena trauma dan nyeri saat pemakaian gigi tiruan, neuralgia benda asing, potensi kerusakan organ vital atau penetrasi pada struktur neurovaskuler. Laporan kasus ini bertujuan membahas keluhan nyeri orofasial pada seorang wanita yang telah diderita selama 3 tahun dan memiliki riwayat pemasangan susuk. Laporan kasus: Pasien wanita, 38 tahun datang dengan keluhan sakit menusuk dan berdenyut pada sisi kanan wajah yang muncul dan hilang timbul sejak kurang lebih 3 tahun yang lalu. Pasien telah memeriksakan diri ke bagian saraf, Telinga Hidung Tenggorokan (THT), dan dokter gigi umum tetapi keluhan tetap ada. Hasil pemeriksaan di bagian Ilmu Penyakit Mulut dalam batas normal, tampak mukosa pucat akibat overextended sayap gigi tiruan sebagian lepasan (GTSL). Hasil radiografi tampak sisa akar 14 dan corpus alienum pada rahang atas dan bawah. Rencana perawatan yaitu ekstraksi akar 14 serta penyesuaian gigi tiruan. Satu tahun kemudian, pasien datang kembali dengan keluhan nyeri telah berkurang, namun terkadang muncul. Lokasi nyeri diawali dari titik corpus alienum (susuk) rahang atas, kemudian menyebar ke bibir dan pipi kanan. Sisa akar 14 dan susuk di regio bukal 16 dianggap sebagai benda asing yang dapat mencetuskan terjadinya neuralgia (foreign body neuralgia). Pencabutan sisa akar mampu mengurangi kualitas nyeri, tetapi susuk belum dihilangkan. Nyeri yang masih tersisa diterapi antikonvulsan, anti nyeri dan multivitamin. Simpulan: Corpus alienum susuk pada gambaran radiografi pasien ini, dapat menjadi salah satu sumber penyebab keluhan nyeri orofasial. Tatalaksana komprehensif dari berbagai disiplin ilmu diperlukan dalam kasus nyeri orofasial.Kata kunci: Nyeri, orofasial, susuk. ABSTRACTIntroduction: Charm needles are metal-based pin inserted within the soft tissue. Orofacial pain in charm needles wearers could be caused by trauma and pain in full denture patients, foreign body neuralgia, and potential damage to vital organs and penetration of neurovascular structures. This case report was aimed to discuss orofacial pain in a woman with charm needles that has been occurred in 3 years. Case report: A 38-year woman, complaining of spontaneous stabbing and throbbing pain on the right side of the face for three years prior. The patient had examinations from the neurologist, otolaryngologist, and general dentist, but the complaint remained. Clinical examinations at the Oral Medicine Department showed a normal and pale mucosa which recognised as an overextended denture. Radiographic findings showed the remaining root of tooth #14 and a corpus alienum over the maxillary and mandibular region. Root extraction and adjustment of denture were performed. One year later, the patient came back with a complaint of reduced pain but sometimes emerged from the point of the maxillary corpus alienum (charm needles), then spread to the right lip and cheek. The remaining root of tooth #14 and the charm needles in the buccal region #16 were considered as foreign objects that can trigger neuralgia (foreign body neuralgia). Root extraction could reduce the pain, but the charm needles was not extracted. Existing pain was treated with anticonvulsants, analgesic, and multivitamins. Conclusion: Corpus alienum in the form of charm needles in the patient’s radiographic finding can be one source of orofacial pain. Comprehensive treatment from different field of disciplines is needed in the orofacial pain case.Keywords: Pain, orofacial, charmed needles.

Kelainan variasi normal lidah yang dipicu makanan pedas dan panas pada pasien dengan kondisi anemiaAbnormalities in normal tongue variation triggered by hot and spicy food in anaemic patients Nuri Fitriasari; Tenny Setiani Dewi; Etis Duhita Rahayuningtyas
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 3 (2021): Februari 2021 (Suplemen 2)
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i3.30723

Pendahuluan: Lidah dalam filosofi medis dipercaya sebagai barometer kesehatan rongga mulut maupun tubuh secara keseluruhan. Permukaan mukosa lidah kadang memperlihatkan gambaran yang berbeda dari kondisi normal sehingga disebut variasi normal. Geographic tongue dan fissured tongue merupakan suatu variasi normal yang asimptomatik namun dapat menjadi simptomatik ketika dipengaruhi suatu kebiasaan baru yang bersifat mengiritasi seperti setiap hari mengkonsumsi makanan yang memiliki rasa pedas yang ekstrim. Tujuan laporan kasus ini memaparkan tentang kelainan pada variasi normal lidah yang dipicu oleh kebiasaan baru konsumsi makanan tersebut pada seorang pasien remaja. Pasien juga kemudian diketahui dalam kondisi anemia. Laporan kasus: Seorang wanita berusia 18 tahun berobat ke Poliklinik Ilmu Penyakit Mulut RSUP.Dr Hasan Sadikin dengan diagnosis geographic tongue disertai fissured tongue. Pasien mengeluhkan sakit pada lidah dan terasa mati rasa serta nyeri seperti tertusuk-tusuk, terutama jika terkena makanan pedas, sejak satu tahun yang lalu. Terdapat riwayat mengonsumsi makanan yang pedas dan panas hampir setiap hari. Hasil pemeriksaan penunjang hematologi menunjukkan pasien dalam kondisi anemia. Penatalaksanan yang dilakukan meliputi instruksi menjaga kesehatan rongga mulut, pemberian preparat Fe, B12, dan asam folat, serta obat kumur. Pasien menunjukkan perbaikan dalam pengobatan selama 3 minggu. Simpulan: Kondisi variasi normal pada lidah yang semula asimtomatik dapat menjadi simtomatik akibat iritasi makanan panas dan pedas, pada pasien dengan kondisi anemia.Kata kunci: Geographic tongue, fissured tongue, variasi normal lidah, makanan pedas dan panas, anemia. ABSTRACTIntroduction: In medical philosophy, the tongue is believed to be a barometer of the oral cavity’s health and the body as a whole. The mucosal tongue surface often shows a different feature from normal conditions, thus called normal variation. Geographic tongue and fissured tongue are normal variations that are asymptomatic but can become symptomatic when influenced by new irritating habits such as daily food consumption with an extremely spicy taste. This case report was aimed to describe abnormalities in normal tongue variation triggered by the new habit of consuming such foods in a teenage patient. The patient was also found to be anaemic. Case report: An 18-year-old woman went to the Oral Medicine Polyclinics of Dr Hasan Sadikin Hospital with a geographic tongue diagnosis accompanied by the fissured tongue. The patient complained of a sore tongue and felt numbness and soreness like being prickly, especially when exposed to spicy food, since one year prior. There was a history of spicy and hot foods consumption almost every day. The results of the haematology examination showed that the patient was in an anaemic condition. The treatment included instructions for maintaining oral health, administration of Fe, B12, folic acid preparations, and mouthwash usage. The patient showed improvement after treatment for three weeks. Conclusion: The condition of normal tongue variation, which initially asymptomatic, can become symptomatic due to irritation of hot and spicy food in anaemic patients.Keywords: Geographic tongue, fissured tongue, normal tongue variations, hot and spicy food, anaemia.

Terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemikOral lesion therapy in patients with Stevens-Johnson syndrome with systemic lupus erythematosus Yongki Tamigoes; Tenny Setiani Dewi
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 30, No 3 (2018): Desember
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Adverse drug reaction (ADR) merupakan salah satu respon tubuh manusia tidak diinginkan dan berbahaya yang disebabkan penggunaan obat meskipun dalam dosis normal. ADR dapat menyebabkan terjadinya sindrom Stevens-Johnson (SJS) serta dapat memicu lupus eritematosus sistemik (SLE), yang salah satu manisfestasinya sebagai krusta hemoragik dan erosi yang luas pada mulut dan peri–oral, dapat mengganggu fungsi mulut sehingga terganggunya asupan makanan. Laporan kasus ini bertujuan untuk menjelaskan terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemik. Laporan kasus: Seorang pasien wanita berusia 57 tahun dengan riwayat penyakit meningitis tuberkulosis dirujuk ke Bagian Penyakit Mulut dari departemen Ilmu Kesehatan Kulit dan Kelamin dengan diagnosis SJS, pasien mengeluhkan kesulitan untuk membuka mulutnya, sakit menelan dan sakit pada bibir. Terdapat riwayat pemakaian obat ofloxacin, streptomysin, dan OAT. Pemeriksaan ekstraoral menunjukkan beberapa lesi diskret pada wajah, konjungtiva anemis, lesi erosif dan krusta hemoragik pada bibir. Pemeriksaan intraoral ditemukan lesi erosif pada mukosa bukal dan palatal serta plak putih pada dorsal lidah. Pemeriksaan darah rutin menunjukkan hemoglobin, hematokrit, leukosit, MCV, MCH, eosinofil, netrofil, limfosit, protein total dan albumin rendah sedangkan uji ANA positif, sehingga diagnosis ditegakkan sebagai lesi oral terkait SJS disertai SLE dan kandidiasis oral. Medikasi yang diberikan adalah Chlorhexidine gluconate 0,1%, nistatin suspensi oral, vitamin B12, asam folat, dan topikal kortikosteroid. Lesi oral menunjukkan perbaikan dalam waktu 3 minggu, pada pasien terjadi SJS dan SLE secara bersamaan hal ini menunjukkan adanya keterlibatan mekanisme imunologi Simpulan: Terapi non farmakologi berupa pemberian kortikosteroid topikal,obat kumur Chlorhexidine gluconate 0,1%, vitamin B12, asam folat, dan nistatin yang menunjukkan perbaikan pada lesi oral dalam 3 minggu perawatan, di tambah dengan terapi non farmakologi berupa pemeliharaan kebersihan rongga mulut dengan obat kumur Chlorhexidine gluconate 0,1% sebagai antiseptik untuk meningkatkan kenyamanan pasien, untuk memfasilitasi epitelisasi dan mencegah komplikasi seperti infeksi.Kata kunci: Adverse Drug Reaction, lesi oral, sindrom Stevens-Johnson, lupus eritematosus sistemik. ABSTRACT Introduction: Adverse drug reaction (ADR) is one of the unwanted and dangerous human body responses caused by the use of medications even in regular doses. ADR can cause Stevens-Johnson syndrome (SJS) and trigger systemic lupus erythematosus (SLE), with manifestation such as extensive haemorrhagic and erosive crusts in the mouth and peri-oral, which can interfere the oral function and disrupt the food intake. This case report was aimed to explain the treatment of oral lesions in patients with Stevens-Johnson syndrome with systemic lupus erythematosus. Case report: A 57-years-old female patient with a history of tuberculous meningitis was referred to the Oral Medicine Department of the Skin and Gynecology Polyclinics with a diagnosis of SJS, chief complaints of difficulty in opening her mouth, ingesting, and lips soreness. There was a medication history of ofloxacin, streptomycin, and OAT drugs. Extraoral examination indicated several facial discrete lesions, anaemic conjunctiva, erosive lesions, and hemorrhagic crusts on the lips. The intraoral examination found erosive lesions of the buccal and palatal mucosa and white plaques on the dorsal tongue. Routine blood tests showed the low level of haemoglobin, haematocrit, leukocytes, MCV, MCH, eosinophils, neutrophils, lymphocytes, and also low total protein and albumin, while the ANA test was positive. Thus the diagnosis was established as oral lesions associated with SJS with SLE and oral candidiasis. Medications administered were 0.1% chlorhexidine gluconate, nystatin oral suspension, vitamin B12, folic acid, and topical corticosteroids. Improvement in the oral lesions healing occurred within 3 weeks. SJS and SLE symptoms were simultaneously occurred in the patient, showed the involvement of immunological mechanisms. Conclusion: Non-pharmacological therapy in the form of topical corticosteroids, 0.1% chlorhexidine gluconate mouthwash, vitamin B12, folic acid, and nystatin, showed improvement in oral lesions within 3 weeks of treatment, added by non-pharmacological therapy in the form of maintaining oral hygiene with 0.1% Chlorhexidine gluconate mouthwash as an antiseptic to improve the patient’s comfort, and facilitate the epithelialisation and prevent complications such as infections.Keywords: Adverse drug reaction, oral lesion, Stevens-Johnson syndrome, systemic lupus erythematosus.

Manajemen perawatan pasien dengan manifestasi oral pasca difteriMedical management of patient with post diphtheria oral manifestations Eliza Kristina Marsintauli Munthe; Tenny Setiani Dewi
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 2 (2019): Agustus 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v31i2.17969

Pendahuluan: Difteri kembali mewabah di Indonesia. Kementerian Kesehatan menetapkan status kejadian luar biasa dengan jumlah 907 kasus dari 29 provinsi hingga 25 Desember 2017. Jawa Barat merupakan provinsi dengan kasus difteri kedua terbanyak dengan jumlah 123 kasus dan jumlah kematian 13 kasus. Difteri merupakan penyakit infeksi akut disebabkan Corynebacterium diphtheriae menghasilkan eksotoksin penyebab kerusakan jaringan, pembentukan pseudomembran dan edema jalan nafas dapat berakhir pada kematian. Penurunan kondisi umum ini dapat menjadi faktor predisposisi mengubah Candida albicans komensal di rongga mulut menjadi patogen oportunistik sehingga mampu menyebabkan infeksi yang memperberat kondisi pasien. Tujuan laporan kasus ini untuk membahas manajemen perawatan multidisiplin ilmu pada pasien dengan manifestasi oral pasca difteri. Laporan kasus: Pasien laki-laki berusia 57 tahun dirujuk dari departemen Ilmu Penyakit Dalam dengan diagnosis tonsilitis difteri disertai kandidiasis orofaringeal. Terdapat keluhan nyeri menelan, disertai timbulnya multipel ulser dan bercak putih pada mukosa oral, serta plak tebal putih kekuningan di posterior rongga mulut. Diagnosis ditegakkan sebagai lesi oral terkait difteri disertai kandidiasis orofaringeal. Sakit menelan menyebabkan pasien kekurangan asupan nutrisi. Medikasi yang diberikan meliputi nistatin oral suspensi, multivitamin, antiseptik klorheksidin glukonat 0,2 %, serta diet cair tinggi kalori. Ulser mengalami penyembuhan, bercak putih menipis dan hilang dalam waktu 6 hari pemberian terapi. Manajemen perawatan lesi oral yang adekuat melalui terapi farmakologis, terapi penunjang dan edukasi yang komprehensif memiliki efikasi bagi pasien. Simpulan: Manajemen perawatan dengan manifestasi oral difteri berhasil dilakukan dengan melalui terapi farmakologis, terapi penunjang dan edukasi yang komprehensif. penekanan kebersihan mulut pasien, karena kebersihan gigi dan mulut dapat mencegah timbulnya infeksi oportunistik yang dapat memperparah keadaan rongga mulut.Kata kunci: Candida albicans, difteri, kandidiasis, lesi rongga mulut ABSTRACTIntroduction: Diphtheria once again is endemic in Indonesia. The Ministry of Health determines the status of extraordinary events with a total of 907 cases from 29 provinces until December 25, 2017. West Java is the province with the second most diphtheria cases with a total of 123 cases and a total of 13 cases of death. Diphtheria is an acute infectious disease caused by Corynebacterium diphtheriae producing exotoxins that cause tissue damage, pseudomembranous formation and airway oedema can end in death. A decrease in this general condition can be a predisposing factor to change commensal Candida albicans in the oral cavity into opportunistic pathogens so that they can cause infections that aggravate the patient's condition. The purpose of this case report is to discuss the management of multidisciplinary science care in patients with post diphtheria oral manifestations. Case report: A 57-year-old male patient was referred from the Internal Medicine department with a diagnosis of diphtheria tonsillitis accompanied by oropharyngeal candidiasis. There are complaints of painful swallowing, accompanied by multiple ulcers and white patches on the oral mucosa, as well as a thick yellowish-white plaque in the posterior oral cavity. The diagnosis is made as an oral diphtheria-associated oral lesion accompanied by oropharyngeal candidiasis. Swallowing pain causes the patient to lack nutritional intake. Medications include oral suspension nystatin, multivitamins, antiseptic chlorhexidine gluconate 0.2%, and a high-calorie liquid diet. The ulcer healed thin white spots and disappeared within 6 days of therapy. Management of adequate oral lesion care through pharmacological therapy, supporting therapy and comprehensive education has efficacy for patients. Conclusion: Treatment management with oral manifestations of diphtheria has been successfully carried out through pharmacological therapy, supporting therapy and comprehensive education. Emphasis on oral hygiene of patients, because dental and oral hygiene can prevent opportunistic infections that can worsen the state of the oral cavity.Keywords: Candida albicans, diphtheria, candidiasis, oral cavity lesions

Oral Opportunistic Infections in Patient with HIV Wasting Syndrome Mega Rafika; Tenny Setiani Dewi
Scientific Dental Journal Vol. 3 No. 1 (2019): JANUARY
Publisher : Faculty of Dentistry, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26912/sdj.v3i1.3608

Background: Human immunodeficiency virus (HIV) wasting syndrome is a condition in which weight loss, fever, and chronic diarrhea occur for more than 30 days without any causes other than HIV infection. HIV causes an immunocompromised condition resulting in susceptibility to infection. The opportunistic infections are oral candidiasis, herpes simplex virus (HSV), and tuberculosis. This study aims to explain oral opportunistic infections in a patient with wasting syndrome. Case Report: A 20-year-old female, who was 165 cm in height and 33.75 kg in weight, with wasting syndrome, pulmonary tuberculosis, oral candidiasis, and angular cheilitis was referred from an internist in Hasan Sadikin Hospital. Extraoral examination showed a yellowish brownish crust on the lips. Intraoral examination showed multiple ulcers covered by a yellowish membrane on the labial mucosa. The white plaques were scrapable, and an erythematous was found on the dorsum of the tongue, buccal mucosa, and palate. Laboratory results revealed a decrease in hemoglobin, hematocrit, leucocyte, erythrocyte, basophil, neutrophil, lymphocyte, albumin, reactive anti-HSV IgG, CD4 16 cell/µl, mycology culture test, chest x-ray, and sputum. On the basis of anamnesis, clinical features, and laboratory examination, the patient was diagnosed with stomatitis herpetica and oral candidiasis. Chlorhexidine gluconate 0.2%, nystatin oral suspension, vitamin B12, folic acid, and vaseline album were administered on the lips. Clinical recovery of oral candidiasis was accomplished after five weeks of therapy. Conclusion: Opportunistic infections in patient with wasting syndrome are oral candidiasis, herpetic stomatitis, and tuberculosis.

HAEM, DIEM atau OEM? Agam Ferry; Tenny Setiani Dewi
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.55770

Diagnosis erythema multiforme (EM) diklasifikasikan menjadi tipe mayor dan minor. EM dapat dipicu oleh obat (drug-induced erythema multiforme/ DIEM) atau infeksi virus herpes simplex (herpes associated erythema multiforme/ HAEM), dengan dua gambaran utama: lesi target tipikal atau atipikal pada kulit dan nekrosis sel satelit atau epitelium yang luas. Oral erythema multiforme (OEM) dimasukkan dalam klasifikasi diagnosis EM kategori ketiga selain tipe mayor dan minor dengan gambaran klinis berupa ulserasi pada bibir dan mukosa intra oral khas EM, tanpa disertai lesi target di kulit. Seorang wanita, 14 tahun, datang ke Poli Ilmu Penyakit Mulut SMF Gimul RSHS setelah sebelumnya dirujuk dari bagian Bedah Mulut RSHS dengan diagnosa suspek EM. Pada pemeriksaan ekstra oral terlihat lesi krusta berwarna coklat kehitaman pada bibir atas dan bawah, yang diakui pasien muncul setelah mengkonsumsi obat untuk penyakit kulit yang dideritanya dan mengganggu aktivitas bicara serta makan. Pasien diterapi menggunakan salep steroid racikan selama 1 minggu disertai instruksi untuk menghentikan pemakaian obat untuk penyakit kulitnya. Pasien meperlihatkan perbaikan yang signifikan pada kunjungan kontrol 1 minggu. Diagnosis suspek DIEM dan suspek Lesi oral terkait hipersensitivitas ditegakkan pada pasien ini. berdasarkan pertimbangan adanya pengaruh medikasi untuk pengobatan kelainan kulit yang dideritanya. Hasil pemeriksaan IgE negatif dan IgG anti HSV-1 yang reaktif serta hasil observasi pada kunjungan kontrol lebih lanjut, juga mengarahkan penegakkan diagnosis HAEM dan OEM. Penting mendiagnosa EM dengan baik, agar mampu melakukan tatalaksana dini yang tepat, untuk mendapatkan prognosis yang baik.

TRANSISI PEMPHIGUS FOLIACEUS MENJADI PEMPHIGUS VULGARIS DENGAN KETERLIBATAN LESI ORAL : LAPORAN KASUS Suniti Suniti; Tenny Setiani Dewi
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 5, Nomor 2, Desember 2018
Publisher : Universitas Baiturrahmah

Pendahuluan Transisi Pemphigus Foliaceus (PF) menjadi Pemphigus Vulgaris (PV) dikonfirmasi dengan pemeriksaan antidesmoglein. Pada PF target perlekatan sel glikoprotein desmoglein-1 (dsg-1) sedangkan target PV di dsg-1 dan desmoglein-3 (dsg-3). Transisi PF menjadi PV merupakan kasus jarang dan sulit dipahami mekanismenya. Tujuan Kasus ini mendeskripsikan transisi PF menjadi PV. Kasus Seorang laki-laki 35 tahun dirujuk dari Ilmu Penyakit Kulit Kelamin didiagnosis PF. Keluhan luka di sudut bibir kiri, nyeri dan sulit membuka mulut. Pemeriksaan ekstraoral didapatkan lesi di sudut bibir kiri menyambung ke pipi ditutupi krusta dan tendesi perdarahan. Intraoral ditemukan lesi eritem, ditutupi pseudomembran putih pada 1/3 dorsum lidah, lateral lidah, kiri, mukosa bukal, tidak sakit. Lesi perbaikan setelah diterapi dan 3 bulan kemudian kambuh didiagnosis PV. Ekstraoral ditemukan lesi erosif, eritem, krusta pada bibir dan intraoral terdapat lesi erosif, eritem di mukosa labial, mukosa bukal, serta dorsum lidah. Penatalaksanaan Terapi diberikan Dexametason, Nystatin, Chlorhexidine gluconate 0,2% dan lesi mengalami perbaikan. Pembahasan Transisi PF menjadi PV pada kasus ini setelah terjadi kekambuhan beberapa kali. Mekanismenya sulit dipahami, diduga adanya inflamasi jaringan terpapar sistem imun karena tingginya aktivitas penyakit. Perubahan PF menjadi PV tergantung kualitas dan kuantitas transisi profil anti-dsg3(-) / dsgl(+) menjadi anti-dsg3(+) / dsgl(+). Secara histopatologi akantolisis pada PF terjadi di suprabasal sedangkan PV di subkorneal. Lesi oral jarang ditemukan terjadi pada PF oral sedangkan PV sebaliknya. Simpulan Transisi PF menjadi PV terjadi dikarenakan kekambuhannya. Lesi oral dapat menjadi salah satu indentifikasi terjadinya transisi PF menjadi PV.

PENTINGNYA MENDETEKSI ORAL LEUKOPLAKIA SEBAGAI ORAL POTENTIALLY MALIGNANT DISORDERS (LAPORAN KASUS) Revi Nelonda; Tenny Setiani Dewi
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 5, Nomor 2, Desember 2018
Publisher : Universitas Baiturrahmah

Oral Leukoplakia (OL) is white plaque lesion in oral mucosa that cannot be scraped and one of Oral Potentially Malignant Disorder (OPMD) with incidence about 2.5% of all populations in the world. The most case of oral squamous cell carcinoma are preceded by OPMD. The aim of this case report is to understand the importance of detection oral lesion that could potentially become malignancy. A 28-year-old male patient complained of sores on his tongue that had not healed for 2 months. Intraoral examination obtained red and white lesion on the left lateral tongue: shallow reddish ulcer with irregular border in region 35-36, followed by unscrapable white plaque lesion with slight induration in region 37-38. Hematological examination showed normal range. According anamnesis and clinical examination, diagnosis of traumatic ulcer and OL were made. Patients were treated with multivitamins and antiseptic mouthwash. Histopathological examination results from lesion biopsies show a hyperplastic mass, parakeratosis and a tissue with polymorphic form, a hyperchromatic nucleus of cells associated with histopathologic criteria of squamous cell carcinomas with well differentiation. The patient was referred to the Hemato-oncology Department for chemotherapy. There are two important parameters should be considered when evaluating the potential for malignant change of OL that is when finding white lesions with or without red lesions should always be suspected as OPMD and always confirm it by histopathological examination as early as possible. Accurate examination and histopathologic examination is essential to obtain a good prognosis in OPMD.

Co-Authors Achmad Noerkhaerin Putra Adji Kusumadjati Agam Ferry Agam Ferry Akbari, Gusti Amira Shafuria Ani Megawati Areta Tera Lova, Areta Tera Arintya, Nabilla Rifda Devi Nasution Dewi Kania Intan Permatasari Dewi Kania Intan Permatasari Dewi Marhaeni Diah Herawati Dewi Zakiawati Djou, Rahmatia Dudi Aripin Eka Chemiawan Eliza Kristina Marsintauli Munthe Erry Mochamad Arief, Erry Mochamad Etis Duhita Rahayuningtyas Etis Duhita Rahayuningtyas Fika Faradillah Drakel Fitri Dona Siregar Hapid, M. Hasan Hasanah, Novia Tri Helen Christine Helen Christine Ida Ayu Astuti, Ida Ayu Indra Gunawan Irna Sufiawati Isnaniah Malik Lefaan, Yannie Febby Mega Rafika Nabilla Rifda Nanny Natalia M Soetedjo Nelly Nainggolan Nuri Fitriasari Rahmatia Djou Rahmatia Djou Rajasa, Adrianus Surya Wira Revi Nelonda Ridho, Faiznur Rita Wardhani Rosiliwati Wihardja, Rosiliwati Rudi Wisaksana Sri Susilawati Sundari, Marini Suniti Suniti Suroso, Diptakanya Murdi Trinugroho Heri Fadjari, Trinugroho Heri Tun Abdul Majid, Tun Shafiqah Vieri, Audrey Amber Wahyu Hidayat Wahyu Hidayat Wicaksono, Imme Kris Yongki Tamigoes Yuliana Yuliana

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