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Pharmacological and low-level laser therapy in radiation-induced oral mucositis in patients with head and neck cancer Wicaksono, Imme Kris; Hapid, M. Hasan; Dewi, Tenny Setiani; Sufiawati, Irna; Kusumadjati, Adji
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 1 (2025): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i1.p95-99

Abstract

Background: Oral mucositis (OM) is common in people undergoing radiotherapy, chemotherapy, or a combination of both. Pharmacological and low-level laser therapy (LLLT) are potential treatments to reduce pain and accelerate the healing process. Purpose: The aim of this case report is to describe the effectiveness of combining pharmacological therapy and LLLT for OM. Case: A 54-year-old man with post-hemi glossectomy diagnosed with tongue cancer was referred from the radio-oncology department with complaints of painful sores all over the oral cavity after receiving radiotherapy. The canker sores worsened when eating but felt more comfortable when drinking cold water. Intraoral examination revealed erythematous lesions accompanied by fibrinous pseudomembranes and yellowish-white plaques, which could be scraped off, leaving erythematous areas with pain. These lesions were present on the upper and lower labial mucosa and the right and left buccal mucosa. The diagnosis was grade-3 OM, according to the World Health Organization (WHO) criteria. Case management: Pharmacological therapy included 0.025% hyaluronic acid gargles three times a day and the use of LLLT with a wavelength of 976 nm. Conclusion: The combination of pharmacological therapy with LLLT was effective in maintaining and improving the condition of the oral mucosa by reducing pain and ultimately improving the patient’s quality of life.
Tata laksana perburukan mukositis oral akibat radiasi pada pasien kanker kepala leher: Laporan kasus Rajasa, Adrianus Surya Wira; Dewi, Tenny Setiani
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 36, No 2 (2024): Agustus 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v36i2.52823

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Pendahuluan: Mukositis oral merupakan kondisi inflamasi dan ulserasi mukosa oral yang salah satunya akibat terapi radiasi. Dokter gigi berperan dalam melakukan tata laksana mukositis oral akibat radioterapi, meski demikian belum ada cara dan strategi yang paling ampuh dalam menanggulanginya. Laporan kasus ini bertujuan untuk membahas tata laksana komprehensif mukositis oral yang bertambah buruk akibat penambahan dosis radiasi. Laporan kasus: Pasien wanita, 33 tahun dirujuk dari bagian onkologi-radiasi ke departemen Ilmu Penyakit Mulut dengan keluhan sulit membuka mulut dan sakit pada seluruh rongga mulutnya. Diagnosis utama adalah kanker sel basal area zigoma, dan sudah dilakukan terapi penyinaran sebanyak 16 kali. Obat-obat dari bagian onkologi-radiasi berupa sulcralfat sirup, mikostatin, klindamisin, parasetamol, metilprednisolon, vitamin B kompleks, dan asam folat. Pemeriksaan ekstra oral terdapat luka bekas jahitan area zigoma bilateral dari operasi sebelumnya yang menyulitkan dalam membuka mulut. Pemeriksaan intra oral terlihat mukostis tingkat 3 skala WHO dan xerostomia sedang skala Challacombe. Instruksi dari bagian Ilmu Penyakit Mulut dengan berkumur dan kompres bibir menggunakan kassa steril yang dilembabkan dengan larutan NaCl 0,9%. Sebagai agen anti-inflamasi diberikan ice chips dan asam hialuronat 0,025%. Pemberian petroleum jelly dan saliva artifisial diberikan terkait rasa kering pada mulut dan bibir pasien. Penambahan dosis radiasi menghambat proses penyembuhan mukositis oral dan mengganggu kemandirian pasien dalam pembersihan rongga mulut, sehingga alat bantu berkumur berupa modifikasi alat cuci-hidung diterapkan. Simpulan: Proses penyembuhan mukositis oral dapat terganggu akibat penambahan dosis radiasi, oleh karena itu tata laksana komprehensif dan simtomatis yang tepat harus dilakukan untuk mencegah perburukan.Management of exacerbation on radiation-induced oral mucositis in head and neck cancer patients: A case reportIntroduction: Radiation-induced oral mucositis (RIOM) is an inflammatory condition and ulceration of the oral mucosa due to radiation therapy. Dentists have an important role in the management of oral mucositis, however, the most effective ways and strategies are yet to be discovered. This case report aims to discuss the comprehensive management of oral mucositis that worsened due to additional radiation dose. Case report: A 33-year-old female patient was referred from the oncology-radiation department to the Oral Medicine department with complaints of difficulties opening her mouth and pain throughout her oral cavity. The patient's initial diagnosis was basal cell carcinoma of the zygoma and had undergone 16 irradiations. Medications from the oncology-radiation department include sucralfate syrup, mycostatin, clindamycin, paracetamol, methylprednisolone, vitamin B complex, and folic acid. Extra oral examination showed suture scars on bilateral zygoma from prior surgeries and limited mouth opening. Intra-oral examination revealed a grade 3 oral mucositis (WHO) and moderate xerostomia in the Challacombe scale. Instructions for rinsing and compressing the lips using sterile gauze moistened with 0.9% NaCl solution. Ice chips and 0.025% hyaluronic acid were given as anti-inflammatory agents. Petroleum jelly and artificial saliva were administered due to the dryness of the patient's oral cavity and lips. Additional radiation dose inhibits the healing process of oral mucositis and independence in oral hygiene, therefore a gargling aid from a modified nasal-rinse device was implemented. Conclusion: The healing process of oral mucositis may be impaired due to additional radiation dose, hence comprehensive and suitable symptomatic management is required to prevent exacerbation.
ORAL LICHEN PLANUS LESION MIMICKING LINEAR GINGIVAL ERYTHEMA : A CASE REPORT Indra Gunawan; Tenny Setiani Dewi
Journal of Syiah Kuala Dentistry Society Vol 2, No 1 (2017): JANUARY
Publisher : Dentistry Faculty

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Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucous membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. Linear Gingival Erythema (LGE) is a progressive disease described in HIV-positive patients and is considered to be an early stage of necrotizing periodontitis. Objective of this case report is to help clinicians to recognize and distinguish OLP lesions from other lesions that have similar appearance such as LGE and give a proper treatment for the oral lesions. We reported a case on a 49-year-old female that was referred to Oral Medicine Department from Periodontology Department with the diagnosis of ANUG and differential diagnosis of Linear Gingival Erythema. On clinical examination, we found Wickhams striae on buccal mucosa and the edge of the lesion. The patients was then diagnosed with Oral Lichen Planus. The patient was treated with sistemic and topical corticosteroid. After 8 weeks of treatment the patient was fully recovered. OLP is seen clinically as reticular, papular, plaque-like, erosive, atrophic or bullous types. Intraorally, the buccal mucosa, tongue and the gingiva are commonly involved although other sites may be rarely affected. Erosive or atrophic types that usually affect the gingiva usually show concomitant reticular form. LGE is limited to the soft tissue of periodontium and characteristically appears as an erythematous linear band that extends approximately 2 3mm from the free gingival margin. OLP lesions may have similarity with other oral lesions such as LGE. It is important for clinicians to recognize the lesions and choosing the proper treatment for the diseasesKeyword: Oral Lichen Planus, Linear Gingival Erythema, HIV, Corticosteroid
Traumatic ulcer distribution of patiens with removable orthodontic appliance in Orthodontics Clinics of Dental Specialist Program Akbari, Gusti; Dewi, Tenny Setiani; Malik, Isnaniah
Padjadjaran Journal of Dentistry Vol 26, No 1 (2014): March 2014
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol26no1.26762

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Introduction: Treatment with fixed orthodontic appliance sometimes cause the oral mucosa lesion, known as a traumatic ulcer. The purpose of this research is to see the distribution of traumatic ulcer on the patient with a fixed orthodontic appliance in PPDGS Orthodontic RSGM FKG Unpad Clinic. Methods: This research used a descriptive observational method. The sample of this research consisted of 39 people who participate in the interview and willing to be examined the condition of their oral mucosa during the study. Results: Twenty three samples or about 59% from all the sample have a traumatic ulcer on the oral mucosa. Conclusion: Most of the patient with a fixed orthodontic appliance has a traumatic ulcer, which mostly located on the buccal mucosa, followed by labial mucosa, and gingiva.
Clinical features of oral cavity of patients with non-Hodgkin’s lymphoma undergoing chemotherapy Suroso, Diptakanya Murdi; Dewi, Tenny Setiani; Fadjari, Trinugroho Heri
Padjadjaran Journal of Dentistry Vol 25, No 2 (2013): July 2013
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol25no2.26798

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Introduction: Non-Hodgkin`s lymphoma is one of hematologic malignancy that responds to chemotherapy. Chemotherapy agent can cause oral complication such as oral mucositis, hemorrhage, xerostomia, hyposalivation and periodontitist. The purpose of this study is to determine the clinical feature of the oral cavity in patients with non-Hodgkin`s lymphoma whose underwent chemotherapy  Method: This study used an observational descriptive method. This type of research is observational descriptive. The study population was non-Hodgkin’s lymphoma sufferers who were undergoing chemotherapy at the Hematology and Medical Oncology Outpatient Installation Division of Internal Medicine at Hasan Sadikin Hospital Bandung. The study sample was taken by consecutive sampling method The numbers of samples in this study were 30 people according to predetermined criteria. Result: The result shows that all samples have abnormalities of the oral cavity that patients who have an abnormality are amounted to 20% and patients who have more than one kind of oral abnormalities amounted to 80%. An abnormality of the oral cavity that the most often found in this study is xerostomia with hyposalivation. Conclusion: Clinical feature of the oral cavity in patients with non-Hodgkin`s lymphoma whose underwent chemotherapy are abnormalities in the oral cavity, where the number of samples that experienced more than one type of oral cavity abnormality was greater when compared to the number of samples with a kind of abnormality. Oral cavity. Most of the samples studied had oral cavity abnormalities in the form of serostomia accompanied by hyposalivation.
Oral manifestations of anemia in HIV/AIDS patients without ARV treatment Hidayat, Wahyu; Dewi, Tenny Setiani; Wisaksana, Rudi
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.792 KB) | DOI: 10.24198/pjd.vol29no1.11752

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AbstractIntroduction: Acquired immunodeficiency syndrome (AIDS) is  a set of symptoms caused by decreases of the immune system that was infected by human immunodeficiency virus (HIV). Blood disorders often found in patient with HIV and associated with HIV infection. Mostly found disorders is anemia of chronic disease. The prevalence of anemia in HIV/AIDS patients reaches 70%. Oral manifestations of anemia are atrophy of the papillae on tongue, glossodynia, pallor, angular cheilitis, glossitis, aphthous ulcers/erosive lesions, candidiasis, and geographic tongue. There are many publications that uses anemia as indicator to determine the prognosis of HIV infection, thus the description of oral manifestation of anemia in the non-ARV HIV/AIDS patients is a necessity. The purpose of this study was to describe the oral manifestation of anemia in the non-ARV HIV/AIDS patients. Methods: The methods used were purposive random sampling. Samples were new HIV/AIDS patients who have not got antiretroviral (ARV) treatment. The study included 40 patients in Teratai Clinic Hasan Sadikin Hospital Bandung. Results: Oral manifestations of anemia were found amongst non-ARV HIV/AIDS patients, which were candidiasis in  37 patients, glossodynia in 28 patients, glossitis in 10 patients, and angular cheilitis in 1 patient. Conclusion: From the study found that oral manifestations of anemia that found in non-ARV HIV/AIDS patients were candidiasis, glossodynia, glossitis and angular cheilitis. HIV/AIDS patients with anemia needed to treat more intensive for better prognosis and quality of life.Keywords: Anemia, HIV/AIDS, Candidiasis, Glossitis, Glossodynia
The prevalence of malposition third molar with traumatic ulcer Tun Abdul Majid, Tun Shafiqah; Astuti, Ida Ayu; Dewi, Tenny Setiani
Padjadjaran Journal of Dentistry Vol 25, No 1 (2013): March 2013
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol25no1.26785

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Introduction: Malposition third molar is a condition when the third molar is erupted but in an abnormal position and relation to maxilla and mandible. Due to a frequent mechanical abrasion between the third molar and oral mucosa, a traumatic ulcer resulted. Hence, this research aims to determine the prevalence of traumatic ulcer in regards to a malposed third molar in Oral and Maxillofacial Surgery Department, Rumah Sakit Hasan Sadikin in a periodic of August 2008 to August 2011.Methods: The samples taken were all medical records which stated the coveted diagnosis which satisfied the variables of the age, gender and malposed third molar. The method of this research was descriptive retrospective study by using secondary data. Results: This research ratiocinates that the prevalence of malposition third molar with traumatic ulcers is 0.012% with tooth 18 caused most traumatic ulcer. Females predominant this condition and it is common in the third decade of age. Conclusion: Derived from the outcomes of this research, it can be concluded that the prevalence of malposition third molar with traumatic ulcer in Oral and Maxillofacial Surgery Department of Rumah Sakit Hasan Sadikin from August 2008 to August 2011 is 0.012%.
The prevalence of hyposalivation in type 2 diabetes mellitus patients at Endocrinology Department, Internal Medicine Sub Department of RSUP Dr Hasan Sadikin Bandung Sundari, Marini; Dewi, Tenny Setiani; Natalia, Nanny
Padjadjaran Journal of Dentistry Vol 25, No 3 (2013): November 2013
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol25no3.26813

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Introduction: The salivary flow rate reduces Hyposalivation. Type 2 diabetes mellitus patient with hyposalivation have a high risk of various oral complications if untreated adequately. The aim of this study was to find the prevalence of hyposalivation in type 2 diabetes mellitus patient at RSUP Dr Hasan Sadikin Bandung. Methods: This study was a descriptive observational with a cross-sectional approach and consecutive sampling method to 30 samples. The study was performed with objective assessment through measuring the unstimulated salivary flow of the whole saliva using spitting method for 5 minutes. Results: The result of this study shows that the prevalence of hyposalivation on type 2 diabetes mellitus patient is 10%. The mean of salivary flow rate sample with hyposalivation is 0,07 mL/minute. Conclusion: The conclusion of this study shows a low prevalence of hyposalivation in type 2 diabetes mellitus patients at RSUP Dr Hasan Sadikin Bandung in October 2011.
Clinical appearance of oral lesions in bronchial asthma patients using inhalation drug Vieri, Audrey Amber; Wihardja, Rosiliwati; Dewi, Tenny Setiani
Padjadjaran Journal of Dentistry Vol 32, No 3 (2020): November 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no3.27472

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Introduction: Inhalation therapy has become the first-line treatment for bronchial asthma patients. Studies have proved that not all of the inhaled drugs reach the target organ, but mostly are deposited in the mouth and cause local immunosuppressant and decrease saliva secretion. These conditions are closely linked to some adverse effects in the mouth. The purpose of this study was to describe the clinical appearance of oral lesion in bronchial asthma patients using inhalation drugs. Methods: This study was descriptive and conducted on 30 bronchial asthma patients that have been using inhalation drug for at least one year, free of other systemic diseases, not using denture and orthodontic appliances. Oral mucosa was examined, and any oral lesion was recorded. Results: The most number of oral lesions found in patients through clinical examinations were plaque (73.3%), followed by a fissure (36.7%), atrophy (30%), and the least oral lesions found were pigmentation (3.3%), bullae (3.3%), and petechiae (3.3%). The lesions found in patients using inhalation drugs in a range of up to 10 years were found more varyingly. Conclusion: Plaque, fissure, atrophy, pigmentation, bullae, and petechiae are oral lesions that are clinically found in bronchial asthma patients using inhalation drugs.
Clinical appearance of oral mucous in children with β-major thalassemia Lova, Areta Tera; Chemiawan, Eka; Dewi, Tenny Setiani
Padjadjaran Journal of Dentistry Vol 23, No 2 (2011): July 2011
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (528.048 KB) | DOI: 10.24198/pjd.vol23no2.14019

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Beta major thalassemia is characterized by severe hereditary hemolytic anemia. The oral mucous of children with beta major thalassemia becomes yellow grayish due to the combination of pallor, icterus/yellowish and grayish pigmentation. The purpose of this research was to obtain a clinical data of oral mucous color of beta major thalassemia children's patients at the Thalassemia Polyclinic of Pediatric Department in Dr. Hasan Sadikin General Hospital Bandung in December 2009 until January 2010. This research was the description method with survey technique. The sampling technique was consecutive sampling. The sample was collected in one month and resulting 129 sample. The data obtained by clinical evaluation of each part of oral mucous. Research result showed that the clinical color of oral mucous of beta major thalassemia children patients becomes pallor, yellowish, yellow, yellow grayish, yellow blackish differently of each part of oral mucous. Pallor mostly at tongue, yellowish at buccal mucous, yellow at soft palate, yellow grayish at sublingual, hard palate, gingival, and yellow blackish at hard palate. The conclusion of this research was that the color of the oral mucous beta major thalassemia children patients was changed and was different with the color of oral mucous in normal children.