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All Journal Signifikan : Jurnal Ilmu Ekonomi JURNAL BISNIS STRATEGI MANDALA of Health Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention MEDISAINS JIET (Jurnal Ilmu Ekonomi Terapan) Journal Of Vocational Health Studies Iqtishoduna: Jurnal Ekonomi Islam Iqtishadia: Jurnal Kajian Ekonomi dan Bisnis Islam Sulawesi Tenggara Educational Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Penamas: Journal of Community Service el-Jizya: Jurnal Ekonomi Islam Al-Muzdahir: Jurnal Ekonomi Syariah Journal of Business Management and Islamic Banking Jurnal Ekonomi, Manajemen, Akuntansi Ulil Albab
Joko Setyono
FK UNSOED
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Bioinformatics Analysis of Rho GTP-ase Activating Protein 35 (ARHGAP35) in Breast Cancer Migration Febrian, Dicky Rizky; Setyono, Joko; Fareza, Muhamad Salman; Choironi, Nur Amalia; Fadlan, Arif; Sarmoko, Sarmoko
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp161-169

Abstract

Breast cancer is a second deadly cancer after lung cancer worldwide. Progression of cancer is driven by mutated cancer drive gene such as ARHGAP35. This study aims to analyze the role of ARHGAP35 in the growth and development of breast cancer cells. ARHGAP35 expression level was analyzed using Oncomine (p-value<1E-4; gene rank top 10%). Overall survival (OS) and disease-free survival (DFS) were evaluated by using GEPIA (median cutoff; HR displayed with 95% CI). STRING was used for analyzing the protein-protein interaction network, while WEBGESTALT for KEGG pathway and gene ontology (GO) of ARHGAP35 and associated proteins and cBioPortal for gene mutation. ARHGAP35 was overexpressed in several types of breast cancer, namely invasive ductal breast carcinoma (IDC), invasive ductal and lobular breast carcinoma (IDLC), invasive lobular breast carcinoma (ILC), male breast carcinoma, and mixed ductal and lobular carcinoma (MDLC). High expression of ARHGAP35 had significantly lower OS (p=0.045) compared to low expression of ARHGAP35 and the difference in DFS was not significant (p=0.98). ARHGAP35 interacted with RHOA, RHOB, RHOC, RHOD, RASA1, RND1, RAC1, CDC42, FYN and SRC. KEGG pathway and GO analysis showed that these proteins are highly involved in actin-based processes through adherent junction, axon guidance, focal adhesion, regulation of actin cytoskeleton, and tight junction. Mutation rate analysis showed 34 missense, 29 truncating, 3 fusion, and 1 in frame on ARHGAP35. Taken together, ARHGAP35 may involve in the growth and development of breast cancer through regulation of actin cytoskeleton pathway.Keywords: ARHGAP35, breast cancer, KEGG pathway, mutation rate, actin cytoskeleton.
PERAN INOVASI TEKNOLOGI DALAM MENJAWAB TANTANGAN PASAR MODAL SYARIAH DI ERA DIGITAL Putri, Melisa; Setyono, Joko
Al-Muzdahir : Jurnal Ekonomi Syariah Vol. 8 No. 1 (2026): Januari : Al-Muzdahir : Jurnal Ekonomi Syariah
Publisher : Institut Pesantren Sunan Drajat Lamongan, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55352/ekis.v8i1.2481

Abstract

Pasar modal syariah di Indonesia semakin berkembang sebagai alternatif investasi yang sesuai dengan prinsip-prinsip syariah Islam. Namun, tantangan utama yang dihadapi adalah memastikan kepatuhan terhadap prinsip syariah dengan cara yang efisien dan transparan. Kemajuan teknologi digital seperti fintech syariah, blockchain, dan kecerdasan buatan memberikan solusi inovatif yang meningkatkan transparansi, efisiensi, dan akuntabilitas transaksi, serta memperkuat kepercayaan investor. Penelitian ini menggunakan metode studi pustaka untuk mengkaji peran teknologi dalam mengatasi tantangan pemenuhan unsur syariah di pasar modal Indonesia. Hasil kajian menunjukkan bahwa teknologi digital merupakan kunci untuk mendorong inklusi dan keinginan pasar modal syariah di era modern.
Perilaku pengelolaan sampah rumah tangga melalui edukasi berbasis behavior change communication (BCC): Studi di Kota Salatiga Yudiana, Fetria Eka; Setyono, Joko
Penamas: Journal of Community Service Vol. 6 No. 2 (2026): Penamas: Journal of Community Service
Publisher : Nur Science Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/penamas.v6i2.2816

Abstract

The issue of household waste in Indonesian cities shows a significant upward trend in line with the growing number of households. In the city of Salatiga, an average of around 80 tons of waste per day is processed at the Ngronggo landfill, with organic waste and plastic being the main contributors to household waste. Data also shows that the number of households is likely to increase by 8.85% in the 2017–2024 period, which will affect the overall volume of waste. This study evaluates changes in household waste management behavior through Behavior Change Communication (BCC)-based education on waste banks in Salatiga City. This study used a quasi-experimental design with a pre-test and post-test, involving 50 respondents across two neighborhood associations. The research instruments included questionnaires on knowledge, attitudes, and waste management practices, which were analyzed using a paired sample t-test. The results showed a significant increase in all indicators after the BCC intervention, indicating that this approach is effective in encouraging changes in household waste management behavior.
Determinants of Intention to Use QRIS as a Transaction Tool for Mobile Banking Users of Islamic Banking Indarningsih, Nur Aisyah; Setyono, Joko
IQTISHADIA Vol 17, No 1 (2024): IQTISHADIA
Publisher : Ekonomi Syariah IAIN Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21043/iqtishadia.v17i1.23691

Abstract

This study aims to analyze the determinants of intention to use the Quick Response Code Indonesian Standard (QRIS) on mobile banking users of Islamic banking by integrating the religiosity variable as a moderator in the Unified Theory of Acceptance and Use of Technology 3 (UTAUT3) model to predict user intentions and behavior. UTAUT3 consists of performance expectancy, effort expectancy, social influence, facilitating conditions, hedonic motivation, price value, habits, and personal innovativeness as determinants of intention and behavior using QRIS mobile banking. A total of 255 respondents were selected as samples using the purposive sampling method. This study uses a quantitative approach with SEM-PLS (Structural Equation Modeling - Partial Least Squares) analysis using SmartPLS software version 3.0. Empirical results show that social influence, facilitating conditions, price value, habits, and personal innovativeness significantly positively affect behavioral intention to use QRIS mobile banking in Islamic banking. Conversely, performance expectancy, effort expectancy, and hedonic motivation do not have a significant effect on this intention. In addition, behavioral intention, habits, and personal innovativeness are proven to have a significant positive influence on the actual behavior of using QRIS mobile banking in Islamic banking. However, facilitating conditions do not have a significant effect on usage behavior. Religiosity as a moderating variable is unable to moderate the relationship between behavioral intention and actual behavior of using QRIS. The implications of this study are to provide insight for the Islamic banking industry to develop marketing strategies based on social values and personal innovativeness and to facilitate users with conditions that support QRIS adoption. This study also contributes to developing consumer behavior theory through a more comprehensive integration of UTAUT3 in the context of Islamic banking.
The Impact of Good Corporate Governance, Company Size nn Corporate Social Responsibility Disclosure: Case Study of Islamic Banking in Indonesia Qoyum, Abdul; Mutmainah, Lu’liyatul; Setyono, Joko; Qizam, Ibnu
IQTISHADIA Vol 10, No 1 (2017): IQTISHADIA
Publisher : Ekonomi Syariah IAIN Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21043/iqtishadia.v10i1.2549

Abstract

Corporate Social Responsibility (CSR) disclosure is very important for Islamic banking, especially in the long term. CSR disclosure is expected can improve the reputation of the company, thus the performance of the company can increase. CSR disclosure is very close with the implementation of Good Corporate Governance in the company. The objectives of this research is to analyze the influence of the elements of good corporate governance (GCG) and company size on corporate social responsibility (CSR) disclosure by using Islamic Social Reporting (ISR) index. There are 10 Islamic banks in Indonesia as the sample of the research, from 2011 to 2014, then there are 40 annual reports that are determined through purposive sampling.Method of this research uses content analysis to evaluate CSR disclosure by using ISR index, whereaspanel regressionis employed to know the influence the elements of GCG (commissioners’ board, independent commissioners, shariah supervision board, and directors’ board) and company size on the CSR disclosure. The regression analysis suggest that the proportion of independent board of commissioners has negative effect on the CSR disclosure in Islamic banking. This research finding shows that independent commissioner is not able in providing maximum supervision on the company, which is affected by the lack of quality, and the dual job of independent commissioners at another company. While, company size has positive impact on the CSR disclosure, due to the strict regulation and society perception. This research finding may serve as an important input for the regulator to regulate properly related to the number of independent commissioner, its qualification and Islamic Social Reporting as a tool in disclosing their CSR.Pengungkapan Corporate Social Responsibility (CSR) sangat penting bagi perbankan syariah, terutama dalam jangka panjang. Pengungkapan CSR diharapkan dapat meningkatkan reputasi perusahaan, sehingga kinerja perusahaan dapat meningkat. Pengungkapan CSR sangat dekat dengan penerapan Good Corporate Governance di perusahaan. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh elemen tata kelola perusahaan (GCG) dan ukuran perusahaan terhadap pengungkapan Corporate Social Responsibility (CSR) dengan menggunakan indeks Islamic Social Reporting (ISR). Ada 10 bank syariah di Indonesia dari tahun 2011-2014 yang menjadi sampel penelitian, maka ada 40 laporan tahunan yang ditentukan melalui purposive sampling. Metode penelitian ini menggunakan content analysis untuk mengevaluasi pengungkapan CSR dengan menggunakan indeks ISR. Sedangkan regresi panel digunakan untuk mengetahui pengaruh unsur GCG (dewan komisaris, komisaris independen, dewan pengawas syariah, dan dewan direksi) dan ukuran perusahaan terhadap pengungkapan CSR. Analisis regresi menunjukkan bahwa proporsi dewan komisaris independen memiliki pengaruh negatif terhadap pengungkapan CSR di perbankan syariah. Temuan penelitian ini menunjukkan bahwa komisaris independen tidak mampu memberikan pengawasan yang maksimal terhadap perusahaan. Hal ini dipengaruhi oleh kurangnya kualitas yang dimiliki, dan rangkap jabatan yang dimiliki oleh komisaris independen di perusahaan lain. Sedangkan, ukuran perusahaan berdampak positif terhadap pengungkapan CSR, karena ketatnya regulasi dan persepsi masyarakat. Temuan penelitian ini dapat menjadi masukan penting bagi regulator untuk mengatur dengan benar terkait dengan jumlah komisaris independen, kualifikasi dan ISR sebagai alat dalam mengungkapkan CSR mereka.
Co-Authors . HERNAYANTI A Fahira Nur A Hamim Sadewa, A Hamim Abdul Qoyum Agus Prastowo Ahmad Choiri Ahyar Ahyar Albab Al Umar, Ahmad Ulil Aminuddin Ardhi, Ardhi Ariga, Adi Dwi Utami Anjarwati Erni Noviani, Erni Fadlan, Arif Fareza, Muhamad Salman Febrian, Dicky Rizky Fitranto Arjadi Heru Ismaya Indarningsih, Nur Aisyah K, Neneng Rika J. Kurniawan, Anang Kusuma, Muhammad Nanang Himawan Lantip Rujito Lintang, Ferlanda Mahfuzh, Muhammad Ady Maliyah Madiyan, Maliyah Melisa Ariani Putri Mujiburrahman, Husnan Mukarromah, Lukluil Mutmainah, Lu’liyatul Nendyah Roestijawati Nur Amalia Choironi Nur Latifah , Ramadhani Nur Rohman Qizam, Ibnu Qodri Santosa, Qodri Ramadan, Hendra Rispriandari, Aulia Ayu Riza, Alex Fahrur Rizak Tiara Yusan Samodro, Pugud Sarmoko Sarmoko Saryono, Siti Rahmawati Soegianto, Jap Yulius Billy Sujiran Untung Gunarto, Untung Wahyu Wibowo Wahyudin Wahyudin Wisesa, Sindhu Yahya, Padli Pawaid Yudiana, Fetria Eka Zainuddin Zainuddin