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All Journal Signifikan : Jurnal Ilmu Ekonomi JURNAL BISNIS STRATEGI MANDALA of Health Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention MEDISAINS JIET (Jurnal Ilmu Ekonomi Terapan) Journal Of Vocational Health Studies Iqtishoduna: Jurnal Ekonomi Islam Sulawesi Tenggara Educational Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) el-Jizya: Jurnal Ekonomi Islam Journal of Business Management and Islamic Banking Jurnal Ekonomi, Manajemen, Akuntansi Ulil Albab
Joko Setyono
FK UNSOED
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Bioinformatics Analysis of Rho GTP-ase Activating Protein 35 (ARHGAP35) in Breast Cancer Migration Febrian, Dicky Rizky; Setyono, Joko; Fareza, Muhamad Salman; Choironi, Nur Amalia; Fadlan, Arif; Sarmoko, Sarmoko
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp161-169

Abstract

Breast cancer is a second deadly cancer after lung cancer worldwide. Progression of cancer is driven by mutated cancer drive gene such as ARHGAP35. This study aims to analyze the role of ARHGAP35 in the growth and development of breast cancer cells. ARHGAP35 expression level was analyzed using Oncomine (p-value<1E-4; gene rank top 10%). Overall survival (OS) and disease-free survival (DFS) were evaluated by using GEPIA (median cutoff; HR displayed with 95% CI). STRING was used for analyzing the protein-protein interaction network, while WEBGESTALT for KEGG pathway and gene ontology (GO) of ARHGAP35 and associated proteins and cBioPortal for gene mutation. ARHGAP35 was overexpressed in several types of breast cancer, namely invasive ductal breast carcinoma (IDC), invasive ductal and lobular breast carcinoma (IDLC), invasive lobular breast carcinoma (ILC), male breast carcinoma, and mixed ductal and lobular carcinoma (MDLC). High expression of ARHGAP35 had significantly lower OS (p=0.045) compared to low expression of ARHGAP35 and the difference in DFS was not significant (p=0.98). ARHGAP35 interacted with RHOA, RHOB, RHOC, RHOD, RASA1, RND1, RAC1, CDC42, FYN and SRC. KEGG pathway and GO analysis showed that these proteins are highly involved in actin-based processes through adherent junction, axon guidance, focal adhesion, regulation of actin cytoskeleton, and tight junction. Mutation rate analysis showed 34 missense, 29 truncating, 3 fusion, and 1 in frame on ARHGAP35. Taken together, ARHGAP35 may involve in the growth and development of breast cancer through regulation of actin cytoskeleton pathway.Keywords: ARHGAP35, breast cancer, KEGG pathway, mutation rate, actin cytoskeleton.
Analysis of Economic Factors Affecting the Financing of Bank Syariah Indonesia (BSI) in 2014–2024 Shoolihah, Muhayyijah Fil Qurbah; Setyono, Joko; Rahmawati, Mega
Journal of Business Management and Islamic Banking Vol.4 No.2 (2025)
Publisher : UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/jbmib.2025.0402-03

Abstract

Research Aims: This study aims to analyze the effect of macroeconomic variables on the total financing distributed by Bank Syariah Indonesia (BSI) during the period 2014–2024. The independent variables examined include the Statutory Reserve Requirement (GWM), Financing to Deposit Ratio (FDR), inflation, interest rates, and money supply. Design/methodology/approach: The research employs a quantitative approach with a descriptive-causal method and uses multiple linear regression analysis as the data analysis technique. The data are secondary in nature, obtained from BSI annual reports, official publications of Bank Indonesia, and the Central Bureau of Statistics. Research Findings: The findings indicate that inflation and GWM have a negative effect on total financing, while interest rates, money supply, and FDR have a positive effect. These results largely align with economic theory, although an anomaly is observed in the positive relationship between interest rates and financing, which theoretically should be negative. Theoretical Contribution/Originality: This study contributes to the understanding of the relationship between macroeconomic conditions and financing activities in Islamic banking, particularly highlighting the unique dynamics of Bank Syariah Indonesia within the Indonesian macroeconomic context. Research limitation and implication: The study is limited to the period 2014–2024 and focuses only on selected macroeconomic indicators. Future research could expand the scope by incorporating additional variables or employing different econometric models. The findings provide practical implications for policymakers and banking practitioners in formulating strategies to strengthen the resilience of Islamic banking amid macroeconomic fluctuations.
Co-Authors . HERNAYANTI A Fahira Nur A Hamim Sadewa, A Hamim Agus Prastowo Ahmad Choiri Ahyar Ahyar Albab Al Umar, Ahmad Ulil Aminuddin Ardhi, Ardhi Ariga, Adi Dwi Utami Anjarwati Erni Noviani, Erni Fadlan, Arif Fareza, Muhamad Salman Febrian, Dicky Rizky Fitranto Arjadi Heru Ismaya K, Neneng Rika J. Kurniawan, Anang Kusuma, Muhammad Nanang Himawan Lantip Rujito Lintang, Ferlanda Mahfuzh, Muhammad Ady Maliyah Madiyan, Maliyah Mega Rahmawati, Mega Mujiburrahman, Husnan Mukarromah, Lukluil Nendyah Roestijawati Nur Amalia Choironi Nur Latifah , Ramadhani Nur Rohman Qodri Santosa, Qodri Ramadan, Hendra Rispriandari, Aulia Ayu Riza, Alex Fahrur Rizak Tiara Yusan Samodro, Pugud Sarmoko Sarmoko Saryono, Shoolihah, Muhayyijah Fil Qurbah Siti Rahmawati Soegianto, Jap Yulius Billy Sujiran Untung Gunarto, Untung Wahyu Wibowo Wahyudin Wahyudin Wisesa, Sindhu Yahya, Padli Pawaid Zainuddin Zainuddin