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All Journal Jurnal Farmasi Andalas JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Pendidikan IPA (JPPIPA) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Farmasi Higea Jurnal Stamina Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Journal of Pharmaceutical and Sciences. Journal of Health Economic and Policy Research (JHEPR) Borneo Journal of Pharmacy Jurnal Sains Farmasi dan Kesehatan
Rahmi Yosmar
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Andalas
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Dampak Terapi Antipsikotik terhadap Lama Rawat Inap dan Gejala Eksitasi pada Pasien Skizofrenia Rahmi Yosmar; Dedy Almasdy; Rahmad Abdillah; Hudiyah Amni
Jurnal Penelitian Pendidikan IPA Vol 11 No 9 (2025): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i9.12125

Abstract

Schizophrenia is a complex psychiatric disorder treated primarily with antipsychotics, yet their impact on clinical outcomes such as hospital stay and excitement symptoms, measured by the Positive and Negative Syndrome Scale–Excitement Component (PANSS-EC), remains uncertain. This study examined the association between antipsychotic therapy, hospital stay duration, and PANSS-EC scores in patients with schizophrenia. A retrospective, cross-sectional analysis was conducted on 271 patients. Sociodemographic data were analyzed descriptively, and the Kruskal–Wallis test was applied for bivariate analysis across treatment groups. The results showed that patients were predominantly male (72.7%), most frequently diagnosed with paranoid-type schizophrenia (42.8%), and commonly aged 26–35 years (33.9%). No significant differences were found in hospital stay or PANSS-EC scores among the antipsychotic treatment groups. However, gender was significantly associated with PANSS-EC score changes, and schizophrenia subtype correlated with hospital stay duration. Antipsychotic therapy demonstrated no direct association with hospital stay or PANSS-EC outcomes. Instead, demographic and clinical factors, particularly gender and schizophrenia subtype, influenced treatment outcomes. These findings underscore the need for further investigation into patient-specific variables to optimize therapeutic strategies in schizophrenia care.
Formulation and Physical Characterization of Chewable Gummy from Galangal Rhizome Extract (Kaempferia galanga L.) as a Nutraceutical Product Alya Zahira Andarifera; Erizal Zaini; Rahmi Yosmar; Lili Fitriani
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.145-155.2025

Abstract

The Kaempferia galanga L rizhome (kencur) extract, known in traditional use as an appetite enhancer, was developed into chewable gummy preparations as a nutraceutical product. Due to the taste and odor of extract from natural plants caused less preferable to consume. Therefore the formulation of chewable gummy was addressed to overcome this problem. This study formulated gummy with a concentration of 2% galangal extract and gelatin as gelling agent with concentration variations of 10% (F1), 12.5% (F2), and 15% (F3). The evaluation of the physical properties of galangal rhizome extract chewable gummy included swelling ratio, syneresis, organoleptic, weight diversity, and texture profile analysis (TPA). In addition, a hedonic test was conducted to determine the level of panelist preference. The results revealed that the higher the gelatin concentration, the more significant the changes in the physical properties of gummies. An increase in gelatin plays a crucial role in forming a denser and more stable preparation structure. This impacts the texture regarding chewiness and increase the hardness. The result of TPA showed a significant differences (p<0.05) in the parameters of hardness, gumminess, and chewiness between the three formulations. The results of the hedonic test showed that F3 was the most preferred by the panelists. Based on these results, a gelatin concentration of 15% is recommended for the formulation of chewable gummy galangal rhizome extract.
Interaksi Obat dalam Terapi Insulin pada Pasien Diabetes Melitus Tipe 1: Studi Retrospektif Intan Kumara Tungga; Dian Ayu Juwita; Rahmi Yosmar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1071

Abstract

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disorder resulting in the destruction of pancreatic β-cells, leading to absolute insulin deficiency and hyperglycemia. Insulin remains the cornerstone of therapy; however, its use may be complicated by drug interactions that alter treatment effectiveness through pharmacodynamic or pharmacokinetic mechanisms. This study aimed to evaluate the prevalence and mechanisms of potential insulin drug interactions in patients with T1DM. A retrospective, cross-sectional study was conducted using a total sampling method. The study was conducted at Dr. M. Djamil General Hospital Padang. The study population consisted of all hospitalized patients diagnosed with type 1 diabetes mellitus (T1DM) during the period 2019–2022. Patient characteristics, patterns of insulin therapy, and the occurrence of drug interactions were analyzed. The majority of patients were female (70%), and most were in the 0–18-year age group (83%). Insulin therapy was prescribed in 86.6% of cases. Potential drug–drug interactions were identified in 33.3% of hospitalized patients with type 1 diabetes mellitus, predominantly pharmacodynamic in nature. The basal–bolus insulin regimen constituted the most frequently prescribed therapeutic option among the patients. The Spearman correlation analysis indicated a statistically insignificant association between the metric of polypharmacy and the incidence of drug interactions. Systematic monitoring remains essential, and larger prospective studies are needed to confirm these findings.
Analisis Interaksi Obat-Obat Kardiovaskular pada Pasien Jantung Koroner dengan Riwayat Hipertensi Amanda Febriyenti; Rahmi Yosmar; Dita Permatasari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1074

Abstract

Coronary heart disease (CHD) accompanied by hypertension often necessitates the use of multiple cardiovascular agents. The concurrent use of multiple drugs increases the risk of drug-drug interactions (DDIs), which may alter drug metabolism, reduce therapeutic efficacy, or cause adverse effects. This study aimed to characterize the potential, mechanisms, and severity of drug interactions; to assess differences in the average number of drugs used per day in relation to the potential for drug interactions; and to assess the clinical profile based on DDI severity levels. A retrospective, analytic, observational method was applied, utilizing secondary data from hospital medical records. Statistical analysis included the Mann–Whitney test to compare the mean number of drugs per day between the interaction potential groups. A total of 52 patients met the inclusion criteria through purposive sampling. The results showed that most CHD patients with a history of hypertension were male (75%) and aged 18–64 years (73.1%). A total of 405 potential DDIs were identified. From these, 80 unique drug-pair interactions were selected for detailed analysis of their mechanisms and severity. Most were pharmacodynamic (77.5%), with aspirin–nitroglycerin the most frequent (7.6%). Among the 80 interactions analyzed in detail, those with moderate severity predominated (58.8%), followed by minor (35%) and major (6.2%). Polypharmacy (defined as the use of three or more medications) was observed in all patients who experienced DDIs. There was a significant difference in the average number of medications per day between patients with potential drug interactions and those without, p = 0.023 (p < 0.05).
Suspected Captopril-Associated Adverse Drug Reactions among Hypertensive Patients: A Prospective Study in a Primary Healthcare Setting: Evaluation of Adverse Drug Reactions of captopril using a causality approach Rahmi Yosmar; Syania Salsabila; Dedy Almasdy
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.211-220.2026

Abstract

Adverse Drug Reactions (ADRs) are unintended and harmful responses to medicines occurring at doses normally used for disease prevention, diagnosis, or treatment. Hypertension is a chronic condition requiring long-term pharmacological therapy, and captopril, an Angiotensin-Converting Enzyme (ACE) inhibitor, is commonly used as an antihypertensive agent. This study aimed to determine the incidence and classification of ADRs and examine the association between sociodemographic characteristics, captopril treatment patterns, and the occurrence of captopril-related ADRs among hypertensive patients. This prospective observational study employed a cross-sectional assessment, with data collected prospectively through patient interviews from March to May 2024 at Andalas Community Health Center, Padang City, Indonesia. The Naranjo Algorithm was used to assess the probability of a causal relationship between captopril use and suspected ADRs. Ethical approval was obtained from the Faculty of Pharmacy, Universitas Andalas (No. 39/UN16.10.D.KEPK-FF/2024). Of the 44 patients receiving captopril therapy, 22 (50.0%) experienced at least one suspected ADR, with a total of 26 suspected ADR events identified. Dry cough was the most frequently reported ADR (69%), followed by dizziness (11%) and nausea (8%), swollen gums (4%), frequent urination (4%), and flatulence (4%). Based on the Naranjo Algorithm, 73% of ADRs were classified as probable and 27% as possible. No significant associations were found between sociodemographic characteristics or captopril treatment patterns and ADR occurrence (p > 0.05). Suspected ADRs were relatively common among patients receiving captopril, with dry cough being the most frequently reported reaction.
Co-Authors Abdillah, Rahmad Ade Fitriani, Ade Almahdy A Alya Zahira Andarifera Amanda Febriyenti Annisa Nurbuana Putri Armenia, Armenia Dedy Almasdy Delva Yeni Dian Ayu Juwita Dita Permatasari Erizal Zaini Febiana, Dian Fifi Yuliagus Fikri, Zahiya Afifah Fitria Rahma Friardi Ismed Fuji Araswati Helmi Arifin Helmice Afriyeni Helmice Afriyeni Hudiyah Amni Ifmaily, Ifmaily Intan Kumara Tungga Jayawarsa, A.A. Ketut Julio Fajar Rahmat Illahi Lailaturrahmi Lailaturrahmi Lili Fitriani Listia Ningsih Meri Andani Muhammad Akram Nadia Putri Inanta Nadira Atiqah Ricardo Najmiatul Fitria Netty Marusin Netty Suharti Nova Syafni Primadhini, Tessa Amanda Rafifah Azzahra Rini Agustin Rini Agustin Rizal, Rosiana Rosiana Rizal Roslinda Rasyid Saafrida Saafrida Saafrida Saafrida Sari, Yelly Oktavia Serdiani, Serdiani Suhatri Suhatri Surya Dharma Syania Salsabila Syukra, Putri Salsabila Eka Ranti Try Andy Sahputra Try Andy Sahputra Uswatul Hasanah Yelly Oktavia Sari Zulkarni R