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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Pengabdian Masyarakat Kesehatan Indonesian Journal of Chemical Analysis (IJCA) Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ners Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian kepada Masyarakat Jurnal EduHealth Jurnal Akademika Kimia ASMAT: Jurnal Pengabmas Jurnal ABDI MERCUSUAR Jurnal Pengabdian Pada Masyarakat Nanggroe: Journal Of Scholarly Service Jurnal Katalisator Nanggroe: Journal of Scholarly Service Jurnal Kesehatan dr. Soebandi Journal of Innovative and Creativity Journal of Medical Laboratory in Infectious and Degenerative Diseases Jurnal Akademika Kimia Sadewa: Jurnal Pengabdian Masyarakat Indonesian Pharmacopeia Journal (IPJ) Journal of Pharmacy and Halal Studies (JPHS) Health Media Journal of Pharmaceutical Sciences and Community
Setyaningrum, Lindawati
Pharmacy Program, Faculty Of Health Sciences, Universitas Dr. Soebandi
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In Vitro Anti-inflammatory Activity Test of Ethanol Extract of Red Dragon Fruit Peel (Hylocereus polyrhizus) Wima Anggitasari; Iski Weni Pebriarti; Lindawati Setyaningrum; Sholihatil Hidayati; Dyan Wigati; Aninda Fellisya Wibowo
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dragon fruit peel contains several compounds that have high antioxidant activity. Oxidative stress, which is one of the triggers for inflammation, is a problem to this day. Red dragon fruit skin contains various antioxidant compounds such as flavonoids and polyphenols. It is hoped that the presence of these antioxidant compounds can also have anti-inflammatory activity. This study aims to examine the anti-inflammatory activity of red dragon fruit skin using the red blood cell stabilization method. The test results showed that the ethanol extract of red dragon fruit peel with a concentration of 1000 ppm had the largest percentage of red blood cell hemolysis protection in induced hypotonicity, namely 92.596%. From these results it can be concluded that the ethanol extract of red dragon fruit peel has potential as an anti-inflammatory by stabilizing red blood cell membranes.
Pengaruh Pelarut Metanol dan Etanol Terhadap Kadar Flavonoid Total Ekstrak Kulit Pohon Waru (Hibiscus tiliaceus L.) Astrid Kusuma Putri; Lunardhi Susanto; Deva Oktavy American Iswardjono; Asti Rahayu; Lindawati Setyaningrum
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.17465

Abstract

Sea hibiscus (Hibiscus tiliaceus L.) is one of the plants in Indonesia that is empirically used as a traditional medicine. The study aims to determine the total flavonoid content of methanol and ethanol extracts from the sea hibiscus tree bark using UV-Vis spectrophotometry. Phytochemical screening of flavonoids is done using concentrated magnesium and hydrochloric acid (HCl). Total flavonoid levels are determined using the AlCl3 method specified in the QE (Quercetin equivalent). The phase of the research method includes preparation of methanol extract and ethanol extracts, phytochemical screening of flavonoid content, quantitative analysis of the flavonoid content (determination of the maximum wavelength (λmax) of quercetin, standard curve preparations of quercetin, and determination of flavonoid contents in methanol extract and ethanol extract), data management and analysis. Phytochemical screening showed methanol extracts and ethanol extract of the Sea Hibiscus tree bark showed positive contain flavonoids. Quantitative tests using UV-Vis spectrophotometry measured at 441 nm wavelengths showed that the concentration of flavonoid compounds in the Sea Hibiscus tree bark methanol extract was 0.109 %b/b, and the concentrations of flavonoids in the ethanol extracts were 0.096 %b/b.
In-Silico Study Of Bioactive Compounds In Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs On The Main Protease Receptor Of COVID-19 (6LU7) As A Candidate For SARS-CoV-2 Antivirus Drug Ulfa Dwi Septiana; Septyaningtyas Eka Wulandari; Nabila Kamalia; Tiara Anjelina Hezni; Mohammad Rofik Usman; Lindawati Setyaningrum
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.40

Abstract

: The COVID-19 viral disease is a new name given by the World Health Organization (WHO) to patients with the novel COVID-19 virus infection which was first reported from the city of Wuhan, China at the end of 2019. The COVID-19 pandemic is still a major problem in the world health. One antiviral regimen that is widely used to treat moderate to severe Covid- 19 patients is favipiravir. Many studies discuss alternative antiviral therapy for COVID-19 patients from active compounds contained in plants. One of the medicinal plants that has an antiviral effect on CoV-2 is Dayak onion (Eleutherine Palmifolia (L.) Merr). Consuming herbal plants can increase the body's immunity as the main key in preventing the Sars-Cov-2 virus. Purpose: This research aims to determine the effect of anchoring the active compound of Dayak onion bulbs on the growth of the corona virus on the main protease receptor for Covid 19 (6LU7). Methods: This type of research uses a molecular docking research method which consists of docking validation stages, a docking process and continues with docking visualization using Discovery Studio Visualizer and PyRx combined with Autodocktool Results: The results of the molecular docking simulation show that the Lysine sulfate compound has the lowest binding affinity value compared to Favipiravir, namely -4.75 kcal/mol with a Ki value of 96.41 μM and has the same interaction as the positive control ligand on the hydrophobic bond of MET A:165
Molecular Docking of Bioactive Compounds from Gynura procumbens Against HMG-CoA Reductase as Potential Anticholesterol Agents Iftinan Syifa Dzulfiqar; Canakya Niti Sastra; Tsalisah Rahmaniyyah Arifin; Winda Sastika; Lindawati Setyaningrum; Asa Falahi; Anies Rohman Dwijayanti; Mohammad Rofik Usman
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 4 No. 1 (2026): Juni
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v4i1.53

Abstract

Background: Hypercholesterolemia is a major risk factor for cardiovascular disease. Statins, which inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are widely used to lower cholesterol levels; however, their use may cause adverse effects, including myopathy and rhabdomyolysis. Therefore, the discovery of natural HMG-CoA reductase inhibitors has attracted considerable attention. Gynura procumbens contains various secondary metabolites that are potentially associated with antihypercholesterolemic activity. Purpose: This study aimed to predict the potential of bioactive compounds from Gynura procumbens as HMG-CoA reductase inhibitors using an in silico molecular docking approach. Methods: A total of 58 compounds identified by LC-MS were initially screened using Lipinski's Rule of Five and ADMET prediction. Five compounds that fulfilled the selection criteria were subjected to molecular docking against HMG-CoA reductase (PDB ID: 3CCW) using AutoDock Tools 1.5.6. Protein–ligand interactions were visualized using Discovery Studio Visualizer and Molegro Molecular Viewer. The docking protocol was validated by re-docking the native ligand and evaluating the Root Mean Square Deviation (RMSD). Results: The docking protocol was successfully validated with an RMSD value of 1.48 Å using a grid box centered at (-15.927, 8.300, 44.720). Among the five selected compounds, malic acid exhibited the highest binding affinity, with a binding free energy (ΔG) of −3.81 kcal/mol and an inhibition constant (Ki) of 1.60 mM, which was the closest to that of the positive control, pravastatin. Furthermore, malic acid shared one hydrogen bond with residue ALA751 and six hydrophobic interactions with LEU853, LYS735, HIS752, LEU857, ASN755, and GLU559, indicating a binding interaction pattern similar to that of pravastatin. Conclusions: Based on the insilico analysis, malic acid was identified as the most promising bioactive compound from Gynura procumbens for inhibiting HMG-CoA reductase among the tested compounds. However, its binding affinity remained lower than that of the native ligand and pravastatin. Therefore, its biological activity should be further validated through in vitro and in vivo studies before it can be considered a potential antihypercholesterolemic agent
MOLECULAR DOCKING ANALYSIS OF ACTIVE COMPOUNDS OF STAR FRUIT PLANTS WULUH (Averrhoa bilimbi. L) AGAINST NEPRILYSIN RECEPTORS AS ANTIHYPERTENSIVE DRUG CANDIDATES Lindawati Setyaningrum; Mohamad Rofiq Usman; Asa Falahi; Anies Rohman Dwijayanti; Neny Poerwahyuningrum; Alwiya Kinanti
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2026): Volume 2 Nomor 2, 2026
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.96

Abstract

Hypertension is a major global health problem that significantly increases the risk of cardiovascular diseases. Neprilysin plays an essential role in blood pressure regulation and has emerged as a promising therapeutic target for antihypertensive drug development. This study aimed to evaluate the potential of active compounds from Averrhoa bilimbi L. as neprilysin inhibitors using an in silico approach. Molecular docking was performed between selected phytochemical compounds (Isocytisoside, Hallacton B, Vitexin 4″-O-rhamnoside, Epiafzelechin 3-O-gallate, and 2,4,6-Triphenyl-1-hexene) and the neprilysin receptor (PDB ID: 5JMY) using AutoDockTools. Docking protocol validation was conducted by redocking the native ligand, with validity determined by an RMSD value ≤ 3 Å. The grid box was set at coordinates x = −20.579, y = 3.317, z = 37.541 with dimensions of 40 × 40 × 40. Physicochemical properties and ADMET profiles were predicted using the pkCSM online server. The docking validation yielded an RMSD value of 1.303 Å, confirming the reliability of the docking protocol. Among the tested compounds, Hallacton B exhibited the most favorable binding affinity among the test ligands, with a binding energy of −9.45 kcal/mol and an inhibition constant (Ki) of 117.49 µM, along with key amino acid interactions comparable to the reference drug sacubitril. ADMET analysis indicated that Hallacton B possesses a favorable safety profile, showing negative results for Ames toxicity and hepatotoxicity, no inhibition of CYP2D6 and CYP3A4 enzymes, and acceptable distribution characteristics, although its intestinal absorption was relatively low (16.71%). Hallacton B demonstrates promising potential as a natural neprilysin inhibitor and warrants further optimization and experimental validation through in vitro and in vivo studies.
PENETAPAN KADAR ALKALOID TOTAL PADA EKSTRAK N-HEKSAN DAN ETANOL BIJI KETUMBAR (Coriandrum sativum) MENGGUNAKAN SPEKTROFOTOMETER UV-Vis lindawati setyaningrum; Dhina Ayu Susanti
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.268

Abstract

Coriander (Coriandrum sativum) is one of the medicinal plants which is known to contain secondary metabolites such as flavonoids, tannins, terpenoids, saponins, steroids, and alkaloids. Alkaloids have therapeutic effects as antimalarials and cancer. Research in determining the alkaloids in coriander was carried out by separating the alkaloids from other substances using the soxhlet method extraction with two solvents ethanol and n-hexane. The total alkaloid content is determined using a UV-VIS spectrophotometer at wavelength 351,5 nm. The reaction of alkaloids with Bromocresol green (BCG) is obtained to form a yellow product. The use of berberine standard was obtained the total alkaloid content of ethanol and n-hexane extract in coriander seed (Coriandrum sativum) were 0.524% and 0.583% respectively, and the ratio of total alkaloid content of ethanol extract was smaller than that of n-hexane extract.
Co-Authors Adelia Royan Suryani Adelia Royan Suryani Aditya F. Ardinsyah Ajeng Retno Ningsih Aliyah Purwanti Aliyah Purwanti Aliyah Purwanti Aliyah Purwanti Alwiya Kinanti Amalia Wardatul Firdaus Anies Rohman D Anies Rohman Dwijayanti Anies Rohman Dwijayanti Aninda Fellisya Wibowo Aninda Fellysia Wibowo Asa Falahi Asa Falahi Asa Falahi Asti Rahayu Astrid Kusuma Putri Ayik Rosita Puspaningtyas1 Ayu Dwi Wardani Canakya Niti Sastra Deva Oktavy American Iswardjono Dewi Rashati Dhina Ayu Susanti Dhina Ayu Susanti Diah Yuli Pangesti Dian Reny Agustina Diana, Ilvid Diana, Nadha Nofa Dina Trianggaluh Fauziah Dina Trianggaluh Fauziah Dina Trianggaluh Fauziah Dwi Koko Pratoko Dyah Purwaningtyas Dyah Purwaningtyas Dyan Wigati Edi Susanto Eka Fitri Yanti, Eka Fitri Falakh Noferyana Hartania Wati Fenti Indah Nirwana Iftinan Syifa Dzulfiqar Ima F. Lestari Inna Armandari Iski Weni Pebrianti Iski Weni Pebriarti Iski Weni Pebriarti Ivana, Nanda Letitia Jenie Palupi Khrisna Agung Cendekiawan Lubis Nuril Ubaidilla Lubis Nuril Ubaidilla Lulut Sasmito Lunardhi Susanto M. Rofik Usman Maasyitoh Sari Latifah Mega T. Wulandari Mohamad Rofiq Usman Mohammad R. Usman Mohammad Rofik Usman Mohammad Rofik Usman Muhamad D. Permana Muhammad Yuwono Nabila Kamalia Nafisah Isnawati Neny Poerwahyuningrum Nur Azizah Perdani Puteri Syahuri Purwanti, Aliyah Qurrotul Aini Retno Eka Lestari Rizki Indah Rahayu ROUDATUL JANNAH Septyaningtyas Eka Wulandari Shinta Mayasari Sholihatil Hidayati Sholihatil Hidayati Sindi Anggraiyani Stephanie D. Artemisia Tiara Anjelina Hezni Tolak Haris Tolak Haris Tsalisah Rahmaniyyah Arifin Ulfa Dwi Septiana Wardani, Astrid Kusuma Widaddhiya Zahra Anggraini Widaddhiya Zahra Anggraini Wima Anggitasari Wima Anggitasari Winda Sastika