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All Journal Indonesian Journal of Urology Folia Medica Indonesiana Medicra (Journal of Medical Laboratory Science/Technology) journal of Basic Medical Veterinary Medicina Biomedica Journal Cermin Dunia Kedokteran
Soetojo Soetojo
Departemen Urologi, Fakultas Kedokteran Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary Other

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COMPARISON BETWEEN GEMCITABINE-CARBOPLATIN AND COMBINATION OF GEMCITABINE-CARBOPLATIN AND CELECOXIB IN UROTHELIAL CARCINOMA CELL APOPTOSIS Pratama, Widya Sakti; Soetojo, Soetojo; Hakim, Lukman
Indonesian Journal of Urology Vol 26 No 1 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i1.542

Abstract

Objective: To determine the combination effect of celecoxib and gemcitabine-carboplatin chemotherapy to the apoptosis of cultured-urothelial cancer cell line. Material & Methods: Urothelial carcinoma cell line originating from Bladder Ca 5637 was cultured and used in this in vitro study. Three-groups of cultured-urothelial cancer cell line consisted of (1) control (C), (2) gemcitabine-carboplatin treated group (GC) and (3) gemcitabine-carboplatin and celecoxib treated group (GCC) were treated with 0.086 µM gemcitabine, 290 µM carboplatin and 25 µM celecoxib. All groups were evaluated at 24 hours following treatment, and the apoptotic index (AI) measured accordingly. Results: Significant mean apoptotic index differences were found between the C and GC group; and between C and GCC groups at 24 hours following treatment. However, the AI of GCC was lower than the GC group although not statistically significant (p>0.05). Conclusion: Our study have shown that gemcitabine-carboplatin and the combination of both with celecoxib may increase the apoptosis of urothelial cancer cell line. The role of celecoxib in the addition of gemcitabine-carboplatin to treat urothelial cancer cell line needs to be elucidated further. 
THE EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON GLOMERULUS AND PROXIMAL KIDNEY TUBULES DAMAGE WHICH RECEIVED CISPLATIN EXPOSURE ON SPRAGUE DAWLEY MICE Rakhmatiar, Fadhilla; Soebadi, Doddy M.; Soetojo, Soetojo
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.597

Abstract

Objective: To analyze the protective effect of Vitamin E on cisplatin toxicity in Sprague Dawley mice nephrons. Material & Methods: This is an experimental study using post-test only control group design, the subject was white male mice (Rattus Norvegicus) adult Sprague Dawley strain (10-12 weeks) of 24 rats divided into four groups. Negative control group (CN) got normal saline 0.9% intraperitoneal 1 cc, Positive control group (CP) got cisplatin 5 mg/kgBB, group P1 got vitamin E 50 mg/kgBB and Cisplatin 5 mg/kgBB, and P2 group got vitamin E 200 mg/kgBB plus cisplatin 5 mg/kgBB intraperitoneal. Cisplatin is conducted in the third week in each treatment group through intraperitoneal injection. Vitamin E is administrated per sonde for the first three weeks resumed on the fourth week to the seventh week. At the end of the seventh week, nephrectomy was performed on the treatment group to analyze the kidney damage. Histopathological observation is performed using a light microscope with a magnification of one hundred and four hundred times magnification. Results: Cisplatin administration resulted in significant tubular and glomerular damage compared to the control group. Increasing the dose of vitamin E in mice that received cisplatin resulted in significant nephron damage compared to the group who received cisplatin alone. Conclusion: Cisplatin administration results in nephrotoxicity in mice. The administration of high dose Vitamin E resulted in increased nephrotoxicity in mice that received cisplatin.
EFFECTS OF X-RAY RADIATION EXPOSURE ON SPERM MOTILITY AND MORPHOLOGY CHANGES OF WISTAR STRAIN RATS Hariyoto, Bangun Oktavian; Soebadi, Doddy M; Soetojo, Soetojo; Soeprijanto, Bambang
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.599

Abstract

Objective: To analyze the differences of sperm motility and viability changes in Wistar Rats that exposed to X-ray radiation compared to Wistar Rats that were not exposed to X-ray radiation. Material and Methods: Experimental laboratory research within vivo design using Wistar strain rats as subjects. There are three treatment groups in this study: rats exposed to 50 mGy X-ray radiation, 100 mGy, and 200 mGy and one untreated control group. Radiation exposure was calibrated using the RTI Piranha dosimetry. After radiation exposure, at week 4, orchidectomy was performed in rats. Sperm analysis was carried out to determine sperm motility by direct observation and sperm viability by Hematoxylin Eosin (HE) staining observations using a light microscope. One Way ANOVA was used to compare motility and viability of rats spermatozoa in the treatment group compared to control group with a significant value of p<0.05. The analysis was continued with a Post Hoc test to determine the differences in each group. Results: The percentage of motile sperm decreased in all treatment groups compared to control group (p<0.05). There was no significant difference in mean sperm motility on rats exposed to 200 mGy X-ray radiation compared to 100 mGy X-ray radiation (p>0.05). Viability counts decreased in all treatment groups compared to control group (p<0.05) and the spermatozoa viability in 200 mGy radiation group was not significantly different from 100 mGy group (p>0.05). Conclusion: X-ray radiation exposure decreases sperm motility and viability in Wistar rats with the optimum doses 100 mGy.
EFFECTS OF COCONUT WATER (COCOS NUCIFERA SP.) ADMINISTRATION AS PREVENTION OF UROLITHIASIS IN CALCIUM OXALATE INDUCED - WHITE RAT WISTAR STRAINS Muhammad Reza Gautama; I Ketut Sudiana; Soetojo; Djojodimedjo, Tarmono
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.698

Abstract

Objective: To analyze the effect of coconut water administration on the occurrence of urolithiasis in calcium oxalate-induced Wistar rats. Material & Methods: Laboratory experimental study with post-test only control group design, using experimental model of male Rattus norwegicus-Wistar strains. The treatment given is ad libitum administration coconut water to observe its effect on renal histopathological changes, microscopic analysis, and renal function markers. Urolithiasis induction uses exposure of 0.75% ethylene glycol (EG), and 2% Ammonium chloride (AC) in drinking water. Results: Descriptive analysis showed the tendency of decreasing in mean of renal function markers, and histopathological nephron damage in the treatment group versus control group: BUN (11.22 versus 14.29); Creatinine Serum (0.5308 versus 0.5714); degree of nephron damage (5.22 versus 10.36). In microscopic analysis, there were calcium deposits in the kidney tubules in the control group, which were not found in the treatment group. Based on the ANOVA test, obtained significant difference in BUN levels with p value=0.023 (p<0.05), and the degree of nephron damage between study groups with p value= 0.000 (p<0.05). There was no significant difference in serum creatinine with p value= 0.23 (p>0.05). Conclusion: Coconut water is potential modality in inhibiting the deposition of calcium oxalate crystals, and protecting from impaired kidney function against urolithiasis in animal-model of calcium oxalate-induced Wistar rats.
NEFROPROTECTOR EFFECT OF CURCUMIN (CURCUMA LONGA) AND VITAMIN E (α-TOCOPHEROL) IN WISTAR STRAIN RATS AFTER CISPLATIN TREATMENT Sirait, Binsar Marshall Maranatha; Wahjoe Djatisoesanto; Soetojo
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.704

Abstract

Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). Further analysis showed that there was a significant difference between the treatment group that received vitamin E and curcumin from the treatment group that received a combination of both (P<0.05). In addition, there were differences in BUN and serum creatinine levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). However, there was no significant difference in BUN levels in the treatment group that received vitamin E with the treatment group that received curcumin or a combination of both (p>0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin.
THE EFFECTIVENESS OF TNF-Α INHIBITOR THERAPY IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS Kholis, Ahmad; Soetojo; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.744

Abstract

Objective: To evaluate the effectiveness of TNF-α inhibitor therapy in Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) patients compared to placebo, assessed using Global Response Assessment (GRA). Material & Methods: A systematic review and meta-analysis. Subjects were patients with moderate to severe diagnosis of BPS/IC who were given TNF-α inhibitor versus placebo, with the Global Response Assessment (GRA) (patient-reported self-reported BPS/IC treatment response scale). A systematic literature search was carried out on the English databases PubMed/MEDLINE and Science Direct, published until September 2020. Data were extracted independently and assessed the bias and quality of each selected article. Results: Initially there were 124 studies. After further selection, 2 RCT studies were included in the criteria for this study. The number of samples obtained was 85 patients. There is 1 study that used 400 mg of certolizumab pegol subcutaneously and 1 study used adalimumab 80 mg subcutaneously and followed by 40 mg subcutaneously for 2 weeks. Both studies had statistically low heterogeneity with I2 = 0% (P = 0.34), so fixed effect statistical model was used to determine the result. Furthermore, there was no significant difference (P = 0.32) between the number of GRA responders from the TNF-α inhibitor and placebo therapy groups, with odds ratio of 1.61 (CI = 0.65-4.00). Conclusion: TNF-α inhibitor therapy did not increase GRA responders when compared to placebo.
THE EFFICACY COMPARISON OF MIRABEGRON AS A MONOTHERAPY VERSUS ITS COMBINATION WITH SOLIFENACIN IN OVERACTIVE BLADDER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Madani, Hasan; Soetojo; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.748

Abstract

Objective: This review aimed to evaluate the efficacy and safety of mirabegron as monotherapy and its combination with solifenacin for patients with overactive bladder (OAB). Material & Methods: A systematic search was conducted in PubMed, Google Scholar, and Science Direct using the keywords Overactive bladder or OAB and mirabegron or beta-3 agonist or β3 adrenoreceptor agonist and solifenacin or antimuscarinic based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline to include relevant randomized controlled trials (RCT)s. The included studies were assessed for their risks of bias using the Cochrane risk of bias tool for randomized controlled trials. Quantitative analysis using forest plot was performed in Review Manager 5.4. Results: A total of 4 RCTs were included from 227 studies. A fixed-effects model was chosen due to the low level of heterogeneity between the studies (I2 = 0%). The average micturition volume of patients in the combination group is higher compared to the monotherapy group (MD 17.13, 95% CI 12.78 - 21.48, p < 0.00001). The mean micturition frequency (MD - 0.54, 95% CI - 0.73 - -0.34, p < 0.00001) and incontinence incidence (MD -0.30, 95% CI -0.48 - -0.12, p = 0.001) in the combined group are significantly lower compared to the monotherapy group. Conclusion: The combination of mirabegron and solifenacin has better efficacy compared to mirabegron as monotherapy for OAB patients with a therapy duration of less than 12 weeks based on the micturition volume, micturition frequency, and incontinence incidence. The administration of combination therapy would not increase adverse event incidence compared to monotherapy.
HISTOPATHOLOGICAL EXAMINATIONS PROFILE OF BLADDER DISEASES IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL FROM JANUARY 2015 TO DECEMBER 2019 Krismaningrum, Veronika Intan; Rahaju, Anny Setijo; Herawati, Lilik; Soetojo
Indonesian Journal of Urology Vol 29 No 1 (2022)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v29i1.761

Abstract

Objective: This study aimed to analyze the profile of bladder disease in Soetomo General Hospital based on histopathological examination. Material & Methods: This study was using secondary data. Histopathological examination data of patients with bladder disease were evaluated based on age, gender, and histopathological types. Results: There were 419 patients with bladder abnormalities. Non-neoplasm bladder diseases were found in 62 patients consisted of 56 patients (90.32%) with cystitis and 6 patients (9.67%) with glandular cystitis. Neoplastic bladder diseases were found in 357 patients and were divided into benign and malignant neoplasm. Benign neoplasms were found in 11 patients consisted of 5 patients (45.45%) with UP and 6 patients (54.54%) with IUP. Malignant neoplasms were found in 340 patients consisted of 300 patients (88.23%) with urothelial carcinoma, 26 patients (7.64%) with adenocarcinoma, 14 patients (4.12%) with SCC. Moreover, six male patients with PUNLMP were also reported. Conclusion: Histopathological examination in patients with bladder abnormalities shows that neoplastic bladder diseases (357/419, 85.20%) were more common than non-neoplastic bladder disease (62/419, 14.80%).
A Rare Case of Neuroendocrine Tumor Following Radical Nephrectomy Muhammad Rozaqy Ishaq; Nafis Audrey Febriansyah; Soetojo Soetojo
Folia Medica Indonesiana Vol. 58 No. 2 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.177 KB) | DOI: 10.20473/fmi.v58i2.33283

Abstract

Highlights: Rare occurrence of a large, well-differentiated primary renal neuroendocrine tumor in a young man. Identifying primary renal NET from the workup and histological examination of renal tumors needs to be done to understand more of this infrequent type of tumor.   Abstract: Neuroendocrine Tumors (NETs) are a diverse range of neoplasms with various biological and histologic features and therapeutic responses. The prevalence of primary renal carcinoids is scarce worldwide. At the moment, complete surgical resection is the primary treatment against primary neuroendocrine tumors of the kidney. Nephrectomy followed by the lymph node dissection is a standard procedure for localized primary renal NETs. Since renal carcinoid tumor is extremely rare, we decided to present a unique case of a 25-years-old male with neuroendocrine renal carcinoid tumor following radical nephrectomy. The results indicated a solid, solitary tumor verified on the frozen section because a postoperative CT–scan showed a recurring mass in the renal fossa following radical nephrectomy. The case emphasized the need to investigate primary renal NET in the workup and histological examination of renal tumors and also contributed to our understanding of this infrequent clinical entity.
CLINICAL AND LABORATORY CHARACTERISTICS OF PERIRENAL ABSCESS CASES AND THEIR MANAGEMENT Aril Rizaldi; Soetojo Soetojo
Medicina Biomedica Journal Vol 2, No 1 (2023)
Publisher : Medicina Biomedica Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/mbj.v1i1.9158

Abstract

BACKGROUND: Perirenal abscess is a rare disease, often leading to morbidity and mortality due to delay in diagnosis and inadequate treatment. Cases of perirenal abscess in RSUD Soetomo often have been going on for a long time and are severe.AIM: The purpose of this study was to determine the characteristics of patients with perirenal abscess and their management.MATERIAL AND METHODS: This research is a descriptive retrospective study. Characteristics of patients with perirenal abscess both clinical, laboratory, and management obtained from medical records at RSUD dr. Soetomo Surabaya during the period 2011-2016 and analyzed using SPSS 20.0.RESULTS: There were 38 patients with perirenal abscess with the mean age was 46.21 11.74 years. Most of the abscesses were mixed (peri-pararenal) namely 21 patients (55.2%), 15 patients (39.5%) perirenal abscess and 2 patients (5.3%) pararenal abscess. The most risk factors for perirenal abscess were 17 patients (44.7%) with kidney/ureter stones and 15 patients (39.5%) with diabetes. The most frequent clinical symptoms were low back/abdominal pain in 38 patients (100%), mass in the waist/lower abdomen in 36 patients (94.7%) and fever in 28 patients (73.7%), CVA tenderness in 28 patients (73, 7%), and nausea/vomiting in 12 patients (31.6%). From the laboratory, 29 patients (76.3%) were anemic, 28 patients (73.7%) had hypoalbuminemia, and 32 patients (84.2%) had leukocytosis. Management in the form of abscess drainage, namely 35 patients (92.1%) underwent open drainage surgery, 3 patients (7.9%) underwent open drainage surgery and nephrectomy.CONCLUSION: Perirenal abscess has non-specific clinical signs and symptoms is sometimes difficult to make a diagnosis. Patients with low back/abdominal pain with a lump in the waist and fever lasting more than 5 days may suggest a perirenal abscess and need further diagnostics. Abscess drainage is the best option for the treatment of perirenal abscesses.
Co-Authors A.A. Ketut Agung Cahyawan W Affandi, Reza Ahmad Kholis Anny Setijo Rahaju, Anny Setijo Aril Rizaldi Ariyo Sakso Bintoro, Ariyo Sakso Azmi, Yufi Aulia Bambang Soeprijanto Boyke Soebhali, Boyke Dimas Sindhu Wibisono Djoyo M Boetoro, Djoyo M Doddy M Soebadi Doddy M. Soebadi Edwin Ongkorahardjo, Edwin Endang Joewarini Faadilah, Ashifa Hasna Farezi, Reza Adrio Haditanojo, Wiyanto Hariyoto, Bangun Oktavian Harmaya, Andri Kusuma HASAN MADANI Hendromartono Hendromartono, Hendromartono HERAWATI, LILIK Herdiansyah, Akbar Dimas Hoetama, Sakti Indarjadi, Ignasius Jamhari, Muhammad Arif Hakim Jayanti Dian Eka Sari, Jayanti Dian Kenconojati, Hapsari Khoirul Kholis, Khoirul Krismaningrum, Veronika Intan Kurnia Penta Seputra Lukman Hakim Moh. Ayodhia Soebadi Mufasirin Muhammad Reza Gautama Muhammad Rozaqy Ishaq Muris, Haviv Muslimah, Bintang Nafis Audrey Febriansyah Negara, Muhammad Surya Nurdin, Ambo Tuwo Nurdin, Ambo Tuwo Nurfaizah, Diza Ulya Oktaviani, Dian Paramita Paksi Satyagraha Praja, Ratih Novita Pratama, Widya Sakti Puspikawati, Septa Indra Rachmat Budi Prasetyo, Rachmat Budi Rakhmatiar, Fadhilla Riza Mazidu Sholihin Rizaldi, Aril S.Pd. M Kes I Ketut Sudiana . Saksono, Bayu septa surya wahyudi, septa surya Sirait, Binsar Marshall Maranatha Soebadi, M Ayodhia Sukarno, Gerda Sunaryo Hardjowijoto Surya, Prima Ardiansah Susilo, Rahadian Indarto Syakri Syahrir, Syakri Tarmono Djojodimedjo wahjoe djatisoesanto Wayan Suarsana Widodo J P Widodo J Pujiraharjo Yuanda, Rameshdo Yudhana, Aditya Zamroni Zamroni Zulfian Hasibuan