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<![CDATA[COMPARISON BETWEEN GEMCITABINE-CARBOPLATIN AND COMBINATION OF GEMCITABINE-CARBOPLATIN AND CELECOXIB IN UROTHELIAL CARCINOMA CELL APOPTOSIS ]]>
<![CDATA[Pratama, Widya Sakti]]>;
<![CDATA[Soetojo, Soetojo]]>;
<![CDATA[Hakim, Lukman]]>
<![CDATA[ Indonesian Journal of Urology Vol 26 No 1 (2019) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v26i1.542
<![CDATA[Objective: To determine the combination effect of celecoxib and gemcitabine-carboplatin chemotherapy to the apoptosis of cultured-urothelial cancer cell line. Material & Methods: Urothelial carcinoma cell line originating from Bladder Ca 5637 was cultured and used in this in vitro study. Three-groups of cultured-urothelial cancer cell line consisted of (1) control (C), (2) gemcitabine-carboplatin treated group (GC) and (3) gemcitabine-carboplatin and celecoxib treated group (GCC) were treated with 0.086 µM gemcitabine, 290 µM carboplatin and 25 µM celecoxib. All groups were evaluated at 24 hours following treatment, and the apoptotic index (AI) measured accordingly. Results: Significant mean apoptotic index differences were found between the C and GC group; and between C and GCC groups at 24 hours following treatment. However, the AI of GCC was lower than the GC group although not statistically significant (p>0.05). Conclusion: Our study have shown that gemcitabine-carboplatin and the combination of both with celecoxib may increase the apoptosis of urothelial cancer cell line. The role of celecoxib in the addition of gemcitabine-carboplatin to treat urothelial cancer cell line needs to be elucidated further. ]]>
<![CDATA[THE EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON GLOMERULUS AND PROXIMAL KIDNEY TUBULES DAMAGE WHICH RECEIVED CISPLATIN EXPOSURE ON SPRAGUE DAWLEY MICE ]]>
<![CDATA[Rakhmatiar, Fadhilla]]>;
<![CDATA[Soebadi, Doddy M.]]>;
<![CDATA[Soetojo, Soetojo]]>
<![CDATA[ Indonesian Journal of Urology Vol 27 No 1 (2020) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v27i1.597
<![CDATA[Objective: To analyze the protective effect of Vitamin E on cisplatin toxicity in Sprague Dawley mice nephrons. Material & Methods: This is an experimental study using post-test only control group design, the subject was white male mice (Rattus Norvegicus) adult Sprague Dawley strain (10-12 weeks) of 24 rats divided into four groups. Negative control group (CN) got normal saline 0.9% intraperitoneal 1 cc, Positive control group (CP) got cisplatin 5 mg/kgBB, group P1 got vitamin E 50 mg/kgBB and Cisplatin 5 mg/kgBB, and P2 group got vitamin E 200 mg/kgBB plus cisplatin 5 mg/kgBB intraperitoneal. Cisplatin is conducted in the third week in each treatment group through intraperitoneal injection. Vitamin E is administrated per sonde for the first three weeks resumed on the fourth week to the seventh week. At the end of the seventh week, nephrectomy was performed on the treatment group to analyze the kidney damage. Histopathological observation is performed using a light microscope with a magnification of one hundred and four hundred times magnification. Results: Cisplatin administration resulted in significant tubular and glomerular damage compared to the control group. Increasing the dose of vitamin E in mice that received cisplatin resulted in significant nephron damage compared to the group who received cisplatin alone. Conclusion: Cisplatin administration results in nephrotoxicity in mice. The administration of high dose Vitamin E resulted in increased nephrotoxicity in mice that received cisplatin.]]>
<![CDATA[EFFECTS OF X-RAY RADIATION EXPOSURE ON SPERM MOTILITY AND MORPHOLOGY CHANGES OF WISTAR STRAIN RATS ]]>
<![CDATA[Hariyoto, Bangun Oktavian]]>;
<![CDATA[Soebadi, Doddy M]]>;
<![CDATA[Soetojo, Soetojo]]>;
<![CDATA[Soeprijanto, Bambang]]>
<![CDATA[ Indonesian Journal of Urology Vol 27 No 1 (2020) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v27i1.599
<![CDATA[Objective: To analyze the differences of sperm motility and viability changes in Wistar Rats that exposed to X-ray radiation compared to Wistar Rats that were not exposed to X-ray radiation. Material and Methods: Experimental laboratory research within vivo design using Wistar strain rats as subjects. There are three treatment groups in this study: rats exposed to 50 mGy X-ray radiation, 100 mGy, and 200 mGy and one untreated control group. Radiation exposure was calibrated using the RTI Piranha dosimetry. After radiation exposure, at week 4, orchidectomy was performed in rats. Sperm analysis was carried out to determine sperm motility by direct observation and sperm viability by Hematoxylin Eosin (HE) staining observations using a light microscope. One Way ANOVA was used to compare motility and viability of rats spermatozoa in the treatment group compared to control group with a significant value of p<0.05. The analysis was continued with a Post Hoc test to determine the differences in each group. Results: The percentage of motile sperm decreased in all treatment groups compared to control group (p<0.05). There was no significant difference in mean sperm motility on rats exposed to 200 mGy X-ray radiation compared to 100 mGy X-ray radiation (p>0.05). Viability counts decreased in all treatment groups compared to control group (p<0.05) and the spermatozoa viability in 200 mGy radiation group was not significantly different from 100 mGy group (p>0.05). Conclusion: X-ray radiation exposure decreases sperm motility and viability in Wistar rats with the optimum doses 100 mGy.]]>
<![CDATA[EFFECTS OF COCONUT WATER (COCOS NUCIFERA SP.) ADMINISTRATION AS PREVENTION OF UROLITHIASIS IN CALCIUM OXALATE INDUCED - WHITE RAT WISTAR STRAINS ]]>
<![CDATA[Muhammad Reza Gautama]]>;
<![CDATA[I Ketut Sudiana]]>;
<![CDATA[Soetojo]]>;
<![CDATA[Djojodimedjo, Tarmono]]>
<![CDATA[ Indonesian Journal of Urology Vol 28 No 1 (2021) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v28i1.698
<![CDATA[Objective: To analyze the effect of coconut water administration on the occurrence of urolithiasis in calcium oxalate-induced Wistar rats. Material & Methods: Laboratory experimental study with post-test only control group design, using experimental model of male Rattus norwegicus-Wistar strains. The treatment given is ad libitum administration coconut water to observe its effect on renal histopathological changes, microscopic analysis, and renal function markers. Urolithiasis induction uses exposure of 0.75% ethylene glycol (EG), and 2% Ammonium chloride (AC) in drinking water. Results: Descriptive analysis showed the tendency of decreasing in mean of renal function markers, and histopathological nephron damage in the treatment group versus control group: BUN (11.22 versus 14.29); Creatinine Serum (0.5308 versus 0.5714); degree of nephron damage (5.22 versus 10.36). In microscopic analysis, there were calcium deposits in the kidney tubules in the control group, which were not found in the treatment group. Based on the ANOVA test, obtained significant difference in BUN levels with p value=0.023 (p<0.05), and the degree of nephron damage between study groups with p value= 0.000 (p<0.05). There was no significant difference in serum creatinine with p value= 0.23 (p>0.05). Conclusion: Coconut water is potential modality in inhibiting the deposition of calcium oxalate crystals, and protecting from impaired kidney function against urolithiasis in animal-model of calcium oxalate-induced Wistar rats.]]>
<![CDATA[NEFROPROTECTOR EFFECT OF CURCUMIN (CURCUMA LONGA) AND VITAMIN E (α-TOCOPHEROL) IN WISTAR STRAIN RATS AFTER CISPLATIN TREATMENT ]]>
<![CDATA[Sirait, Binsar Marshall Maranatha]]>;
<![CDATA[Wahjoe Djatisoesanto]]>;
<![CDATA[Soetojo]]>
<![CDATA[ Indonesian Journal of Urology Vol 28 No 1 (2021) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v28i1.704
<![CDATA[Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). Further analysis showed that there was a significant difference between the treatment group that received vitamin E and curcumin from the treatment group that received a combination of both (P<0.05). In addition, there were differences in BUN and serum creatinine levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). However, there was no significant difference in BUN levels in the treatment group that received vitamin E with the treatment group that received curcumin or a combination of both (p>0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin.]]>
<![CDATA[THE EFFECTIVENESS OF TNF-Α INHIBITOR THERAPY IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS ]]>
<![CDATA[Kholis, Ahmad]]>;
<![CDATA[Soetojo]]>;
<![CDATA[Djatisoesanto, Wahjoe]]>
<![CDATA[ Indonesian Journal of Urology Vol 28 No 2 (2021) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v28i2.744
<![CDATA[Objective: To evaluate the effectiveness of TNF-α inhibitor therapy in Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) patients compared to placebo, assessed using Global Response Assessment (GRA). Material & Methods: A systematic review and meta-analysis. Subjects were patients with moderate to severe diagnosis of BPS/IC who were given TNF-α inhibitor versus placebo, with the Global Response Assessment (GRA) (patient-reported self-reported BPS/IC treatment response scale). A systematic literature search was carried out on the English databases PubMed/MEDLINE and Science Direct, published until September 2020. Data were extracted independently and assessed the bias and quality of each selected article. Results: Initially there were 124 studies. After further selection, 2 RCT studies were included in the criteria for this study. The number of samples obtained was 85 patients. There is 1 study that used 400 mg of certolizumab pegol subcutaneously and 1 study used adalimumab 80 mg subcutaneously and followed by 40 mg subcutaneously for 2 weeks. Both studies had statistically low heterogeneity with I2 = 0% (P = 0.34), so fixed effect statistical model was used to determine the result. Furthermore, there was no significant difference (P = 0.32) between the number of GRA responders from the TNF-α inhibitor and placebo therapy groups, with odds ratio of 1.61 (CI = 0.65-4.00). Conclusion: TNF-α inhibitor therapy did not increase GRA responders when compared to placebo.]]>
<![CDATA[THE EFFICACY COMPARISON OF MIRABEGRON AS A MONOTHERAPY VERSUS ITS COMBINATION WITH SOLIFENACIN IN OVERACTIVE BLADDER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS ]]>
<![CDATA[Madani, Hasan]]>;
<![CDATA[Soetojo]]>;
<![CDATA[Djatisoesanto, Wahjoe]]>
<![CDATA[ Indonesian Journal of Urology Vol 28 No 2 (2021) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v28i2.748
<![CDATA[Objective: This review aimed to evaluate the efficacy and safety of mirabegron as monotherapy and its combination with solifenacin for patients with overactive bladder (OAB). Material & Methods: A systematic search was conducted in PubMed, Google Scholar, and Science Direct using the keywords Overactive bladder or OAB and mirabegron or beta-3 agonist or β3 adrenoreceptor agonist and solifenacin or antimuscarinic based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline to include relevant randomized controlled trials (RCT)s. The included studies were assessed for their risks of bias using the Cochrane risk of bias tool for randomized controlled trials. Quantitative analysis using forest plot was performed in Review Manager 5.4. Results: A total of 4 RCTs were included from 227 studies. A fixed-effects model was chosen due to the low level of heterogeneity between the studies (I2 = 0%). The average micturition volume of patients in the combination group is higher compared to the monotherapy group (MD 17.13, 95% CI 12.78 - 21.48, p < 0.00001). The mean micturition frequency (MD - 0.54, 95% CI - 0.73 - -0.34, p < 0.00001) and incontinence incidence (MD -0.30, 95% CI -0.48 - -0.12, p = 0.001) in the combined group are significantly lower compared to the monotherapy group. Conclusion: The combination of mirabegron and solifenacin has better efficacy compared to mirabegron as monotherapy for OAB patients with a therapy duration of less than 12 weeks based on the micturition volume, micturition frequency, and incontinence incidence. The administration of combination therapy would not increase adverse event incidence compared to monotherapy.]]>
<![CDATA[HISTOPATHOLOGICAL EXAMINATIONS PROFILE OF BLADDER DISEASES IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL FROM JANUARY 2015 TO DECEMBER 2019 ]]>
<![CDATA[Krismaningrum, Veronika Intan]]>;
<![CDATA[Rahaju, Anny Setijo]]>;
<![CDATA[Herawati, Lilik]]>;
<![CDATA[Soetojo]]>
<![CDATA[ Indonesian Journal of Urology Vol 29 No 1 (2022) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v29i1.761
<![CDATA[Objective: This study aimed to analyze the profile of bladder disease in Soetomo General Hospital based on histopathological examination. Material & Methods: This study was using secondary data. Histopathological examination data of patients with bladder disease were evaluated based on age, gender, and histopathological types. Results: There were 419 patients with bladder abnormalities. Non-neoplasm bladder diseases were found in 62 patients consisted of 56 patients (90.32%) with cystitis and 6 patients (9.67%) with glandular cystitis. Neoplastic bladder diseases were found in 357 patients and were divided into benign and malignant neoplasm. Benign neoplasms were found in 11 patients consisted of 5 patients (45.45%) with UP and 6 patients (54.54%) with IUP. Malignant neoplasms were found in 340 patients consisted of 300 patients (88.23%) with urothelial carcinoma, 26 patients (7.64%) with adenocarcinoma, 14 patients (4.12%) with SCC. Moreover, six male patients with PUNLMP were also reported. Conclusion: Histopathological examination in patients with bladder abnormalities shows that neoplastic bladder diseases (357/419, 85.20%) were more common than non-neoplastic bladder disease (62/419, 14.80%).]]>
<![CDATA[The Correlation of Prostate Volume with Uroflowmetry and International Prostatic Symptoms Score (IPSS) on Patient with Benign Prostatic Hyperplasia without Urinary Retention ]]>
<![CDATA[Arif Rananda]]>;
<![CDATA[Reny I’tishom]]>;
<![CDATA[Wahjoe Djatisoesanto]]>;
<![CDATA[Soetojo]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
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DOI: 10.37506/ijfmt.v15i3.15613
<![CDATA[Objective: To value the correlation of Prostate Volume with Uroflowmetry and IPSS on patients with BPHwithout urinary retention that would be conducted at Dr. Soetomo 2015-2017. Method: This research usedretrospective descriptive study using secondary data from medical records to determine the relationshipbetween Prostate Volume (PV) and Uroflowmetry and the International Prostatic Symptom Score (IPSS)of Benign Prostate Hyperplasia (BPH) patients without urinary retention. Uroflowmetry basic parametersis Qmax, Vvoid, and PVR. The sampling technique used the total sampling method that used all existingdata in a certain period. Result: 86 medical records of BPH patients, the age range 45-64 years: 52 patients(60.46%), and the age range> 65 years: 34 patients (39.54%). PV statistical test with Qmax (r = 0.012;p = 0.913), the correlation was not significant. PV with Vvoid (r = 0.112; p = 0.305), the correlation wasnot significant. PV with PVR (r = -0.015; p = 0.892), the correlation was not significant. PV with IPSS (r= 0.048; p = 0.660), the correlation was not significant. Conclusion: There is no correlation on ProstateVolume with Uroflowmetry and IPSS on patient with BPH without urinary retention.]]>
<![CDATA[BEKAM SEBAGAI TERAPI ALTERNATIF UNTUK NYERI ]]>
<![CDATA[Hanik Badriyah Hidayati]]>;
<![CDATA[Mohammad Hasan Machfoed]]>;
<![CDATA[Kuntoro Kuntoro]]>;
<![CDATA[Soetojo Soetojo]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Suroto Suroto]]>;
<![CDATA[Budi Utomo]]>
<![CDATA[ NEURONA Vol 36 No 2 (2019) ]]>
Publisher : <![CDATA[PERDOSNI ]]>
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DOI: 10.52386/neurona.v36i2.69
<![CDATA[ CUPPING AS PAIN ALTERNATIVE THERAPYABSTRACTPain is still a world’s problem. Current pain treatment is still unsatisfactory due to its chronicity and existing drugs’ side effects. Due to dissatisfaction with the existing treatment, many patients are choosing a traditional therapy for their pain treatment. Cupping therapy is one of the traditional therapies that is widely used to relieve pain. Cupping therapy has been used in many countries in the world. Some of these countries have used cupping therapy as a pain treatment in hospitals. Neurologists are handling pain cases in their daily practice. Nearly 80% of patients come to the doctor with one of their complaint related to pain directly. The knowledge of cupping therapy for pain is important for the development of new therapies in order to solve the pain problems that so far have not reached a satisfactory level.Keyword: Alternative therapy, cupping therapy, pain, pain problemsABSTRAKNyeri masih merupakan masalah dunia. Pengobatan nyeri saat ini masih belum sampai tahap yang memuaskan terkait kronisitas dan efek samping obat yang ada. Akibat ketidakpuasan dengan pengobatan yang ada, banyak pasien yang memilih terapi tradisional untuk pengobatan nyerinya. Terapi bekam merupakan salah satu terapi tradisional yang banyak dipakai untuk meredakan keluhan nyeri. Terapi bekam telah dipakai di banyak negara di dunia. Sebagian negara tersebut telah menggunakan bekam sebagai terapi nyeri di rumah sakit. Bekam menurunkan nyeri melalui efek antinosiseptifnya, dengan cara stimulasi sistem saraf perifer dan menurunkan stres oksidatif. Studi terbaru menunjukkan bahwa terapi bekam basah dapat meningkatkan ekspresi ß-endorphin dan HSP70 keratinosit pada lokasi bekam. Dalam praktek sehari-hari dokter spesialis saraf menangani kasus nyeri. Hampir 80% pasien datang ke dokter dengan disertai salah satu keluhan yang berkaitan dengan nyeri secara langsung. Pengetahuan tentang terapi bekam untuk nyeri penting diketahui untuk pengembangan terapi baru guna menyelesaikan permasalahan nyeri yang sampai saat ini belum sampai pada tahap yang memuaskan.Kata kunci: Masalah nyeri, nyeri, terapi alternatif, terapi bekam ]]>
