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All Journal Pharmed: Journal of Pharmaceutical Science and Medical Research Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Prima Medika Sains Stannum : Jurnal Sains dan Terapan Kimia Jurnal Penelitian Farmasi dan Herbal Jurnal Pengmas Kestra (JPK) Jurnal Sains dan Kesehatan
Sinurat, Jhon Patar
INSTITUT KESEHATAN MEDISTRA LUBUK PAKAM
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL FARMASIMED (JFM)

 1 
UJI SENYAWA FLAVONOID TOTAL DARI EKSTRAK ETANOL HERBA BINARA (ARTEMISIA ANNUA) MENGGUNAKAN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TAHUN 2019 Purba, Novandi; Sinurat, Jhon Patar; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.988 KB) | DOI: 10.35451/jfm.v2i1.323

Abstract

ABSTRAK Herba binara (Artemisia Annua) is one of the plants that contains flavonoids which are efficacious as antioxidants and anticancer. The purpose of this study was to determine the total flavonoid compounds contained in ethanol extract of binara herbs (Artemisia Annua). Compounds in ethanol extract of binara herbs were identified by phytochemical screening. The results showed that the ethanol extract of binara herbs contained alkaloids, flavonoids, saponins, and tannins. Extraction was carried out in two stages, namely maceration stage with 96% ethanol and fat removal stage by hydrolysis using distilled water solvent. The extract was partitioned with ethyl acetate and n-hexane solvents, then the partitions were examined by TLC using the mobile phase of chloroform and ethyl acetate (7: 3). Ribbon patches that have the same Rf and color prices as the initial detection are taken and searched. Then analyzed using High Performance Liquid Chromatography (HPLC). Based on the wavelength as well as the TLC test, a partial structure which was strongly suspected of total flavonoids was 0.93 g. Kata Kunci :Herba Binara (Artemisia Annua), flavonoid, KLT, High Performance Liquid Chromatography(HPLC).
ANTIBAKTERI SENYAWA FENOLIK DARI ALANG -ALANG (IMPERATA CYLINDRICA) Sinurat, Jhon Patar; Wulandari, Suci; Berutu, Rinaldo
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.684

Abstract

Phytochemical screening test proved that the extract of Reeds (Imperata cylindrica) contained phenolic compounds tested using 5% FeCl3 reagent. Antibacterial test using agar diffusion method against Reeds extract in DMSO solvent. The phenolic compounds obtained from the saputangan leaves Reeds extract were 36.96 grams after undergoing maceration. Reeds extract of phenolic compounds with concentrations (200; 100; 50 and 25 ppm) had strength antibacterial where the average inhibition zone of Staphylococcus aureus bacteria was 10.0 mm and the average inhibition zone was at Escherichia coli bacteria measuring 10.3 mm.
Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

Abstract

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.
Processing of Rice Straw (Oryza sativa) into Activated Carbon and Its Formulation in Facial Cleansing Soap Products Tampubolon, Regina Elianda; Wulandari, Suci; Sinurat, Jhon Patar; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cpmerg17

Abstract

Rice straw is an abundant agricultural by-product commonly used as livestock feed or burned as waste. It contains cellulose, hemicellulose, lignin, and silica, which can be processed into activated carbon capable of adsorbing impurities and excess oil from the skin. To date, the utilization of rice straw has been limited mainly to compost fertilizer and planting media. Meanwhile, facial cleansing soaps made from natural extracts, eco-friendly ingredients, and affordable materials are increasingly popular. The objective of this study was to produce activated carbon from rice straw and apply it in the formulation of a facial cleansing soap product.This research employed an experimental laboratory approach with a quantitative descriptive method to determine the effectiveness of rice straw–based activated carbon in facial soap formulations. The procedure began with the carbonization of rice straw powder, followed by characterization of the activated carbon through moisture content analysis, ash content test, and FT-IR functional group analysis. The liquid soap was formulated into three variations and evaluated for its quality through organoleptic observation, pH measurement, cleansing ability test, and oil adsorption test.The results showed that activated carbon derived from rice straw had a moisture content of 8.92%, ash content of 7.68%, and exhibited functional groups such as –OH, aliphatic C–H, aromatic C=C, aldehyde C=O, and alcohol C–O based on FT-IR analysis. The facial soap formulations containing rice straw–based activated carbon demonstrated safe pH values—F1 = 5.46, F2 = 6.04, and F3 = 6.8—and exhibited enhanced cleansing and oil-adsorbing properties, with the highest oil adsorption value reaching 86%. These findings indicate that activated carbon from rice straw can be effectively applied in the formulation of facial cleansing soap that is safe and beneficial for skin health.
Evaluation of Antidiabetic Potential (α-Glucosidase and α-Amylase Enzyme Inhibition Assay) of Mundu Leaf Extract [Garcinia dulcis (Roxb.) Kurz] Purba, Novandi; Br Turnip, Nur Ulina M.; Sinurat, Jhon Patar
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nex3ag44

Abstract

Diabetes Mellitus (DM) is a chronic disease that requires appropriate solutions for its management. To date, synthetic antidiabetic drugs frequently cause side effects in the body. The search for natural antidiabetic agents has therefore been carried out by exploring the potential of mundu leaves, which are considered safer as they originate from natural sources. Mundu leaves contain flavonoids, phenols, and tannins, which may act as natural antidiabetic agents due to their richness in hydroxyl and aromatic compounds. Antioxidant compounds play a role in protecting body cells from oxidative stress, which is strongly associated with diabetes. Several species from the Garcinia genus have been studied, but to date, no research has focused on the antidiabetic potential of mundu leaves. Through assays of mundu leaf extract in inhibiting α-amylase and α-glucosidase enzymes, as well as antioxidant tests, DM could potentially be better controlled, providing a reference for its use as a natural antidiabetic and antioxidant agent. Mundu leaves were prepared and macerated using ethanol as a solvent, followed by evaporation with a rotary evaporator. Phytochemical screening was conducted to detect the presence of active compounds. The inhibitory activity of mundu leaf extract against α-glucosidase and α-amylase enzymes was measured using a UV-Visible spectrophotometer to obtain absorbance values. The absorbance data were then used to determine the percentage of inhibition, allowing the calculation of IC50 values as a benchmark for antidiabetic activity. The results demonstrated that the mundu leaf extract exhibited antidiabetic properties, with IC50 values of 51.058 ppm and 33.004 ppm, categorized as strong and very strong, respectively.
Co-Authors Ayuningsari, Laras Berutu, Rinaldo Br Turnip, Nur Ulina M. Cahya, Cucu Arum Dwi Fahma Shufyani Fibrini, Dewi Fioni, Fioni Ginting, Wira Maria Harahap, Rahmat Ali Putra Husna, Miftahul Khairunnisa Batubara Margaretta Olivia Br Manik Purba, Novandi Putranto Manalu Reh Malem br Karo Reh Malem Br Karo Reh Malem br Karo Reh Malem Br Karo Rinaldo Berutu Rinaldo Berutu Rinaldo Berutu Rizki, Nadya Romaulianna Theresia Marbun SAADAH SIREGAR Sirait, Reni Aprinawaty Suci Wulandari Syarifuddin, Aminah Syarifuddin, Shofian Tampubolon, Regina Elianda Telova, Yurizki Visensius Krisdianilo Yanna Rotua Sihombing Yanti, Dian Anggri