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Pintata Sembiring
Institut Kesehatan Deli Husada Deli Tua
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulasi Dan Aktivitas Antibakteri Sediaan Face Spray Gel Ekstrak Etanol KulitMarkisa Ungu (Passiflora Edulis Sims.) Terhadap Propionibacterium Acnes SebelumDan Sesudah Cycling Test Romi Ramadiansyah; pintata sembiring; Firdaus Fahdi; Rika Puspita Sari
Jurnal Biogenerasi Vol. 11 No. 3 (2026): Juli - September 2026
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/pgpr3s80

Abstract

Purple passion fruit peel (Passiflora edulis Sims.) is commonly discarded as waste, yet it contains secondary metabolites with potential to inhibit the growth of Propionibacterium acnes, the main bacterium responsible for Acne vulgaris. This study aimed to formulate the ethanolic extract of purple passion fruit peel into a face spray gel, evaluate its physical characteristics and stability, and examine its antibacterial activity before and after a cycling test. The simplicia was characterized for moisture content, drying loss, water- and ethanol-soluble extractive values, total ash, and acid-insoluble ash, followed by maceration extraction with 96% ethanol. The extract was phytochemically screened and formulated into four variants: F0 (base without extract), F1 (10%), F2 (15%), and F3 (20%). Physical evaluation covered organoleptic properties, homogeneity, pH, spreadability, adhesiveness, viscosity, and spray pattern, followed by stability testing at low, room, and high temperatures, centrifugation, and a seven-cycle cycling test. Antibacterial activity was assessed using the disc-diffusion method against P. acnes before and after the cycling test. The simplicia met quality requirements with 1.67% moisture content, 9.15% drying loss, 42.33% water-soluble extractive value, 69.31% ethanol-soluble extractive value, 4.04% total ash, and 0.80% acid-insoluble ash. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and steroids. All formulas met the requirements for pH, viscosity, adhesiveness, and homogeneity, although the spreadability of F2 and F3 exceeded the required range. Stability testing showed that F0, F1, and F2 were unstable under extreme conditions, whereas F3 remained stable at low and high temperatures, after centrifugation, and after the cycling test. The highest inhibition zone was obtained by F3, at 42.12±6.60 mm before and 15.17±2.35 mm after the cycling test, still exceeding the comparator control (5.23±1.50 mm). One-way ANOVA indicated a highly significant difference among formulas (p=0.000). The ethanolic extract of purple passion fruit peel can be formulated into a face spray gel with antibacterial activity against P. acnes, with F3 showing the best activity and stability despite a marked reduction in inhibition after the cycling test.
Co-Authors ., Erdiwan ., Nadiya Barita Esman Dabukke Damanik, Yunita Syahputri Delisma Simorangkir Efrata Sembiring Elysa Elysa Elysa Elysa FAHDI, FIRDAUS Harahap, indah Putri Harahap, Nina Irmayanti Harahap, Nurul Dahlia Linta Meliala MARBUN, VIKTOR EDYWARD Masria Phetheresia Sianipar Masria Phetheresia Sianipar Mona Fitri Gurusinga Nurul Dahlia Harahap Purba, Jhan Saberlan Rahmi, Sofia Ratna Sari Putri Br Tarigan Ratna Sari Tarigan Rika Puspita Sari Romi Ramadiansyah Sianipar, Masria Phetheresia Simanjuntak, Afrilius Sitio, Sri Sudewi Pratiwi Sofia Eliasari Br Bangun Sofia Rahmi Tambusai Sriyunita Perangin angin Sulasmi Sulasmi Syafitri, Anggun