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All Journal BALI MEDICAL JOURNAL (BMJ) journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Teknik ITS IPTEK Journal of Proceedings Series R.E.M (Rekyasa Energi Manufaktur) Jurnal Berkala Kedokteran The Indonesian Biomedical Journal Jurnal Administrasi Pendidikan Indonesia Jurnal Penyakit Dalam Udayana Jurnal Kelautan Nasional Wave: Jurnal Ilmiah Teknologi Maritim ISM (Intisari Sains Medis) : Jurnal Kedokteran International Journal of Marine Engineering Innovation and Research Jurnal Sosial dan Teknologi MAHESA : Malahayati Health Student Journal GANESHA MEDICINA Public Health and Preventive Medicine Archive Makara Journal of Technology Jurnal Penyakit Dalam Indonesia
I Ketut Suastika
Institut Teknologi Sepuluh Nopember Surabaya
Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Transportation

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Diabetes Risk Allele of Transcription Factor 7-like 2 (TCF7L2) Polymorphisms is Associated with Higher Glucagon-like Peptide 1 (GLP1) and Lower Insulin Secretion Saraswati, Made Ratna; Suastika, Ketut; Budhiarta, Anak Agung Gde; Oktavianthi, Suksma; Malik, Safarina G.
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3202

Abstract

BACKGROUND: The most influential susceptible gene associated with diabetes, transcription factor 7-like 2 (TCF7L2), has been observed in diverse populations. TCF7L2 influences type 2 diabetes risk through glucagon-like peptide 1 (GLP1) production. The presence of risk allele of TCF7L2 leads to the alteration of gene expression in pancreatic beta cells; however, how the mechanism is related with GLP1 remains unclear. This study was conducted to explore the variations of GLP1 increment and insulin secretion between individuals with and without diabetes risk allele of single nucleotide polymorphisms (SNPs) in TCF7L2.METHODS: A cross-sectional analytic study was conducted involving individuals subjects who harbored known variants of SNPs in the TCF7L2: heterozygote or mutant of rs12255372 (GT or TT), rs7903146 (CT or TT), rs10885406 (AG or GG); as well as control subjects with wild type of rs12255372 (GG), rs7903146 (CC), and rs10885406 (AA). Anthropometric parameters, blood glucose, insulin, and GLP1 were measured; and homeostasis model assessment-beta cell (HOMA-%B) index was calculated.RESULTS: The GLP1 increment response was higher in subjects carrying the diabetes risk allele (0.34±0.80 ng/mL) than those with the wild type (-0.04±0.57 ng/mL) (p=0.041). The HOMA-%B was reduced in subjects carrying the diabetes risk allele (71.64±24.72) than those with the wild type (103.23±68.00) (p=0.011). Among individuals carrying the diabetes risk allele, the likelihood of GLP1 increment with high response was twice as high (p=0.007), while the occurrence of low HOMA-%B was 1.47 more frequent (p=0.011).CONCLUSION: TCF7L2 polymorphisms were associated with the GLP1 increment response and reduced HOMA-%B, which might be potentially contributing to GLP1 resistance in patients with diabetes risk factors.KEYWORDS: diabetes risk, TCF7L2, GLP1, HOMA-%B
Relationship between Interleukin 6 and Estradiol Levels in Obese and Adult Men Dwipayana, I Made Pande; Semadi, I Made Siswadi; Nugraha, Ida Bagus Aditya; Gotera, Wira; Saraswati, Made Ratna; Suastika, Ketut; Saraswati, Putu Ayu Indah
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24498

Abstract

Obesity is a chronic disease characterized by a pathophysiological process that causes an increase in adipose tissue mass, leading to an increased risk of morbidity and mortality. Currently, there are many conditions that allow the interaction between environmental factors and genes that lead to various metabolic disease complications, such as diabetes mellitus and heart attack. Health workers are at the forefront of managing obesity and its associated complications. The study was conducted at Ngoerah Hospital from March to October 2024. The target population in this study were adult male medical personnel with and without obesity, working at Ngurah Hospital. The inclusion criteria in this study: male health workers in the environment at Ngoerah Hospital aged 18-45 years and willing to participate in the study by signing informed consent. Exclusion criteria in this study were all male health workers with infectious or inflammatory diseases, and or suffering from malignancies or a history of chemotherapy, and or with the use of hormonal therapy. The sample size of the study was 64 subjects. Data analysis included descriptive statistics, a normality test using the Kolmogorov-Smirnov test, a comparison test using the Mann-Whitney U test, and a correlation test using the Spearman rank correlation. This study was approved by the Research Ethics Commission, approval number 1697/UN14.2.2.VII.14/LT/2024. The results of this study found that IL-6 and estradiol levels in the obese group were higher than the non-obese group, however, the differences were not statistically significant. This may be attributed to the relatively young age of the subjects and the absence of significant inflammation in the early stages of obesity. There was no significant correlation between IL-6 and estradiol in all subjects, obese and non-obese groups.
Hubungan Antara Kadar Gula Darah dengan Kejadian Inkontinensia Urin pada Lansia di Desa Tabanan, Bali Kurniawan, I Made Dwi; Suastika, Ketut
Jurnal Sosial Teknologi Vol. 6 No. 1 (2026): Jurnal Sosial dan Teknologi
Publisher : CV. Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsostech.v6i1.32653

Abstract

Urinary incontinence is a common issue in the elderly, impacting their quality of life. One of the risk factors for its occurrence is blood sugar levels. This study aimed to determine the relationship between blood sugar levels and urinary incontinence in elderly individuals in Tabanan, Bali. A cross-sectional design was used, with simple random sampling. Interviews were conducted to gather demographic data and assess complaints of urinary incontinence, while blood tests were performed to measure blood sugar levels. The cut point for blood sugar was determined using the ROC curve. Chi-square bivariate analysis was performed to assess the relationship between blood sugar levels and urinary incontinence. The study involved 64 subjects, with 10 (15.6%) males and 54 (84.4%) females. Of the 39 subjects (60.9%) who reported urinary incontinence, 20 (51.3%) had blood sugar levels above the cut point, and 19 (48.7%) had levels below it. The results showed a statistically significant association (p = 0.048). In conclusion, blood sugar levels are associated with the incidence of urinary incontinence in the elderly.
Differences Between Serum Total Testosterone Levels in Obese and Non-Obese Male Health Workers Saraswati, Putu Ayu Indah; Suastika, Ketut; Dwipayana, I Made Pande
MAHESA : Malahayati Health Student Journal Vol 6, No 3 (2026): Volume 6 Nomor 3 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i3.20851

Abstract

ABSTRACT Obesity is a metabolic condition that poses a global health challenge and is associated with various complications, including reduced testosterone levels. Low testosterone is a critical component in metabolic syndrome and hormonal dysfunction in men. This study aims to analyze the differences in total serum testosterone levels between obese and non-obese male healthcare workers and identify factors influencing low testosterone levels at Prof. dr. I.G.N.G. Ngoerah General Hospital, Denpasar. This cross-sectional study involved 89 male healthcare workers grouped based on body mass index (BMI): obese (BMI ≥ 25 kg/m²) and non-obese (BMI 25 kg/m²). Total serum testosterone levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical analysis included bivariate tests using Chi-Square and Fisher-Exact tests, followed by multivariate logistic regression to determine the relationship between obesity and low testosterone levels, adjusting for confounding factors such as age, type 2 diabetes mellitus, hypertension, and heart disease. The mean total serum testosterone level was 528.74 ± 265.13 ng/dL. The prevalence of low testosterone was significantly higher in the obese group (82.6%) compared to the non-obese group (17.4%), with an odds ratio (OR) of 13.691 (p 0.001). Multivariate analysis identified obesity as an independent predictor of low testosterone, with an adjusted odds ratio (AOR) of 6.101 (95% CI: 1.531–24.307; p = 0.010). Age was also a significant factor, with participants aged ≥30 years having a higher risk of low testosterone compared to younger participants (AOR: 4.961; 95% CI: 1.118–22.004; p = 0.035). Type 2 diabetes mellitus was strongly associated with low testosterone levels (OR: 22.909; p 0.001) but was not significant in the multivariate analysis (p = 0.060). Obesity is a significant risk factor for low testosterone levels in male healthcare workers, with age being another key determinant. These findings highlight the importance of early detection and management of obesity to prevent hormonal dysfunction. Keywords: Obesity, Total Serum Testosterone, Male Healthcare Workers.
Co-Authors A Santoso A. A. Mas-Putrawati AAG Budhiarta AAG Budhitresna Ade Reza Hariyadi Agung Pranoto Agus Joko Purwanto An Apriyani Tebiary Anak Agung Ayu Mirah Adi Anak Agung Gde Budhiarta Anak Agung Gde Budhiarta Anak Agung Gede Sudewa Djelantik Angga Yustiawan Anwar Santoso Ardi Nugroho Yulianto Aries Sulisetyono Aryana, I Gust Putu Suka Aryawan, Wasis Dwi Askandar Tjokroprawiro Astika, I Nyoman Buana Ma'ruf Buana Ma'ruf Budhiarta, Anak Agung Gde Dedi B. Purwanto Dewa Putu Gede Purwa Samatra Dian Purnamasari Dian Purnamasari Dikantoro, Regi Y. Djoenaidi Widjaja Djoko W. Soeatmadji Dwija Sanjaya Ericson Estrada Sipayung Gede Kambayana Gede Putu Arsana Gede Sukrawan Giles Anthony Thomas Gunanta, Julhari H Taniguchi H. S. Habiba Muhiddin, H. S. Habiba Hari Bagianto I Gusti Agung Dewi Sarihati I Gusti Ayu Mardewi I Gusti Putu Suka Aryana I Ketut Aria Pria Utama I Made Bakta I Made Jawi I Made Jawi I Made Pande Dwipayana I Made Siswadi Semadi I Made Siswadi Semadi I Made Siswadi Semadi I Nyoman Astika I NYOMAN MANTIK ASTAWA I Nyoman Wande I Nyoman Wande I P G. Adiatmika I Putu Gede Adiatmika I Wayan Mustika I Wayan Mustika I Wayan Putu Sutirta Yasa I Wayan Weta I Wayan Wita Ida Bagus Aditya Nugraha Ida Bagus Ekaputra Ida Bagus Ekaputra, Ida Bagus Ida Bagus Ngurah Wises Ida Bagus Putu Putrawan IGN Gunadi Ignatius Ferdi Yuatmadja IMR Saraswati Iswara, Ni Putu Ayu Astri Prana K Badjra Nadha K Rina K Tangking Widarsa Kadek Ngurah Hariawa Ketut Adi Jaya Sutana Ketut Suata Komang Ayu Kartika Sari Kurniawan, I Made Dwi Luh Gede Sri Yenny Luh Seri Ani Made Ratna Saraswat MADE RATNA SARASWATI . Made Wardhana Made Wiryana Malik, Safarina G. Marisye Christantia N Kajiwara N. K. Niti Susila, N. K. Ni Ketut Rai Purnami Ni Made Suaniti Ni Nyoman Trisna Yuliharti Tersinanda Ni Putu Ayu Astri Prana Iswara Noor Virliantarto Nurhadi Nurhadi Nym Astika Oktavianthi, Suksma Pradana Soewondo Purnami, Ni Ketut Rai Purwanto, Dedi B. Putra, Wing H. A. Putri Virliani Putri Virliani Putri Virliani R. A.T. Kuswardhani R. Prawira Bayu Putra Dewa Raka-Sudewi A. A. Regi Y. Dikantoro Regi Yudha Dikantoro S. Soetjiningsih, S. S., Hantono Saraswati, Putu Ayu Indah Setyawan, Dony Sidartawan Soegondo Siorcani, Putu Tasha Sri Trisnawati Sri Trisnawati Sri Yuniari Sri Yuniari, Sri Sutanegara - Sutjahjo Suherman, Sutjahjo Teguh Putranto Thomas Eko Purwata Tuty Kuswardani W Wita Wasis Akriananta Wibowo Harso Nugroho Wibowo Nugroho, Wibowo Wing H. A. Putra Wira Gotera Wisnu Firstdhitama