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All Journal VALENSI Jurnal Natur Indonesia Jurnal Matematika & Sains Bulletin of Chemical Reaction Engineering & Catalysis Journal of Mathematical and Fundamental Sciences Jurnal Industri Hasil Perkebunan Jurnal Penelitian Sains Jurnal Sains Teh dan Kina ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Journal of Microbial Systematics and Biotechnology Molekul: Jurnal Ilmiah Kimia al Kimiya : Jurnal Ilmu Kimia dan Terapan

Yana Maolana Syah

Biochemistry Research Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung

Author-ID : 398733

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Energy Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Physics

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Synthesis and Characterization of Oligomer 4-Vinylpyridine as A Corrosion Inhibitor for Mild Steel in CO2 Saturated Brine Solution Ilim Ilim; Alan Jefferson; Wasinton Simanjuntak; Marc Jeannin; Yana Maolana Syah; Bunbun Bundjali; Buchari Buchari
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

In this work, the oligomer of 4-vinylpyridine designated as O(4-VP) was synthesized by hydrogen peroxide initiated chain growth polymerization and characterized in terms of molecular weight and structure by matrix assisted laser desorption ionization time of flight mass spectroscopy (MALDI-TOF MS). The oligomer was tested as corrosion inhibitor of mild steel in brine solution saturated with carbon dioxide, with the main purpose to investigate the effect of inhibitor concentrations and temperatures on the inhibition activity defined in terms of corrosion rate and percent of protection. The inhibition tests were carried out using the methods of weight loss (WL) and linear polarization (LP). Characterization using MALDI-TOF MS revealed that the oligomer has the mass (m/z) in the range 200-2400, which corresponds to chain length of 2-22 repeating units. The results of corrosion rate measurements show that the corrosion rate with the use of oligomer is significantly lower than that without inhibitor, demonstrating that the oligomer functioned as effective corrosion inhibitor, while the 4-vinyl pyridine monomer was found to promote the corrosion. It was also found that the protection by the oligomer increased with increasing temperature and it was predicted the oligomer was chemically adsorbed by the surface of the metal.

Antibacterial Activity of Germacrane Type Sesquiterpenes from Curcuma heyneana Rhizomes Hartiwi Diastuti; Yana Maolana Syah; Lia Dewi Juliawaty; Marlia Singgih
Indonesian Journal of Chemistry Vol 14, No 1 (2014)
Publisher : Universitas Gadjah Mada

The isolation of terpenoids from C. heyneana rhizomes and their antibacterial activity have been conducted. The terpenoids were isolated by using vacuum liquid chromatography and radial chromatography. The structures of the compounds were determined based on spectroscopic data (1H-NMR, 13C-NMR (1D and 2D)). The antibacterial activity was carried out by using microdilution method and evaluated against eight bacteria. Three germacrane type sesquiterpenes have been isolated from C. heyneana rhizhomes and were identified as germacrone, dehydrocurdione, and 1(10),4(5)-diepoxygermacrone. Germacrone showed highest antibacterial activity against P. aeruginosa with MIC values of 15.6 µg/mL and MBC values 31.2 µg/mL. Dehydrocurdione showed highest antibacterial activity against B. subtilis with MIC values of 31.2 µg/mL and MBC values of 31.2 µg/mL. However, 1(10),4(5)-diepoxygermacrone showed a weak antibacterial activity.

FLAVANONES FROM THE WOOD OF Morus nigra WITH CYTOTOXIC ACTIVITY Ferlinahayati Ferlinahayati; Yana Maolana Syah; Lia Dewi Juliawaty; Euis Holisotan Hakim
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Two flavanone derivatives, norartocarpanone (1) and euchrenone a7 (2) had been isolated for the first time from the methanol extract of the wood of Morus nigra. The structures of these compounds were determined base on spectral evidence, including UV, IR, and NMR. The first compound also confirmed by comparison with the reported data. Cytotoxic properties of these compounds were evaluated against murine leukemia P-388 cells. Euchrenone a7 (2) was found more cytotoxic than norartocarpanone (1) with their IC50 7.8 and 12.7 mg/mL respectively.

RESVERATROL DIMERS FROM STEM BARK OF Hopea gregaria AND THEIR CYTOTOXIC PROPERTIES Sahidin Sahidin; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawaty; Sjamsul Arifin Achmad; Laily Bin Din; Jalifah Latip
Indonesian Journal of Chemistry Vol 8, No 2 (2008)
Publisher : Universitas Gadjah Mada

Six resveratrol dimers have been isolated from the stem bark of H. gregaria, ampelopsin A (1), balanocarpol (2), ε-viniferin (3), hopeafuran (4), heimiol A (5), and parviflorol (6). The structures of these compounds were determined based on spectroscopic evidence such as UV, IR, 1-D, 2-D NMR and comparison with the reported data. These compound inventions are strengthen conclusion that Hopea tends to produce resveratrol dimers. Biological activity of those compounds against murine leukemia P-388 cells showed that ε-viniferin (3) is the most active compound with IC50 value 5.1 ± 0.3 μg/mL.

(-)-AMPELOPSIN A : A DIMER RESVERATROL FROM Dryobalanops oblongifolia (dipterocarpaceae) Nanik Siti Aminah; Sjamsul Arifin Achmad; Masatake Niwa; Yana Maolana Syah; Euis Holisotan Hakim
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

A dimer resveratrol compound named (-)-ampelopsin A was isolated from acetone extract of the stem bark of Dryobalanops oblongifolia (Dipterocarpaceae). The structure of this compound was determined on the basis of NMR spectroscopic data.

Metabolite Profile Evaluation of Indonesian Roasted Robusta Coffees by 1H NMR Technique and Chemometrics Nizar Happyana; Elvira Hermawati; Yana Maolana Syah; Euis Holisotan Hakim
Indonesian Journal of Chemistry Vol 20, No 4 (2020)
Publisher : Universitas Gadjah Mada

In this work, 1H NMR analysis, along with a chemometrics approach, had been applied for investigating metabolite profiles of Indonesian roasted Robusta coffees obtained from Lampung and Aceh. In total, 24 compounds had been successfully detected in the 1H NMR spectra of the Robusta coffee extracts. Concentrations of some identified metabolites present in the coffees were determined by the quantitative 1H NMR technique. Orthogonal projection to latent structure-discriminant analysis (OPLSDA) was used as a primary method for the chemometric approach. OPLSDA had classified clearly the Robusta coffee samples corresponding to their origin. Loading plot and S-plot of the OPLSDA revealed characteristic metabolites for each Robusta coffee. The results indicated that quinic acid, mannose, arabinoses, and acetic acid were an important discriminant compound for Lampung Robusta coffees. Meanwhile, lipids, lactic acid, and 5-caffeoylquinic acid were found as characteristic metabolites for Aceh Robusta coffee. This report provided knowledge about the chemical composition of Lampung and Aceh Robusta coffees and shed more light on the diversity of Indonesian Robusta coffees. Furthermore, it confirmed that 1H NMR analysis coupled with chemometrics was a powerful method for evaluating and classifying metabolite profiles of the roasted Robusta coffees.

Aktivitas Sitotoksik Alkaloid Dari Cryptocarya archboldiana Allen Suwandri Suwandri; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawaty
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 01 Juli 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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ABSTRAK Cryptocarya merupakan salah satu genus terbesar dari famili Lauraceae dan sebagian besar spesiesnya tumbuh di hutan hujan tropis Asia-Pasifik antara lain hutan di Indonesia. Secara umum genus Cryptocarya mengandung metabolit sekunder utama golongan alkaloid, 2-piron dan flavonoid serta memiliki berbagai aktivitas biologis. Tiga senyawa alkaloid yang telah dikenal telah diisolasi dari tumbuhan Cryptocarya archboldiana; boldin, laurolitsin, dan retikulin. Struktur molekul ketiga senyawa tersebut telah ditetapkan berdasarkan analisis spektroskopi (UV, 1H dan 13C NMR) serta perbandingan dengan data spektrum senyawa yang telah dilaporkan. Senyawa laurolitsin menunjukkan aktivitas sitoksisitas yang moderat, sedangkan boldin dan retikulin memiliki aktivitas yang lemah terhadap sel murine leukemia P388. Kata kunci: C. archboldiana, alkaloid, sitotoksik, aporfin, benzilisokuinolin. ABSTRACT Cryptocarya is one of the largest genus of Lauraceae and most of the species grow in the tropical rain forests of Asia-Pacific, include in Indonesian forest. Generally Cryptocarya contains alkaloids, 2-piron, and flavonoids as well as has a variety of biological activities. Three alkaloids have been isolated from Cryptocarya archboldiana; boldine, laurolitsine, and reticuline. The molecular structure of all these compounds have been established by spectroscopic analysis (UV, 1H, and 13C NMR) and comparison with the spectral data of compounds that have been reported. The cytotoxic of laurolitsine showed moderate activity, while boldine and reticuline have weak activity against P388 murine leukemia cells. Key words: C. archboldiana, alkaloid, cytotoxic, aporphine, benzylisoquinoline.

Development of a dimer-based screening system for dimerization inhibitor of HIV-1 protease I Dewa Agung Panji Dwipayana; Yana Maolana Syah; Reza Aditama; Feraliana Feraliana; Azzania Fibriani
Journal of Microbial Systematics and Biotechnology Vol 2, No 2 (2020): December 2020
Publisher : Microbiology Division, Research Center for Biology, Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37604/jmsb.v2i2.42

An in vitro dimer-based screening system (DBSS) for selecting new HIV-1 protease dimerization inhibitor candidates from natural compounds had been established. This system utilizes a fusion between HIV-1 protease and dimer binding domain of AraC protein (proteaseHIV1-AraCDBD) where fluorescence signal will be emitted in the presence of HIV-1 protease inhibitor. However, this screening system had not been evaluated. Therefore, this study was aimed to evaluate it in recombinant Escherichia coli culture. The expression of proteaseHIV1-AraCDBD fusion gene was observed for 18 hours. Its crude lysate isolation was done once every 3 hours and analyzed using SDS PAGE. To test the DBSS, darunavir was used as positive control, and Nigella sativa extract (JH3) was used as the test compound. The results of SDS PAGE analysis on crude lysates presented a ~24.2 kDa band, which was the predicted size of the proteaseHIV1-AraCDBD fusion protein based on its amino acid sequence. The growth curve and protein expression profiles revealed that the 15 hours was the optimum culture age to be used in the screening system. Darunavir testing in DBSS showed an increase in fluorescence signal compared to the negative control. The same increase in fluorescence signal was also obtained from the JH3 compound test. In conclusion, DBSS could be used as an assay to screen for new HIV-1 protease inhibitors, and the JH3 compound demonstrated the ability to inhibit HIV-1 protease dimerization.

Lignans from Phyllanthus niruri L. and Their Antifusarium Properties Neneng Windayani; Yaya Rukayadi; Yana Maolana Syah; Tri Cahyanto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.25057

In this study, two lignan compounds were isolated from acetone extract of Phyllanthus niruri L. nirtetralin B (1) and phyllanthin (2) using several chromatographic methods followed by molecular structure elucidation mainly based on 1D and 2D of 1H and 13C NMR spectrum. The isolated compounds were tested for their antimicrobial properties against the plant pathogenic fungus, Fusarium oxysporum, using the agar plate well diffusion method. The microdilution method determined the minimum inhibitory concentration (MIC) and the minimum fungicide concentration (MFC). In addition, the microconidia germination inhibition test was carried out using the agar diffusion method. As a result, compound 1 had MIC and MFC values of 4 and 16 μg/mL, respectively. While compound 2 showed the same MIC and MFC values of 16 μg/mL. Further testing on the inhibition of germination of F. oxysporum microconidia showed that compound 2 inhibited microconidia germination 100% at a concentration of 2 × MIC. In comparison, compound 1 at the same concentration was only able to inhibit germination by 29%. This study revealed that compound 2 is a potential new fungicide derived from local medicinal plants. However, further research is needed to identify the interaction mechanism between the test compound and the fungal pathogen F. oxysporum to develop new antifungal agents.

Synthesis and Antibacterial Activity of 1,3,5,7-Tetrahydroxy-9,10-Anthraquinone and Anthrone Derivatives Siti Nurbayti; Didin Mujahidin; Yana Maolana Syah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.25279

In this research, the synthesis of 1,3,5,7-tetrahydroxy-9,10-anthraquinone (1) and two anthrone derivatives, 1,3,5,7-tetrahydroxy-10H-anthracene-9-one (2) and 1-hydroxy-3,5,7,9-tetramethoxyanthracene (3) has been done. Compound 1 was synthesized by a symmetrical condensation reaction of 3,5-dihydroxybenzoic acid in concentrated sulfuric acid. Reduction of the carbonyl group in compound 1 with SnCl2/HCl-HOAc affords compound 2. Compound 3 was prepared by modifying the hydroxy groups of compound 2 by a methylation reaction. The synthesized compounds were identified using nuclear magnetic resonance spectroscopy (NMR) and a high-resolution mass spectrometry (HR-ESI-MS). The antibacterial activity test of the synthesized compounds against four pathogenic bacteria, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Salmonella typhi, was carried out using the microdilution method. Compound 3 showed moderate activity against B. subtilis, E. coli and S. typhi with a MIC value of 37.5 µg/mL. Moderate activity was also shown by compound 2 against S. aureus, while compound 1 showed weak activity with a MIC value of 75 µg/mL against the four test bacteria.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Saifuddin Noer Affrida Affrida Aisyah Aisyah Aisyah Aisyah Alan Jefferson Aliefman Hakim Asep Aripin Asep Kadarohman Azzania Fibriani Bambang Ariwahjoedi Buchari Buchari Buchari Buchari Bunbun Bundjali Deana Wahyuningrum Debbie Soefie Soefie Dessy Natalia Devitri Amisa Dian Nugraheni Didin - Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Dikhi Firmansyah Eliza Eliza Elvira Hermawati Elvira Hermawati Emilia L Ghisalberti Emilia L. Ghisalberti Emilio L Ghisalberti Endang Rosdiana Eri Bachtiar Eri Bakhtiar Euis Holishotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotasn Hakim Feraliana Feraliana Ferlinahayati Ferlinahayati Firdaus, Firdaus Hanapi Usman Hartiwi Diastuti Hartiwi Diastuti Hartiwi Diastuti Haryoto Haryoto Hendra Helmanto Hernandi Sujono Hiromitsu Takayama Hiromitsu Takayama I Dewa Agung Panji Dwipayana I Nyoman Adi Winata Ihsanawati Ihsanawati Ikram M. Said Ilim Ilim Ilimu, Edi Iqbal M. Choudhary Jalifah Latip Jalifah Latip Joko Santoso Kholifatu Rosyidah Laily Bin Din Lia Dewi Juliawati Lia Dewi Juliawati Lia Dewi Juliawaty Lia Dewi Juliawaty Lia Dewi Juliawaty Liliasari Liliasari Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur M I Choudhary Marc Jeannin Mariko Katajima Mariko Kitajima Mariko Kitajima Marlia Singgih Marlia Singgih Marlia Singgih Masatake Niwa Melina Melina Muhamad Abdulkadir Martoprawiro Muhammad N. Jalaluddin Muhtadi Muhtadi Nanik Siti Aminah Nia Sri Hardianti Nila Berghuis Tamaela Nila Berghuis Tamaela, Nila Berghuis Nizar Happyana Nizar Happyana Nordin Hj Lajis Norio Aimi Norio Aimi Norio Aimi Noviany Noviany Nunuk H Soekamto Nunuk Hariani Soekamto Purkan Purkan Reza Aditama Rusjdi Tamin Sadijah Achmad Sahidin . Sahidin Sahidin Senadi Budiman Siti Nurbayti Siti Zubaidah Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Soerya Dewi Marliyana Sri Atun Suci Zulaikha Hildayani Sukrido Sukrido Suwandri Suwandri Suwandri Suwandri Tia Setiawati Tjodi Harlim Tri Cahyanto Valentina Adimurti Valentina Adimurti Kusumaningtyas Wasinton Simanjuntak Windayani, Neneng Yaya Rukayadi Yuliana, Trisna Zakaria Zakaria

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