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Striving for smoke-free families: Wives’ role in Gayo Lues, Aceh-Indonesia Saffutra, Hasrizal; Yahya, Mustanir; Rosemary, Rizanna; Indah, Rosaria; Syahrizal, Dedy
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1960

Smoking remains a prevalent habit in many households, particularly in regions where cultural norms strongly accept tobacco use. The aim of this study was to examine the influential role of wives in Gayo Lues, Aceh, Indonesia, in promoting smoking cessation within their families. Amidst cultural norms that widely accept smoking, these wives employed both persuasive and, occasionally, coercive methods to encourage healthier behaviors among family members. Utilizing a qualitative approach with Participatory Action Research (PAR), data were collected through in-depth interviews with seven wives who have firsthand experience with smoking behaviors in their families. The findings revealed that wives in Gayo Lues act as both health monitors and guardians, balancing emotional support with firm boundaries to foster a smoke-free home environment. Their roles extended beyond traditional caregiving, as they actively shape family health outcomes. In conclusion, this study underscored the importance of empowering wives as health advocates in public health efforts, particularly in culturally conservative settings. Future research could further explore the broader socio-cultural dynamics influencing wives’ health advocacy roles and assess the sustainability of these behaviors over time.

COMPARATIVE STUDY OF BLOOD GLUCOSE LEVELS AND THE DEGREE OF LIVER AND KIDNEY DAMAGE IN DIABETIC ANIMAL MODELS INDUCED BY ALLOXAN, STREPTOZOTOCIN, AND STREPTOZOTOCIN-NICOTINAMIDE Miswari, Irna; Husna, Fauzul; Zulkarnain, Zulkarnain; Syahrizal, Dedy; Syahputra, Andika Ari; Hasan, Denny Irmawati
Jurnal Kedokteran Hewan Vol 19, No 2 (2025): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i2.40839

The objective of this study was to assess differences in body weight, blood glucose levels, and liver and kidney tissue damage among rats induced with alloxan, streptozotocin, or streptozotocin-nicotinamide. This was an experimental study using a completely randomized design. The rats were allocated into four experimental groups. Group 1 (KN) was considered as the normal control group, while groups K1, K2, and K3 were induced with streptozotocin (60 mg/kg bw), alloxan (150 mg/kg bw), and nicotinamide (120 mg/kg bw) followed by streptozotocin (60 mg/kg bw), respectively. The compounds were administered intraperitoneally using suitable solvents. Body weight and blood glucose levels were monitored weekly. Upon completion of the study, liver and kidney tissues were harvested and processed for histopathological analysis using hematoxylin-eosin staining. The findings revealed that all diabetic induction models had significantly elevated blood glucose levels compared to the control group. Additionally, there were significantly differences (P0.05) in liver and kidney tissue damage among the groups treated with streptozotocin (STZ), alloxan, and STZnicotinamide. In conclusion, STZ induction produced more consistent hyperglycemia with less tissue damage compared to alloxan, while, nicotinamide co-administration effectively reduced cellular degeneration, suggesting its protective role against diabetes-induced tissue injury.

The Impact of Photoaging on Skin: A Systematic Review Analysis Asyi, Muhammad Shanan; Syahrizal, Dedy; Sary, Nirwana Lazuardi; Husna, Fauzul
Journal of Social Research Vol. 3 No. 1 (2023): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i1.1708

Aging of the skin is a complex biological process. The process of skin aging can be divided into two categories namely intrinsic and extrinsic aging. Intrinsic skin aging or natural aging is caused by changes in skin elasticity that occur with age. This type of aging cannot be prevented. While extrinsic skin aging is caused by environmental factors such as exposure to solar radiation (photoaging). In this study, the type of research approach used is a type of qualitative research through a literature review. The type of data used is the type of secondary data. Secondary data is a type of data obtained from certain parties or media indirectly, meaning that certain parties become intermediaries where they obtain and record these data beforehand. The aging process of the skin is influenced by intrinsic and extrinsic factors. The extrinsic factor that most influences the aging process of the skin is chronic sun exposure which is called photoaging. Sunlight contains 96% UVA and has the most significant biological effect compared to UVB and UVC. Several factors that affect photodamaging are skin type, pigmentation, and acclimatization. Skin changes that occur in photoaging include the presence of vesicles in the epidermis, reduced Langerhans cells, and enlarged and pale epidermal cells; in the dermis, there is an elastic mass; pigment changes in the form of dotted (irregular pigmentation) and hyperpigmentation.

Effect of Elastomull® elastic bandaging on second-degree burn wound healing in Wistar rats: A preliminary study Zulfachri, Naynuunis; Syahrizal, Dedy; Muhsin
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.194

Background: Second-degree burns are the most common burn injuries, requiring effective wound management to prevent complications. While silver sulfadiazine is the gold standard treatment, the role of elastic bandaging in enhancing healing remains unclear. Objective: To investigate the effectiveness of Elastomull® elastic bandaging combined with silver sulfadiazine in treating second-degree burns in Wistar rats. Methods: Six male Wistar rats were divided into two groups: K(+) group treated with silver sulfadiazine and Elastomull® bandaging, and K(-) group treated with silver sulfadiazine alone. Second-degree burns were induced using a 100°C iron applied for 5 seconds. Wound areas were measured every three days for 18 days and analyzed using Independent-Samples T-Test. Results: The K(+) group consistently showed smaller wound areas from day 3 onwards, with greater total healing (1.87 ± 0.25 cm²) compared to K(-) group (1.03 ± 0.53 cm²). However, differences were not statistically significant (p > 0.05). Conclusion: Elastomull® bandaging showed clinical trends toward improved burn healing but lacked statistical significance, likely due to small sample size. Larger studies are needed to confirm these findings.

Enhancing neuromuscular recovery after sciatic nerve injury using stem cell therapy: Evidence from a preliminary preclinical study Firlana, Cut R.; Emril, Dessy R.; Dedy Syahrizal; Sartika, Cynthia R.; Lestari, Nova D.; Habibie, Yopie A.
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3018

Sciatic nerve injury results in motor dysfunction and muscle atrophy, with limited effective therapies. Umbilical cord–derived mesenchymal stem cells (UC-MSCs) may promote neuromuscular recovery, but their effects on functional and muscle recovery remain unclear. This study aimed to evaluate the effects of UC-MSC therapy on functional and muscle recovery in an animal model of sciatic nerve injury. An animal experimental study with a post-test-only control group was conducted using adult male Wistar rats. Rats were randomly allocated into three groups: sham operation, saline control with sciatic nerve injury, and UC-MSC treatment after sciatic nerve injury. UC-MSCs were administered at a dose of 1×10⁶ cells/kg body weight immediately after nerve injury. Functional recovery was assessed using the extensor postural thrust (EPT) test, and muscle recovery was evaluated using the gastrocnemius muscle index (GMI) post 35 days of observation. Data were analyzed using one-way ANOVA for EPT percentage recovery and Kruskal–Wallis tests for GMI values, followed by post-hoc analysis. Our data indicated there was no significant EPT percentage recovery among the study groups. In contrast, relative gastrocnemius muscle mass was significantly different across groups (p=0.012), with post-hoc analysis demonstrating a significantly higher GMI in the UC-MSC group compared to the saline control group (109.75% vs 81.68%, p=0.003), indicating improved preservation of gastrocnemius muscle mass following UC-MSC therapy. This study highlights that UC-MSC therapy significantly improved gastrocnemius muscle preservation after sciatic nerve injury but did not result in detectable functional motor recovery at the observation time point. These findings suggest that UC-MSCs might exert early structural benefits that may precede functional recovery.

Enhancing neuromuscular recovery after sciatic nerve injury using stem cell therapy: Evidence from a preliminary preclinical study Firlana, Cut R.; Emril, Dessy R.; Dedy Syahrizal; Sartika, Cynthia R.; Lestari, Nova D.; Habibie, Yopie A.
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3018

Sciatic nerve injury results in motor dysfunction and muscle atrophy, with limited effective therapies. Umbilical cord–derived mesenchymal stem cells (UC-MSCs) may promote neuromuscular recovery, but their effects on functional and muscle recovery remain unclear. This study aimed to evaluate the effects of UC-MSC therapy on functional and muscle recovery in an animal model of sciatic nerve injury. An animal experimental study with a post-test-only control group was conducted using adult male Wistar rats. Rats were randomly allocated into three groups: sham operation, saline control with sciatic nerve injury, and UC-MSC treatment after sciatic nerve injury. UC-MSCs were administered at a dose of 1×10⁶ cells/kg body weight immediately after nerve injury. Functional recovery was assessed using the extensor postural thrust (EPT) test, and muscle recovery was evaluated using the gastrocnemius muscle index (GMI) post 35 days of observation. Data were analyzed using one-way ANOVA for EPT percentage recovery and Kruskal–Wallis tests for GMI values, followed by post-hoc analysis. Our data indicated there was no significant EPT percentage recovery among the study groups. In contrast, relative gastrocnemius muscle mass was significantly different across groups (p=0.012), with post-hoc analysis demonstrating a significantly higher GMI in the UC-MSC group compared to the saline control group (109.75% vs 81.68%, p=0.003), indicating improved preservation of gastrocnemius muscle mass following UC-MSC therapy. This study highlights that UC-MSC therapy significantly improved gastrocnemius muscle preservation after sciatic nerve injury but did not result in detectable functional motor recovery at the observation time point. These findings suggest that UC-MSCs might exert early structural benefits that may precede functional recovery.

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