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All Journal Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Indonesian Journal of Pharmaceutical Science and Technology Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Narra J Jurnal Kedokteran Hewan
Dedy Syahrizal
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Analysis of Differences between INA CBG’s Rates and Hospital Real Rates in Hemophilia Patients at RSUD Zainoel Abidin Banda Aceh Haslinur, Sari; Saputra, Irwan; Syahrizal, Dedy; Bakhtiar, Bakhtiar; Usman, Said
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 3, No 3 (2020): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v3i3.1107

Abstract

INA CBG’s rate is system of health financing packages from government based on cased and hospital services. Real tariff are the actual costs incurred by hospitals service based to local governments. During this time there are differences between INA CBGs rated and hospital rates. Hemophilia is a high-cost disease paid by INA CBGs. The aim of this study was to analyze the differences of INA CBGs and real rates in Hemophilia Patients at RSUDZA Banda Aceh. The research used quantitative analyticmethod. Data collection was carried out by taking secondary data from visits of hemophilia patients at RSUDZA in January-Desember 2019. The study population was all hemophilia patients in RSUDZA in 2019 with purpousive random sample of 100 people. There was a significant difference between INA CBGs rated and hospital rates rates in Hemophilia Patients at RSUDZA Banda Aceh.which indicated by p-value 0,000. Differences between INA CBGs and real rates of hospital are Rp.-431.095.538 or -25%. Differences of INA CBGs rated dan real rates causes’ hospital loss, but hospital needs to re-review the calculation of more efficient service cost to improve the quality of service.
Gambaran hasil spirometri pada wanita pedesaan Krueng Raya Dedy Syahrizal; Novita Andayani; Rahmi Aprilianti
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18500

Abstract

Abstrak. Pemeriksaan spirometri adalah pemeriksaan yang dilakukan untuk mengukur volume dan kapasitas paru-paru. Pemeriksaan ini bertujuan untuk mengetahui kapasitas vital, kapasitas vital paksa, volume ekspirasi paksa dalam satu detik dan aliran pernafasan maksimal. Tujuan pada penelitian ini adalah untuk melihat gambaran hasil spirometri pada wanita pedesaan Krueng Raya, keterkaitan dengan keadaan lingkungan Krueng Raya terdapat pelabuhan pertamina dan pabrik semen. Penelitian ini dilakukan di Puskesmas Masjid Raya Krueng Raya pada tanggal 30 Agustus sampai dengan 16 September 2019 terhadap 40 pasien. Metode sampling non probability sampling dengan teknik accidental sampling. Pemeriksaan dilakukan dengan menggunakan alat spirometri vitalograph dengan menganalisis interpretasi hasil pemeriksaan. Hasil analisis didapatkan pada penelitian ini melibatkan wanita Krueng Raya (100%) pemeriksaan spirometri didapatkan hasil normal sebanyak 42.5%, restriksi 47.5%, obstruksi 5% dan restriksi dan obstruksi 5%. Analisis yang dilakukan secara univariat untuk melihat gambaran hasil spirometri dengan pengaruh faktor lain seperti lingkungan, BMI dan kebiasaan lainnya. Kata Kunci: Hasil Spirometri, Fungsi Paru, VEP1, KVPAbstract. Spirometry examination is an examination carried out to measure the volume and capacity of the lungs. This examination aims to determine the vital capacity, forced vital capacity, forced expiratory volume in one second and maximum respiratory flow. The purpose of this study was to look at the description of spirometry results in rural women in Krueng Raya, the relationship with Krueng Raya's environmental conditions contained Pertamina ports and cement factories. The research was conducted at the Krueng Raya Masjid Raya Health Center on 30 August to 16 September 2019 on 40 patients. Non-probability sampling method with accidental sampling technique. The examination is carried out using a vitalograph spirometry tool by analyzing the interpretation of the results of the examination. The analysis results obtained in this study involved Krueng Raya women (100%) spirometry examination showed normal results of 42.5%, 47.5% restriction, obstruction of 5% and restriction and obstruction of 5%. Univariate analysis is done to see the spirometry results with the influence of other factors such as the environment, BMI and other habits. Keywords: Spirometry Results, Lung Function, FEV1, FVC
Helminthiasis prevalence in brick makers at Lambada Peukan Village, Aceh Besar Region, Indonesia Dedy Syahrizal; Cut Mustika; . Ikhsan; Mulkan Azhary
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (66.076 KB)

Abstract

Helminthiasis are the common health problem in the develop country. WHO prediction  400 million people had infection of helminthiasis. Soil is the usual media to transmitted helminth to human (soil transmitted helminthiasis). One of the rule worker that has hard contact  to helminth is the brick maker. This activity usual doing with convensional technique.The objective of  this devotion are to knowing helminthiasis prevalence on brick maker in Lambada Peukan Village. The primer data is the count of helminthiasis that get from feces examination in laboratory. This result overgo to promotive, preventive and curative activity.The helminthiasis prevalence in Lambada Peukan is 37,5%. To resolve this problem we doing the preventive and curative activity with giving albendazole preparat and Ferrum. Beside that we also make education activity to the workers. The aim of this activity is to increase need and ability of  the worker  to maintance from helminthiasis. The workers who in participated in this programme had having positive response that they want  to participated in all off this programme. 
Analysis of Perception Factors, Knowledge and Attitudes of Coffee Shop Visitors to the Risk of Spreading Covid -19 Ferdi Riansyah; Dedy Syahrizal; Said Usman; Mudatsir Mudatsir; Irwan Saputra
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.4090

Abstract

Corona Virus is a large family of viruses that are known to cause serious lung disease. The cause of the crowds is the activities carried out that can create a crowd of masses such as crowds of coffee shops, wedding parties, face-to-face schools, and whipping processions in public places. The purpose of this study was to determine the relationship between the characteristics of coffee shop visitors with perceptions, knowledge and attitudes, the spread of covid-19 in Banda Aceh City. This research was conducted using a quasi-questionnaire, with the method of Quantitative Analytical, with a cross sectional approach. The analysis carried out is the square test. This research has received approval from the Research Ethics Committee of the Faculty of Medicine, Syiah Kuala University RSUDZA with No: 067/EA/FK-RSUDZA/2021. The Chi square test showed that there was a relationship between the characteristics of coffee shop visitors and the last education with perception (p value = 0.002), knowledge (p value = 0.000), attitude (p value = 0.000), occupation with knowledge (p value = 0.049), and place Stay with the attitude (p value = 0.040) the spread of covid-19 in Banda Aceh City. The results of the Chi square test also obtained a non-significant value between age and perception (p value = 0.160), knowledge (p value = 0.059), attitude (p value = 0.262), gender and perception (p value = 0.148), knowledge (p value = 0.182), attitude (p value = 0.065), between work and perception (p value = 0.147), attitude (p value = 0.207), between residence and perception (p value = 0.481), knowledge (p value = 0.240), the spread of covid-19 in Banda Aceh City. There is a relationship between the characteristics of the last education with perceptions, knowledge and attitudes, work with knowledge and residence with attitudes. There is no relationship between age characteristics with perceptions, knowledge and attitudes, gender with perceptions of knowledge and attitudes, work with perceptions and attitudes, residence with perceptions and knowledge of the spread of covid 19 in Banda Aceh City.
Perbandingan risiko fraktur berdasarkan Indeks Singh dan Fracture Risk Assessment pada penderita autoimun yang mendapat terapi steroid di RSUD dr. Zainoel Abidin Banda Aceh Dytha Putri Harwani; Maryatun Hasan; Dedy Syahrizal; Safrizal Rahman; Suryawati Suryawati
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.31127

Abstract

Abstrak. Penyakit autoimun adalah sekelompok penyakit yang ditandai dengan tidak berfungsinya sistem kekebalan tubuh yang menyebabkan hilangnya toleransi terhadap antigen diri sendiri. Penggunaan steroid jangka panjang menyebabkan efek yang kompleks terhadap tulang. Patah tulang belakang dan tulang pinggul merupakan karakteristik dari osteoporosis yang diinduksi oleh steroid. Metode yang relatif mudah untuk dilakukan dan cukup akurat untuk melihat risiko fraktur adalah menggunakan Indeks Singh pada foto polos panggul dan penilaian menggunakan kuesioner Fracture Risk Assessment (FRAX). Tujuan penelitian ini adalah untuk mengetahui perbandingan risiko fraktur berdasarkan Indeks Singh dan FRAX pada penderita autoimun yang mendapat terapi steroid. Jenis penelitian ini adalah analitik obervasional dengan desain cross sectional, dilaksanakan di RSUD dr. Zainoel Abidin, Banda Aceh, pada bulan Desember 2020 hingga Januari 2021 dengan teknik purposive sampling. Hasil penelitian didapatkan dari 45 responden, sebanyak 35 orang (77,8%) mengalami Osteopenia (Grade 4-5) berdasarkan Indeks Singh dan sebanyak 42 pasien (93,3%) mengalami risiko fraktur rendah berdasarkan penilaian FRAX score. Hasil analisis bivariat menggunakan uji Chi Square didapatkan P value=0,000, yang menunjukkan terdapat perbedaan risiko fraktur antara penilaian menggunakan metode Indeks Singh dan metode FRAX score pada penderita autoimun yang mendapat terapi steroid di RSUD dr. Zainoel Abidin Banda Aceh.   Kata kunci: Penyakit Autoimun, Steroid, Risiko Fraktur, Indeks Singh, FRAX Score Abstract. Autoimmune disease is a group of diseases characterized by improper immune system. This condition causes the body to lose its tolerance to its own antigen. The use of steroid over a long period of time can affect the bones. Spinal and pelvic bone fracture are the characteristic of steroid-induced osteoporosis. The accurate and easily used method to see the risk factors of having bone fracture is by using Singh Index based on the result of pelvic bone x-ray, and by using FRAX questionnaire. This study aims to compare the risk factors of having bone fracture by using Singh index and FRAX score on patients with autoimmune diseases that were prescribed with steroid therapy. This is an analytical observational study with cross-sectional design. This study was carried out in Zainoel Abidin Hospital, Banda Aceh, from December 2020 to January 2021 with purposive sampling method. The result of this study with 45 respondents found that 35 patiens (77,8%) had osteopenia (Grade 4-5) based on the Singh Index and 42 patiens (93,3%) had low fracture risk based on the FRAX score. The result of bivariate analysis using the Chi-Square test obtained P value=0.000, which indicated that there was a difference in fracture risk between assessments using the Singh Index method and the FRAX score method in autoimmune patients receiving steroid therapy at Zainoel Abidin Hospital, Banda Aceh. Keywords: autoimmune disease, steroid, risk for bone fracture, Singh index, FRAX score 
Antioxidant and antiaging activity of Cinnamomum burmannii and Michelia champaca extract and combinations Qarani, Waisul; Husna, Fauzul; Yulia, Winda; Zulkarnain, Zulkarnain; Syahrizal, Dedy; Gani, Basri A.; Sary, Nirwana L.; Wardhani, Bantari WK.
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.111

Abstract

Aging is a natural skin process that occurs due to intrinsic and extrinsic factors, such as excessive exposure to ultraviolet light (photoaging). The mechanism of damage involves the production of excess free radicals that trigger oxidative stress in the skin. Determining the natural products that have high antioxidant activities as antiaging is up most important. Cinnamomum burmannii and Michelia champaca are typical Aceh plants that are believed to have high antioxidant effects. The aim of this study was to determining the contents of C. burmannii and M. champaca as well as to determine the antioxidant and antiaging activities of either individually or combinations. The qualitative phytochemical and semi-quantitative analysis of the extracts were conducted using gas chromatography and mass spectroscopy (GC-MS). The antioxidant activity was examined by radical scavenging using the DPPH radical while the antiaging activity was tested the tyrosinase enzyme inhibition test. The phenolic and flavonoid contents of C. burmannii were higher than M. champaca (66.34 vs 24.71 mg gallic acid equivalent/gr) and (80.52 vs 60.20 mg quercetin equivalent/gr). The inhibitory concentration (IC₅₀) of M. champaca extract in inhibiting DPPH indicated that M. champaca had a better antioxidant activity than C. burmannii. The combination of C. burmannii and M. champaca extracts had a lower IC₅₀ compared to M. champaca alone. C. burmannii and M. champaca extract had a weak potential to inhibit tyrosinase activity (IC₅₀ value ≥1000 µg/mL). In conclusion, this study indicates that M. champaca and C. burmannii have strong antioxidant activities and these might associate with polyphenol contents.
Effect of umbilical cord mesenchymal stem cells on hypoxia-inducible factor-1 alpha (HIF-1α) production in arteriovenous fistula (AVF) animal model: A preliminary study Habibie, Yopie A.; Emril, Dessy R.; Azharuddin, Azharuddin; Syahrizal, Dedy
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.225

Abstract

Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that plays a crucial role in cellular responses to hypoxia, such as in the development of intimal hyperplasia, a common complication in arteriovenous fistula (AVF) creation. While the application of umbilical cord mesenchymal stem cells (UC-MSCs) has shown promise in various regenerative medicine applications, including tissue repair and angiogenesis, the effect of UC-MSCs on HIF-1α level in the AVF has not been tested. Therefore, the aim of this study was to evaluate the effect of UC-MSCs administration on HIF-1α levels in the AVF animal model. An experimental study was conducted on 28 local male rabbits (Lepus domestica) using a post-test-only design. The rabbits were divided randomly into four groups: normal rabbit group (negative control), placebo-treated AVF rabbit group (positive control), AVF rabbits treated with in-situ UC-MSCs injection (one dose, 106 UC-MSCs/kg body weight), and AVF rabbits treated with intravenous UC-MSCs (one dose, 106 UC-MSCs/kg body weight (BW). HIF-1α level was measured using ELISA method after 28 days post- treatment. All data were analyzed using the one-way analysis of variance (ANOVA) and continued with the Duncan’s post-hoc test. The data indicated that the levels of HIF-1α were different among all four groups (p<0.001). The post-hoc analysis revealed that the HIF-1α levels in both UC-MSC treated groups were significantly lower compared to untreated AVF rabbits(p<0.05). This study suggests that UC-MSCs could be a promising therapy to prevent and reduce intimal hyperplasia in AVF.
Effect of black garlic (Allium sativum) on gonadosomatic index, follicle-stimulating hormone level and spermatozoa quality: A study in monosodium glutamate-exposed rat model Bani, Ika I.; Zulkarnain, Zulkarnain; Gholib, Gholib; Syahrizal, Dedy; Nugraha, Taufiq P.; Ramadhan, Akmal; Akmal, Muslim; Maulina, Nora
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.617

Abstract

Infertility rates have risen significantly, one of which is due to monosodium glutamate (MSG) consumption. Recent studies have shown that flavonoids in black garlic (Allium sativum) act as antioxidants. The aim of this study was to assess the effect of black garlic extract (BGE) on gonadosomatic index, follicle-stimulating hormone (FSH) levels, and spermatozoa quality in rats exposed to MSG. Twenty-five healthy rats, aged ten to twelve weeks, were divided equally into five experimental groups: (1) negative control (NC), no intervention; (2) positive control (PC), fed with MSG 8 mg/kg; and (3) fed with MSG + BGE 200 mg/kg; (4) fed with MSG + BGE 400 mg/kg; and (5) fed with MSG + BGE 600 mg/kg. Oral MSG was administered once a day for two weeks before BGE administration was started for two weeks. The measured endpoints were gonadosomatic index, FSH levels, and spermatozoa concentration and quality (spermatozoa motility and abnormality). Analysis of variance (ANOVA) followed by Duncan's post hoc analysis was used to assess the measurement differences. The result suggested that the administration of BGE did not significantly affect the gonadosomatic index (p=0.513). Significant decreases in FSH levels (p=0.005) and spermatozoa concentration were observed in the PC group compared to other groups (p<0.001). Additionally, spermatozoa motility was significantly lower in the PC group compared to NC, BGE200, BGE400, and BGE600 (p<0.001), with higher motility noted in BGE200, BGE400, and BGE600 compared to PC (p<0.001). Furthermore, PC had significantly higher spermatozoa abnormalities compared to NC, BGE200, BGE400, and BGE600 (p<0.001). In conclusion, administration of BGE had a significant effect on the improvement of FSH levels and the quality of spermatozoa in rats exposed to MSG.
Antioxidant Potential, Anti-Diabetes, and Toxicity of Aceh Cinnamon Extract (Cinnamomum burmannii) Husna, Fauzul; Suhaila, Suhaila; Syahrizal, Dedy; Zulkarnain, Zulkarnain; Washilah, Hasya; Sahriana, Ananda Putri
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.43182

Abstract

Indonesia as a mega biodiversity country must take a role in the development of herbal-based medicine. Cinnamon is often used empirically to overcome various health problems, especially diabetes.   This study aims to assess the effectiveness of Aceh cinnamon extract as an antioxidant and antidiabetic in vitro and to evaluate the toxicity of the extract. Cinnamons, obtained from coffee plantations in Simpang Teritit, Bener Meriah, Aceh, were macerated with 96% ethanol for extraction.  Furthermore, the extract phytochemical content was determined qualitatively, semiquantitatively (GC-MS), and quantitatively (levels of phenols, flavonoids, and total tannins).  The toxicity level was measured by an acute toxicity test based on the OECD and the BSLT assay.  The effectiveness as an antioxidant and anti-diabetes was determined in vitro by the DPPH inhibition method and α-glucosidase inhibition. The results of this study showed that cinnamon extract contains alkaloids, flavonoids, polyphenols, tannins, quinones, saponins, and triterpenoid compounds. The total amount of phenol, flavonoid, and tannin extract levels were 66.34 mg GAE/gr, 80.52 mg QE/gr, and 566.33 mg AT/gr. The IC50 extract value against DPPH was 16.07 ppm and against the enzyme, α-glucosidase was 123.52 ppm. In the acute toxicity test, the value of LD50 ≥15 grkg BWW was obtained and in the toxicity test with BSLT, LC50 extract was 350.57 ppm. Aceh cinnamon extract (Cinnamomum burmannii) has LD50 > 15 gr/kg BW and LC50 value >500 ppp which is categorized as a practically non-toxic ingredient and low toxicity agent with strong antioxidant activity and moderate antidiabetics.
Efisiensi ICU Rumah Sakit Pemerintah Dengan Metode Data Envelopment Analysis (DEA) Salsabila, Hilwa; Saputra, Irwan; Syahrizal, Dedy; Zaman, Nasrul; Usman, Said
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 10, No 1 (2024): JMK Yayasan RS.Dr.Soetomo, Pertama 2024
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29241/jmk.v10i1.1814

Abstract

Efficiency defined by optimizing any resources which used to produce an output in a maximal level. Since INA-CBG was applied to hospital payment system, hospital was forced to keep the resources that used for producing process is less than the cost of National Health Assurance. Intensive Care Unit (ICU) is a ward needed advanced technology. qualified human resources, and high cost. Thus, ICU should be concern about their efficiency. Aim of this study is to measure the efficiency of the ICU at a public hospital. This is a quantitative study with a cross-sectional design. The study was conduct at type A public hospital in Banda Aceh, Aceh Province, Indonesia. We include six units of intensive care such as MICU, CSICU, ICCU, PICU, NICU, RICU. Data Envelopment Analysis (DEA) model is used to measure the efficiency at period 2022. DEA measurement performed by MAXDEA Lite 2.0. Results: ICU, CSICU, ICCU, PICU, and RICU efficiency score was one (efficient), while NICU was 0,87 (inefficient). Conclusion of the study that MICU, CSICU, ICCU, PICU, and RICU are efficient. NICU are not efficient.
Co-Authors . Ikhsan Azharuddin Azharuddin, Azharuddin Bakhtiar Bakhtiar Bani, Ika I. Basri A. Gani, Basri A. Cut Mustika Dytha Putri Harwani Emril, Dessy R. Ferdi Riansyah Gholib Gholib, Gholib Habibie, Yopie A. Hasan, Denny Irmawati Haslinur, Sari Husna, Fauzul Irwan Saputra Maryatun Hasan Miswari, Irna Mudatsir Mudatsir Mulkan Azhary Muslim Akmal Nora Maulina, Nora Novita Andayani Qarani, Waisul Rahmi Aprilianti Ramadhan, Akmal Rizanna Rosemary Rosaria Indah Saffutra, Hasrizal Safrizal Rahman Sahriana, Ananda Putri Said Usman Salsabila, Hilwa Saputra, Irwan Sary, Nirwana L. Suhaila, Suhaila Suryawati Suryawati Syahputra, Andika Ari Taufiq P. Nugraha, Taufiq P. Usman, Said Wardhani, Bantari WK. Washilah, Hasya Winda Yulia Yahya, Mustanir Zaman, Nasrul Zulkarnain Zulkarnain